GREMLIN Database
ERA - GTPase Era
UniProt: P06616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10270
Length: 301 (259)
Sequences: 7288 (5401)
Seq/√Len: 335.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_Y170_R3.0931.00
93_I122_A2.8641.00
150_D168_I2.7621.00
27_K159_G2.6491.00
140_Q143_A2.6101.00
48_V59_I2.4321.00
259_I263_K2.4221.00
265_M269_F2.3921.00
152_V168_I2.3361.00
168_I171_K2.3351.00
141_F145_Q2.3331.00
219_E234_L2.3241.00
201_K264_D2.3221.00
178_H182_E2.2751.00
98_G123_V2.2631.00
256_T260_E2.2331.00
13_I25_L2.1911.00
27_K162_V2.1871.00
168_I172_H2.0251.00
198_I233_G1.9851.00
140_Q144_S1.9811.00
141_F144_S1.9801.00
258_G262_R1.9151.00
99_T128_N1.8931.00
24_L95_V1.8841.00
13_I93_I1.8401.00
138_H141_F1.8081.00
93_I169_V1.8021.00
106_E145_Q1.8011.00
224_N230_D1.7931.00
139_L153_P1.7841.00
125_K128_N1.7371.00
122_A165_I1.7151.00
24_L28_L1.6971.00
91_L169_V1.6881.00
93_I165_I1.6541.00
122_A154_I1.6341.00
79_N82_A1.6121.00
53_E170_R1.6011.00
124_N156_A1.5861.00
94_F109_L1.5861.00
202_L206_L1.5781.00
12_A89_V1.5721.00
211_P214_V1.5711.00
202_L214_V1.5641.00
262_R266_Q1.5621.00
129_V135_L1.5431.00
210_L214_V1.5361.00
11_I58_A1.5301.00
209_E212_Y1.5281.00
28_L162_V1.5121.00
121_L148_F1.4871.00
135_L138_H1.4801.00
209_E213_S1.4761.00
229_Y271_A1.4751.00
190_Q197_I1.4671.00
260_E263_K1.4441.00
120_I172_H1.4371.00
220_R232_N1.4351.00
106_E110_N1.4341.00
240_E244_K1.4211.00
247_I251_G1.4131.00
202_L205_F1.4101.00
223_S271_A1.4061.00
83_S111_K1.4061.00
72_R75_N1.3941.00
55_A170_R1.3911.00
23_T156_A1.3911.00
229_Y269_F1.3841.00
204_R207_G1.3751.00
24_L154_I1.3701.00
130_Q160_L1.3701.00
134_D138_H1.3691.00
263_K267_E1.3671.00
212_Y216_V1.3621.00
43_T49_G1.3521.00
191_R194_A1.3521.00
213_S242_Q1.3511.00
95_V124_N1.3501.00
121_L149_L1.3461.00
16_R105_D1.3451.00
91_L172_H1.3421.00
51_H166_A1.3361.00
163_D167_A1.3321.00
205_F260_E1.3001.00
139_L143_A1.2871.00
103_P107_M1.2831.00
189_S193_M1.2731.00
23_T36_T1.2721.00
16_R102_T1.2591.00
109_L112_L1.2561.00
120_I168_I1.2381.00
201_K204_R1.2371.00
241_G245_M1.2321.00
25_L60_Y1.2261.00
196_E199_R1.2221.00
110_N114_E1.2101.00
109_L113_R1.2081.00
96_V121_L1.2011.00
50_I57_Q1.1991.00
188_R192_F1.1991.00
161_N164_T1.1981.00
164_T168_I1.1931.00
143_A151_I1.1901.00
243_K247_I1.1861.00
28_L166_A1.1821.00
213_S217_E1.1721.00
16_R104_D1.1721.00
101_W106_E1.1711.00
150_D172_H1.1681.00
119_V149_L1.1641.00
208_A214_V1.1591.00
162_V166_A1.1591.00
186_T191_R1.1561.00
123_V139_L1.1531.00
232_N236_L1.1501.00
108_V112_L1.1411.00
192_F196_E1.1341.00
105_D108_V1.1341.00
205_F256_T1.1221.00
192_F195_S1.1141.00
208_A211_P1.1101.00
206_L210_L1.0981.00
189_S192_F1.0971.00
136_L139_L1.0961.00
194_A221_F1.0911.00
203_M212_Y1.0901.00
188_R193_M1.0781.00
190_Q193_M1.0781.00
137_P140_Q1.0731.00
208_A212_Y1.0731.00
194_A265_M1.0671.00
194_A198_I1.0671.00
203_M207_G1.0641.00
53_E166_A1.0591.00
110_N113_R1.0551.00
52_T178_H1.0501.00
242_Q245_M1.0431.00
211_P215_T1.0411.00
137_P141_F1.0401.00
253_K256_T1.0391.00
53_E56_Y1.0361.00
24_L165_I1.0361.00
200_E204_R1.0291.00
189_S196_E1.0261.00
216_V219_E1.0261.00
91_L120_I1.0231.00
126_V153_P1.0221.00
11_I169_V1.0201.00
205_F209_E1.0191.00
68_M104_D1.0101.00
181_P184_Y1.0081.00
255_K259_I1.0041.00
195_S198_I1.0041.00
209_E214_V1.0031.00
28_L51_H1.0001.00
167_A171_K0.9991.00
164_T167_A0.9981.00
123_V153_P0.9871.00
216_V220_R0.9871.00
120_I150_D0.9851.00
190_Q194_A0.9831.00
252_A256_T0.9831.00
261_A265_M0.9791.00
201_K205_F0.9771.00
97_E124_N0.9731.00
203_M206_L0.9671.00
103_P106_E0.9651.00
186_T190_Q0.9621.00
111_K114_E0.9601.00
135_L139_L0.9541.00
152_V161_N0.9521.00
195_S199_R0.9481.00
204_R208_A0.9431.00
191_R195_S0.9431.00
193_M197_I0.9381.00
97_E125_K0.9371.00
244_K254_I0.9351.00
126_V129_V0.9311.00
119_V146_M0.9281.00
247_I254_I0.9221.00
25_L29_L0.9221.00
67_H75_N0.9181.00
218_I224_N0.9101.00
24_L162_V0.9011.00
29_L51_H0.9001.00
166_A169_V0.8991.00
239_R242_Q0.8981.00
240_E243_K0.8801.00
77_L81_A0.8781.00
142_L145_Q0.8721.00
43_T48_V0.8701.00
217_E220_R0.8681.00
159_G162_V0.8681.00
108_V111_K0.8671.00
138_H142_L0.8591.00
218_I233_G0.8591.00
202_L210_L0.8511.00
94_F112_L0.8471.00
261_A264_D0.8461.00
238_E242_Q0.8451.00
52_T55_A0.8441.00
250_K254_I0.8421.00
132_K135_L0.8421.00
233_G238_E0.8421.00
113_R145_Q0.8411.00
43_T50_I0.8391.00
77_L80_K0.8351.00
107_M111_K0.8351.00
214_V218_I0.8351.00
215_T219_E0.8341.00
149_L172_H0.8291.00
120_I152_V0.8291.00
251_G254_I0.8261.00
185_I189_S0.8251.00
97_E100_R0.8211.00
43_T46_R0.8181.00
219_E222_V0.8181.00
81_A86_I0.8081.00
69_E75_N0.8061.00
139_L142_L0.8021.00
73_A76_R0.8001.00
134_D137_P0.7981.00
237_V241_G0.7831.00
113_R147_N0.7811.00
197_I265_M0.7801.00
189_S194_A0.7741.00
257_I261_A0.7721.00
52_T57_Q0.7691.00
37_S204_R0.7641.00
121_L151_I0.7591.00
243_K250_K0.7531.00
38_R204_R0.7460.99
51_H60_Y0.7450.99
230_D234_L0.7430.99
202_L207_G0.7420.99
227_G231_I0.7400.99
241_G244_K0.7390.99
248_G251_G0.7370.99
45_H192_F0.7350.99
207_G214_V0.7280.99
255_K258_G0.7270.99
205_F208_A0.7230.99
233_G236_L0.7230.99
11_I91_L0.7200.99
247_I250_K0.7190.99
206_L217_E0.7180.99
205_F217_E0.7120.99
80_K84_S0.7040.99
29_L33_I0.7030.99
236_L240_E0.7020.99
224_N228_G0.7010.99
228_G231_I0.6970.99
206_L214_V0.6970.99
254_I258_G0.6920.99
245_M248_G0.6900.99
165_I169_V0.6900.99
166_A170_R0.6860.99
122_A153_P0.6820.99
105_D109_L0.6810.99
53_E167_A0.6800.99
263_K266_Q0.6790.99
104_D107_M0.6770.99
250_K256_T0.6770.99
245_M249_N0.6770.99
123_V138_H0.6750.99
220_R224_N0.6750.99
19_V123_V0.6660.99
192_F197_I0.6620.99
12_A92_V0.6510.99
170_R173_L0.6510.99
92_V119_V0.6460.99
258_G261_A0.6450.99
75_N79_N0.6420.98
16_R19_V0.6390.98
25_L49_G0.6380.98
62_D65_G0.6380.98
107_M110_N0.6300.98
129_V137_P0.6280.98
267_E270_E0.6270.98
24_L156_A0.6260.98
94_F119_V0.6240.98
249_N252_A0.6220.98
60_Y166_A0.6220.98
243_K248_G0.6220.98
118_P149_L0.6190.98
102_T105_D0.6150.98
167_A170_R0.6150.98
181_P186_T0.6130.98
95_V154_I0.6130.98
102_T107_M0.6110.98
188_R196_E0.6100.98
234_L237_V0.6090.98
219_E223_S0.6080.98
185_I190_Q0.6060.98
205_F213_S0.6050.98
244_K248_G0.6040.98
229_Y233_G0.6030.98
221_F269_F0.6010.98
218_I222_V0.6000.98
214_V221_F0.5990.98
126_V160_L0.5980.98
19_V97_E0.5970.98
99_T123_V0.5960.98
207_G211_P0.5950.97
51_H58_A0.5940.97
61_V88_D0.5920.97
238_E241_G0.5910.97
233_G237_V0.5910.97
17_P40_A0.5900.97
214_V222_V0.5870.97
163_D166_A0.5860.97
203_M217_E0.5840.97
212_Y221_F0.5830.97
98_G126_V0.5830.97
251_G255_K0.5830.97
93_I120_I0.5790.97
221_F225_E0.5780.97
248_G254_I0.5780.97
54_G178_H0.5760.97
217_E236_L0.5750.97
94_F108_V0.5740.97
136_L140_Q0.5720.97
78_M81_A0.5710.97
251_G262_R0.5690.97
190_Q195_S0.5680.97
68_M78_M0.5670.97
206_L216_V0.5670.97
66_L82_A0.5660.97
44_R49_G0.5620.96
228_G232_N0.5610.96
66_L69_E0.5610.96
127_D155_S0.5600.96
16_R67_H0.5590.96
232_N235_I0.5570.96
247_I252_A0.5570.96
199_R202_L0.5560.96
243_K246_V0.5560.96
19_V105_D0.5560.96
256_T259_I0.5510.96
230_D233_G0.5510.96
248_G255_K0.5500.96
112_L115_G0.5500.96
50_I59_I0.5490.96
242_Q247_I0.5490.96
126_V135_L0.5470.96
243_K257_I0.5470.96
113_R146_M0.5470.96
38_R41_Q0.5460.96
213_S216_V0.5430.96
243_K249_N0.5430.96
258_G266_Q0.5430.96
37_S41_Q0.5430.96
242_Q248_G0.5410.96
191_R198_I0.5400.96
259_I262_R0.5390.96
239_R250_K0.5390.96
244_K247_I0.5360.95
210_L213_S0.5350.95
172_H176_A0.5350.95
170_R174_P0.5340.95
216_V225_E0.5320.95
208_A217_E0.5310.95
264_D268_M0.5280.95
247_I255_K0.5280.95
239_R243_K0.5240.95
183_D187_D0.5240.95
74_I77_L0.5230.95
67_H82_A0.5230.95
33_I49_G0.5230.95
202_L209_E0.5210.95
261_A266_Q0.5200.95
98_G138_H0.5190.95
25_L34_S0.5190.95
257_I262_R0.5180.95
242_Q254_I0.5150.94
29_L49_G0.5120.94
220_R230_D0.5110.94
12_A63_T0.5100.94
253_K257_I0.5090.94
243_K254_I0.5070.94
206_L213_S0.5060.94
205_F214_V0.5040.94
237_V242_Q0.5040.94
143_A150_D0.5030.94
171_K175_E0.5020.94
158_T161_N0.5020.94
131_E160_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1egaA 2 0.9734 100 0.331 Contact Map
1wf3A 1 0.9668 100 0.347 Contact Map
3ievA 1 0.9801 100 0.358 Contact Map
2j69A 1 0.9701 100 0.454 Contact Map
4aurA 1 0.9767 100 0.504 Contact Map
3a1sA 1 0.8439 100 0.52 Contact Map
4dcuA 1 0.8272 100 0.525 Contact Map
1mkyA 1 0.794 100 0.526 Contact Map
3j8gX 1 0.8571 100 0.527 Contact Map
3geeA 2 0.6877 100 0.532 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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