BTUC - ECOLI - GREMLIN Contacts

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BTUC - Vitamin B12 import system permease protein BtuC

UniProt:	P06609	Sequences: MLTLARQQQRQNIRWLLCLSVLMLLALLLSLCAGEQWISPGDWFTPRGELFVWQIRLPRTLAVLLVGAALAISGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPNWALGLCAIAGALIITLILLRFARRHLSTSRLLLAGVALGIICSALMTWAIYFSTSVDLRQLMYWMMGGFGGVDWRQSWLMLALIPVLLWICCQSRPMNMLALGEISARQLGLPLWFWRNVLVAATGWMVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASALLLADIVARLALAAAELPIGVVTATLGAPVFIWLLLKAGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10127
Length:	326 (309)
Sequences:	13839 (9859)
Seq/√Len:	560.9

ECOLI - BTUC FEPG FEPD FECC FECD FHUB
BACSU - FHUB FHUG YFME YFHA YVRB YFMD YFIZ YCLN FEUB FEUC YCLO
HALSA - Q9HMG7 Q9HMG0 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
212_N	271_D	4.093	1.00
68_A	280_A	3.758	1.00
104_A	120_C	3.582	1.00
26_A	289_L	3.536	1.00
76_V	204_I	3.469	1.00
227_P	230_F	3.261	1.00
27_L	60_T	3.139	1.00
76_V	235_L	3.086	1.00
69_A	198_I	2.885	1.00
64_L	284_A	2.880	1.00
264_L	282_A	2.828	1.00
42_D	48_G	2.821	1.00
63_V	183_F	2.813	1.00
62_A	186_V	2.578	1.00
72_I	280_A	2.574	1.00
69_A	242_M	2.510	1.00
99_V	159_L	2.489	1.00
27_L	64_L	2.388	1.00
69_A	246_S	2.387	1.00
218_E	232_R	2.387	1.00
23_M	285_S	2.328	1.00
66_V	246_S	2.287	1.00
72_I	201_L	2.216	1.00
75_A	279_C	2.208	1.00
268_G	278_G	2.173	1.00
64_L	288_L	2.157	1.00
22_L	285_S	2.156	1.00
210_P	231_W	2.133	1.00
32_C	40_P	2.131	1.00
197_L	245_V	2.114	1.00
39_S	42_D	2.085	1.00
66_V	250_A	2.085	1.00
45_T	48_G	2.050	1.00
23_M	64_L	2.023	1.00
65_L	195_L	1.969	1.00
49_E	53_W	1.963	1.00
103_A	107_L	1.962	1.00
207_Q	210_P	1.962	1.00
99_V	156_C	1.940	1.00
213_M	226_L	1.917	1.00
77_M	239_T	1.892	1.00
79_A	272_H	1.887	1.00
16_L	278_G	1.885	1.00
46_P	49_E	1.865	1.00
59_R	291_D	1.839	1.00
203_W	238_A	1.837	1.00
102_I	160_M	1.825	1.00
212_N	272_H	1.769	1.00
30_S	60_T	1.735	1.00
207_Q	234_V	1.734	1.00
26_A	285_S	1.720	1.00
186_V	190_Q	1.650	1.00
192_W	196_A	1.632	1.00
230_F	234_V	1.632	1.00
75_A	275_L	1.626	1.00
207_Q	231_W	1.617	1.00
187_D	190_Q	1.604	1.00
61_L	191_S	1.592	1.00
293_V	297_A	1.559	1.00
256_I	287_L	1.550	1.00
29_L	32_C	1.547	1.00
29_L	33_A	1.501	1.00
19_L	281_L	1.496	1.00
101_L	121_A	1.466	1.00
129_T	240_G	1.465	1.00
15_W	278_G	1.459	1.00
125_A	244_G	1.452	1.00
30_S	292_I	1.419	1.00
183_F	287_L	1.408	1.00
294_A	305_I	1.408	1.00
264_L	278_G	1.400	1.00
274_V	277_P	1.400	1.00
26_A	288_L	1.388	1.00
203_W	207_Q	1.383	1.00
293_V	308_V	1.370	1.00
100_G	120_C	1.370	1.00
23_M	281_L	1.360	1.00
207_Q	235_L	1.329	1.00
196_A	200_V	1.316	1.00
19_L	278_G	1.300	1.00
260_I	282_A	1.295	1.00
222_R	229_W	1.295	1.00
73_S	242_M	1.294	1.00
128_I	156_C	1.286	1.00
47_R	50_L	1.284	1.00
19_L	282_A	1.281	1.00
50_L	54_Q	1.279	1.00
220_S	223_Q	1.271	1.00
260_I	286_A	1.270	1.00
213_M	224_L	1.260	1.00
192_W	195_L	1.259	1.00
62_A	249_L	1.258	1.00
98_G	160_M	1.256	1.00
94_S	243_V	1.249	1.00
65_L	191_S	1.247	1.00
230_F	233_N	1.240	1.00
16_L	274_V	1.239	1.00
250_A	253_I	1.235	1.00
100_G	124_G	1.231	1.00
63_V	288_L	1.231	1.00
155_I	314_A	1.229	1.00
71_A	260_I	1.229	1.00
23_M	284_A	1.225	1.00
202_L	206_C	1.217	1.00
264_L	275_L	1.202	1.00
203_W	234_V	1.194	1.00
194_M	249_L	1.189	1.00
96_G	128_I	1.186	1.00
37_W	40_P	1.185	1.00
68_A	284_A	1.183	1.00
272_H	275_L	1.179	1.00
80_L	235_L	1.174	1.00
14_R	17_L	1.173	1.00
231_W	234_V	1.170	1.00
229_W	233_N	1.164	1.00
102_I	175_L	1.147	1.00
98_G	179_M	1.129	1.00
119_L	123_A	1.127	1.00
153_G	157_S	1.125	1.00
229_W	232_R	1.120	1.00
75_A	276_L	1.119	1.00
204_I	238_A	1.117	1.00
277_P	280_A	1.105	1.00
19_L	285_S	1.105	1.00
99_V	103_A	1.093	1.00
43_W	52_V	1.088	1.00
106_L	163_A	1.082	1.00
65_L	194_M	1.082	1.00
62_A	191_S	1.082	1.00
63_V	287_L	1.079	1.00
122_I	241_W	1.075	1.00
95_N	156_C	1.067	1.00
130_L	134_R	1.056	1.00
196_A	199_P	1.054	1.00
36_Q	51_F	1.047	1.00
120_C	124_G	1.042	1.00
294_A	308_V	1.042	1.00
162_W	166_F	1.041	1.00
113_P	116_A	1.037	1.00
21_V	25_L	1.036	1.00
194_M	198_I	1.035	1.00
32_C	43_W	1.030	1.00
61_L	188_W	1.024	1.00
68_A	71_A	1.020	1.00
268_G	274_V	1.019	1.00
94_S	252_A	1.017	1.00
231_W	235_L	1.015	1.00
211_M	235_L	1.010	1.00
217_G	221_A	1.007	1.00
295_R	302_E	1.006	1.00
96_G	124_G	0.997	1.00
285_S	289_L	0.994	1.00
53_W	57_L	0.988	1.00
103_A	163_A	0.988	1.00
253_I	287_L	0.986	1.00
260_I	264_L	0.981	1.00
20_S	24_L	0.976	1.00
14_R	18_C	0.973	1.00
315_P	319_W	0.972	1.00
274_V	278_G	0.965	1.00
75_A	272_H	0.965	1.00
127_I	131_I	0.956	1.00
112_L	116_A	0.954	1.00
106_L	167_S	0.954	1.00
293_V	296_L	0.953	1.00
271_D	274_V	0.949	1.00
298_L	301_A	0.948	1.00
49_E	54_Q	0.945	1.00
132_L	152_L	0.940	1.00
60_T	292_I	0.930	1.00
233_N	237_A	0.926	1.00
28_L	32_C	0.920	1.00
218_E	222_R	0.920	1.00
275_L	279_C	0.918	1.00
99_V	160_M	0.916	1.00
15_W	19_L	0.915	1.00
33_A	296_L	0.915	1.00
291_D	295_R	0.913	1.00
226_L	231_W	0.912	1.00
267_C	282_A	0.912	1.00
289_L	293_V	0.906	1.00
20_S	281_L	0.902	1.00
27_L	288_L	0.902	1.00
203_W	206_C	0.896	1.00
188_W	191_S	0.894	1.00
316_V	319_W	0.894	1.00
31_L	60_T	0.893	1.00
26_A	292_I	0.892	1.00
15_W	18_C	0.891	1.00
193_L	196_A	0.888	1.00
246_S	250_A	0.887	1.00
189_R	192_W	0.886	1.00
170_V	174_Q	0.881	1.00
93_V	125_A	0.880	1.00
167_S	171_D	0.877	1.00
310_A	315_P	0.875	1.00
190_Q	249_L	0.871	1.00
219_I	222_R	0.868	1.00
175_L	179_M	0.861	1.00
132_L	136_A	0.860	1.00
116_A	119_L	0.854	1.00
123_A	127_I	0.850	1.00
60_T	288_L	0.846	1.00
46_P	50_L	0.845	1.00
97_A	125_A	0.844	1.00
236_V	240_G	0.841	1.00
73_S	239_T	0.841	1.00
65_L	198_I	0.840	1.00
212_N	273_R	0.839	1.00
294_A	304_P	0.838	1.00
34_G	56_R	0.838	1.00
89_G	94_S	0.837	1.00
23_M	27_L	0.832	1.00
207_Q	238_A	0.830	1.00
296_L	299_A	0.829	1.00
68_A	201_L	0.828	1.00
69_A	73_S	0.828	1.00
101_L	117_L	0.826	1.00
228_L	232_R	0.825	1.00
74_G	261_P	0.824	1.00
264_L	268_G	0.821	1.00
99_V	163_A	0.819	1.00
133_L	233_N	0.818	1.00
218_E	228_L	0.816	1.00
57_L	188_W	0.814	1.00
208_S	273_R	0.813	1.00
30_S	295_R	0.813	1.00
173_R	176_M	0.812	1.00
32_C	37_W	0.812	1.00
45_T	49_E	0.811	1.00
50_L	53_W	0.809	1.00
281_L	285_S	0.800	1.00
96_G	156_C	0.799	1.00
105_V	117_L	0.793	1.00
206_C	210_P	0.789	1.00
104_A	117_L	0.783	1.00
117_L	120_C	0.783	1.00
28_L	40_P	0.782	1.00
93_V	129_T	0.781	1.00
103_A	159_L	0.781	1.00
195_L	199_P	0.781	1.00
265_R	275_L	0.780	1.00
298_L	303_L	0.776	1.00
205_C	208_S	0.774	1.00
68_A	198_I	0.772	1.00
256_I	309_T	0.772	1.00
31_L	57_L	0.770	1.00
122_I	126_L	0.769	1.00
210_P	226_L	0.764	1.00
221_A	228_L	0.762	1.00
62_A	194_M	0.758	1.00
24_L	27_L	0.754	1.00
311_T	315_P	0.752	1.00
115_W	119_L	0.752	1.00
131_I	134_R	0.749	1.00
24_L	28_L	0.748	1.00
204_I	235_L	0.747	1.00
59_R	302_E	0.747	1.00
194_M	245_V	0.747	1.00
266_L	320_L	0.743	1.00
126_L	244_G	0.743	1.00
71_A	75_A	0.743	1.00
77_M	91_L	0.742	1.00
72_I	204_I	0.742	1.00
37_W	41_G	0.741	1.00
297_A	300_A	0.737	1.00
87_E	90_L	0.737	1.00
168_T	171_D	0.736	1.00
199_P	202_L	0.735	1.00
194_M	197_L	0.734	1.00
73_S	243_V	0.734	1.00
137_R	140_L	0.733	1.00
103_A	108_G	0.731	1.00
41_G	44_F	0.730	1.00
104_A	116_A	0.727	1.00
61_L	65_L	0.727	1.00
25_L	28_L	0.725	1.00
33_A	37_W	0.724	1.00
287_L	309_T	0.723	1.00
133_L	229_W	0.722	1.00
319_W	323_K	0.721	1.00
102_I	164_I	0.720	1.00
59_R	295_R	0.720	1.00
284_A	288_L	0.719	1.00
214_L	228_L	0.718	1.00
38_I	52_V	0.718	1.00
263_I	266_L	0.717	1.00
95_N	98_G	0.717	1.00
245_V	249_L	0.711	1.00
126_L	240_G	0.710	1.00
201_L	205_C	0.710	1.00
253_I	305_I	0.710	1.00
264_L	267_C	0.709	1.00
245_V	248_A	0.706	1.00
198_I	246_S	0.702	1.00
129_T	236_V	0.702	1.00
125_A	129_T	0.698	1.00
135_F	148_A	0.696	1.00
141_S	144_R	0.695	1.00
123_A	126_L	0.694	1.00
18_C	22_L	0.693	1.00
287_L	305_I	0.689	1.00
222_R	228_L	0.686	1.00
157_S	179_M	0.682	1.00
38_I	48_G	0.680	1.00
259_V	263_I	0.677	1.00
128_I	132_L	0.676	1.00
72_I	276_L	0.675	1.00
19_L	23_M	0.674	1.00
183_F	305_I	0.673	1.00
235_L	239_T	0.673	1.00
256_I	286_A	0.672	1.00
71_A	280_A	0.671	1.00
70_L	256_I	0.670	1.00
188_W	192_W	0.669	1.00
171_D	174_Q	0.668	1.00
105_V	174_Q	0.667	1.00
197_L	241_W	0.666	1.00
272_H	277_P	0.666	1.00
290_A	308_V	0.664	1.00
95_N	153_G	0.661	1.00
79_A	215_A	0.660	1.00
167_S	172_L	0.659	1.00
161_T	165_Y	0.659	1.00
98_G	252_A	0.659	1.00
76_V	238_A	0.655	1.00
23_M	288_L	0.652	1.00
68_A	72_I	0.649	1.00
36_Q	40_P	0.648	1.00
210_P	213_M	0.646	1.00
286_A	290_A	0.646	1.00
100_G	104_A	0.645	1.00
33_A	292_I	0.645	1.00
50_L	55_I	0.644	1.00
107_L	110_G	0.643	1.00
214_L	231_W	0.642	1.00
164_I	176_M	0.642	1.00
286_A	312_L	0.642	1.00
81_F	146_L	0.639	1.00
240_G	244_G	0.638	1.00
25_L	29_L	0.636	1.00
66_V	183_F	0.635	1.00
289_L	292_I	0.633	1.00
263_I	282_A	0.631	1.00
148_A	151_A	0.629	1.00
161_T	178_W	0.628	1.00
36_Q	39_S	0.628	1.00
189_R	193_L	0.624	1.00
104_A	108_G	0.624	1.00
94_S	97_A	0.623	1.00
280_A	284_A	0.621	1.00
294_A	297_A	0.621	1.00
52_V	57_L	0.620	1.00
176_M	179_M	0.620	1.00
234_V	238_A	0.620	1.00
95_N	157_S	0.614	1.00
28_L	44_F	0.614	1.00
259_V	317_F	0.611	1.00
57_L	61_L	0.611	1.00
125_A	240_G	0.611	1.00
209_R	212_N	0.607	1.00
277_P	281_L	0.607	1.00
263_I	286_A	0.607	1.00
263_I	316_V	0.604	1.00
259_V	316_V	0.604	1.00
294_A	302_E	0.603	1.00
40_P	44_F	0.603	1.00
212_N	277_P	0.603	1.00
16_L	20_S	0.602	1.00
261_P	279_C	0.600	1.00
31_L	52_V	0.599	1.00
18_C	21_V	0.599	1.00
16_L	281_L	0.599	1.00
62_A	250_A	0.597	1.00
20_S	23_M	0.597	1.00
193_L	197_L	0.595	1.00
157_S	161_T	0.593	1.00
258_L	320_L	0.592	1.00
87_E	257_G	0.591	1.00
82_E	218_E	0.591	1.00
198_I	201_L	0.591	1.00
282_A	285_S	0.590	1.00
191_S	194_M	0.589	1.00
206_C	209_R	0.589	1.00
26_A	29_L	0.589	1.00
143_S	146_L	0.587	1.00
105_V	175_L	0.586	1.00
133_L	136_A	0.584	1.00
244_G	248_A	0.583	1.00
183_F	250_A	0.582	1.00
136_A	148_A	0.576	0.99
15_W	267_C	0.576	0.99
15_W	268_G	0.576	0.99
27_L	31_L	0.576	0.99
243_V	247_V	0.575	0.99
148_A	152_L	0.575	0.99
30_S	288_L	0.574	0.99
129_T	133_L	0.572	0.99
140_L	144_R	0.571	0.99
40_P	43_W	0.569	0.99
114_N	118_G	0.567	0.99
117_L	121_A	0.566	0.99
16_L	19_L	0.564	0.99
227_P	234_V	0.563	0.99
234_V	237_A	0.561	0.99
136_A	145_L	0.561	0.99
319_W	322_L	0.559	0.99
164_I	172_L	0.559	0.99
292_I	296_L	0.557	0.99
164_I	175_L	0.556	0.99
191_S	195_L	0.554	0.99
62_A	66_V	0.554	0.99
200_V	203_W	0.553	0.99
76_V	239_T	0.553	0.99
77_M	86_A	0.552	0.99
77_M	93_V	0.549	0.99
63_V	305_I	0.549	0.99
155_I	159_L	0.548	0.99
81_F	84_P	0.548	0.99
212_N	215_A	0.545	0.99
17_L	21_V	0.538	0.99
124_G	128_I	0.537	0.99
198_I	202_L	0.536	0.99
128_I	152_L	0.535	0.99
164_I	179_M	0.534	0.99
273_R	277_P	0.533	0.99
32_C	44_F	0.532	0.99
93_V	132_L	0.532	0.99
77_M	240_G	0.532	0.99
177_Y	182_G	0.532	0.99
96_G	152_L	0.529	0.99
211_M	276_L	0.529	0.99
174_Q	177_Y	0.529	0.99
38_I	51_F	0.529	0.99
36_Q	48_G	0.528	0.99
127_I	130_L	0.526	0.99
288_L	292_I	0.526	0.99
21_V	24_L	0.525	0.99
204_I	276_L	0.525	0.99
227_P	233_N	0.524	0.99
29_L	292_I	0.521	0.99
291_D	302_E	0.520	0.99
102_I	163_A	0.520	0.99
193_L	245_V	0.519	0.99
263_I	267_C	0.519	0.99
22_L	26_A	0.517	0.99
165_Y	180_M	0.514	0.99
139_H	144_R	0.514	0.99
39_S	48_G	0.512	0.99
101_L	120_C	0.512	0.99
75_A	264_L	0.512	0.99
172_L	175_L	0.512	0.99
131_I	152_L	0.511	0.99
125_A	132_L	0.509	0.99
97_A	121_A	0.508	0.99
201_L	280_A	0.508	0.99
206_C	234_V	0.508	0.99
35_E	300_A	0.506	0.99
158_A	161_T	0.504	0.99
133_L	140_L	0.504	0.99
76_V	211_M	0.503	0.99
158_A	310_A	0.502	0.99
172_L	177_Y	0.501	0.99
140_L	229_W	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qi9A	2	0.9939	100	0.172	Contact Map
4g1uA	2	0.9049	100	0.203	Contact Map
2nq2A	2	0.9387	100	0.211	Contact Map
3wajA	1	0.7454	19.9	0.962	Contact Map
2m8rA	1	0.1135	19	0.963	Contact Map
4z7fA	2	0.5	11	0.967	Contact Map
4lz6A	1	0.4264	10	0.967	Contact Map
2b2hA	3	0.6319	8.4	0.968	Contact Map
3rceA	1	0.7638	7.9	0.969	Contact Map
4f35D	2	0.6166	5.6	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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