GREMLIN Database
DLD - D-lactate dehydrogenase
UniProt: P06149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10231
Length: 571 (549)
Sequences: 326 (187)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
463_R466_D6.5461.00
524_Q538_P5.1281.00
400_G404_A4.3650.98
405_K421_V4.2860.98
180_N186_T4.0860.98
319_E375_S4.0030.97
310_M437_A3.8320.96
32_T36_R3.7640.96
41_S83_E3.7120.96
396_M404_A3.6420.95
174_S253_S3.6330.95
108_H211_I3.5340.94
116_V119_Y3.3030.92
396_M400_G3.2730.92
107_L122_T3.2030.91
296_I300_F3.0480.88
190_H252_E2.9700.87
445_Q511_K2.9210.86
205_K210_R2.8660.85
478_D484_K2.8170.84
306_A431_F2.7940.83
315_Y382_K2.7940.83
178_R186_T2.7810.83
118_A193_I2.6760.80
300_F400_G2.6260.79
164_V491_M2.5880.78
326_F376_H2.5710.78
62_L554_M2.5270.76
541_L545_Y2.5200.76
56_L204_S2.4910.75
278_V427_G2.4910.75
400_G403_E2.4710.75
316_D385_R2.4600.74
173_M223_A2.4430.74
296_I396_M2.4150.73
330_D429_K2.4050.72
319_E382_K2.4000.72
62_L261_A2.3770.71
53_G103_R2.3720.71
179_I553_S2.3400.70
290_T495_F2.3090.69
56_L60_R2.2960.69
315_Y381_M2.2790.68
119_Y511_K2.2680.68
393_L431_F2.2560.67
375_S382_K2.2310.66
300_F396_M2.2020.65
438_A487_Y2.1810.65
260_L544_F2.1710.64
83_E88_N2.1630.64
351_L362_T2.1560.64
111_G114_E2.0980.61
198_T201_Q2.0860.61
234_D237_A2.0680.60
438_A441_A2.0620.60
300_F404_A2.0570.60
227_D248_D2.0490.59
64_A68_A2.0000.57
306_A393_L1.9910.57
62_L185_L1.9760.57
295_H407_W1.9730.56
56_L198_T1.9630.56
57_E60_R1.9600.56
247_P540_T1.9600.56
286_P470_Y1.9540.56
511_K515_L1.9450.55
185_L554_M1.9450.55
300_F403_E1.9270.55
12_F64_A1.9210.54
231_R445_Q1.9130.54
155_I267_L1.8890.53
41_S511_K1.8780.53
314_I437_A1.8640.52
480_Q513_Q1.8440.51
156_C524_Q1.8420.51
305_V398_G1.8360.51
12_F70_K1.8240.50
235_I298_A1.7870.49
508_H512_E1.7800.49
396_M403_E1.7710.48
106_K207_D1.7600.48
117_L267_L1.7590.48
13_L17_A1.7570.48
325_T436_A1.7490.47
77_A386_D1.7450.47
74_M261_A1.7440.47
63_K67_T1.7350.47
115_Q119_Y1.7130.46
476_E513_Q1.6970.45
417_G420_F1.6920.45
115_Q118_A1.6790.44
312_R389_E1.6780.44
275_N398_G1.6720.44
475_P479_S1.6630.44
105_D126_S1.6390.43
388_Y417_G1.6310.42
296_I400_G1.6270.42
427_G431_F1.6230.42
316_D319_E1.6220.42
77_A100_S1.6150.42
83_E345_G1.6010.41
396_M491_M1.5970.41
524_Q540_T1.5930.41
296_I404_A1.5930.41
165_Q256_C1.5830.41
37_K260_L1.5820.41
508_H515_L1.5730.40
477_I510_L1.5690.40
422_C426_E1.5670.40
119_Y456_L1.5550.39
174_S260_L1.5540.39
348_D362_T1.5500.39
271_E411_Y1.5480.39
441_A498_D1.5470.39
62_L177_A1.5310.39
423_T427_G1.5270.38
271_E419_F1.5150.38
201_Q204_S1.5140.38
83_E445_Q1.4960.37
99_I491_M1.4890.37
301_E403_E1.4780.36
179_I261_A1.4740.36
96_V165_Q1.4730.36
272_A306_A1.4690.36
70_K95_D1.4650.36
286_P327_L1.4530.36
62_L72_I1.4290.35
447_V470_Y1.4240.34
178_R181_E1.4230.34
381_M433_H1.4160.34
102_L397_A1.4120.34
453_E501_V1.4050.34
394_L404_A1.3760.33
174_S495_F1.3720.33
51_F83_E1.3640.32
12_F68_A1.3590.32
106_K126_S1.3500.32
327_L373_F1.3500.32
83_E456_L1.3460.32
83_E351_L1.3430.32
442_I446_A1.3410.31
400_G407_W1.3390.31
129_K335_D1.3320.31
212_K215_D1.3290.31
207_D327_L1.3280.31
156_C348_D1.3230.31
512_E515_L1.3160.31
77_A102_L1.3110.30
231_R511_K1.3080.30
223_A349_A1.3050.30
471_E486_Y1.2910.30
256_C260_L1.2880.30
111_G115_Q1.2840.29
60_R198_T1.2800.29
46_A98_I1.2770.29
343_L388_Y1.2720.29
83_E511_K1.2710.29
453_E503_K1.2700.29
538_P541_L1.2690.29
396_M401_V1.2540.28
198_T235_I1.2460.28
211_I215_D1.2430.28
41_S88_N1.2410.28
319_E436_A1.2410.28
41_S445_Q1.2400.28
67_T107_L1.2390.28
224_H524_Q1.2380.28
146_C150_S1.2340.28
337_M340_F1.2150.27
508_H511_K1.2110.27
35_Y51_F1.2090.27
314_I445_Q1.2020.27
273_E398_G1.2010.27
86_T348_D1.1960.27
296_I403_E1.1950.27
438_A485_L1.1950.27
58_L104_L1.1950.27
50_V61_V1.1920.26
357_F361_F1.1910.26
245_A337_M1.1890.26
152_I427_G1.1890.26
284_N389_E1.1860.26
236_E294_R1.1860.26
137_E306_A1.1810.26
101_T150_S1.1760.26
485_L514_M1.1710.26
276_Q398_G1.1670.26
398_G401_V1.1670.26
173_M360_H1.1660.26
151_V314_I1.1640.26
137_E431_F1.1620.26
454_D460_I1.1500.25
58_L261_A1.1460.25
416_E420_F1.1430.25
300_F407_W1.1410.25
128_E146_C1.1380.25
486_Y497_Q1.1380.25
225_D248_D1.1370.25
229_V303_L1.1350.25
107_L417_G1.1330.25
110_L222_H1.1320.25
156_C538_P1.1300.25
438_A514_M1.1280.24
480_Q505_V1.1190.24
130_A133_P1.1160.24
448_H455_I1.1140.24
407_W554_M1.1130.24
505_V510_L1.1050.24
125_Y292_I1.0970.24
524_Q541_L1.0970.24
315_Y384_W1.0940.23
77_A99_I1.0920.23
296_I491_M1.0910.23
35_Y98_I1.0890.23
72_I181_E1.0870.23
259_K366_M1.0870.23
302_N400_G1.0850.23
58_L72_I1.0850.23
119_Y445_Q1.0840.23
235_I256_C1.0810.23
122_T542_Q1.0760.23
524_Q539_E1.0750.23
35_Y54_S1.0720.23
147_I337_M1.0710.23
36_R58_L1.0700.23
83_E119_Y1.0670.23
295_H300_F1.0590.22
71_I93_D1.0550.22
58_L453_E1.0540.22
441_A487_Y1.0500.22
77_A202_I1.0460.22
83_E231_R1.0380.22
475_P478_D1.0340.22
518_L534_L1.0330.22
25_L31_K1.0310.22
328_M349_A1.0240.21
349_A403_E1.0230.21
175_L261_A1.0160.21
105_D366_M1.0150.21
137_E305_V1.0140.21
95_D360_H1.0110.21
65_C95_D1.0100.21
70_K98_I1.0100.21
453_E507_V1.0100.21
423_T426_E1.0070.21
481_L501_V1.0060.21
19_L90_N1.0040.21
337_M345_G1.0030.21
222_H226_Y1.0030.21
172_E207_D1.0020.21
26_L32_T1.0010.21
445_Q456_L1.0000.21
165_Q178_R0.9980.21
152_I262_V0.9980.21
502_K551_T0.9950.21
34_R345_G0.9920.21
24_H53_G0.9900.21
122_T162_S0.9860.20
134_L364_R0.9850.20
180_N419_F0.9820.20
276_Q314_I0.9810.20
151_V247_P0.9800.20
34_R364_R0.9780.20
74_M99_I0.9760.20
317_I485_L0.9760.20
497_Q521_R0.9760.20
323_K503_K0.9750.20
351_L358_R0.9700.20
277_Q398_G0.9680.20
155_I542_Q0.9670.20
61_V120_P0.9650.20
172_E256_C0.9620.20
361_F365_A0.9600.20
164_V545_Y0.9580.20
73_L205_K0.9570.20
272_A553_S0.9550.20
119_Y151_V0.9530.20
173_M343_L0.9520.20
122_T353_K0.9520.20
77_A385_R0.9520.20
114_E118_A0.9510.20
69_D100_S0.9510.20
324_D443_R0.9480.19
46_A152_I0.9460.19
30_A251_F0.9420.19
286_P369_F0.9400.19
276_Q437_A0.9390.19
315_Y371_H0.9390.19
336_K339_F0.9350.19
194_D215_D0.9340.19
485_L500_I0.9300.19
326_F377_L0.9280.19
56_L208_D0.9210.19
418_D422_C0.9200.19
419_F472_H0.9200.19
151_V353_K0.9170.19
109_V155_I0.9140.19
147_I329_I0.9120.19
325_T366_M0.9110.19
207_D463_R0.9100.18
384_W405_K0.9090.18
176_F406_S0.9070.18
58_L64_A0.9070.18
181_E239_T0.9070.18
392_L534_L0.9070.18
172_E515_L0.9060.18
418_D421_V0.9060.18
165_Q273_E0.9060.18
172_E296_I0.9060.18
288_V416_E0.9030.18
207_D480_Q0.9030.18
204_S238_D0.9020.18
66_V179_I0.9010.18
332_L373_F0.9010.18
353_K553_S0.9000.18
456_L460_I0.8990.18
71_I514_M0.8990.18
33_A69_D0.8980.18
388_Y544_F0.8980.18
47_L312_R0.8960.18
110_L220_G0.8960.18
41_S551_T0.8930.18
285_Q386_D0.8900.18
33_A46_A0.8890.18
104_L516_E0.8870.18
245_A438_A0.8860.18
441_A485_L0.8850.18
30_A350_M0.8850.18
102_L345_G0.8840.18
14_N17_A0.8830.18
454_D457_A0.8820.18
314_I519_Q0.8800.18
463_R514_M0.8790.18
466_D514_M0.8750.18
41_S351_L0.8740.18
314_I511_K0.8730.18
60_R208_D0.8730.18
147_I211_I0.8730.18
45_D243_Y0.8730.18
147_I332_L0.8710.18
221_R251_F0.8710.18
398_G415_A0.8690.17
196_G199_P0.8660.17
96_V237_A0.8640.17
394_L491_M0.8630.17
235_I463_R0.8620.17
256_C500_I0.8600.17
77_A261_A0.8540.17
17_A260_L0.8520.17
53_G57_E0.8510.17
19_L64_A0.8490.17
105_D256_C0.8490.17
365_A548_N0.8490.17
535_Y538_P0.8470.17
134_L178_R0.8470.17
438_A498_D0.8450.17
393_L427_G0.8440.17
12_F58_L0.8430.17
346_R352_E0.8420.17
46_A349_A0.8410.17
54_S365_A0.8400.17
448_H453_E0.8390.17
548_N554_M0.8370.17
376_H495_F0.8370.17
39_F328_M0.8350.17
150_S367_Q0.8310.17
179_I351_L0.8310.17
178_R442_I0.8300.17
114_E119_Y0.8290.17
89_G500_I0.8290.17
114_E117_L0.8280.17
317_I487_Y0.8270.17
511_K551_T0.8260.16
247_P270_F0.8260.16
296_I401_V0.8250.16
432_L435_F0.8240.16
116_V151_V0.8230.16
108_H111_G0.8200.16
41_S456_L0.8180.16
165_Q513_Q0.8180.16
31_K63_K0.8180.16
277_Q456_L0.8180.16
36_R458_L0.8170.16
61_V383_N0.8160.16
74_M439_G0.8140.16
231_R305_V0.8130.16
102_L553_S0.8130.16
24_H57_E0.8110.16
110_L433_H0.8110.16
17_A25_L0.8100.16
155_I423_T0.8090.16
278_V393_L0.8060.16
177_A554_M0.8060.16
367_Q412_F0.8050.16
81_L487_Y0.8050.16
270_F381_M0.8030.16
151_V345_G0.8030.16
162_S395_K0.7990.16
125_Y305_V0.7990.16
436_A457_A0.7980.16
178_R185_L0.7970.16
11_A475_P0.7970.16
86_T146_C0.7960.16
491_M548_N0.7960.16
73_L173_M0.7930.16
77_A275_N0.7920.16
14_N67_T0.7910.16
184_K409_V0.7900.16
315_Y337_M0.7890.16
118_A207_D0.7890.16
328_M351_L0.7880.16
54_S198_T0.7880.16
436_A514_M0.7880.16
205_K209_D0.7870.16
388_Y418_D0.7830.16
69_D310_M0.7820.16
107_L179_I0.7810.16
96_V366_M0.7790.15
243_Y315_Y0.7790.15
41_S362_T0.7780.15
70_K96_V0.7760.15
132_K381_M0.7760.15
51_F72_I0.7740.15
335_D366_M0.7740.15
476_E520_Q0.7720.15
254_S554_M0.7710.15
315_Y375_S0.7690.15
24_H388_Y0.7630.15
99_I296_I0.7630.15
273_E397_A0.7620.15
314_I456_L0.7610.15
268_D458_L0.7610.15
305_V397_A0.7600.15
274_K318_A0.7590.15
71_I96_V0.7590.15
15_E67_T0.7590.15
184_K384_W0.7580.15
197_E201_Q0.7580.15
29_P46_A0.7570.15
78_N146_C0.7530.15
61_V483_H0.7520.15
204_S208_D0.7510.15
152_I511_K0.7510.15
234_D248_D0.7490.15
41_S51_F0.7470.15
180_N221_R0.7470.15
145_S249_R0.7440.15
74_M429_K0.7430.15
63_K185_L0.7420.15
448_H503_K0.7420.15
98_I152_I0.7410.15
292_I388_Y0.7400.15
291_E388_Y0.7400.15
178_R256_C0.7390.15
95_D201_Q0.7380.15
441_A514_M0.7370.15
298_A400_G0.7370.15
54_S194_D0.7360.15
54_S379_P0.7350.15
13_L478_D0.7350.15
392_L498_D0.7340.15
364_R447_V0.7320.14
215_D468_E0.7320.14
146_C249_R0.7300.14
67_T387_K0.7300.14
477_I480_Q0.7290.14
334_T458_L0.7290.14
424_P428_S0.7290.14
343_L346_R0.7280.14
146_C501_V0.7280.14
292_I427_G0.7280.14
346_R502_K0.7270.14
107_L310_M0.7270.14
91_D230_H0.7220.14
37_K495_F0.7210.14
202_I256_C0.7200.14
83_E314_I0.7190.14
125_Y352_E0.7170.14
450_D547_E0.7170.14
221_R358_R0.7160.14
72_I179_I0.7130.14
283_T510_L0.7110.14
14_N208_D0.7100.14
65_C70_K0.7100.14
211_I551_T0.7090.14
346_R354_V0.7080.14
129_K460_I0.7060.14
291_E509_A0.7050.14
27_T100_S0.7050.14
227_D318_A0.7030.14
395_K498_D0.7020.14
194_D210_R0.7010.14
207_D285_Q0.7000.14
323_K514_M0.6990.14
146_C156_C0.6980.14
72_I467_T0.6980.14
186_T194_D0.6940.14
375_S407_W0.6930.14
300_F447_V0.6930.14
176_F251_F0.6900.14
334_T460_I0.6900.14
334_T441_A0.6890.14
380_R426_E0.6890.14
362_T383_N0.6870.14
65_C97_V0.6860.14
290_T460_I0.6860.14
109_V360_H0.6860.14
182_D186_T0.6860.14
155_I419_F0.6860.14
402_G405_K0.6860.14
172_E198_T0.6840.14
173_M224_H0.6830.14
428_S439_G0.6830.14
501_V507_V0.6810.13
201_Q274_K0.6800.13
310_M352_E0.6800.13
312_R386_D0.6800.13
37_K558_I0.6790.13
180_N247_P0.6780.13
310_M314_I0.6770.13
39_F366_M0.6770.13
39_F442_I0.6760.13
62_L179_I0.6740.13
396_M407_W0.6730.13
155_I388_Y0.6730.13
447_V453_E0.6730.13
224_H248_D0.6720.13
132_K182_D0.6720.13
98_I147_I0.6700.13
156_C553_S0.6680.13
438_A486_Y0.6680.13
100_S383_N0.6680.13
448_H452_V0.6670.13
272_A393_L0.6670.13
33_A352_E0.6670.13
347_T362_T0.6670.13
305_V396_M0.6660.13
83_E512_E0.6660.13
417_G421_V0.6640.13
225_D249_R0.6640.13
205_K371_H0.6640.13
224_H268_D0.6620.13
56_L203_L0.6620.13
61_V287_E0.6620.13
337_M438_A0.6620.13
33_A83_E0.6620.13
250_L465_N0.6610.13
328_M437_A0.6610.13
468_E482_V0.6590.13
251_F352_E0.6590.13
362_T366_M0.6580.13
69_D211_I0.6570.13
20_V256_C0.6570.13
241_A314_I0.6570.13
379_P383_N0.6550.13
29_P354_V0.6550.13
180_N554_M0.6540.13
481_L510_L0.6520.13
102_L296_I0.6520.13
417_G422_C0.6510.13
323_K396_M0.6510.13
421_V426_E0.6500.13
277_Q310_M0.6500.13
216_V221_R0.6500.13
256_C515_L0.6490.13
407_W491_M0.6490.13
295_H299_N0.6480.13
39_F439_G0.6480.13
132_K281_I0.6470.13
455_I486_Y0.6470.13
60_R286_P0.6470.13
281_I448_H0.6460.13
392_L490_F0.6460.13
272_A446_A0.6450.13
179_I350_M0.6440.13
283_T318_A0.6440.13
460_I486_Y0.6440.13
367_Q443_R0.6430.13
105_D345_G0.6420.13
280_Y391_H0.6420.13
280_Y486_Y0.6390.13
29_P406_S0.6380.13
83_E362_T0.6380.13
295_H447_V0.6370.13
47_L313_D0.6360.13
371_H450_D0.6350.13
306_A395_K0.6350.13
77_A256_C0.6340.13
125_Y512_E0.6340.13
241_A445_Q0.6320.13
180_N184_K0.6310.13
272_A524_Q0.6310.13
17_A286_P0.6270.12
156_C262_V0.6260.12
117_L431_F0.6260.12
286_P463_R0.6250.12
402_G406_S0.6230.12
335_D401_V0.6220.12
90_N429_K0.6220.12
328_M382_K0.6210.12
265_V318_A0.6210.12
137_E272_A0.6200.12
83_E335_D0.6200.12
90_N178_R0.6200.12
89_G237_A0.6190.12
180_N371_H0.6180.12
174_S275_N0.6160.12
286_P478_D0.6150.12
32_T58_L0.6150.12
302_N399_D0.6140.12
392_L457_A0.6140.12
224_H327_L0.6140.12
41_S119_Y0.6140.12
37_K230_H0.6130.12
261_A276_Q0.6130.12
231_R507_V0.6110.12
174_S283_T0.6110.12
428_S502_K0.6110.12
354_V383_N0.6110.12
223_A248_D0.6100.12
77_A107_L0.6100.12
420_F426_E0.6090.12
100_S174_S0.6090.12
178_R407_W0.6090.12
531_V541_L0.6080.12
328_M456_L0.6080.12
170_Y451_E0.6080.12
176_F188_V0.6080.12
207_D517_L0.6070.12
98_I383_N0.6070.12
98_I326_F0.6060.12
33_A224_H0.6050.12
234_D302_N0.6050.12
51_F104_L0.6050.12
41_S231_R0.6050.12
345_G352_E0.6040.12
125_Y427_G0.6040.12
53_G467_T0.6030.12
102_L398_G0.6030.12
182_D298_A0.6020.12
194_D198_T0.6020.12
217_R238_D0.6010.12
384_W418_D0.5990.12
95_D453_E0.5990.12
272_A276_Q0.5960.12
396_M551_T0.5960.12
380_R423_T0.5960.12
410_D414_Q0.5940.12
162_S487_Y0.5910.12
225_D278_V0.5870.12
261_A477_I0.5870.12
119_Y305_V0.5870.12
343_L402_G0.5860.12
115_Q208_D0.5860.12
364_R449_S0.5850.12
234_D319_E0.5850.12
271_E442_I0.5850.12
90_N276_Q0.5820.12
64_A453_E0.5820.12
63_K409_V0.5820.12
313_D487_Y0.5820.12
123_T367_Q0.5800.12
66_V211_I0.5790.12
51_F445_Q0.5780.12
480_Q510_L0.5770.12
537_A540_T0.5760.12
60_R402_G0.5760.12
196_G202_I0.5750.12
288_V403_E0.5750.12
260_L540_T0.5750.12
460_I495_F0.5750.12
328_M332_L0.5740.12
162_S419_F0.5740.12
301_E477_I0.5740.12
305_V349_A0.5730.12
349_A400_G0.5730.12
90_N274_K0.5730.12
23_S30_A0.5720.12
114_E306_A0.5710.12
514_M518_L0.5710.12
173_M514_M0.5710.12
46_A83_E0.5700.11
427_G437_A0.5700.11
46_A395_K0.5690.11
62_L323_K0.5680.11
47_L102_L0.5660.11
245_A441_A0.5660.11
111_G272_A0.5640.11
190_H289_L0.5640.11
101_T348_D0.5630.11
413_K547_E0.5630.11
51_F397_A0.5630.11
245_A334_T0.5630.11
207_D428_S0.5630.11
47_L373_F0.5620.11
272_A379_P0.5620.11
506_D509_A0.5620.11
506_D510_L0.5600.11
17_A96_V0.5600.11
392_L518_L0.5590.11
276_Q395_K0.5580.11
505_V513_Q0.5580.11
198_T460_I0.5570.11
46_A450_D0.5560.11
132_K198_T0.5560.11
12_F20_V0.5560.11
61_V216_V0.5560.11
412_F417_G0.5560.11
470_Y495_F0.5560.11
243_Y369_F0.5550.11
338_P525_Y0.5550.11
391_H516_E0.5550.11
243_Y402_G0.5550.11
380_R420_F0.5540.11
33_A107_L0.5540.11
113_G119_Y0.5530.11
50_V179_I0.5530.11
133_P342_N0.5520.11
122_T209_D0.5520.11
285_Q544_F0.5510.11
43_Q109_V0.5510.11
115_Q151_V0.5500.11
245_A487_Y0.5500.11
23_S175_L0.5490.11
37_K43_Q0.5480.11
120_P334_T0.5480.11
317_I366_M0.5480.11
37_K456_L0.5470.11
452_V503_K0.5470.11
352_E356_F0.5470.11
383_N546_R0.5460.11
72_I107_L0.5450.11
102_L106_K0.5440.11
288_V414_Q0.5440.11
248_D516_E0.5440.11
96_V384_W0.5440.11
314_I508_H0.5430.11
95_D482_V0.5430.11
66_V89_G0.5430.11
271_E288_V0.5420.11
260_L460_I0.5420.11
265_V498_D0.5410.11
23_S28_D0.5410.11
156_C256_C0.5400.11
165_Q276_Q0.5390.11
162_S447_V0.5370.11
183_G492_C0.5370.11
260_L442_I0.5370.11
249_R435_F0.5360.11
225_D231_R0.5360.11
200_E235_I0.5360.11
183_G422_C0.5360.11
98_I355_K0.5350.11
392_L395_K0.5350.11
98_I510_L0.5350.11
108_H483_H0.5330.11
78_N150_S0.5330.11
176_F291_E0.5330.11
199_P202_I0.5330.11
96_V106_K0.5320.11
276_Q351_L0.5310.11
317_I441_A0.5310.11
253_S463_R0.5310.11
51_F88_N0.5300.11
72_I229_V0.5300.11
231_R456_L0.5290.11
100_S117_L0.5290.11
327_L352_E0.5280.11
193_I424_P0.5280.11
36_R518_L0.5280.11
490_F498_D0.5280.11
477_I515_L0.5270.11
111_G116_V0.5270.11
442_I516_E0.5250.11
315_Y358_R0.5250.11
516_E543_K0.5240.11
71_I325_T0.5240.11
519_Q525_Y0.5220.11
164_V301_E0.5210.11
28_D31_K0.5200.11
424_P491_M0.5200.11
146_C435_F0.5180.11
68_A501_V0.5170.11
369_F373_F0.5170.11
445_Q512_E0.5160.11
54_S343_L0.5160.11
328_M345_G0.5150.11
448_H451_E0.5150.11
107_L524_Q0.5150.11
425_E429_K0.5140.11
96_V351_L0.5140.11
16_L50_V0.5140.11
436_A441_A0.5130.11
340_F437_A0.5130.11
287_E291_E0.5130.11
108_H175_L0.5110.11
36_R414_Q0.5110.11
310_M456_L0.5100.11
209_D292_I0.5100.11
419_F554_M0.5100.11
111_G119_Y0.5090.11
190_H518_L0.5090.11
15_E277_Q0.5080.10
96_V107_L0.5080.10
299_N356_F0.5070.10
212_K260_L0.5070.10
479_S502_K0.5060.10
456_L507_V0.5060.10
64_A181_E0.5060.10
123_T267_L0.5060.10
384_W508_H0.5060.10
375_S505_V0.5050.10
137_E162_S0.5040.10
17_A184_K0.5040.10
322_G486_Y0.5040.10
317_I544_F0.5040.10
35_Y347_T0.5040.10
490_F534_L0.5020.10
238_D379_P0.5020.10
198_T204_S0.5010.10
41_S345_G0.5010.10
126_S310_M0.5010.10
172_E507_V0.5000.10
118_A358_R0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f0xA 1 0.8792 100 0.611 Contact Map
4bbyA 2 0.7863 100 0.836 Contact Map
3pm9A 5 0.7618 100 0.851 Contact Map
2uuuA 2 0.7776 100 0.857 Contact Map
2exrA 1 0.7303 100 0.866 Contact Map
1w1oA 1 0.7058 100 0.874 Contact Map
4o95A 1 0.6743 100 0.875 Contact Map
1wvfA 2 0.8179 100 0.876 Contact Map
4mlaA 1 0.711 100 0.884 Contact Map
1e8gA 5 0.8266 100 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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