GREMLIN Database
CDH - CDP-diacylglycerol pyrophosphatase
UniProt: P06282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10138
Length: 251 (238)
Sequences: 262 (192)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_V79_M4.6991.00
175_H241_E4.4931.00
196_L212_L3.8220.99
125_S243_Q3.7600.99
35_R138_H3.7500.99
31_S137_N3.6920.99
240_E245_H3.2220.97
210_Y226_A3.0670.97
75_Q245_H2.9250.95
63_G82_Y2.5750.91
130_S133_G2.4730.89
182_V214_M2.4430.89
213_A239_A2.4270.88
126_L141_I2.3990.88
66_V110_F2.3410.86
151_R155_D2.3190.86
121_D220_N2.2940.85
69_D72_G2.1870.82
111_M124_V2.0930.79
30_E36_K2.0580.78
128_I200_V2.0510.78
172_L242_I2.0500.78
33_T37_I2.0340.77
89_S137_N2.0330.77
46_Q52_P2.0160.77
107_A110_F2.0070.76
93_T207_M1.9580.74
144_S245_H1.8650.71
81_T100_F1.8540.70
35_R39_L1.8150.68
213_A226_A1.8020.68
13_V164_R1.7960.68
168_L179_A1.7840.67
161_I223_V1.7830.67
75_Q243_Q1.7780.67
227_T235_N1.7600.66
68_K75_Q1.7310.65
111_M144_S1.7150.64
115_Y119_V1.6690.62
32_D36_K1.6050.59
146_I215_V1.5870.58
133_G238_S1.5860.58
112_S121_D1.5520.56
42_C55_C1.5500.56
196_L225_L1.5300.55
100_F150_V1.5260.55
178_L226_A1.5170.54
227_T237_A1.5110.54
97_T100_F1.5010.53
84_I197_A1.4960.53
67_L70_L1.4850.53
109_D113_K1.4770.52
55_C58_V1.4770.52
75_Q240_E1.4730.52
35_R195_M1.4660.52
66_V182_V1.4490.51
17_V20_G1.4090.49
69_D77_L1.3990.48
161_I179_A1.3950.48
57_E107_A1.3920.48
227_T239_A1.3760.47
56_A76_Y1.3520.46
130_S177_Y1.3510.46
144_S213_A1.3260.44
115_Y237_A1.2630.41
97_T191_S1.2600.41
177_Y241_E1.2540.41
55_C145_C1.2410.40
101_F127_A1.2410.40
125_S242_I1.2230.39
212_L224_L1.2120.39
75_Q114_K1.2070.39
79_M138_H1.2060.38
39_L65_V1.2010.38
175_H238_S1.1830.37
191_S194_M1.1800.37
128_I207_M1.1620.36
128_I211_G1.1480.36
238_S241_E1.1470.36
210_Y228_Q1.1360.35
133_G237_A1.1280.35
83_R139_F1.1280.35
68_K245_H1.1210.34
68_K77_L1.1180.34
117_Q242_I1.1180.34
37_I67_L1.1120.34
89_S108_R1.1050.34
14_I20_G1.1030.34
88_E104_A1.1010.34
137_N149_D1.1010.34
75_Q144_S1.0960.33
160_N167_P1.0860.33
101_F210_Y1.0800.33
135_T145_C1.0710.32
136_Q145_C1.0670.32
210_Y213_A1.0620.32
35_R85_N1.0620.32
66_V107_A1.0480.31
156_N186_E1.0410.31
58_V68_K1.0410.31
100_F104_A1.0380.31
100_F177_Y1.0330.31
16_V19_A1.0290.30
65_V235_N1.0220.30
129_N134_R1.0220.30
87_T210_Y1.0200.30
134_R140_H1.0190.30
72_G77_L1.0120.30
55_C135_T0.9990.29
13_V19_A0.9980.29
34_L42_C0.9960.29
74_L115_Y0.9950.29
132_T148_P0.9950.29
244_D247_C0.9940.29
100_F178_L0.9920.29
161_I168_L0.9800.28
13_V20_G0.9760.28
199_E203_A0.9710.28
85_N131_R0.9630.28
42_C145_C0.9570.27
121_D238_S0.9560.27
14_I19_A0.9540.27
84_I193_F0.9480.27
178_L211_G0.9400.27
82_Y87_T0.9390.27
68_K72_G0.9320.26
214_M231_L0.9230.26
179_A223_V0.9230.26
101_F125_S0.9210.26
31_S37_I0.9200.26
15_A248_E0.9200.26
114_K144_S0.9150.26
145_C247_C0.9130.26
191_S195_M0.9110.25
123_A151_R0.9090.25
143_I174_G0.9070.25
164_R182_V0.9050.25
31_S89_S0.9050.25
84_I100_F0.8950.25
13_V22_G0.8860.25
77_L105_W0.8860.25
118_P182_V0.8830.24
182_V190_R0.8830.24
41_E67_L0.8820.24
32_D83_R0.8810.24
92_L108_R0.8800.24
63_G124_V0.8720.24
133_G235_N0.8700.24
122_R155_D0.8700.24
68_K71_N0.8630.24
34_L140_H0.8630.24
157_N170_G0.8620.24
24_W161_I0.8580.23
128_I193_F0.8550.23
169_P172_L0.8440.23
187_L212_L0.8430.23
81_T181_R0.8380.23
53_S229_R0.8360.23
85_N157_N0.8320.23
65_V81_T0.8300.22
214_M224_L0.8290.22
72_G105_W0.8240.22
74_L144_S0.8230.22
64_Y97_T0.8210.22
179_A225_L0.8210.22
108_R145_C0.8190.22
178_L210_Y0.8190.22
92_L128_I0.8160.22
187_L214_M0.8120.22
214_M221_S0.8040.22
12_I22_G0.8030.22
21_I156_N0.8000.21
36_K40_E0.7990.21
45_N53_S0.7980.21
79_M178_L0.7980.21
88_E129_N0.7970.21
66_V109_D0.7970.21
98_P220_N0.7970.21
19_A249_I0.7960.21
131_R217_Q0.7960.21
154_L215_V0.7930.21
133_G224_L0.7920.21
175_H212_L0.7850.21
16_V20_G0.7820.21
78_L240_E0.7820.21
93_T193_F0.7790.21
101_F243_Q0.7770.21
108_R121_D0.7720.20
12_I27_T0.7710.20
18_A205_E0.7700.20
127_A226_A0.7650.20
139_F211_G0.7610.20
87_T139_F0.7590.20
33_T78_L0.7580.20
21_I246_Q0.7580.20
125_S186_E0.7580.20
185_S212_L0.7570.20
101_F146_I0.7550.20
197_A203_A0.7540.20
130_S227_T0.7530.20
113_K242_I0.7490.20
112_S120_P0.7460.20
211_G227_T0.7450.20
235_N238_S0.7440.20
101_F226_A0.7420.19
127_A146_I0.7410.19
66_V222_F0.7410.19
181_R221_S0.7400.19
15_A22_G0.7360.19
116_G126_L0.7360.19
13_V233_T0.7350.19
235_N241_E0.7340.19
156_N170_G0.7270.19
39_L138_H0.7250.19
33_T108_R0.7250.19
133_G175_H0.7220.19
133_G150_V0.7200.19
101_F175_H0.7190.19
17_V205_E0.7190.19
98_P241_E0.7180.19
38_V43_L0.7180.19
35_R165_W0.7150.19
34_L55_C0.7150.19
43_L58_V0.7100.18
203_A207_M0.7070.18
134_R141_I0.7040.18
44_P237_A0.7030.18
144_S229_R0.7020.18
211_G235_N0.6960.18
196_L224_L0.6960.18
76_Y245_H0.6910.18
162_S166_L0.6880.18
16_V205_E0.6870.18
14_I17_V0.6870.18
86_G142_H0.6860.18
38_V65_V0.6840.18
34_L134_R0.6820.18
85_N138_H0.6820.18
213_A229_R0.6810.18
16_V249_I0.6800.18
37_I75_Q0.6790.18
237_A245_H0.6780.18
169_P174_G0.6780.18
37_I77_L0.6750.17
51_N185_S0.6700.17
78_L143_I0.6690.17
23_Y26_L0.6680.17
54_P137_N0.6670.17
192_P223_V0.6660.17
111_M114_K0.6650.17
171_G176_E0.6650.17
41_E54_P0.6650.17
75_Q135_T0.6630.17
179_A192_P0.6590.17
43_L99_N0.6580.17
89_S145_C0.6560.17
72_G75_Q0.6550.17
130_S237_A0.6550.17
108_R143_I0.6530.17
97_T232_L0.6510.17
66_V160_N0.6500.17
16_V61_N0.6480.17
81_T130_S0.6460.17
64_Y84_I0.6450.17
214_M222_F0.6440.17
195_M222_F0.6430.17
220_N229_R0.6410.16
74_L111_M0.6360.16
58_V239_A0.6360.16
12_I248_E0.6350.16
181_R209_R0.6320.16
153_Q157_N0.6300.16
88_E134_R0.6280.16
87_T138_H0.6280.16
103_L226_A0.6270.16
66_V220_N0.6260.16
116_G167_P0.6260.16
138_H195_M0.6250.16
74_L203_A0.6240.16
97_T137_N0.6220.16
184_E215_V0.6210.16
124_V217_Q0.6190.16
24_W236_R0.6190.16
180_R237_A0.6170.16
21_I200_V0.6160.16
64_Y198_E0.6150.16
147_R182_V0.6140.16
162_S171_G0.6060.15
144_S240_E0.6020.15
127_A238_S0.6000.15
84_I89_S0.5990.15
50_Q237_A0.5970.15
138_H190_R0.5970.15
135_T240_E0.5960.15
50_Q223_V0.5960.15
43_L143_I0.5930.15
15_A23_Y0.5900.15
128_I159_A0.5890.15
161_I181_R0.5840.15
37_I125_S0.5830.15
12_I23_Y0.5800.15
100_F139_F0.5790.15
213_A224_L0.5790.15
144_S210_Y0.5780.15
135_T247_C0.5760.15
182_V212_L0.5710.15
45_N54_P0.5710.15
138_H170_G0.5700.15
92_L211_G0.5680.14
122_R217_Q0.5640.14
112_S220_N0.5630.14
38_V79_M0.5610.14
128_I230_N0.5600.14
107_A222_F0.5560.14
231_L243_Q0.5560.14
44_P58_V0.5520.14
163_S219_D0.5510.14
67_L131_R0.5510.14
38_V77_L0.5510.14
41_E44_P0.5500.14
28_G119_V0.5490.14
57_E66_V0.5470.14
12_I17_V0.5460.14
20_G63_G0.5460.14
75_Q203_A0.5460.14
47_Q71_N0.5440.14
74_L119_V0.5420.14
86_G140_H0.5420.14
48_Q137_N0.5410.14
155_D191_S0.5410.14
59_K221_S0.5400.14
13_V25_K0.5390.14
37_I72_G0.5380.14
152_K179_A0.5370.14
12_I20_G0.5360.14
50_Q62_A0.5330.14
162_S179_A0.5320.14
106_Q167_P0.5290.14
199_E219_D0.5280.14
86_G129_N0.5260.13
129_N142_H0.5260.13
35_R209_R0.5230.13
126_L240_E0.5210.13
68_K105_W0.5190.13
35_R130_S0.5180.13
151_R192_P0.5170.13
77_L165_W0.5170.13
35_R82_Y0.5170.13
45_N49_N0.5120.13
29_E66_V0.5120.13
225_L237_A0.5090.13
68_K76_Y0.5090.13
37_I41_E0.5080.13
49_N111_M0.5030.13
213_A232_L0.5010.13
195_M201_P0.5000.13
85_N102_W0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pofA 1 0.8765 100 0.407 Contact Map
1fitA 2 0.4861 93.5 0.939 Contact Map
3o1cA 2 0.4422 93.4 0.939 Contact Map
3ksvA 2 0.5458 92.4 0.941 Contact Map
3imiA 2 0.5538 90.6 0.943 Contact Map
2eo4A 2 0.5777 88.7 0.946 Contact Map
4zglA 2 0.3904 87.8 0.946 Contact Map
3n1sA 6 0.4582 87.6 0.947 Contact Map
3o0mA 2 0.5339 86.4 0.948 Contact Map
3l7xA 2 0.5538 86.2 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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