GREMLIN Database
TTDA - L(+)-tartrate dehydratase subunit alpha
UniProt: P05847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11168
Length: 303 (278)
Sequences: 1670 (838)
Seq/√Len: 50.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_K146_E4.6511.00
19_A107_K3.3991.00
8_Q90_L3.0741.00
45_T251_N2.9501.00
19_A103_E2.9251.00
175_V233_R2.8821.00
99_Q102_E2.6671.00
89_L145_A2.6041.00
154_G268_T2.5231.00
180_E184_T2.4961.00
41_K54_H2.4151.00
61_Q65_D2.4021.00
17_I285_L2.4021.00
146_E284_T2.3931.00
15_T99_Q2.3621.00
46_S49_G2.3461.00
99_Q103_E2.3311.00
154_G264_R2.2501.00
136_W204_E2.2121.00
15_T103_E2.2031.00
138_I212_K2.1611.00
166_M169_E2.0871.00
101_V133_W2.0601.00
70_A279_A2.0461.00
161_R184_T2.0441.00
222_H227_A2.0421.00
161_R181_N2.0401.00
81_V97_L2.0231.00
82_K138_I1.9911.00
195_V238_L1.9700.99
178_V234_L1.9640.99
34_V64_I1.9630.99
79_F149_V1.9570.99
176_K180_E1.9510.99
39_Q43_A1.9010.99
103_E107_K1.8950.99
102_E129_S1.8820.99
221_R232_L1.8590.99
22_T104_A1.8520.99
35_D39_Q1.8410.99
148_E284_T1.8300.99
92_E95_S1.7960.99
234_L238_L1.7880.99
219_G258_H1.7600.99
189_A193_V1.7520.99
276_G280_H1.7270.99
216_R260_E1.7150.99
210_S274_S1.7110.99
170_G173_G1.7050.99
76_E154_G1.6190.98
236_E240_R1.6160.98
76_E114_A1.6020.98
179_F234_L1.5910.98
18_V97_L1.5870.98
217_P220_S1.5860.98
203_V207_A1.5730.97
195_V275_T1.5670.97
246_Q276_G1.5590.97
158_L268_T1.5580.97
205_T262_A1.5560.97
81_V147_I1.5530.97
212_K260_E1.5410.97
238_L254_V1.5390.97
197_V273_V1.5310.97
172_E176_K1.5220.97
28_R64_I1.5100.97
16_E103_E1.4940.97
221_R256_G1.4860.96
24_M28_R1.4850.96
264_R268_T1.4710.96
230_L259_I1.4680.96
235_E254_V1.4510.96
20_N24_M1.4470.96
144_D286_L1.4240.95
78_M136_W1.4120.95
165_L173_G1.4080.95
193_V254_V1.4010.95
58_D61_Q1.3950.95
11_V89_L1.3930.95
31_D35_D1.3790.95
94_Q138_I1.3740.94
14_L97_L1.3390.94
11_V15_T1.3300.93
237_G241_L1.3300.93
225_P229_E1.3190.93
79_F101_V1.3170.93
134_V202_S1.3140.93
218_I256_G1.3120.93
227_A259_I1.3100.93
175_V237_G1.3000.93
25_I283_G1.2880.92
160_G203_V1.2840.92
193_V275_T1.2720.92
12_N16_E1.2610.91
161_R180_E1.2600.91
125_K128_G1.2570.91
13_K16_E1.2520.91
94_Q98_K1.2510.91
81_V137_D1.2430.91
12_N15_T1.2330.91
176_K237_G1.2180.90
179_F241_L1.2150.90
145_A287_V1.2100.90
14_L147_I1.2060.90
10_A13_K1.2050.89
181_N184_T1.2040.89
162_S203_V1.1890.89
32_D216_R1.1840.89
171_Y175_V1.1820.89
38_K61_Q1.1740.88
228_A232_L1.1680.88
209_L260_E1.1550.87
204_E208_V1.1500.87
79_F97_L1.1470.87
123_T226_K1.1450.87
27_T67_N1.1440.87
22_T77_I1.1380.87
57_F60_M1.1350.86
87_F145_A1.1340.86
163_K177_F1.1310.86
203_V272_A1.1270.86
195_V257_V1.1120.85
49_G251_N1.1090.85
49_G245_P1.1030.85
11_V145_A1.1020.85
245_P252_S1.0980.85
94_Q137_D1.0950.84
92_E141_D1.0770.83
81_V93_L1.0700.83
34_V38_K1.0640.83
195_V254_V1.0630.83
83_V145_A1.0610.82
237_G240_R1.0600.82
8_Q88_P1.0560.82
11_V90_L1.0510.82
226_K229_E1.0470.82
95_S98_K1.0380.81
28_R67_N1.0370.81
119_D123_T1.0300.81
171_Y230_L1.0250.80
116_E125_K1.0170.80
146_E286_L1.0130.79
209_L212_K1.0100.79
82_K212_K1.0070.79
179_F237_G1.0030.79
199_I271_V1.0010.79
25_I151_M0.9960.78
150_Y215_L0.9950.78
236_E239_N0.9930.78
33_V37_L0.9920.78
91_G96_I0.9900.78
17_I20_N0.9810.77
36_K39_Q0.9760.77
122_N230_L0.9760.77
197_V259_I0.9730.77
114_A154_G0.9710.76
35_D38_K0.9570.75
160_G207_A0.9450.74
206_A272_A0.9440.74
78_M204_E0.9380.74
77_I149_V0.9330.74
232_L236_E0.9320.73
210_S272_A0.9280.73
86_R142_N0.9260.73
16_E20_N0.9190.72
83_V137_D0.9180.72
167_P269_I0.9180.72
209_L262_A0.9170.72
199_I259_I0.9140.72
43_A251_N0.9090.72
177_F181_N0.9080.71
41_K57_F0.9080.71
96_I100_A0.9050.71
21_F285_L0.9010.71
162_S207_A0.8900.70
177_F273_V0.8890.70
19_A23_A0.8880.70
21_F283_G0.8840.69
34_V61_Q0.8800.69
54_H58_D0.8780.69
186_A191_P0.8760.69
22_T149_V0.8750.69
104_A108_A0.8730.68
163_K181_N0.8720.68
98_K133_W0.8720.68
207_A272_A0.8710.68
183_S241_L0.8700.68
24_M283_G0.8660.68
9_Q87_F0.8650.68
119_D227_A0.8600.67
52_I248_L0.8600.67
234_L237_G0.8570.67
220_S223_P0.8530.67
116_E123_T0.8510.66
76_E264_R0.8490.66
93_L145_A0.8450.66
150_Y282_R0.8420.66
85_S90_L0.8420.66
22_T100_A0.8420.66
14_L89_L0.8390.65
46_S242_G0.8310.65
116_E119_D0.8290.64
39_Q42_D0.8280.64
136_W208_V0.8280.64
56_M60_M0.8200.64
77_I105_T0.8180.63
10_A90_L0.8160.63
97_L135_T0.8140.63
220_S258_H0.8120.63
227_A261_S0.8120.63
49_G252_S0.8080.62
105_T112_H0.8030.62
219_G256_G0.7980.61
85_S88_P0.7980.61
230_L237_G0.7970.61
122_N125_K0.7960.61
203_V264_R0.7860.60
76_E268_T0.7810.60
178_V197_V0.7810.60
116_E127_T0.7750.59
120_E124_G0.7700.59
165_L169_E0.7690.59
164_V270_G0.7670.58
201_T270_G0.7630.58
22_T26_S0.7630.58
176_K184_T0.7570.57
59_N63_A0.7560.57
185_L188_N0.7530.57
159_P166_M0.7520.57
122_N226_K0.7510.57
46_S251_N0.7470.56
119_D226_K0.7470.56
171_Y233_R0.7440.56
169_E276_G0.7390.56
276_G279_A0.7330.55
35_D240_R0.7320.55
41_K50_K0.7320.55
23_A108_A0.7310.55
198_G209_L0.7270.54
182_I238_L0.7180.53
165_L174_V0.7180.53
182_I275_T0.7140.53
162_S271_V0.7130.53
9_Q13_K0.7090.52
38_K57_F0.7070.52
232_L256_G0.7060.52
159_P185_L0.7020.52
116_E261_S0.7010.52
57_F61_Q0.7010.52
123_T224_N0.6980.51
43_A252_S0.6980.51
205_T208_V0.6960.51
60_M279_A0.6950.51
50_K54_H0.6950.51
134_V204_E0.6940.51
74_T154_G0.6930.51
97_L137_D0.6890.50
176_K179_F0.6840.50
156_C280_H0.6840.50
154_G258_H0.6830.50
31_D36_K0.6780.49
268_T276_G0.6770.49
178_V237_G0.6720.49
194_L276_G0.6700.48
26_S151_M0.6680.48
202_S206_A0.6680.48
35_D43_A0.6680.48
120_E266_P0.6660.48
55_T204_E0.6650.48
113_N266_P0.6650.48
20_N285_L0.6650.48
58_D62_K0.6640.48
114_A127_T0.6610.48
199_I269_I0.6580.47
83_V93_L0.6580.47
38_K42_D0.6570.47
194_L218_I0.6550.47
72_Q267_S0.6550.47
39_Q176_K0.6530.47
50_K145_A0.6520.47
12_N41_K0.6510.47
147_I285_L0.6510.47
220_S260_E0.6510.47
113_N124_G0.6500.46
160_G274_S0.6490.46
175_V234_L0.6490.46
161_R177_F0.6460.46
182_I237_G0.6440.46
265_H270_G0.6440.46
36_K218_I0.6440.46
78_M134_V0.6430.46
8_Q11_V0.6410.46
148_E215_L0.6370.45
154_G202_S0.6350.45
115_V119_D0.6340.45
37_L60_M0.6280.44
229_E232_L0.6220.44
42_D232_L0.6200.43
187_V276_G0.6190.43
97_L147_I0.6160.43
29_M60_M0.6150.43
100_A104_A0.6140.43
81_V94_Q0.6110.42
258_H268_T0.6100.42
37_L56_M0.6090.42
225_P228_A0.6090.42
105_T113_N0.6090.42
40_L255_M0.6070.42
222_H228_A0.6050.42
119_D221_R0.6050.42
29_M214_I0.6030.42
79_F230_L0.6030.42
14_L18_V0.6030.42
124_G263_A0.6020.42
40_L53_Y0.6020.42
19_A104_A0.5990.41
36_K40_L0.5970.41
165_L271_V0.5960.41
47_S251_N0.5940.41
119_D122_N0.5920.41
37_L53_Y0.5910.40
115_V264_R0.5910.40
222_H225_P0.5850.40
82_K284_T0.5840.40
14_L91_G0.5820.40
33_V218_I0.5820.40
225_P232_L0.5810.39
23_A104_A0.5800.39
107_K236_E0.5770.39
159_P188_N0.5770.39
17_I21_F0.5760.39
185_L278_W0.5750.39
178_V238_L0.5750.39
24_M285_L0.5750.39
197_V234_L0.5740.39
159_P189_A0.5730.39
40_L252_S0.5720.39
224_N227_A0.5720.39
35_D219_G0.5710.39
97_L100_A0.5700.38
163_K169_E0.5700.38
202_S205_T0.5690.38
182_I197_V0.5690.38
114_A264_R0.5660.38
80_F215_L0.5660.38
89_L137_D0.5650.38
53_Y252_S0.5640.38
114_A134_V0.5640.38
162_S177_F0.5640.38
113_N133_W0.5610.38
266_P278_W0.5610.38
92_E236_E0.5610.38
174_V209_L0.5590.37
277_C281_R0.5570.37
34_V60_M0.5560.37
207_A274_S0.5540.37
56_M246_Q0.5540.37
229_E233_R0.5530.37
111_R153_G0.5510.37
224_N261_S0.5510.37
119_D224_N0.5500.36
246_Q268_T0.5490.36
163_K207_A0.5480.36
11_V93_L0.5440.36
215_L218_I0.5430.36
202_S226_K0.5430.36
258_H264_R0.5420.36
81_V89_L0.5420.36
124_G131_V0.5410.36
93_L214_I0.5390.35
49_G242_G0.5370.35
189_A275_T0.5370.35
33_V280_H0.5340.35
41_K52_I0.5330.35
9_Q145_A0.5320.35
30_P33_V0.5320.35
216_R282_R0.5320.35
175_V230_L0.5310.35
116_E226_K0.5300.35
200_A270_G0.5300.35
78_M202_S0.5290.35
83_V97_L0.5280.34
98_K135_T0.5280.34
108_A113_N0.5250.34
114_A131_V0.5250.34
121_V199_I0.5250.34
98_K144_D0.5250.34
237_G243_I0.5240.34
171_Y234_L0.5240.34
10_A39_Q0.5240.34
60_M64_I0.5230.34
13_K287_V0.5220.34
159_P210_S0.5220.34
50_K64_I0.5200.34
34_V57_F0.5200.34
62_K160_G0.5200.34
151_M156_C0.5190.34
218_I221_R0.5160.33
17_I287_V0.5150.33
69_P267_S0.5140.33
195_V218_I0.5140.33
78_M158_L0.5120.33
178_V184_T0.5120.33
50_K53_Y0.5090.33
102_E127_T0.5060.32
189_A280_H0.5050.32
126_N129_S0.5050.32
243_I253_S0.5040.32
120_E227_A0.5020.32
78_M274_S0.5020.32
179_F197_V0.5020.32
62_K235_E0.5020.32
113_N263_A0.5020.32
55_T248_L0.5010.32
122_N227_A0.5010.32
176_K240_R0.5000.32
12_N286_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jliA 1 0.3069 27.5 0.973 Contact Map
3bzsA 1 0.2871 27.4 0.973 Contact Map
4z7xA 1 0.3003 24.1 0.974 Contact Map
3gykA 3 0.3168 23.6 0.974 Contact Map
4p3yB 1 0.3102 20.3 0.975 Contact Map
3kzqA 3 0.33 19.9 0.975 Contact Map
4gxzA 1 0.3201 19.7 0.975 Contact Map
1r4wA 2 0.3564 17.5 0.975 Contact Map
2in3A 1 0.33 14.6 0.976 Contact Map
2iz1A 2 0.3993 13.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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