GREMLIN Database
BTUC - Vitamin B12 import system permease protein BtuC
UniProt: P06609 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10127
Length: 326 (309)
Sequences: 13839 (9859)
Seq/√Len: 560.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_N271_D4.0931.00
68_A280_A3.7581.00
104_A120_C3.5821.00
26_A289_L3.5361.00
76_V204_I3.4691.00
227_P230_F3.2611.00
27_L60_T3.1391.00
76_V235_L3.0861.00
69_A198_I2.8851.00
64_L284_A2.8801.00
264_L282_A2.8281.00
42_D48_G2.8211.00
63_V183_F2.8131.00
62_A186_V2.5781.00
72_I280_A2.5741.00
69_A242_M2.5101.00
99_V159_L2.4891.00
27_L64_L2.3881.00
69_A246_S2.3871.00
218_E232_R2.3871.00
23_M285_S2.3281.00
66_V246_S2.2871.00
72_I201_L2.2161.00
75_A279_C2.2081.00
268_G278_G2.1731.00
64_L288_L2.1571.00
22_L285_S2.1561.00
210_P231_W2.1331.00
32_C40_P2.1311.00
197_L245_V2.1141.00
39_S42_D2.0851.00
66_V250_A2.0851.00
45_T48_G2.0501.00
23_M64_L2.0231.00
65_L195_L1.9691.00
49_E53_W1.9631.00
103_A107_L1.9621.00
207_Q210_P1.9621.00
99_V156_C1.9401.00
213_M226_L1.9171.00
77_M239_T1.8921.00
79_A272_H1.8871.00
16_L278_G1.8851.00
46_P49_E1.8651.00
59_R291_D1.8391.00
203_W238_A1.8371.00
102_I160_M1.8251.00
212_N272_H1.7691.00
30_S60_T1.7351.00
207_Q234_V1.7341.00
26_A285_S1.7201.00
186_V190_Q1.6501.00
192_W196_A1.6321.00
230_F234_V1.6321.00
75_A275_L1.6261.00
207_Q231_W1.6171.00
187_D190_Q1.6041.00
61_L191_S1.5921.00
293_V297_A1.5591.00
256_I287_L1.5501.00
29_L32_C1.5471.00
29_L33_A1.5011.00
19_L281_L1.4961.00
101_L121_A1.4661.00
129_T240_G1.4651.00
15_W278_G1.4591.00
125_A244_G1.4521.00
30_S292_I1.4191.00
183_F287_L1.4081.00
294_A305_I1.4081.00
264_L278_G1.4001.00
274_V277_P1.4001.00
26_A288_L1.3881.00
203_W207_Q1.3831.00
293_V308_V1.3701.00
100_G120_C1.3701.00
23_M281_L1.3601.00
207_Q235_L1.3291.00
196_A200_V1.3161.00
19_L278_G1.3001.00
260_I282_A1.2951.00
222_R229_W1.2951.00
73_S242_M1.2941.00
128_I156_C1.2861.00
47_R50_L1.2841.00
19_L282_A1.2811.00
50_L54_Q1.2791.00
220_S223_Q1.2711.00
260_I286_A1.2701.00
213_M224_L1.2601.00
192_W195_L1.2591.00
62_A249_L1.2581.00
98_G160_M1.2561.00
94_S243_V1.2491.00
65_L191_S1.2471.00
230_F233_N1.2401.00
16_L274_V1.2391.00
250_A253_I1.2351.00
100_G124_G1.2311.00
63_V288_L1.2311.00
155_I314_A1.2291.00
71_A260_I1.2291.00
23_M284_A1.2251.00
202_L206_C1.2171.00
264_L275_L1.2021.00
203_W234_V1.1941.00
194_M249_L1.1891.00
96_G128_I1.1861.00
37_W40_P1.1851.00
68_A284_A1.1831.00
272_H275_L1.1791.00
80_L235_L1.1741.00
14_R17_L1.1731.00
231_W234_V1.1701.00
229_W233_N1.1641.00
102_I175_L1.1471.00
98_G179_M1.1291.00
119_L123_A1.1271.00
153_G157_S1.1251.00
229_W232_R1.1201.00
75_A276_L1.1191.00
204_I238_A1.1171.00
277_P280_A1.1051.00
19_L285_S1.1051.00
99_V103_A1.0931.00
43_W52_V1.0881.00
106_L163_A1.0821.00
65_L194_M1.0821.00
62_A191_S1.0821.00
63_V287_L1.0791.00
122_I241_W1.0751.00
95_N156_C1.0671.00
130_L134_R1.0561.00
196_A199_P1.0541.00
36_Q51_F1.0471.00
120_C124_G1.0421.00
294_A308_V1.0421.00
162_W166_F1.0411.00
113_P116_A1.0371.00
21_V25_L1.0361.00
194_M198_I1.0351.00
32_C43_W1.0301.00
61_L188_W1.0241.00
68_A71_A1.0201.00
268_G274_V1.0191.00
94_S252_A1.0171.00
231_W235_L1.0151.00
211_M235_L1.0101.00
217_G221_A1.0071.00
295_R302_E1.0061.00
96_G124_G0.9971.00
285_S289_L0.9941.00
53_W57_L0.9881.00
103_A163_A0.9881.00
253_I287_L0.9861.00
260_I264_L0.9811.00
20_S24_L0.9761.00
14_R18_C0.9731.00
315_P319_W0.9721.00
274_V278_G0.9651.00
75_A272_H0.9651.00
127_I131_I0.9561.00
112_L116_A0.9541.00
106_L167_S0.9541.00
293_V296_L0.9531.00
271_D274_V0.9491.00
298_L301_A0.9481.00
49_E54_Q0.9451.00
132_L152_L0.9401.00
60_T292_I0.9301.00
233_N237_A0.9261.00
28_L32_C0.9201.00
218_E222_R0.9201.00
275_L279_C0.9181.00
99_V160_M0.9161.00
15_W19_L0.9151.00
33_A296_L0.9151.00
291_D295_R0.9131.00
226_L231_W0.9121.00
267_C282_A0.9121.00
289_L293_V0.9061.00
20_S281_L0.9021.00
27_L288_L0.9021.00
203_W206_C0.8961.00
188_W191_S0.8941.00
316_V319_W0.8941.00
31_L60_T0.8931.00
26_A292_I0.8921.00
15_W18_C0.8911.00
193_L196_A0.8881.00
246_S250_A0.8871.00
189_R192_W0.8861.00
170_V174_Q0.8811.00
93_V125_A0.8801.00
167_S171_D0.8771.00
310_A315_P0.8751.00
190_Q249_L0.8711.00
219_I222_R0.8681.00
175_L179_M0.8611.00
132_L136_A0.8601.00
116_A119_L0.8541.00
123_A127_I0.8501.00
60_T288_L0.8461.00
46_P50_L0.8451.00
97_A125_A0.8441.00
236_V240_G0.8411.00
73_S239_T0.8411.00
65_L198_I0.8401.00
212_N273_R0.8391.00
294_A304_P0.8381.00
34_G56_R0.8381.00
89_G94_S0.8371.00
23_M27_L0.8321.00
207_Q238_A0.8301.00
296_L299_A0.8291.00
68_A201_L0.8281.00
69_A73_S0.8281.00
101_L117_L0.8261.00
228_L232_R0.8251.00
74_G261_P0.8241.00
264_L268_G0.8211.00
99_V163_A0.8191.00
133_L233_N0.8181.00
218_E228_L0.8161.00
57_L188_W0.8141.00
208_S273_R0.8131.00
30_S295_R0.8131.00
173_R176_M0.8121.00
32_C37_W0.8121.00
45_T49_E0.8111.00
50_L53_W0.8091.00
281_L285_S0.8001.00
96_G156_C0.7991.00
105_V117_L0.7931.00
206_C210_P0.7891.00
104_A117_L0.7831.00
117_L120_C0.7831.00
28_L40_P0.7821.00
93_V129_T0.7811.00
103_A159_L0.7811.00
195_L199_P0.7811.00
265_R275_L0.7801.00
298_L303_L0.7761.00
205_C208_S0.7741.00
68_A198_I0.7721.00
256_I309_T0.7721.00
31_L57_L0.7701.00
122_I126_L0.7691.00
210_P226_L0.7641.00
221_A228_L0.7621.00
62_A194_M0.7581.00
24_L27_L0.7541.00
311_T315_P0.7521.00
115_W119_L0.7521.00
131_I134_R0.7491.00
24_L28_L0.7481.00
204_I235_L0.7471.00
59_R302_E0.7471.00
194_M245_V0.7471.00
266_L320_L0.7431.00
126_L244_G0.7431.00
71_A75_A0.7431.00
77_M91_L0.7421.00
72_I204_I0.7421.00
37_W41_G0.7411.00
297_A300_A0.7371.00
87_E90_L0.7371.00
168_T171_D0.7361.00
199_P202_L0.7351.00
194_M197_L0.7341.00
73_S243_V0.7341.00
137_R140_L0.7331.00
103_A108_G0.7311.00
41_G44_F0.7301.00
104_A116_A0.7271.00
61_L65_L0.7271.00
25_L28_L0.7251.00
33_A37_W0.7241.00
287_L309_T0.7231.00
133_L229_W0.7221.00
319_W323_K0.7211.00
102_I164_I0.7201.00
59_R295_R0.7201.00
284_A288_L0.7191.00
214_L228_L0.7181.00
38_I52_V0.7181.00
263_I266_L0.7171.00
95_N98_G0.7171.00
245_V249_L0.7111.00
126_L240_G0.7101.00
201_L205_C0.7101.00
253_I305_I0.7101.00
264_L267_C0.7091.00
245_V248_A0.7061.00
198_I246_S0.7021.00
129_T236_V0.7021.00
125_A129_T0.6981.00
135_F148_A0.6961.00
141_S144_R0.6951.00
123_A126_L0.6941.00
18_C22_L0.6931.00
287_L305_I0.6891.00
222_R228_L0.6861.00
157_S179_M0.6821.00
38_I48_G0.6801.00
259_V263_I0.6771.00
128_I132_L0.6761.00
72_I276_L0.6751.00
19_L23_M0.6741.00
183_F305_I0.6731.00
235_L239_T0.6731.00
256_I286_A0.6721.00
71_A280_A0.6711.00
70_L256_I0.6701.00
188_W192_W0.6691.00
171_D174_Q0.6681.00
105_V174_Q0.6671.00
197_L241_W0.6661.00
272_H277_P0.6661.00
290_A308_V0.6641.00
95_N153_G0.6611.00
79_A215_A0.6601.00
167_S172_L0.6591.00
161_T165_Y0.6591.00
98_G252_A0.6591.00
76_V238_A0.6551.00
23_M288_L0.6521.00
68_A72_I0.6491.00
36_Q40_P0.6481.00
210_P213_M0.6461.00
286_A290_A0.6461.00
100_G104_A0.6451.00
33_A292_I0.6451.00
50_L55_I0.6441.00
107_L110_G0.6431.00
214_L231_W0.6421.00
164_I176_M0.6421.00
286_A312_L0.6421.00
81_F146_L0.6391.00
240_G244_G0.6381.00
25_L29_L0.6361.00
66_V183_F0.6351.00
289_L292_I0.6331.00
263_I282_A0.6311.00
148_A151_A0.6291.00
161_T178_W0.6281.00
36_Q39_S0.6281.00
189_R193_L0.6241.00
104_A108_G0.6241.00
94_S97_A0.6231.00
280_A284_A0.6211.00
294_A297_A0.6211.00
52_V57_L0.6201.00
176_M179_M0.6201.00
234_V238_A0.6201.00
95_N157_S0.6141.00
28_L44_F0.6141.00
259_V317_F0.6111.00
57_L61_L0.6111.00
125_A240_G0.6111.00
209_R212_N0.6071.00
277_P281_L0.6071.00
263_I286_A0.6071.00
263_I316_V0.6041.00
259_V316_V0.6041.00
294_A302_E0.6031.00
40_P44_F0.6031.00
212_N277_P0.6031.00
16_L20_S0.6021.00
261_P279_C0.6001.00
31_L52_V0.5991.00
18_C21_V0.5991.00
16_L281_L0.5991.00
62_A250_A0.5971.00
20_S23_M0.5971.00
193_L197_L0.5951.00
157_S161_T0.5931.00
258_L320_L0.5921.00
87_E257_G0.5911.00
82_E218_E0.5911.00
198_I201_L0.5911.00
282_A285_S0.5901.00
191_S194_M0.5891.00
206_C209_R0.5891.00
26_A29_L0.5891.00
143_S146_L0.5871.00
105_V175_L0.5861.00
133_L136_A0.5841.00
244_G248_A0.5831.00
183_F250_A0.5821.00
136_A148_A0.5760.99
15_W267_C0.5760.99
15_W268_G0.5760.99
27_L31_L0.5760.99
243_V247_V0.5750.99
148_A152_L0.5750.99
30_S288_L0.5740.99
129_T133_L0.5720.99
140_L144_R0.5710.99
40_P43_W0.5690.99
114_N118_G0.5670.99
117_L121_A0.5660.99
16_L19_L0.5640.99
227_P234_V0.5630.99
234_V237_A0.5610.99
136_A145_L0.5610.99
319_W322_L0.5590.99
164_I172_L0.5590.99
292_I296_L0.5570.99
164_I175_L0.5560.99
191_S195_L0.5540.99
62_A66_V0.5540.99
200_V203_W0.5530.99
76_V239_T0.5530.99
77_M86_A0.5520.99
77_M93_V0.5490.99
63_V305_I0.5490.99
155_I159_L0.5480.99
81_F84_P0.5480.99
212_N215_A0.5450.99
17_L21_V0.5380.99
124_G128_I0.5370.99
198_I202_L0.5360.99
128_I152_L0.5350.99
164_I179_M0.5340.99
273_R277_P0.5330.99
32_C44_F0.5320.99
93_V132_L0.5320.99
77_M240_G0.5320.99
177_Y182_G0.5320.99
96_G152_L0.5290.99
211_M276_L0.5290.99
174_Q177_Y0.5290.99
38_I51_F0.5290.99
36_Q48_G0.5280.99
127_I130_L0.5260.99
288_L292_I0.5260.99
21_V24_L0.5250.99
204_I276_L0.5250.99
227_P233_N0.5240.99
29_L292_I0.5210.99
291_D302_E0.5200.99
102_I163_A0.5200.99
193_L245_V0.5190.99
263_I267_C0.5190.99
22_L26_A0.5170.99
165_Y180_M0.5140.99
139_H144_R0.5140.99
39_S48_G0.5120.99
101_L120_C0.5120.99
75_A264_L0.5120.99
172_L175_L0.5120.99
131_I152_L0.5110.99
125_A132_L0.5090.99
97_A121_A0.5080.99
201_L280_A0.5080.99
206_C234_V0.5080.99
35_E300_A0.5060.99
158_A161_T0.5040.99
133_L140_L0.5040.99
76_V211_M0.5030.99
158_A310_A0.5020.99
172_L177_Y0.5010.99
140_L229_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.9939 100 0.172 Contact Map
4g1uA 2 0.9049 100 0.203 Contact Map
2nq2A 2 0.9387 100 0.211 Contact Map
3wajA 1 0.7454 19.9 0.962 Contact Map
2m8rA 1 0.1135 19 0.963 Contact Map
4z7fA 2 0.5 11 0.967 Contact Map
4lz6A 1 0.4264 10 0.967 Contact Map
2b2hA 3 0.6319 8.4 0.968 Contact Map
3rceA 1 0.7638 7.9 0.969 Contact Map
4f35D 2 0.6166 5.6 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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