GREMLIN Database
TOP1 - DNA topoisomerase 1
UniProt: P06612 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11013
Length: 865 (792)
Sequences: 1704 (875)
Seq/√Len: 31.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_K255_Q7.8731.00
74_D77_H5.5841.00
250_N253_Q5.2201.00
662_C665_C4.7121.00
707_P717_E4.3411.00
413_L453_V4.1951.00
277_T407_K4.1671.00
662_C666_G4.0161.00
78_N565_D3.9811.00
815_A818_P3.7001.00
94_S98_Q3.6831.00
716_S732_T3.6341.00
218_E470_F3.6311.00
794_A802_R3.4921.00
553_V563_V3.4341.00
303_K386_D3.4131.00
552_Q557_E3.3601.00
716_S733_N3.2051.00
270_E455_K3.1901.00
664_K668_A3.1671.00
809_E813_Y3.0261.00
105_H135_S3.0171.00
662_C668_A2.9971.00
802_R805_D2.9451.00
34_I126_V2.9201.00
416_G419_D2.9161.00
781_L788_K2.8861.00
791_E794_A2.8621.00
762_P765_K2.8611.00
317_I394_I2.8141.00
665_C668_A2.7731.00
666_G669_M2.7701.00
261_L464_L2.7511.00
426_G451_P2.7361.00
7_I106_I2.6791.00
803_F806_R2.6571.00
664_K667_T2.6481.00
664_K669_M2.6331.00
662_C669_M2.6231.00
683_C689_C2.6171.00
385_A389_K2.5601.00
812_R815_A2.5371.00
665_C669_M2.5231.00
386_D389_K2.4610.99
259_S262_E2.4550.99
663_P667_T2.4460.99
511_R520_E2.4270.99
795_P798_E2.4150.99
222_V257_A2.3960.99
218_E468_Q2.3910.99
5_L100_A2.3870.99
159_I163_N2.3630.99
269_L416_G2.3400.99
219_F469_H2.3310.99
392_Q396_R2.3310.99
762_P767_D2.3200.99
340_S345_K2.3040.99
599_C602_C2.2460.99
710_E717_E2.2330.99
485_E489_R2.2270.99
809_E812_R2.2200.99
78_N561_K2.2170.99
752_K755_P2.2050.99
339_I348_L2.2040.99
693_E696_E2.2020.99
12_A16_T2.1800.99
255_Q258_V2.1450.98
302_K502_S2.1440.98
440_A443_K2.1440.98
651_A655_A2.1440.98
258_V262_E2.1210.98
711_C731_C2.1120.98
804_R808_P2.1100.98
585_G588_R2.1040.98
144_K148_R2.1000.98
814_L817_A2.1000.98
808_P812_R2.0950.98
753_E757_P2.0790.98
662_C667_T2.0590.98
768_A785_T2.0280.98
810_K814_L2.0190.98
83_Y165_Q2.0070.97
377_A380_L1.9980.97
408_Y435_T1.9910.97
559_E562_A1.9880.97
711_C714_C1.9810.97
266_Y417_A1.9720.97
299_F307_M1.9660.97
135_S156_E1.9630.97
811_L814_L1.9600.97
325_T357_S1.9570.97
267_S458_A1.9550.97
100_A106_I1.9460.97
802_R806_R1.9370.97
808_P815_A1.9360.97
666_G671_S1.9220.97
770_F800_L1.9140.97
651_A654_N1.8750.96
773_R782_A1.8750.96
273_D409_D1.8730.96
737_K741_K1.8580.96
108_L120_A1.8570.96
663_P671_S1.8400.96
790_R794_A1.8100.95
279_K405_P1.8090.95
590_N594_L1.8080.95
662_C671_S1.8050.95
746_G749_A1.8040.95
208_E476_R1.7950.95
227_T462_V1.7930.95
663_P668_A1.7840.95
812_R816_D1.7770.95
800_L804_R1.7670.95
502_S506_D1.7670.95
238_V242_N1.7660.95
298_G515_R1.7590.94
411_T428_I1.7470.94
420_F486_L1.7310.94
228_T459_L1.7290.94
293_A390_L1.7190.94
454_N457_D1.7180.94
689_C692_Y1.7130.94
753_E756_V1.7080.94
224_A415_V1.7050.93
664_K671_S1.7020.93
264_A417_A1.6880.93
668_A671_S1.6830.93
813_Y816_D1.6810.93
145_N149_Q1.6800.93
808_P814_L1.6730.93
204_V510_V1.6650.93
669_M672_Y1.6600.93
652_E655_A1.6550.92
77_H80_E1.6520.92
663_P666_G1.6470.92
760_E771_V1.6450.92
763_C783_A1.6450.92
228_T457_D1.6440.92
408_Y429_L1.6430.92
261_L417_A1.6330.92
599_C619_C1.6150.91
299_F304_T1.6070.91
730_A733_N1.6040.91
803_F808_P1.5930.91
663_P669_M1.5900.91
811_L815_A1.5890.91
809_E817_A1.5880.91
225_S465_T1.5800.91
226_T266_Y1.5690.90
766_S785_T1.5680.90
592_M599_C1.5550.90
226_T422_L1.5530.90
546_M563_V1.5430.89
299_F386_D1.5430.89
664_K670_D1.5410.89
712_E751_P1.5410.89
738_N741_K1.5390.89
662_C670_D1.5380.89
810_K815_A1.5290.89
805_D809_E1.5290.89
414_T423_K1.5120.88
619_C630_C1.5040.88
711_C751_P1.4970.88
688_T691_G1.4920.88
808_P811_L1.4870.88
812_R817_A1.4820.87
776_A792_T1.4820.87
483_V498_A1.4800.87
346_K436_K1.4790.87
806_R810_K1.4750.87
240_H421_R1.4740.87
673_L676_P1.4740.87
741_K749_A1.4680.87
747_E751_P1.4640.87
665_C671_S1.4560.86
226_T415_V1.4550.86
395_W399_V1.4540.86
149_Q153_K1.4520.86
264_A418_G1.4510.86
477_F485_E1.4490.86
668_A672_Y1.4470.86
549_S566_H1.4390.86
265_R458_A1.4370.86
157_L162_V1.4370.86
276_T408_Y1.4350.86
817_A822_P1.4340.86
650_D653_T1.4280.85
414_T421_R1.4270.85
762_P768_A1.4270.85
799_E805_D1.4240.85
804_R816_D1.4230.85
270_E414_T1.4160.85
415_V459_L1.4150.85
782_A787_P1.4070.84
485_E488_K1.4050.84
770_F804_R1.4020.84
801_Y815_A1.4020.84
292_A295_T1.4000.84
799_E803_F1.3970.84
716_S730_A1.3920.84
803_F812_R1.3880.84
216_P470_F1.3880.84
802_R808_P1.3870.84
816_D822_P1.3840.83
593_V600_P1.3820.83
599_C630_C1.3810.83
719_H730_A1.3800.83
759_P772_L1.3700.83
694_I699_F1.3690.83
273_D411_T1.3690.83
409_D430_R1.3680.83
4_A105_H1.3610.82
221_E246_F1.3590.82
667_T671_S1.3580.82
781_L790_R1.3520.82
285_I357_S1.3460.82
799_E806_R1.3420.82
592_M600_P1.3420.82
83_Y166_Q1.3400.81
4_A107_Y1.3390.81
788_K794_A1.3300.81
770_F808_P1.3300.81
223_D235_A1.3290.81
593_V602_C1.3280.81
802_R815_A1.3270.81
38_P199_V1.3250.81
486_L500_I1.3250.81
16_T19_K1.3230.81
721_K728_Y1.3200.80
802_R811_L1.3160.80
378_E381_K1.3130.80
649_E652_E1.3120.80
241_Q420_F1.3090.80
593_V599_C1.3070.80
766_S783_A1.3060.80
299_F303_K1.3030.80
740_R749_A1.3000.79
63_E66_A1.2980.79
68_V71_M1.2880.79
225_S463_E1.2840.79
602_C619_C1.2820.78
293_A304_T1.2790.78
200_A486_L1.2780.78
246_F257_A1.2770.78
124_R134_Y1.2770.78
275_P407_K1.2750.78
808_P813_Y1.2740.78
26_V103_A1.2710.78
62_D69_N1.2710.78
310_R387_A1.2680.78
228_T232_E1.2660.78
308_A317_I1.2650.77
226_T236_L1.2640.77
669_M673_L1.2600.77
799_E813_Y1.2590.77
800_L810_K1.2500.77
348_L429_L1.2440.76
347_Y431_F1.2430.76
305_M317_I1.2310.76
754_D757_P1.2270.75
757_P771_V1.2270.75
805_D812_R1.2250.75
549_S558_A1.2240.75
805_D811_L1.2230.75
255_Q259_S1.2220.75
652_E657_R1.2180.75
92_V95_E1.2130.74
234_L453_V1.2120.74
589_P594_L1.2110.74
720_L745_N1.2080.74
179_V537_L1.2070.74
225_S235_A1.2030.74
592_M602_C1.1990.74
803_F811_L1.1950.73
756_V807_L1.1950.73
512_V515_R1.1920.73
765_K768_A1.1920.73
706_G720_L1.1830.73
805_D816_D1.1830.73
739_T743_L1.1810.72
296_R440_A1.1790.72
788_K791_E1.1730.72
660_R663_P1.1680.72
707_P719_H1.1670.71
657_R660_R1.1650.71
758_L806_R1.1650.71
416_G421_R1.1640.71
504_I508_G1.1620.71
806_R811_L1.1620.71
803_F810_K1.1600.71
801_Y804_R1.1570.71
224_A464_L1.1560.71
202_R531_E1.1500.70
785_T802_R1.1500.70
404_T407_K1.1460.70
779_V796_L1.1450.70
597_I602_C1.1430.70
178_M575_L1.1430.70
777_A780_F1.1420.70
300_G453_V1.1400.70
598_D603_G1.1400.70
772_L781_L1.1380.70
805_D808_P1.1370.69
815_A822_P1.1290.69
384_E387_A1.1270.69
665_C672_Y1.1250.69
332_V354_Q1.1220.68
148_R152_N1.1200.68
721_K730_A1.1200.68
575_L579_E1.1180.68
779_V789_S1.1160.68
276_T410_S1.1160.68
343_F399_V1.1140.68
720_L736_C1.1110.68
818_P822_P1.1100.68
426_G450_L1.1060.67
597_I600_P1.1020.67
74_D80_E1.1010.67
141_E146_A1.1000.67
805_D822_P1.0990.67
335_V399_V1.0990.67
665_C670_D1.0950.66
810_K816_D1.0940.66
249_V253_Q1.0930.66
226_T453_V1.0900.66
306_M310_R1.0900.66
655_A659_K1.0890.66
729_M742_I1.0860.66
651_A657_R1.0850.66
662_C672_Y1.0840.66
25_Y107_Y1.0810.65
606_M632_T1.0760.65
164_A291_Q1.0750.65
138_V147_I1.0730.65
260_L420_F1.0720.65
337_G341_D1.0700.65
760_E769_Y1.0680.65
201_V504_I1.0670.64
234_L459_L1.0670.64
593_V597_I1.0670.64
275_P411_T1.0660.64
664_K672_Y1.0620.64
584_E587_M1.0620.64
736_C745_N1.0620.64
372_D375_V1.0590.64
718_M729_M1.0570.64
812_R818_P1.0560.64
256_A260_L1.0530.63
756_V760_E1.0510.63
303_K306_M1.0490.63
799_E810_K1.0480.63
762_P769_Y1.0460.63
790_R793_R1.0460.63
447_D685_N1.0460.63
655_A658_A1.0450.63
644_N650_D1.0400.62
658_A661_R1.0360.62
592_M604_R1.0350.62
592_M595_T1.0340.62
663_P670_D1.0330.62
766_S770_F1.0330.62
761_L800_L1.0300.62
803_F813_Y1.0300.62
763_C804_R1.0260.61
598_D604_R1.0260.61
28_K96_L1.0230.61
589_P600_P1.0230.61
289_L304_T1.0210.61
254_T464_L1.0190.61
36_D169_R1.0140.60
809_E815_A1.0120.60
665_C673_L1.0100.60
805_D813_Y1.0090.60
301_V498_A1.0090.60
758_L774_D1.0080.60
766_S804_R1.0080.60
764_E783_A1.0070.60
591_Q600_P1.0070.60
40_S43_A1.0050.60
623_A630_C1.0030.60
720_L742_I1.0030.60
254_T466_P1.0020.60
505_Q512_V0.9980.59
602_C606_M0.9960.59
753_E768_A0.9950.59
806_R812_R0.9910.59
15_K282_A0.9900.59
670_D676_P0.9840.58
640_N643_L0.9810.58
295_T440_A0.9810.58
666_G670_D0.9800.58
654_N657_R0.9790.58
655_A661_R0.9780.58
4_A24_D0.9770.58
670_D674_I0.9770.58
432_D436_K0.9770.58
669_M677_K0.9740.57
672_Y675_D0.9710.57
738_N743_L0.9710.57
649_E656_L0.9700.57
809_E814_L0.9700.57
677_K692_Y0.9680.57
766_S811_L0.9670.57
799_E808_P0.9660.57
708_I729_M0.9660.57
604_R621_G0.9650.57
205_V519_A0.9620.56
667_T674_I0.9610.56
243_D268_V0.9600.56
294_S480_A0.9590.56
766_S789_S0.9590.56
267_S416_G0.9580.56
590_N596_S0.9580.56
269_L421_R0.9580.56
810_K813_Y0.9560.56
251_K455_K0.9540.56
796_L802_R0.9540.56
285_I325_T0.9530.56
217_E249_V0.9520.56
741_K745_N0.9510.55
67_L71_M0.9500.55
40_S44_A0.9490.55
708_I720_L0.9490.55
589_P592_M0.9480.55
287_S490_G0.9480.55
592_M597_I0.9470.55
266_Y461_L0.9460.55
762_P804_R0.9420.55
178_M408_Y0.9400.55
238_V241_Q0.9370.54
590_N593_V0.9340.54
422_L464_L0.9330.54
412_T425_R0.9330.54
327_L398_F0.9300.54
791_E802_R0.9280.54
756_V771_V0.9270.54
653_T657_R0.9270.54
806_R815_A0.9260.53
622_Y630_C0.9250.53
290_Q498_A0.9250.53
346_K389_K0.9230.53
343_F506_D0.9220.53
27_V32_G0.9210.53
792_T795_P0.9210.53
44_A62_D0.9190.53
665_C675_D0.9180.53
799_E804_R0.9170.53
743_L759_P0.9150.53
671_S675_D0.9140.53
648_G651_A0.9120.52
337_G340_S0.9120.52
574_Q578_A0.9110.52
593_V596_S0.9090.52
814_L818_P0.9090.52
725_F739_T0.9080.52
764_E804_R0.9060.52
141_E329_Q0.9050.52
802_R813_Y0.9050.52
764_E768_A0.9040.52
806_R809_E0.9040.52
417_A422_L0.8990.51
667_T672_Y0.8990.51
766_S769_Y0.8980.51
671_S674_I0.8970.51
346_K407_K0.8940.51
376_M379_S0.8940.51
707_P710_E0.8910.51
666_G672_Y0.8890.50
667_T670_D0.8890.50
782_A785_T0.8880.50
271_R413_L0.8880.50
755_P760_E0.8880.50
544_A609_R0.8860.50
770_F803_F0.8840.50
655_A660_R0.8840.50
799_E802_R0.8820.50
160_D163_N0.8790.50
261_L466_P0.8780.50
790_R797_V0.8770.50
268_V413_L0.8760.49
179_V325_T0.8750.49
595_T598_D0.8750.49
813_Y817_A0.8730.49
772_L788_K0.8720.49
137_V151_F0.8690.49
791_E798_E0.8690.49
777_A787_P0.8680.49
757_P773_R0.8670.49
85_V88_G0.8660.49
791_E804_R0.8660.49
241_Q257_A0.8640.48
783_A786_F0.8640.48
804_R817_A0.8630.48
222_V466_P0.8630.48
602_C630_C0.8610.48
794_A805_D0.8580.48
90_E94_S0.8570.48
793_R796_L0.8570.48
722_M728_Y0.8570.48
63_E68_V0.8560.48
62_D66_A0.8560.48
78_N102_K0.8560.48
669_M675_D0.8550.48
594_L602_C0.8550.48
700_R743_L0.8550.48
813_Y818_P0.8520.47
781_L806_R0.8520.47
768_A811_L0.8520.47
12_A140_N0.8510.47
310_R314_A0.8510.47
334_M372_D0.8510.47
238_V243_D0.8500.47
708_I718_M0.8480.47
23_S101_E0.8480.47
278_S434_W0.8470.47
149_Q152_N0.8460.47
759_P813_Y0.8450.47
779_V795_P0.8440.47
222_V254_T0.8440.47
124_R128_G0.8440.47
66_A71_M0.8430.47
137_V154_P0.8420.47
801_Y812_R0.8410.47
476_R509_Y0.8400.47
762_P812_R0.8390.46
376_M380_L0.8380.46
802_R810_K0.8380.46
268_V455_K0.8370.46
593_V598_D0.8370.46
273_D455_K0.8360.46
251_K258_V0.8350.46
335_V807_L0.8350.46
407_K431_F0.8340.46
143_T550_L0.8320.46
263_K389_K0.8300.46
292_A296_R0.8300.46
221_E467_A0.8290.46
10_S13_K0.8280.46
171_M550_L0.8280.46
123_L126_V0.8260.45
783_A807_L0.8260.45
183_L193_A0.8250.45
298_G389_K0.8250.45
738_N753_E0.8230.45
204_V281_G0.8200.45
804_R809_E0.8190.45
785_T811_L0.8190.45
635_N638_P0.8180.45
801_Y808_P0.8170.45
143_T146_A0.8160.45
228_T460_T0.8150.45
270_E569_S0.8130.44
677_K680_L0.8110.44
801_Y805_D0.8090.44
562_A565_D0.8080.44
788_K810_K0.8080.44
605_K609_R0.8060.44
651_A658_A0.8050.44
138_V155_G0.8050.44
654_N658_A0.8040.44
775_G778_G0.8030.44
340_S348_L0.8020.43
141_E328_S0.8000.43
246_F249_V0.8000.43
594_L597_I0.7980.43
767_D796_L0.7970.43
112_L140_N0.7950.43
803_F815_A0.7940.43
652_E656_L0.7910.43
299_F390_L0.7900.43
619_C649_E0.7900.43
327_L401_C0.7900.43
280_P353_N0.7900.43
704_Y727_K0.7880.42
114_R164_A0.7870.42
390_L394_I0.7850.42
582_P587_M0.7850.42
599_C604_R0.7840.42
608_I634_I0.7840.42
714_C751_P0.7820.42
362_Q369_R0.7820.42
732_T752_K0.7810.42
752_K794_A0.7810.42
643_L646_L0.7810.42
594_L598_D0.7810.42
792_T818_P0.7790.42
684_G687_P0.7780.42
806_R813_Y0.7760.41
81_A167_A0.7760.41
755_P810_K0.7750.41
800_L803_F0.7750.41
754_D797_V0.7740.41
277_T350_E0.7730.41
650_D660_R0.7730.41
424_A450_L0.7720.41
765_K810_K0.7720.41
268_V459_L0.7700.41
302_K306_M0.7690.41
616_F619_C0.7680.41
223_D467_A0.7670.41
794_A797_V0.7670.41
659_K669_M0.7660.41
762_P807_L0.7660.41
298_G432_D0.7650.41
254_T258_V0.7650.41
722_M742_I0.7640.40
307_M383_M0.7630.40
461_L464_L0.7620.40
659_K662_C0.7610.40
593_V601_T0.7600.40
313_E550_L0.7600.40
758_L766_S0.7590.40
35_R122_H0.7590.40
275_P430_R0.7580.40
399_V572_T0.7570.40
109_A195_R0.7570.40
657_R664_K0.7550.40
759_P790_R0.7550.40
296_R438_M0.7550.40
427_R472_K0.7520.40
748_V751_P0.7510.39
694_I697_G0.7490.39
781_L794_A0.7480.39
351_S354_Q0.7470.39
720_L743_L0.7440.39
195_R543_T0.7440.39
292_A440_A0.7440.39
785_T792_T0.7420.39
160_D554_A0.7420.39
725_F737_K0.7390.39
740_R744_R0.7390.39
562_A566_H0.7380.38
758_L789_S0.7380.38
721_K732_T0.7370.38
394_I508_G0.7370.38
8_V13_K0.7370.38
26_V102_K0.7370.38
284_F292_A0.7370.38
415_V461_L0.7370.38
589_P593_V0.7360.38
12_A154_P0.7350.38
612_S744_R0.7350.38
740_R743_L0.7350.38
193_A494_P0.7340.38
453_V459_L0.7340.38
800_L806_R0.7320.38
404_T431_F0.7310.38
757_P769_Y0.7310.38
142_I171_M0.7300.38
287_S377_A0.7300.38
552_Q558_A0.7290.38
680_L683_C0.7290.38
260_L464_L0.7280.38
783_A811_L0.7280.38
791_E809_E0.7270.38
649_E661_R0.7260.38
590_N595_T0.7250.37
717_E737_K0.7240.37
589_P595_T0.7230.37
599_C606_M0.7220.37
222_V261_L0.7210.37
811_L816_D0.7210.37
598_D605_K0.7210.37
795_P802_R0.7200.37
549_S552_Q0.7180.37
793_R797_V0.7180.37
410_S427_R0.7180.37
788_K798_E0.7170.37
654_N659_K0.7170.37
202_R807_L0.7170.37
789_S806_R0.7170.37
808_P816_D0.7170.37
786_F811_L0.7170.37
245_P453_V0.7160.37
417_A459_L0.7150.37
686_N742_I0.7150.37
768_A771_V0.7140.37
124_R157_L0.7130.37
400_A426_G0.7130.37
699_F702_K0.7100.36
657_R661_R0.7090.36
292_A443_K0.7090.36
670_D675_D0.7080.36
418_G467_A0.7070.36
371_S375_V0.7060.36
793_R805_D0.7060.36
580_K585_G0.7060.36
273_D428_I0.7060.36
805_D810_K0.7050.36
205_V426_G0.7040.36
10_S493_R0.7030.36
616_F630_C0.7030.36
9_E14_A0.7020.36
737_K752_K0.7010.36
295_T515_R0.7000.36
785_T810_K0.7000.36
179_V193_A0.6990.36
559_E809_E0.6990.36
74_D82_H0.6980.35
396_R439_P0.6980.35
198_S369_R0.6970.35
809_E822_P0.6970.35
756_V784_N0.6960.35
509_Y519_A0.6960.35
668_A673_L0.6960.35
780_F787_P0.6950.35
609_R618_G0.6950.35
165_Q324_S0.6940.35
809_E816_D0.6940.35
764_E769_Y0.6930.35
598_D601_T0.6930.35
565_D569_S0.6920.35
347_Y432_D0.6920.35
732_T777_A0.6920.35
67_L70_R0.6910.35
7_I128_G0.6900.35
62_D67_L0.6880.35
302_K501_I0.6880.35
205_V524_E0.6870.35
782_A786_F0.6870.35
711_C736_C0.6860.35
316_Y504_I0.6840.34
23_S477_F0.6840.34
84_E477_F0.6830.34
458_A562_A0.6830.34
269_L419_D0.6800.34
236_L424_A0.6800.34
789_S815_A0.6790.34
660_R671_S0.6780.34
43_A63_E0.6780.34
753_E758_L0.6770.34
13_K313_E0.6760.34
761_L772_L0.6760.34
802_R822_P0.6760.34
28_K99_L0.6750.34
340_S553_V0.6750.34
407_K515_R0.6740.34
702_K706_G0.6740.34
301_V486_L0.6730.34
729_M734_E0.6730.34
385_A388_Q0.6720.34
69_N73_V0.6720.34
125_E128_G0.6710.33
645_V649_E0.6690.33
681_H722_M0.6680.33
797_V800_L0.6680.33
722_M739_T0.6670.33
251_K468_Q0.6670.33
350_E404_T0.6660.33
215_V444_G0.6660.33
123_L302_K0.6660.33
766_S803_F0.6660.33
753_E815_A0.6660.33
209_R528_D0.6650.33
13_K32_G0.6640.33
650_D658_A0.6630.33
295_T392_Q0.6620.33
790_R800_L0.6610.33
806_R814_L0.6600.33
206_E540_Y0.6600.33
373_V399_V0.6590.33
600_P604_R0.6580.33
732_T776_A0.6580.33
661_R669_M0.6560.32
603_G612_S0.6550.32
772_L795_P0.6550.32
94_S453_V0.6550.32
667_T673_L0.6540.32
797_V812_R0.6540.32
235_A289_L0.6540.32
12_A18_N0.6530.32
359_E488_K0.6530.32
41_G68_V0.6530.32
323_D543_T0.6520.32
799_E816_D0.6520.32
478_S518_Y0.6520.32
298_G472_K0.6520.32
670_D673_L0.6510.32
149_Q703_G0.6510.32
27_V33_H0.6510.32
753_E789_S0.6500.32
88_G504_I0.6500.32
753_E784_N0.6500.32
786_F812_R0.6480.32
226_T517_F0.6460.32
653_T656_L0.6450.32
772_L779_V0.6450.32
257_A300_G0.6450.32
754_D758_L0.6440.32
292_A441_L0.6440.32
463_E580_K0.6440.32
752_K791_E0.6440.32
7_I126_V0.6430.32
755_P794_A0.6430.32
478_S509_Y0.6430.32
360_N548_N0.6420.31
720_L725_F0.6420.31
762_P815_A0.6420.31
13_K542_F0.6420.31
317_I483_V0.6420.31
224_A388_Q0.6410.31
795_P804_R0.6410.31
44_A63_E0.6400.31
353_N405_P0.6390.31
298_G409_D0.6390.31
397_Q611_A0.6390.31
779_V788_K0.6390.31
709_V747_E0.6380.31
234_L243_D0.6370.31
802_R809_E0.6370.31
31_V92_V0.6370.31
762_P766_S0.6360.31
763_C771_V0.6360.31
393_L438_M0.6340.31
633_T638_P0.6340.31
187_I191_L0.6340.31
206_E210_E0.6330.31
781_L789_S0.6320.31
411_T426_G0.6320.31
222_V464_L0.6320.31
122_H366_E0.6310.31
656_L660_R0.6310.31
291_Q542_F0.6300.31
710_E733_N0.6290.31
761_L790_R0.6290.31
256_A263_K0.6280.30
789_S802_R0.6270.30
573_Q577_K0.6260.30
40_S72_G0.6260.30
36_D506_D0.6250.30
316_Y383_M0.6250.30
768_A815_A0.6250.30
76_W80_E0.6250.30
772_L798_E0.6230.30
258_V466_P0.6230.30
765_K783_A0.6230.30
799_E812_R0.6230.30
703_G759_P0.6210.30
565_D580_K0.6210.30
478_S516_R0.6210.30
598_D643_L0.6210.30
43_A185_K0.6190.30
75_P211_I0.6190.30
718_M747_E0.6190.30
426_G438_M0.6190.30
33_H309_Q0.6180.30
502_S505_Q0.6180.30
338_Y373_V0.6180.30
300_G303_K0.6180.30
330_D478_S0.6170.30
792_T796_L0.6170.30
759_P794_A0.6170.30
771_V782_A0.6160.30
661_R664_K0.6160.30
810_K817_A0.6160.30
595_T599_C0.6150.30
605_K632_T0.6150.30
93_V204_V0.6140.30
455_K458_A0.6140.30
110_T120_A0.6130.29
223_D237_Q0.6130.29
108_L123_L0.6130.29
578_A582_P0.6130.29
652_E659_K0.6110.29
119_I509_Y0.6100.29
599_C618_G0.6100.29
665_C674_I0.6090.29
475_A516_R0.6090.29
7_I327_L0.6080.29
366_E369_R0.6070.29
735_E738_N0.6060.29
804_R812_R0.6060.29
233_A462_V0.6060.29
378_E392_Q0.6060.29
294_S300_G0.6050.29
412_T423_K0.6050.29
275_P409_D0.6040.29
298_G310_R0.6040.29
444_G448_R0.6040.29
296_R301_V0.6030.29
617_L638_P0.6030.29
478_S514_N0.6030.29
63_E67_L0.6030.29
199_V527_T0.6020.29
198_S364_A0.6020.29
220_W251_K0.6020.29
770_F785_T0.6020.29
758_L770_F0.6020.29
83_Y138_V0.6010.29
113_D507_R0.6000.29
436_K439_P0.6000.29
486_L534_F0.5990.29
248_P301_V0.5990.29
807_L810_K0.5990.29
20_Y144_K0.5990.29
414_T425_R0.5980.28
595_T602_C0.5980.28
813_Y822_P0.5970.28
29_S32_G0.5970.28
608_I618_G0.5970.28
5_L9_E0.5970.28
61_K64_R0.5960.28
798_E808_P0.5960.28
683_C694_I0.5950.28
641_E644_N0.5950.28
193_A476_R0.5950.28
301_V517_F0.5950.28
220_W519_A0.5950.28
211_I602_C0.5940.28
258_V464_L0.5930.28
178_M276_T0.5930.28
88_G515_R0.5930.28
762_P806_R0.5920.28
619_C652_E0.5920.28
329_Q333_N0.5920.28
773_R783_A0.5920.28
725_F738_N0.5910.28
753_E803_F0.5910.28
643_L648_G0.5910.28
165_Q173_R0.5900.28
612_S714_C0.5900.28
239_T274_K0.5890.28
644_N648_G0.5880.28
196_V323_D0.5880.28
600_P618_G0.5880.28
195_R550_L0.5870.28
400_A438_M0.5860.28
119_I315_G0.5850.28
261_L264_A0.5850.28
142_I158_N0.5840.28
75_P140_N0.5840.28
9_E21_L0.5830.27
794_A806_R0.5830.27
618_G622_Y0.5830.27
779_V802_R0.5820.27
788_K795_P0.5820.27
723_G728_Y0.5820.27
201_V523_G0.5810.27
24_D565_D0.5810.27
80_E231_G0.5810.27
601_T632_T0.5810.27
787_P790_R0.5810.27
554_A597_I0.5800.27
622_Y636_L0.5800.27
465_T767_D0.5790.27
759_P769_Y0.5790.27
164_A509_Y0.5790.27
84_E106_I0.5780.27
219_F402_Q0.5770.27
777_A782_A0.5770.27
171_M507_R0.5770.27
106_I132_A0.5770.27
710_E716_S0.5760.27
754_D774_D0.5760.27
26_V99_L0.5760.27
579_E582_P0.5760.27
752_K760_E0.5750.27
405_P435_T0.5740.27
289_L463_E0.5740.27
376_M381_K0.5730.27
447_D450_L0.5730.27
394_I402_Q0.5730.27
569_S573_Q0.5720.27
17_I147_I0.5720.27
33_H313_E0.5720.27
602_C618_G0.5710.27
190_G522_M0.5710.27
753_E790_R0.5700.27
731_C736_C0.5700.27
590_N600_P0.5700.27
405_P504_I0.5690.27
65_G69_N0.5690.27
302_K480_A0.5670.26
257_A261_L0.5670.26
799_E811_L0.5670.26
63_E500_I0.5670.26
752_K789_S0.5670.26
205_V451_P0.5660.26
580_K584_E0.5650.26
239_T414_T0.5650.26
8_V493_R0.5650.26
295_T441_L0.5640.26
757_P760_E0.5640.26
307_M384_E0.5640.26
120_A179_V0.5630.26
32_G174_V0.5630.26
338_Y376_M0.5620.26
791_E796_L0.5620.26
800_L815_A0.5620.26
785_T789_S0.5610.26
141_E301_V0.5610.26
73_V177_Y0.5600.26
181_P184_W0.5600.26
175_V537_L0.5600.26
141_E327_L0.5600.26
445_D817_A0.5600.26
768_A789_S0.5600.26
801_Y816_D0.5590.26
234_L238_V0.5590.26
62_D70_R0.5590.26
504_I510_V0.5580.26
650_D657_R0.5580.26
198_S362_Q0.5580.26
381_K388_Q0.5580.26
776_A793_R0.5580.26
728_Y743_L0.5580.26
444_G566_H0.5560.26
801_Y813_Y0.5550.26
669_M676_P0.5550.26
410_S554_A0.5550.26
251_K654_N0.5550.26
68_V185_K0.5550.26
706_G727_K0.5540.26
572_T576_D0.5540.26
801_Y806_R0.5540.26
292_A393_L0.5530.26
578_A759_P0.5530.26
85_V210_E0.5530.26
770_F811_L0.5520.26
183_L530_L0.5520.26
268_V457_D0.5520.26
545_Q562_A0.5520.26
800_L808_P0.5520.26
227_T552_Q0.5510.25
765_K789_S0.5510.25
330_D359_E0.5510.25
106_I257_A0.5500.25
762_P772_L0.5490.25
753_E770_F0.5490.25
796_L822_P0.5490.25
737_K749_A0.5480.25
784_N787_P0.5470.25
164_A406_A0.5470.25
18_N384_E0.5460.25
725_F774_D0.5450.25
234_L242_N0.5450.25
803_F817_A0.5430.25
121_W162_V0.5430.25
662_C689_C0.5430.25
784_N791_E0.5430.25
333_N337_G0.5430.25
755_P792_T0.5430.25
222_V438_M0.5430.25
431_F534_F0.5420.25
287_S472_K0.5420.25
710_E755_P0.5420.25
120_A485_E0.5410.25
203_L285_I0.5410.25
291_Q484_K0.5400.25
316_Y371_S0.5400.25
224_A417_A0.5400.25
226_T461_L0.5390.25
631_K660_R0.5390.25
383_M519_A0.5390.25
437_V562_A0.5390.25
204_V499_S0.5380.25
343_F441_L0.5380.25
582_P585_G0.5380.25
31_V112_L0.5370.25
753_E797_V0.5370.25
757_P811_L0.5370.25
109_A543_T0.5370.25
425_R809_E0.5370.25
330_D392_Q0.5370.25
744_R766_S0.5370.25
185_K524_E0.5370.25
784_N807_L0.5360.25
683_C692_Y0.5360.25
744_R759_P0.5360.25
222_V765_K0.5360.25
766_S793_R0.5360.25
334_M338_Y0.5360.25
296_R443_K0.5360.25
798_E802_R0.5350.24
645_V648_G0.5350.24
294_S517_F0.5340.24
119_I308_A0.5340.24
633_T652_E0.5340.24
688_T815_A0.5310.24
112_L137_V0.5310.24
375_V383_M0.5310.24
765_K800_L0.5300.24
299_F512_V0.5300.24
261_L486_L0.5290.24
752_K765_K0.5290.24
667_T675_D0.5290.24
788_K793_R0.5290.24
360_N633_T0.5290.24
598_D602_C0.5280.24
742_I748_V0.5280.24
664_K673_L0.5280.24
118_A162_V0.5270.24
765_K813_Y0.5270.24
110_T121_W0.5270.24
235_A268_V0.5260.24
791_E803_F0.5260.24
707_P716_S0.5260.24
43_A66_A0.5260.24
766_S802_R0.5260.24
204_V337_G0.5260.24
501_I774_D0.5250.24
331_A544_A0.5250.24
745_N752_K0.5250.24
600_P632_T0.5250.24
108_L121_W0.5250.24
11_P16_T0.5240.24
413_L446_E0.5240.24
785_T803_F0.5240.24
209_R335_V0.5230.24
195_R497_Y0.5230.24
361_S497_Y0.5230.24
791_E795_P0.5220.24
93_V126_V0.5220.24
686_N740_R0.5220.24
714_C732_T0.5220.24
589_P598_D0.5210.24
342_N348_L0.5210.24
286_T315_G0.5210.24
801_Y810_K0.5210.24
252_E569_S0.5210.24
206_E270_E0.5210.24
681_H702_K0.5200.24
648_G656_L0.5200.24
87_P579_E0.5200.24
110_T361_S0.5190.24
807_L815_A0.5190.24
380_L385_A0.5190.24
463_E466_P0.5180.23
396_R634_I0.5180.23
714_C731_C0.5180.23
6_V25_Y0.5170.23
35_R121_W0.5160.23
757_P809_E0.5160.23
592_M598_D0.5150.23
153_K222_V0.5150.23
759_P762_P0.5150.23
324_S327_L0.5150.23
256_A345_K0.5140.23
223_D454_N0.5130.23
611_A634_I0.5130.23
765_K804_R0.5130.23
782_A818_P0.5120.23
178_M578_A0.5120.23
25_Y147_I0.5120.23
230_S270_E0.5120.23
439_P442_R0.5120.23
141_E550_L0.5120.23
233_A329_Q0.5110.23
363_E369_R0.5110.23
595_T600_P0.5110.23
14_A140_N0.5110.23
222_V263_K0.5110.23
379_S382_D0.5110.23
3_K26_V0.5100.23
766_S782_A0.5100.23
719_H740_R0.5100.23
804_R815_A0.5090.23
140_N499_S0.5090.23
689_C693_E0.5090.23
761_L769_Y0.5090.23
592_M596_S0.5090.23
785_T813_Y0.5080.23
290_Q496_T0.5070.23
296_R441_L0.5070.23
155_G174_V0.5070.23
755_P795_P0.5070.23
265_R345_K0.5060.23
242_N337_G0.5060.23
269_L418_G0.5050.23
125_E407_K0.5050.23
781_L786_F0.5040.23
13_K37_L0.5040.23
412_T532_E0.5040.23
418_G453_V0.5040.23
18_N26_V0.5040.23
284_F437_V0.5030.23
766_S806_R0.5030.23
790_R798_E0.5020.23
805_D814_L0.5020.23
436_K490_G0.5020.23
17_I21_L0.5020.23
781_L805_D0.5020.23
725_F729_M0.5020.23
378_E385_A0.5020.23
14_A474_P0.5020.23
619_C622_Y0.5010.23
650_D656_L0.5010.23
32_G309_Q0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gaiA 1 0.6578 100 0.337 Contact Map
1mw9X 1 0.6428 100 0.354 Contact Map
4cgyA 1 0.6624 100 0.354 Contact Map
1i7dA 1 0.6497 100 0.384 Contact Map
4dduA 1 0.6035 100 0.436 Contact Map
1gkuB 1 0.5746 100 0.44 Contact Map
1vddA 7 0.1283 99.9 0.917 Contact Map
3vdpA 2 0.1249 99 0.956 Contact Map
2fcjA 2 0.1318 98.8 0.96 Contact Map
1yuaA 1 0.141 98.8 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0193 seconds.