GREMLIN Database
FTSQ - Cell division protein FtsQ
UniProt: P06136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10342
Length: 276 (229)
Sequences: 3130 (2580)
Seq/√Len: 170.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_Y139_D4.9671.00
114_Q120_K3.5191.00
63_T122_H2.9891.00
70_R73_D2.8391.00
100_E109_V2.8381.00
79_L121_I2.8021.00
92_V113_K2.7441.00
62_L74_I2.5211.00
92_V111_V2.4941.00
61_V120_K2.4861.00
59_K118_E2.4581.00
107_K141_E2.4351.00
71_N75_R2.3741.00
78_I103_L2.3731.00
69_T103_L2.3121.00
202_T208_K2.3001.00
107_K124_V2.2841.00
61_V118_E2.2791.00
126_Y143_N2.2781.00
91_D94_I2.2131.00
99_I123_L2.1441.00
209_L223_F2.1431.00
212_G219_R2.1091.00
100_E108_Q2.0981.00
63_T120_K2.0981.00
220_L228_P2.0891.00
96_Q100_E2.0161.00
95_I111_V1.9341.00
187_T204_N1.9161.00
81_L98_Q1.9071.00
203_L209_L1.8771.00
107_K140_A1.8741.00
72_D76_Q1.8221.00
99_I106_I1.8131.00
87_F115_W1.7711.00
139_D143_N1.7501.00
243_Y255_G1.7421.00
107_K126_Y1.7271.00
66_R125_E1.7151.00
108_Q124_V1.6721.00
200_Q208_K1.6191.00
58_S117_D1.5641.00
94_I98_Q1.5611.00
110_S122_H1.5551.00
112_R122_H1.5471.00
55_L88_M1.5331.00
92_V96_Q1.5331.00
210_N243_Y1.5291.00
96_Q111_V1.5051.00
161_Y190_E1.4831.00
161_Y192_A1.4831.00
220_L226_L1.4711.00
68_Y105_W1.4611.00
62_L75_R1.4471.00
215_D218_K1.4391.00
203_L206_D1.4381.00
208_K243_Y1.4191.00
130_A160_L1.4121.00
223_F244_V1.4111.00
29_L33_T1.4101.00
112_R120_K1.3931.00
106_I109_V1.3861.00
105_W145_F1.3831.00
220_L224_V1.3751.00
198_S212_G1.3711.00
220_L223_F1.3701.00
176_E217_M1.3621.00
219_R223_F1.3591.00
79_L119_L1.3371.00
68_Y125_E1.3331.00
66_R71_N1.3211.00
22_G26_A1.3211.00
129_I140_A1.3051.00
72_D75_R1.3001.00
189_K202_T1.2971.00
130_A138_V1.2901.00
136_H144_T1.2861.00
223_F246_L1.2861.00
75_R79_L1.2711.00
176_E180_M1.2531.00
66_R74_I1.2351.00
195_A198_S1.2291.00
97_T100_E1.2131.00
103_L106_I1.1791.00
223_F227_Y1.1751.00
173_G176_E1.1631.00
189_K204_N1.1401.00
93_N96_Q1.1381.00
172_Q176_E1.1291.00
173_G191_A1.1261.00
109_V121_I1.1201.00
190_E202_T1.1141.00
188_L201_L1.1121.00
73_D78_I1.1051.00
87_F113_K1.1011.00
24_R27_G1.0901.00
36_T40_V1.0821.00
223_F228_P1.0821.00
26_A29_L1.0791.00
66_R69_T1.0791.00
55_L86_T1.0751.00
19_R23_T1.0731.00
194_T198_S1.0731.00
74_I123_L1.0721.00
96_Q108_Q1.0661.00
21_N25_L1.0631.00
219_R226_L1.0611.00
22_G25_L1.0550.99
248_Y251_G1.0530.99
133_N159_M1.0520.99
69_T99_I1.0510.99
128_P157_L1.0460.99
242_S255_G1.0370.99
175_R178_G1.0310.99
35_L39_L1.0270.99
207_I241_I1.0160.99
79_L99_I1.0060.99
174_Y178_G1.0020.99
29_L32_L0.9810.99
52_A84_P0.9750.99
57_L90_Q0.9680.99
219_R222_R0.9640.99
28_I32_L0.9530.99
90_Q119_L0.9490.99
201_L209_L0.9490.99
200_Q210_N0.9430.99
21_N24_R0.9420.99
194_T212_G0.9400.99
219_R224_V0.9360.99
222_R226_L0.9360.99
167_A170_V0.9290.99
79_L95_I0.9220.99
106_I123_L0.9180.99
81_L119_L0.9170.99
210_N245_D0.9150.99
111_V121_I0.9100.98
248_Y253_A0.9080.98
34_V38_V0.9040.98
26_A30_F0.9040.98
184_D203_L0.9030.98
131_R159_M0.8930.98
75_R80_A0.8910.98
25_L28_I0.8890.98
42_G46_L0.8890.98
90_Q95_I0.8820.98
127_V140_A0.8780.98
59_K117_D0.8690.98
207_I244_V0.8630.98
43_W47_G0.8620.98
19_R22_G0.8610.98
241_I254_V0.8600.98
159_M190_E0.8580.98
46_L50_E0.8540.98
217_M220_L0.8510.98
137_M145_F0.8450.98
105_W130_A0.8440.98
87_F117_D0.8420.97
33_T37_T0.8350.97
30_F40_V0.8310.97
40_V44_V0.8270.97
31_L35_L0.8260.97
191_A201_L0.8220.97
66_R123_L0.8220.97
26_A32_L0.8210.97
114_Q118_E0.8170.97
105_W146_S0.8140.97
41_S44_V0.8110.97
68_Y128_P0.8050.97
25_L35_L0.8030.97
226_L252_A0.8030.97
201_L211_L0.7990.97
23_T26_A0.7970.97
171_L175_R0.7940.96
113_K119_L0.7940.96
69_T105_W0.7930.96
132_W199_W0.7820.96
20_N23_T0.7800.96
211_L215_D0.7790.96
173_G177_M0.7790.96
82_G98_Q0.7780.96
69_T74_I0.7730.96
86_T89_T0.7720.96
105_W148_P0.7700.96
95_I99_I0.7690.96
251_G254_V0.7660.96
41_S45_V0.7650.96
109_V113_K0.7620.96
30_F33_T0.7620.96
192_A200_Q0.7590.95
20_N33_T0.7560.95
93_N97_T0.7540.95
31_L42_G0.7540.95
173_G178_G0.7500.95
224_V228_P0.7480.95
87_F119_L0.7370.95
176_E181_L0.7310.94
57_L139_D0.7300.94
22_G42_G0.7270.94
95_I98_Q0.7260.94
20_N25_L0.7250.94
194_T200_Q0.7190.94
145_F163_P0.7190.94
31_L37_T0.7180.94
173_G193_M0.7180.94
26_A40_V0.7170.94
219_R228_P0.7120.94
19_R31_L0.7070.93
252_A255_G0.7060.93
221_A225_E0.7060.93
178_G182_A0.6980.93
63_T66_R0.6940.93
113_K116_P0.6930.93
42_G45_V0.6880.92
30_F41_S0.6880.92
131_R137_M0.6880.92
151_R154_K0.6860.92
67_H125_E0.6840.92
25_L29_L0.6830.92
98_Q102_R0.6820.92
83_E90_Q0.6780.92
193_M196_R0.6780.92
50_E53_Q0.6770.92
19_R24_R0.6760.92
31_L34_V0.6650.91
23_T27_G0.6620.91
113_K145_F0.6620.91
164_E167_A0.6600.91
96_Q199_W0.6600.91
56_P85_G0.6580.91
136_H148_P0.6570.91
145_F191_A0.6550.90
159_M189_K0.6540.90
172_Q218_K0.6510.90
134_D156_V0.6490.90
38_V41_S0.6460.90
131_R157_L0.6460.90
99_I121_I0.6440.90
225_E229_V0.6370.89
225_E228_P0.6350.89
20_N26_A0.6330.89
99_I109_V0.6330.89
79_L98_Q0.6300.89
92_V184_D0.6280.89
164_E182_A0.6250.88
113_K136_H0.6230.88
128_P137_M0.6200.88
194_T219_R0.6150.87
132_W248_Y0.6150.87
222_R249_D0.6140.87
192_A198_S0.6140.87
74_I106_I0.6120.87
198_S210_N0.6110.87
249_D252_A0.6090.87
56_P89_T0.6080.87
170_V173_G0.6080.87
220_L227_Y0.6070.87
69_T123_L0.6040.87
125_E203_L0.6040.87
64_G121_I0.6020.86
25_L32_L0.6000.86
29_L40_V0.5980.86
27_G31_L0.5970.86
170_V178_G0.5960.86
237_D240_R0.5950.86
95_I119_L0.5950.86
80_A98_Q0.5930.86
199_W211_L0.5930.86
176_E179_Q0.5930.86
28_I97_T0.5920.85
88_M113_K0.5910.85
247_R253_A0.5900.85
99_I103_L0.5870.85
132_W247_R0.5860.85
60_L251_G0.5850.85
32_L39_L0.5850.85
25_L38_V0.5820.84
69_T146_S0.5800.84
241_I244_V0.5790.84
131_R219_R0.5790.84
69_T126_Y0.5770.84
21_N26_A0.5770.84
199_W213_R0.5760.84
25_L39_L0.5740.84
220_L249_D0.5730.84
34_V41_S0.5730.84
61_V122_H0.5710.83
115_W145_F0.5700.83
20_N24_R0.5700.83
70_R204_N0.5670.83
173_G181_L0.5660.83
20_N28_I0.5650.83
150_E154_K0.5630.82
105_W220_L0.5620.82
226_L241_I0.5620.82
180_M223_F0.5590.82
193_M198_S0.5580.82
244_V248_Y0.5550.82
203_L207_I0.5540.81
198_S213_R0.5500.81
24_R31_L0.5480.81
162_G219_R0.5470.81
224_V244_V0.5460.81
75_R81_L0.5460.81
88_M249_D0.5450.80
23_T28_I0.5450.80
81_L95_I0.5440.80
61_V114_Q0.5430.80
33_T43_W0.5400.80
63_T218_K0.5390.80
125_E201_L0.5390.80
31_L38_V0.5350.79
53_Q58_S0.5330.79
165_G170_V0.5300.79
20_N29_L0.5300.79
238_G244_V0.5300.79
39_L43_W0.5290.78
211_L246_L0.5280.78
129_I171_L0.5280.78
69_T125_E0.5260.78
129_I137_M0.5250.78
128_P145_F0.5250.78
196_R213_R0.5240.78
31_L97_T0.5220.78
45_V72_D0.5220.78
78_I99_I0.5200.77
217_M224_V0.5200.77
130_A157_L0.5200.77
71_N104_P0.5190.77
23_T40_V0.5180.77
189_K206_D0.5170.77
34_V62_L0.5150.77
37_T41_S0.5130.76
133_N161_Y0.5130.76
81_L90_Q0.5130.76
211_L220_L0.5130.76
55_L139_D0.5090.76
28_I31_L0.5080.76
71_N120_K0.5060.75
82_G85_G0.5050.75
105_W113_K0.5050.75
86_T115_W0.5040.75
28_I43_W0.5020.75
192_A202_T0.5010.75
92_V115_W0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vh2A 1 0.7246 100 0.292 Contact Map
2vh1A 1 0.7246 100 0.317 Contact Map
1yr1A 1 0.4022 99.4 0.723 Contact Map
3j00Z 1 0.3514 99.1 0.755 Contact Map
4k3bA 1 0.7464 95 0.882 Contact Map
3efcA 1 0.7464 88.4 0.903 Contact Map
2qdfA 1 0.7609 86.2 0.907 Contact Map
2x8xX 1 0.7645 76.3 0.916 Contact Map
3q6bA 1 0.413 49.9 0.929 Contact Map
2kogA 1 0.1884 45.4 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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