GREMLIN Database
ADA - Bifunctional transcriptional activator/DNA repair enzyme Ada
UniProt: P06134 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10029
Length: 354 (288)
Sequences: 1102 (764)
Seq/√Len: 45.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_C72_C5.1221.00
326_R332_S4.6671.00
90_A116_L4.5761.00
288_V293_L4.4531.00
193_L223_I4.3991.00
117_H127_T4.3431.00
189_V211_C4.2271.00
307_A311_A3.9411.00
195_D200_R3.9211.00
291_Q327_G3.7241.00
73_Q76_K3.7111.00
183_G231_P3.5031.00
69_C74_P3.4881.00
149_S152_T3.4741.00
188_A234_D3.3591.00
274_Q299_K3.3361.00
129_K133_Q2.9681.00
308_S311_A2.8791.00
189_V206_S2.8211.00
205_E242_F2.6551.00
62_L75_E2.5801.00
121_K127_T2.5171.00
95_E135_W2.5081.00
203_V210_I2.4381.00
101_T104_A2.4121.00
343_Q347_R2.3971.00
140_L165_Y2.3961.00
343_Q346_R2.3441.00
205_E245_H2.3131.00
154_I161_D2.2881.00
100_V132_Q2.2281.00
93_L108_Q2.2021.00
287_T345_L2.1971.00
153_S157_A2.1701.00
282_I288_V2.1541.00
331_L338_V2.1261.00
292_Q295_N2.0991.00
220_A224_S1.9900.99
308_S312_A1.9890.99
277_Q281_T1.9310.99
112_S115_H1.8790.99
342_A346_R1.8140.99
333_G338_V1.7840.98
297_I303_V1.7290.98
288_V296_A1.6610.97
278_A281_T1.6500.97
164_S167_R1.6420.97
179_Q187_L1.6230.97
250_I253_L1.6170.97
159_F168_K1.6030.97
277_Q280_R1.5970.97
308_S332_S1.5920.97
214_L225_E1.5910.97
152_T155_L1.5910.97
98_T101_T1.5810.97
197_E253_L1.5600.96
317_I344_L1.5170.96
200_R219_D1.5160.96
175_M180_F1.5060.95
118_R278_A1.4850.95
188_A236_A1.4650.95
317_I347_R1.4180.94
281_T296_A1.4150.94
124_T127_T1.4030.93
93_L109_V1.3940.93
106_A116_L1.3620.92
289_S307_A1.3440.92
245_H248_E1.3420.92
103_E113_P1.3330.91
153_S156_N1.3250.91
224_S228_Q1.3040.90
93_L105_L1.3010.90
288_V292_Q1.2990.90
90_A109_V1.2970.90
225_E229_M1.2900.90
95_E121_K1.2850.90
213_I318_I1.2820.90
310_C335_R1.2550.89
101_T105_L1.2430.88
288_V308_S1.2330.88
66_F72_C1.2260.87
253_L256_R1.2230.87
251_A257_D1.2230.87
189_V204_A1.2200.87
152_T156_N1.2150.87
86_K111_M1.1910.86
194_A242_F1.1830.86
170_D208_R1.1570.84
174_G183_G1.1520.84
266_I319_I1.1510.84
69_C73_Q1.1490.84
87_I111_M1.1470.84
66_F69_C1.1430.84
124_T130_A1.1430.84
70_K73_Q1.1300.83
160_P164_S1.1300.83
194_A201_C1.1270.83
96_Q108_Q1.1230.82
98_T104_A1.1180.82
203_V213_I1.0990.81
102_L127_T1.0950.81
227_Q237_P1.0930.81
316_A335_R1.0920.81
315_L319_I1.0890.80
151_T174_G1.0770.80
293_L297_I1.0640.79
293_L308_S1.0530.78
266_I273_Q1.0530.78
203_V325_V1.0460.78
149_S210_I1.0430.77
248_E262_L1.0410.77
229_M314_K1.0400.77
98_T103_E1.0350.77
176_T179_Q1.0280.76
117_H121_K1.0260.76
218_D221_T1.0230.76
117_H124_T1.0090.75
165_Y177_A1.0040.75
293_L301_K1.0020.75
210_I318_I1.0010.74
147_G286_E0.9960.74
101_T210_I0.9920.74
223_I227_Q0.9870.73
126_M206_S0.9840.73
173_L316_A0.9830.73
303_V307_A0.9790.73
103_E121_K0.9770.73
217_D340_R0.9690.72
89_H108_Q0.9600.71
268_G272_Q0.9580.71
206_S209_G0.9530.71
146_K196_C0.9510.71
135_W138_R0.9430.70
126_M270_A0.9390.70
87_I168_K0.9360.69
68_P291_Q0.9320.69
74_P77_A0.9280.69
174_G270_A0.9220.68
274_Q297_I0.9180.68
191_Y237_P0.9160.68
73_Q77_A0.9140.68
143_S156_N0.9140.68
237_P243_Q0.9130.67
70_K179_Q0.9120.67
227_Q235_N0.9080.67
226_L231_P0.9070.67
116_L119_L0.9040.67
117_H130_A0.9030.67
148_E152_T0.9000.66
292_Q303_V0.8970.66
259_P274_Q0.8940.66
175_M203_V0.8900.65
293_L324_V0.8830.65
175_M183_G0.8770.64
299_K302_A0.8750.64
248_E252_S0.8650.63
145_A213_I0.8640.63
67_R72_C0.8630.63
311_A333_G0.8620.63
74_P205_E0.8540.62
147_G196_C0.8470.62
187_L207_E0.8390.61
249_V252_S0.8370.61
191_Y195_D0.8350.60
104_A308_S0.8340.60
252_S260_L0.8330.60
66_F74_P0.8280.60
214_L314_K0.8270.60
206_S211_C0.8270.60
192_A265_D0.8260.60
227_Q238_A0.8170.59
88_T92_R0.8130.58
239_D315_L0.8120.58
183_G232_A0.8110.58
193_L200_R0.8100.58
189_V213_I0.8090.58
61_A65_G0.8080.58
137_A141_R0.8050.58
238_A243_Q0.8030.57
92_R95_E0.8020.57
117_H332_S0.8000.57
242_F318_I0.7890.56
191_Y200_R0.7890.56
151_T154_I0.7810.55
95_E131_W0.7800.55
140_L154_I0.7760.55
69_C159_F0.7750.55
79_A83_R0.7750.55
61_A67_R0.7750.55
190_R236_A0.7680.54
197_E254_N0.7660.54
282_I293_L0.7640.54
251_A256_R0.7620.53
240_L243_Q0.7620.53
297_I306_V0.7520.53
174_G192_A0.7510.52
98_T220_A0.7510.52
75_E78_N0.7480.52
196_C335_R0.7450.52
291_Q303_V0.7450.52
326_R330_T0.7450.52
89_H186_N0.7440.52
197_E347_R0.7430.52
216_G222_L0.7430.52
346_R349_A0.7390.51
102_L112_S0.7390.51
89_H109_V0.7370.51
255_Q258_T0.7350.51
293_L303_V0.7350.51
181_R296_A0.7330.51
154_I165_Y0.7330.51
289_S308_S0.7330.51
310_C336_W0.7320.51
241_M245_H0.7300.50
314_K343_Q0.7280.50
94_L131_W0.7270.50
225_E314_K0.7260.50
172_T210_I0.7250.50
105_L108_Q0.7240.50
178_K185_E0.7230.50
259_P319_I0.7210.50
221_T234_D0.7170.49
138_R156_N0.7160.49
270_A296_A0.7150.49
175_M222_L0.7140.49
96_Q311_A0.7130.49
288_V324_V0.7110.49
62_L76_K0.7110.49
68_P168_K0.7110.49
155_L162_S0.7090.48
245_H345_L0.7060.48
212_A335_R0.7060.48
156_N281_T0.7020.48
216_G307_A0.7010.48
204_A267_R0.7000.47
299_K303_V0.6990.47
133_Q182_H0.6980.47
174_G230_F0.6970.47
69_C311_A0.6970.47
308_S333_G0.6960.47
131_W272_Q0.6940.47
259_P315_L0.6920.47
163_S311_A0.6920.47
287_T325_V0.6920.47
138_R142_E0.6890.46
222_L335_R0.6880.46
175_M233_A0.6810.46
110_A113_P0.6810.46
67_R71_R0.6800.46
332_S338_V0.6780.45
186_N295_N0.6760.45
163_S178_K0.6750.45
65_G69_C0.6740.45
61_A69_C0.6690.44
201_C213_I0.6660.44
195_D227_Q0.6640.44
63_A143_S0.6580.43
262_L265_D0.6580.43
190_R207_E0.6570.43
264_L319_I0.6570.43
181_R342_A0.6530.43
182_H185_E0.6530.43
291_Q325_V0.6520.43
211_C242_F0.6520.43
180_F245_H0.6480.42
243_Q246_V0.6470.42
185_E232_A0.6430.42
118_R121_K0.6420.42
224_S237_P0.6400.42
140_L169_A0.6400.42
103_E236_A0.6400.42
97_E100_V0.6390.42
255_Q284_C0.6380.42
87_I302_A0.6380.42
282_I324_V0.6350.41
77_A133_Q0.6350.41
144_L153_S0.6330.41
64_A69_C0.6280.41
137_A224_S0.6280.41
201_C215_L0.6270.40
243_Q247_R0.6270.40
192_A246_V0.6270.40
127_T317_I0.6260.40
307_A345_L0.6230.40
161_D177_A0.6220.40
331_L342_A0.6190.40
107_D157_A0.6160.39
195_D219_D0.6160.39
275_V293_L0.6150.39
159_F165_Y0.6110.39
70_K141_R0.6110.39
87_I116_L0.6100.39
207_E225_E0.6080.39
85_D232_A0.6070.39
140_L177_A0.6060.39
154_I162_S0.6040.38
204_A265_D0.6040.38
84_L123_T0.6040.38
159_F253_L0.6020.38
201_C319_I0.6000.38
311_A332_S0.6000.38
74_P229_M0.6000.38
156_N257_D0.5990.38
209_G265_D0.5980.38
325_V328_D0.5960.38
209_G230_F0.5950.38
302_A327_G0.5950.38
273_Q280_R0.5940.37
273_Q308_S0.5930.37
237_P324_V0.5920.37
123_T126_M0.5910.37
91_C124_T0.5880.37
194_A319_I0.5860.37
301_K350_E0.5850.37
85_D147_G0.5830.36
87_I119_L0.5830.36
102_L117_H0.5830.36
73_Q177_A0.5820.36
255_Q259_P0.5820.36
140_L163_S0.5820.36
219_D223_I0.5800.36
303_V314_K0.5780.36
191_Y227_Q0.5770.36
101_T301_K0.5770.36
291_Q307_A0.5760.36
213_I324_V0.5750.36
178_K207_E0.5750.36
175_M202_L0.5740.36
198_L317_I0.5730.36
126_M249_V0.5730.36
87_I123_T0.5730.36
109_V119_L0.5730.36
203_V246_V0.5700.35
72_C159_F0.5690.35
152_T170_D0.5690.35
70_K76_K0.5690.35
295_N315_L0.5680.35
188_A219_D0.5670.35
179_Q186_N0.5650.35
303_V327_G0.5650.35
179_Q297_I0.5640.35
107_D350_E0.5630.35
143_S153_S0.5630.35
72_C311_A0.5620.35
83_R123_T0.5620.35
217_D234_D0.5600.34
115_H124_T0.5600.34
69_C76_K0.5580.34
211_C264_L0.5580.34
240_L295_N0.5570.34
252_S259_P0.5540.34
68_P192_A0.5540.34
293_L296_A0.5530.34
88_T315_L0.5520.34
272_Q278_A0.5510.34
175_M209_G0.5500.34
191_Y239_D0.5500.34
196_C234_D0.5500.34
83_R119_L0.5500.34
66_F168_K0.5490.33
100_V105_L0.5470.33
113_P311_A0.5460.33
253_L260_L0.5450.33
132_Q136_R0.5440.33
66_F144_L0.5440.33
144_L227_Q0.5430.33
211_C272_Q0.5410.33
213_I310_C0.5400.33
61_A131_W0.5390.33
145_A232_A0.5380.32
97_E139_R0.5360.32
278_A283_P0.5360.32
237_P251_A0.5330.32
163_S308_S0.5320.32
207_E298_G0.5320.32
92_R98_T0.5320.32
297_I301_K0.5320.32
204_A223_I0.5310.32
240_L261_T0.5300.32
256_R270_A0.5300.32
196_C201_C0.5300.32
164_S177_A0.5290.32
269_T272_Q0.5270.32
64_A71_R0.5260.31
107_D114_F0.5260.31
210_I315_L0.5260.31
165_Y237_P0.5250.31
310_C333_G0.5240.31
222_L310_C0.5230.31
135_W178_K0.5220.31
173_L269_T0.5210.31
142_E190_R0.5200.31
90_A210_I0.5190.31
248_E261_T0.5180.31
327_G330_T0.5180.31
207_E277_Q0.5170.31
72_C205_E0.5170.31
130_A174_G0.5170.31
61_A64_A0.5160.31
136_R159_F0.5150.31
91_C94_L0.5130.30
130_A134_A0.5130.30
178_K268_G0.5130.30
198_L347_R0.5120.30
272_Q319_I0.5120.30
196_C214_L0.5120.30
73_Q138_R0.5120.30
194_A250_I0.5100.30
148_E339_S0.5100.30
112_S117_H0.5100.30
224_S227_Q0.5080.30
256_R259_P0.5080.30
211_C235_N0.5070.30
246_V253_L0.5060.30
163_S211_C0.5060.30
237_P244_Q0.5060.30
79_A319_I0.5050.30
86_K93_L0.5040.30
80_Q315_L0.5040.30
173_L318_I0.5040.30
175_M272_Q0.5040.30
188_A207_E0.5040.30
94_L105_L0.5040.30
202_L298_G0.5030.30
64_A80_Q0.5030.30
92_R269_T0.5030.30
159_F230_F0.5020.29
183_G328_D0.5010.29
85_D88_T0.5010.29
146_K299_K0.5010.29
189_V205_E0.5000.29
219_D237_P0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sfeA 1 0.4661 100 0.619 Contact Map
3l00A 1 0.4209 100 0.675 Contact Map
4bhbA 1 0.4492 100 0.678 Contact Map
1eh6A 1 0.4463 100 0.679 Contact Map
1wrjA 1 0.4209 100 0.688 Contact Map
1u8bA 1 0.3729 100 0.712 Contact Map
1mgtA 1 0.435 100 0.725 Contact Map
2g7hA 1 0.4181 100 0.737 Contact Map
2kifA 1 0.2458 100 0.777 Contact Map
3gvaA 1 0.2486 100 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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