GREMLIN Database
BTUE - Vitamin B12 transport periplasmic protein BtuE
UniProt: P06610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10129
Length: 183 (156)
Sequences: 4195 (2640)
Seq/√Len: 211.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_E51_K3.1721.00
52_A174_M3.0031.00
153_G157_K2.8571.00
76_D95_S2.8321.00
174_M178_K2.5641.00
12_D16_E2.4481.00
45_Q169_E2.2911.00
97_I105_H2.2201.00
98_E103_G2.2191.00
162_F176_S2.1801.00
26_N59_M2.0951.00
61_L94_F2.0671.00
21_E24_A2.0241.00
9_V17_V1.9901.00
63_F94_F1.9421.00
104_R109_Q1.9401.00
18_T23_F1.9351.00
159_I180_A1.8891.00
100_N112_I1.8851.00
11_K17_V1.8571.00
27_V154_R1.7841.00
67_Q98_E1.7691.00
5_I28_L1.7651.00
14_D80_K1.7461.00
13_I93_M1.6791.00
50_Q54_V1.6461.00
47_E90_T1.6361.00
104_R112_I1.6351.00
11_K95_S1.5801.00
13_I76_D1.5711.00
18_T22_K1.5511.00
8_T110_K1.5431.00
39_L164_P1.5301.00
9_V19_T1.5291.00
75_S78_E1.5201.00
43_Y72_E1.5121.00
66_N73_P1.4991.00
48_N52_A1.4991.00
153_G180_A1.4961.00
44_E84_T1.4891.00
160_Q176_S1.4841.00
27_V180_A1.4801.00
12_D18_T1.4791.00
50_Q59_M1.4591.00
29_L173_V1.4551.00
48_N169_E1.4471.00
56_R178_K1.4351.00
66_N70_E1.4091.00
115_A158_V1.4091.00
29_L151_L1.3951.00
4_S7_T1.3751.00
148_E161_R1.3481.00
44_E48_N1.3131.00
19_T22_K1.3031.00
153_G159_I1.2871.00
6_L24_A1.2821.00
63_F97_I1.2721.00
51_K90_T1.2671.00
5_I8_T1.2651.00
62_G93_M1.2641.00
45_Q167_T1.2591.00
18_T94_F1.2521.00
10_V105_H1.2171.00
143_I150_F1.1961.00
8_T107_L1.1771.00
74_G78_E1.1431.00
81_T85_T1.1341.00
151_L176_S1.1221.00
53_W174_M1.1191.00
80_K84_T1.1141.00
54_V59_M1.1131.00
62_G89_V1.0951.00
13_I80_K1.0821.00
144_L148_E1.0801.00
10_V63_F1.0531.00
62_G72_E1.0501.00
33_V43_Y1.0331.00
40_T43_Y1.0331.00
40_T82_Y1.0301.00
117_T163_S1.0291.00
10_V94_F1.0261.00
73_P96_K1.0181.00
114_A158_V1.0171.00
28_L59_M1.0151.00
5_I20_L1.0131.00
35_S72_E1.0121.00
29_L58_F1.0021.00
5_I30_I0.9991.00
176_S179_L0.9961.00
175_E178_K0.9931.00
116_P141_D0.9871.00
23_F94_F0.9781.00
143_I148_E0.9551.00
65_C98_E0.9481.00
59_M92_P0.9481.00
104_R142_D0.9481.00
39_L165_D0.9460.99
53_W178_K0.9270.99
100_N104_R0.9230.99
113_A141_D0.9210.99
45_Q48_N0.9180.99
36_K69_L0.8970.99
117_T139_Y0.8960.99
97_I108_Y0.8940.99
20_L107_L0.8890.99
148_E163_S0.8870.99
166_M170_D0.8840.99
72_E93_M0.8790.99
31_V46_L0.8640.99
35_S93_M0.8570.99
10_V107_L0.8400.99
49_I177_I0.8380.99
79_I96_K0.8350.99
35_S82_Y0.8240.99
53_W57_G0.8200.99
148_E164_P0.8180.99
138_L141_D0.8080.98
150_F161_R0.8050.98
67_Q100_N0.8040.98
36_K86_T0.7910.98
42_Q83_C0.7890.98
163_S166_M0.7890.98
30_I152_V0.7880.98
13_I95_S0.7840.98
5_I107_L0.7740.98
38_G71_Q0.7680.98
35_S62_G0.7640.98
50_Q92_P0.7620.98
176_S180_A0.7610.98
50_Q60_V0.7600.98
160_Q173_V0.7570.98
82_Y87_W0.7500.97
162_F173_V0.7440.97
27_V58_F0.7430.97
36_K73_P0.7350.97
110_K113_A0.7190.97
76_D79_I0.7180.97
112_I143_I0.7160.97
66_N74_G0.7160.97
43_Y79_I0.7150.97
57_G181_L0.7130.96
114_A157_K0.7120.96
41_P87_W0.7120.96
39_L144_L0.7090.96
116_P139_Y0.7050.96
53_W56_R0.7030.96
51_K54_V0.7030.96
51_K88_G0.6910.96
25_G155_D0.6830.96
50_Q58_F0.6780.95
23_F28_L0.6740.95
30_I107_L0.6580.95
78_E81_T0.6560.94
26_N58_F0.6490.94
80_K85_T0.6470.94
67_Q103_G0.6410.94
74_G79_I0.6410.94
100_N142_D0.6390.94
144_L165_D0.6360.93
10_V20_L0.6360.93
43_Y74_G0.6350.93
110_K114_A0.6310.93
154_R180_A0.6310.93
39_L148_E0.6280.93
8_T105_H0.6270.93
22_K92_P0.6260.93
47_E89_V0.6220.93
72_E79_I0.6160.92
31_V108_Y0.6130.92
4_S157_K0.6130.92
30_I61_L0.6110.92
169_E174_M0.6100.92
153_G158_V0.6100.92
13_I79_I0.6100.92
52_A178_K0.6060.92
45_Q173_V0.6050.92
4_S8_T0.6030.92
67_Q99_V0.5990.91
151_L162_F0.5980.91
61_L92_P0.5960.91
5_I110_K0.5960.91
173_V177_I0.5950.91
13_I62_G0.5940.91
66_N96_K0.5940.91
168_P173_V0.5910.91
43_Y82_Y0.5880.91
47_E83_C0.5840.90
25_G156_G0.5810.90
84_T88_G0.5810.90
33_V72_E0.5780.90
143_I161_R0.5740.89
95_S105_H0.5720.89
23_F92_P0.5690.89
63_F105_H0.5680.89
6_L110_K0.5680.89
23_F61_L0.5670.89
54_V90_T0.5640.89
62_G91_F0.5630.89
79_I82_Y0.5600.88
107_L111_L0.5580.88
47_E91_F0.5540.88
83_C89_V0.5520.88
84_T87_W0.5520.88
6_L154_R0.5480.87
71_Q145_W0.5460.87
63_F107_L0.5460.87
73_P79_I0.5440.87
39_L69_L0.5420.87
43_Y93_M0.5370.86
33_V108_Y0.5370.86
39_L100_N0.5370.86
48_N51_K0.5360.86
173_V176_S0.5330.86
80_K93_M0.5300.85
42_Q45_Q0.5300.85
83_C86_T0.5290.85
41_P167_T0.5250.85
41_P44_E0.5250.85
140_P148_E0.5250.85
65_C100_N0.5250.85
117_T140_P0.5240.85
36_K85_T0.5190.84
117_T138_L0.5140.84
72_E89_V0.5140.84
77_E81_T0.5100.83
140_P163_S0.5070.83
10_V13_I0.5070.83
36_K70_E0.5060.83
105_H109_Q0.5030.82
33_V148_E0.5020.82
43_Y147_F0.5020.82
34_A37_C0.5010.82
74_G96_K0.5000.82
36_K78_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p5qA 3 0.8689 100 0.609 Contact Map
2i3yA 3 0.9617 100 0.614 Contact Map
2r37A 3 0.9617 100 0.615 Contact Map
2f8aA 3 0.9781 99.9 0.623 Contact Map
3dwvA 1 0.8743 99.9 0.641 Contact Map
2vupA 1 0.8852 99.9 0.643 Contact Map
2p31A 1 0.8415 99.9 0.647 Contact Map
3cmiA 1 0.776 99.9 0.648 Contact Map
3kijA 1 0.8579 99.9 0.655 Contact Map
2v1mA 1 0.8798 99.9 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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