ERA - ECOLI - GREMLIN Contacts

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ERA - GTPase Era

UniProt:	P06616	Sequences: MSIDKSYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGAYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLREGKAPVILAVNKVDNVQEKADLLPHLQFLASQMNFLDIVPISAETGLNVDTIAAIVRKHLPEATHHFPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVSNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDDL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10270
Length:	301 (259)
Sequences:	7288 (5401)
Seq/√Len:	335.6

ECOLI - ERA YFJP YKFA CRFC DER MNME ENGB HFLX FEOB
BACSU - ERA YPBR DER ENGB MNME HFLX
HALSA - Q9HQ88 Q9HMC2 Q9HMD6 ENGB
SULSO - HFLX Q7LXR6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_Y	170_R	3.093	1.00
93_I	122_A	2.864	1.00
150_D	168_I	2.762	1.00
27_K	159_G	2.649	1.00
140_Q	143_A	2.610	1.00
48_V	59_I	2.432	1.00
259_I	263_K	2.422	1.00
265_M	269_F	2.392	1.00
152_V	168_I	2.336	1.00
168_I	171_K	2.335	1.00
141_F	145_Q	2.333	1.00
219_E	234_L	2.324	1.00
201_K	264_D	2.322	1.00
178_H	182_E	2.275	1.00
98_G	123_V	2.263	1.00
256_T	260_E	2.233	1.00
13_I	25_L	2.191	1.00
27_K	162_V	2.187	1.00
168_I	172_H	2.025	1.00
198_I	233_G	1.985	1.00
140_Q	144_S	1.981	1.00
141_F	144_S	1.980	1.00
258_G	262_R	1.915	1.00
99_T	128_N	1.893	1.00
24_L	95_V	1.884	1.00
13_I	93_I	1.840	1.00
138_H	141_F	1.808	1.00
93_I	169_V	1.802	1.00
106_E	145_Q	1.801	1.00
224_N	230_D	1.793	1.00
139_L	153_P	1.784	1.00
125_K	128_N	1.737	1.00
122_A	165_I	1.715	1.00
24_L	28_L	1.697	1.00
91_L	169_V	1.688	1.00
93_I	165_I	1.654	1.00
122_A	154_I	1.634	1.00
79_N	82_A	1.612	1.00
53_E	170_R	1.601	1.00
124_N	156_A	1.586	1.00
94_F	109_L	1.586	1.00
202_L	206_L	1.578	1.00
12_A	89_V	1.572	1.00
211_P	214_V	1.571	1.00
202_L	214_V	1.564	1.00
262_R	266_Q	1.562	1.00
129_V	135_L	1.543	1.00
210_L	214_V	1.536	1.00
11_I	58_A	1.530	1.00
209_E	212_Y	1.528	1.00
28_L	162_V	1.512	1.00
121_L	148_F	1.487	1.00
135_L	138_H	1.480	1.00
209_E	213_S	1.476	1.00
229_Y	271_A	1.475	1.00
190_Q	197_I	1.467	1.00
260_E	263_K	1.444	1.00
120_I	172_H	1.437	1.00
220_R	232_N	1.435	1.00
106_E	110_N	1.434	1.00
240_E	244_K	1.421	1.00
247_I	251_G	1.413	1.00
202_L	205_F	1.410	1.00
223_S	271_A	1.406	1.00
83_S	111_K	1.406	1.00
72_R	75_N	1.394	1.00
55_A	170_R	1.391	1.00
23_T	156_A	1.391	1.00
229_Y	269_F	1.384	1.00
204_R	207_G	1.375	1.00
24_L	154_I	1.370	1.00
130_Q	160_L	1.370	1.00
134_D	138_H	1.369	1.00
263_K	267_E	1.367	1.00
212_Y	216_V	1.362	1.00
43_T	49_G	1.352	1.00
191_R	194_A	1.352	1.00
213_S	242_Q	1.351	1.00
95_V	124_N	1.350	1.00
121_L	149_L	1.346	1.00
16_R	105_D	1.345	1.00
91_L	172_H	1.342	1.00
51_H	166_A	1.336	1.00
163_D	167_A	1.332	1.00
205_F	260_E	1.300	1.00
139_L	143_A	1.287	1.00
103_P	107_M	1.283	1.00
189_S	193_M	1.273	1.00
23_T	36_T	1.272	1.00
16_R	102_T	1.259	1.00
109_L	112_L	1.256	1.00
120_I	168_I	1.238	1.00
201_K	204_R	1.237	1.00
241_G	245_M	1.232	1.00
25_L	60_Y	1.226	1.00
196_E	199_R	1.222	1.00
110_N	114_E	1.210	1.00
109_L	113_R	1.208	1.00
96_V	121_L	1.201	1.00
50_I	57_Q	1.199	1.00
188_R	192_F	1.199	1.00
161_N	164_T	1.198	1.00
164_T	168_I	1.193	1.00
143_A	151_I	1.190	1.00
243_K	247_I	1.186	1.00
28_L	166_A	1.182	1.00
213_S	217_E	1.172	1.00
16_R	104_D	1.172	1.00
101_W	106_E	1.171	1.00
150_D	172_H	1.168	1.00
119_V	149_L	1.164	1.00
208_A	214_V	1.159	1.00
162_V	166_A	1.159	1.00
186_T	191_R	1.156	1.00
123_V	139_L	1.153	1.00
232_N	236_L	1.150	1.00
108_V	112_L	1.141	1.00
192_F	196_E	1.134	1.00
105_D	108_V	1.134	1.00
205_F	256_T	1.122	1.00
192_F	195_S	1.114	1.00
208_A	211_P	1.110	1.00
206_L	210_L	1.098	1.00
189_S	192_F	1.097	1.00
136_L	139_L	1.096	1.00
194_A	221_F	1.091	1.00
203_M	212_Y	1.090	1.00
188_R	193_M	1.078	1.00
190_Q	193_M	1.078	1.00
137_P	140_Q	1.073	1.00
208_A	212_Y	1.073	1.00
194_A	265_M	1.067	1.00
194_A	198_I	1.067	1.00
203_M	207_G	1.064	1.00
53_E	166_A	1.059	1.00
110_N	113_R	1.055	1.00
52_T	178_H	1.050	1.00
242_Q	245_M	1.043	1.00
211_P	215_T	1.041	1.00
137_P	141_F	1.040	1.00
253_K	256_T	1.039	1.00
53_E	56_Y	1.036	1.00
24_L	165_I	1.036	1.00
200_E	204_R	1.029	1.00
189_S	196_E	1.026	1.00
216_V	219_E	1.026	1.00
91_L	120_I	1.023	1.00
126_V	153_P	1.022	1.00
11_I	169_V	1.020	1.00
205_F	209_E	1.019	1.00
68_M	104_D	1.010	1.00
181_P	184_Y	1.008	1.00
255_K	259_I	1.004	1.00
195_S	198_I	1.004	1.00
209_E	214_V	1.003	1.00
28_L	51_H	1.000	1.00
167_A	171_K	0.999	1.00
164_T	167_A	0.998	1.00
123_V	153_P	0.987	1.00
216_V	220_R	0.987	1.00
120_I	150_D	0.985	1.00
190_Q	194_A	0.983	1.00
252_A	256_T	0.983	1.00
261_A	265_M	0.979	1.00
201_K	205_F	0.977	1.00
97_E	124_N	0.973	1.00
203_M	206_L	0.967	1.00
103_P	106_E	0.965	1.00
186_T	190_Q	0.962	1.00
111_K	114_E	0.960	1.00
135_L	139_L	0.954	1.00
152_V	161_N	0.952	1.00
195_S	199_R	0.948	1.00
204_R	208_A	0.943	1.00
191_R	195_S	0.943	1.00
193_M	197_I	0.938	1.00
97_E	125_K	0.937	1.00
244_K	254_I	0.935	1.00
126_V	129_V	0.931	1.00
119_V	146_M	0.928	1.00
247_I	254_I	0.922	1.00
25_L	29_L	0.922	1.00
67_H	75_N	0.918	1.00
218_I	224_N	0.910	1.00
24_L	162_V	0.901	1.00
29_L	51_H	0.900	1.00
166_A	169_V	0.899	1.00
239_R	242_Q	0.898	1.00
240_E	243_K	0.880	1.00
77_L	81_A	0.878	1.00
142_L	145_Q	0.872	1.00
43_T	48_V	0.870	1.00
217_E	220_R	0.868	1.00
159_G	162_V	0.868	1.00
108_V	111_K	0.867	1.00
138_H	142_L	0.859	1.00
218_I	233_G	0.859	1.00
202_L	210_L	0.851	1.00
94_F	112_L	0.847	1.00
261_A	264_D	0.846	1.00
238_E	242_Q	0.845	1.00
52_T	55_A	0.844	1.00
250_K	254_I	0.842	1.00
132_K	135_L	0.842	1.00
233_G	238_E	0.842	1.00
113_R	145_Q	0.841	1.00
43_T	50_I	0.839	1.00
77_L	80_K	0.835	1.00
107_M	111_K	0.835	1.00
214_V	218_I	0.835	1.00
215_T	219_E	0.834	1.00
149_L	172_H	0.829	1.00
120_I	152_V	0.829	1.00
251_G	254_I	0.826	1.00
185_I	189_S	0.825	1.00
97_E	100_R	0.821	1.00
43_T	46_R	0.818	1.00
219_E	222_V	0.818	1.00
81_A	86_I	0.808	1.00
69_E	75_N	0.806	1.00
139_L	142_L	0.802	1.00
73_A	76_R	0.800	1.00
134_D	137_P	0.798	1.00
237_V	241_G	0.783	1.00
113_R	147_N	0.781	1.00
197_I	265_M	0.780	1.00
189_S	194_A	0.774	1.00
257_I	261_A	0.772	1.00
52_T	57_Q	0.769	1.00
37_S	204_R	0.764	1.00
121_L	151_I	0.759	1.00
243_K	250_K	0.753	1.00
38_R	204_R	0.746	0.99
51_H	60_Y	0.745	0.99
230_D	234_L	0.743	0.99
202_L	207_G	0.742	0.99
227_G	231_I	0.740	0.99
241_G	244_K	0.739	0.99
248_G	251_G	0.737	0.99
45_H	192_F	0.735	0.99
207_G	214_V	0.728	0.99
255_K	258_G	0.727	0.99
205_F	208_A	0.723	0.99
233_G	236_L	0.723	0.99
11_I	91_L	0.720	0.99
247_I	250_K	0.719	0.99
206_L	217_E	0.718	0.99
205_F	217_E	0.712	0.99
80_K	84_S	0.704	0.99
29_L	33_I	0.703	0.99
236_L	240_E	0.702	0.99
224_N	228_G	0.701	0.99
228_G	231_I	0.697	0.99
206_L	214_V	0.697	0.99
254_I	258_G	0.692	0.99
245_M	248_G	0.690	0.99
165_I	169_V	0.690	0.99
166_A	170_R	0.686	0.99
122_A	153_P	0.682	0.99
105_D	109_L	0.681	0.99
53_E	167_A	0.680	0.99
263_K	266_Q	0.679	0.99
104_D	107_M	0.677	0.99
250_K	256_T	0.677	0.99
245_M	249_N	0.677	0.99
123_V	138_H	0.675	0.99
220_R	224_N	0.675	0.99
19_V	123_V	0.666	0.99
192_F	197_I	0.662	0.99
12_A	92_V	0.651	0.99
170_R	173_L	0.651	0.99
92_V	119_V	0.646	0.99
258_G	261_A	0.645	0.99
75_N	79_N	0.642	0.98
16_R	19_V	0.639	0.98
25_L	49_G	0.638	0.98
62_D	65_G	0.638	0.98
107_M	110_N	0.630	0.98
129_V	137_P	0.628	0.98
267_E	270_E	0.627	0.98
24_L	156_A	0.626	0.98
94_F	119_V	0.624	0.98
249_N	252_A	0.622	0.98
60_Y	166_A	0.622	0.98
243_K	248_G	0.622	0.98
118_P	149_L	0.619	0.98
102_T	105_D	0.615	0.98
167_A	170_R	0.615	0.98
181_P	186_T	0.613	0.98
95_V	154_I	0.613	0.98
102_T	107_M	0.611	0.98
188_R	196_E	0.610	0.98
234_L	237_V	0.609	0.98
219_E	223_S	0.608	0.98
185_I	190_Q	0.606	0.98
205_F	213_S	0.605	0.98
244_K	248_G	0.604	0.98
229_Y	233_G	0.603	0.98
221_F	269_F	0.601	0.98
218_I	222_V	0.600	0.98
214_V	221_F	0.599	0.98
126_V	160_L	0.598	0.98
19_V	97_E	0.597	0.98
99_T	123_V	0.596	0.98
207_G	211_P	0.595	0.97
51_H	58_A	0.594	0.97
61_V	88_D	0.592	0.97
238_E	241_G	0.591	0.97
233_G	237_V	0.591	0.97
17_P	40_A	0.590	0.97
214_V	222_V	0.587	0.97
163_D	166_A	0.586	0.97
203_M	217_E	0.584	0.97
212_Y	221_F	0.583	0.97
98_G	126_V	0.583	0.97
251_G	255_K	0.583	0.97
93_I	120_I	0.579	0.97
221_F	225_E	0.578	0.97
248_G	254_I	0.578	0.97
54_G	178_H	0.576	0.97
217_E	236_L	0.575	0.97
94_F	108_V	0.574	0.97
136_L	140_Q	0.572	0.97
78_M	81_A	0.571	0.97
251_G	262_R	0.569	0.97
190_Q	195_S	0.568	0.97
68_M	78_M	0.567	0.97
206_L	216_V	0.567	0.97
66_L	82_A	0.566	0.97
44_R	49_G	0.562	0.96
228_G	232_N	0.561	0.96
66_L	69_E	0.561	0.96
127_D	155_S	0.560	0.96
16_R	67_H	0.559	0.96
232_N	235_I	0.557	0.96
247_I	252_A	0.557	0.96
199_R	202_L	0.556	0.96
243_K	246_V	0.556	0.96
19_V	105_D	0.556	0.96
256_T	259_I	0.551	0.96
230_D	233_G	0.551	0.96
248_G	255_K	0.550	0.96
112_L	115_G	0.550	0.96
50_I	59_I	0.549	0.96
242_Q	247_I	0.549	0.96
126_V	135_L	0.547	0.96
243_K	257_I	0.547	0.96
113_R	146_M	0.547	0.96
38_R	41_Q	0.546	0.96
213_S	216_V	0.543	0.96
243_K	249_N	0.543	0.96
258_G	266_Q	0.543	0.96
37_S	41_Q	0.543	0.96
242_Q	248_G	0.541	0.96
191_R	198_I	0.540	0.96
259_I	262_R	0.539	0.96
239_R	250_K	0.539	0.96
244_K	247_I	0.536	0.95
210_L	213_S	0.535	0.95
172_H	176_A	0.535	0.95
170_R	174_P	0.534	0.95
216_V	225_E	0.532	0.95
208_A	217_E	0.531	0.95
264_D	268_M	0.528	0.95
247_I	255_K	0.528	0.95
239_R	243_K	0.524	0.95
183_D	187_D	0.524	0.95
74_I	77_L	0.523	0.95
67_H	82_A	0.523	0.95
33_I	49_G	0.523	0.95
202_L	209_E	0.521	0.95
261_A	266_Q	0.520	0.95
98_G	138_H	0.519	0.95
25_L	34_S	0.519	0.95
257_I	262_R	0.518	0.95
242_Q	254_I	0.515	0.94
29_L	49_G	0.512	0.94
220_R	230_D	0.511	0.94
12_A	63_T	0.510	0.94
253_K	257_I	0.509	0.94
243_K	254_I	0.507	0.94
206_L	213_S	0.506	0.94
205_F	214_V	0.504	0.94
237_V	242_Q	0.504	0.94
143_A	150_D	0.503	0.94
171_K	175_E	0.502	0.94
158_T	161_N	0.502	0.94
131_E	160_L	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1egaA	2	0.9734	100	0.331	Contact Map
1wf3A	1	0.9668	100	0.347	Contact Map
3ievA	1	0.9801	100	0.358	Contact Map
2j69A	1	0.9701	100	0.454	Contact Map
4aurA	1	0.9767	100	0.504	Contact Map
3a1sA	1	0.8439	100	0.52	Contact Map
4dcuA	1	0.8272	100	0.525	Contact Map
1mkyA	1	0.794	100	0.526	Contact Map
3j8gX	1	0.8571	100	0.527	Contact Map
3geeA	2	0.6877	100	0.532	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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