GREMLIN Database
ILVY - HTH-type transcriptional regulator IlvY
UniProt: P05827 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10503
Length: 297 (282)
Sequences: 79567 (58125)
Seq/√Len: 3461.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_Q74_Q3.7171.00
15_S24_A3.5021.00
96_F141_A2.6161.00
67_F81_T2.5051.00
233_V240_A2.3641.00
11_H24_A2.3391.00
92_E123_K2.2541.00
20_R23_R2.1701.00
184_E187_D2.1581.00
92_E121_E2.1561.00
14_E69_Q2.1491.00
8_T35_Q2.1061.00
45_Q60_A2.0881.00
94_H123_K2.0431.00
230_V250_S2.0411.00
10_L65_R2.0381.00
67_F74_Q2.0251.00
10_L69_Q2.0071.00
112_R292_I1.9951.00
11_H14_E1.9671.00
10_L14_E1.9651.00
234_A257_R1.9641.00
194_I238_G1.9531.00
165_A244_E1.9471.00
71_T75_Y1.9451.00
11_H15_S1.9371.00
13_A57_L1.9331.00
8_T32_L1.9281.00
163_N271_E1.8981.00
18_F36_I1.8931.00
234_A250_S1.8931.00
65_R69_Q1.8671.00
175_C191_V1.8441.00
159_S294_P1.8421.00
132_A144_A1.8211.00
170_A261_L1.7971.00
163_N269_P1.7801.00
64_L78_L1.7771.00
49_V56_T1.7771.00
192_P220_Y1.7561.00
160_M271_E1.7281.00
63_E81_T1.7231.00
135_K140_E1.6871.00
160_M163_N1.6781.00
13_A65_R1.6561.00
113_F289_F1.6451.00
14_E24_A1.6401.00
9_F65_R1.6261.00
15_S20_R1.6161.00
10_L68_A1.5991.00
8_T27_V1.5961.00
5_D35_Q1.5551.00
113_F120_V1.5551.00
134_E138_T1.5511.00
88_S119_S1.5471.00
19_G29_P1.5431.00
59_E62_E1.5201.00
28_S31_T1.5141.00
202_R206_E1.5041.00
5_D42_D1.5001.00
46_P49_V1.4981.00
67_F70_Q1.4801.00
17_H20_R1.4781.00
5_D38_R1.4761.00
11_H25_M1.4561.00
157_A278_K1.4481.00
10_L72_L1.4461.00
146_A275_C1.4401.00
158_F273_G1.4241.00
67_F77_Q1.4151.00
103_Y227_E1.4141.00
71_T78_L1.4131.00
148_K273_G1.4051.00
282_H286_I1.4001.00
90_S119_S1.3901.00
172_A257_R1.3641.00
143_L286_I1.3581.00
167_V244_E1.3551.00
274_V290_W1.3541.00
94_H125_T1.3511.00
135_K141_A1.3391.00
276_A290_W1.3351.00
64_L79_R1.3351.00
3_L75_Y1.3331.00
136_V144_A1.3231.00
209_F214_I1.3201.00
51_D56_T1.3171.00
143_L274_V1.3141.00
191_V239_V1.3141.00
288_A291_K1.3001.00
159_S276_A1.2941.00
229_M240_A1.2931.00
42_D79_R1.2931.00
74_Q77_Q1.2861.00
112_R116_E1.2821.00
114_R220_Y1.2801.00
250_S257_R1.2791.00
66_V70_Q1.2631.00
290_W294_P1.2621.00
203_R207_L1.2521.00
67_F78_L1.2481.00
231_S234_A1.2341.00
37_Q41_E1.2271.00
62_E66_V1.2211.00
181_V259_M1.2151.00
63_E66_V1.2141.00
9_F48_F1.2141.00
114_R192_P1.2111.00
157_A276_A1.2101.00
244_E248_E1.2061.00
111_D115_A1.2031.00
170_A239_V1.1991.00
27_V31_T1.1861.00
112_R115_A1.1691.00
167_V260_I1.1681.00
9_F13_A1.1521.00
244_E260_I1.1491.00
194_I229_M1.1481.00
93_L289_F1.1481.00
9_F47_L1.1471.00
111_D235_L1.1461.00
34_R38_R1.1441.00
34_R37_Q1.1391.00
123_K222_T1.1331.00
116_E292_I1.1321.00
182_S264_S1.1261.00
33_S37_Q1.1241.00
277_Q280_R1.1191.00
102_A126_T1.1181.00
176_P191_V1.1121.00
18_F55_V1.1111.00
192_P218_M1.1101.00
6_L68_A1.1081.00
223_V229_M1.1051.00
117_H288_A1.1041.00
12_L21_S1.1001.00
70_Q77_Q1.0981.00
113_F292_I1.0961.00
230_V234_A1.0931.00
11_H21_S1.0861.00
71_T74_Q1.0851.00
164_L245_V1.0821.00
7_K76_Q1.0811.00
63_E67_F1.0751.00
183_V187_D1.0651.00
4_R7_K1.0631.00
260_I263_R1.0621.00
287_E291_K1.0611.00
57_L61_G1.0601.00
35_Q38_R1.0561.00
108_P235_L1.0511.00
185_K265_D1.0501.00
231_S235_L1.0411.00
172_A259_M1.0221.00
251_P256_N1.0211.00
249_N255_R1.0181.00
169_I260_I1.0131.00
203_R206_E1.0111.00
178_R192_P1.0091.00
27_V32_L1.0091.00
8_T25_M1.0071.00
79_R83_D1.0061.00
76_Q80_H1.0031.00
170_A175_C0.9961.00
175_C178_R0.9961.00
96_F132_A0.9951.00
13_A48_F0.9921.00
76_Q79_R0.9871.00
113_F117_H0.9861.00
291_K294_P0.9861.00
64_L68_A0.9851.00
223_V232_M0.9791.00
193_F217_P0.9721.00
12_L18_F0.9691.00
73_L77_Q0.9681.00
9_F57_L0.9641.00
195_M219_I0.9621.00
135_K138_T0.9591.00
109_I293_L0.9571.00
158_F275_C0.9561.00
125_T135_K0.9481.00
283_E286_I0.9481.00
109_I292_I0.9421.00
9_F39_L0.9331.00
21_S32_L0.9321.00
48_F55_V0.9311.00
38_R41_E0.9291.00
13_A61_G0.9221.00
137_V154_G0.9221.00
45_Q82_I0.9181.00
63_E85_Q0.9101.00
96_F146_A0.9101.00
141_A144_A0.9011.00
20_R24_A0.8961.00
137_V152_L0.8951.00
121_E218_M0.8881.00
66_V69_Q0.8881.00
99_V225_G0.8811.00
192_P219_I0.8811.00
19_G23_R0.8761.00
160_M273_G0.8751.00
120_V285_L0.8731.00
16_R56_T0.8631.00
148_K271_E0.8601.00
207_L211_R0.8571.00
133_M137_V0.8561.00
25_M32_L0.8531.00
70_Q73_L0.8461.00
158_F294_P0.8401.00
125_T141_A0.8401.00
60_A85_Q0.8331.00
95_I143_L0.8271.00
165_A269_P0.8261.00
51_D54_T0.8241.00
187_D190_T0.8211.00
29_P33_S0.8211.00
184_E264_S0.8171.00
96_F144_A0.8171.00
111_D237_C0.8171.00
91_G285_L0.8141.00
282_H287_E0.8131.00
208_W212_N0.8121.00
175_C181_V0.8101.00
60_A82_I0.8101.00
9_F64_L0.8091.00
37_Q46_P0.8081.00
13_A16_R0.8061.00
16_R62_E0.8051.00
12_L36_I0.8041.00
157_A160_M0.7991.00
247_L250_S0.7991.00
3_L72_L0.7981.00
175_C179_N0.7981.00
75_Y78_L0.7971.00
74_Q78_L0.7961.00
14_E65_R0.7921.00
247_L251_P0.7911.00
205_I209_F0.7871.00
171_P236_G0.7841.00
159_S162_E0.7841.00
186_P189_S0.7841.00
131_D134_E0.7811.00
232_M237_C0.7801.00
12_L48_F0.7791.00
16_R54_T0.7781.00
15_S21_S0.7751.00
91_G120_V0.7721.00
4_R35_Q0.7721.00
177_V191_V0.7711.00
171_P237_C0.7701.00
89_L117_H0.7691.00
77_Q81_T0.7631.00
250_S255_R0.7611.00
75_Y79_R0.7611.00
143_L289_F0.7611.00
114_R237_C0.7591.00
60_A63_E0.7561.00
159_S290_W0.7551.00
284_P288_A0.7501.00
5_D8_T0.7491.00
205_I208_W0.7461.00
165_A262_E0.7451.00
208_W211_R0.7421.00
243_P246_V0.7401.00
68_A71_T0.7381.00
7_K11_H0.7361.00
49_V58_T0.7341.00
18_F32_L0.7321.00
113_F288_A0.7281.00
204_R208_W0.7271.00
78_L82_I0.7251.00
83_D86_G0.7231.00
137_V156_V0.7211.00
57_L62_E0.7211.00
31_T35_Q0.7201.00
12_L32_L0.7201.00
56_T62_E0.7181.00
207_L210_R0.7151.00
202_R222_T0.7141.00
97_C102_A0.7131.00
204_R207_L0.7111.00
94_H141_A0.7101.00
116_E288_A0.7061.00
168_L171_P0.7041.00
164_L244_E0.7031.00
69_Q73_L0.7031.00
168_L239_V0.7021.00
169_I247_L0.6981.00
196_A229_M0.6981.00
40_E45_Q0.6981.00
60_A64_L0.6951.00
197_D222_T0.6901.00
280_R283_E0.6881.00
170_A177_V0.6861.00
165_A267_K0.6861.00
49_V54_T0.6851.00
190_T218_M0.6851.00
145_I293_L0.6841.00
62_E65_R0.6831.00
59_E63_E0.6801.00
225_G228_A0.6801.00
73_L76_Q0.6701.00
139_G277_Q0.6701.00
94_H142_D0.6691.00
40_E50_R0.6681.00
97_C106_L0.6661.00
182_S262_E0.6651.00
221_A232_M0.6631.00
142_D286_I0.6631.00
202_R208_W0.6581.00
68_A72_L0.6571.00
154_G278_K0.6561.00
64_L82_I0.6551.00
173_L259_M0.6541.00
179_N182_S0.6531.00
93_L285_L0.6521.00
206_E210_R0.6511.00
36_I40_E0.6501.00
77_Q80_H0.6501.00
178_R259_M0.6491.00
184_E265_D0.6481.00
126_T224_G0.6471.00
23_R26_H0.6451.00
203_R208_W0.6431.00
121_E222_T0.6431.00
251_P260_I0.6411.00
18_F54_T0.6411.00
7_K10_L0.6411.00
156_V275_C0.6401.00
193_F239_V0.6361.00
103_Y231_S0.6321.00
21_S25_M0.6291.00
67_F71_T0.6281.00
288_A292_I0.6261.00
189_S214_I0.6231.00
170_A173_L0.6221.00
170_A259_M0.6211.00
136_V275_C0.6181.00
63_E82_I0.6131.00
12_L17_H0.6111.00
90_S121_E0.6081.00
289_F293_L0.6061.00
284_P287_E0.6041.00
80_H84_Q0.6031.00
143_L290_W0.6021.00
106_L109_I0.5981.00
126_T225_G0.5961.00
93_L143_L0.5931.00
197_D224_G0.5911.00
131_D135_K0.5901.00
162_E272_L0.5891.00
206_E209_F0.5881.00
4_R38_R0.5871.00
57_L65_R0.5861.00
147_G270_F0.5851.00
4_R8_T0.5811.00
30_S34_R0.5811.00
232_M238_G0.5811.00
132_A139_G0.5791.00
48_F57_L0.5781.00
229_M233_V0.5731.00
169_I242_L0.5731.00
108_P111_D0.5721.00
276_A287_E0.5721.00
7_K72_L0.5711.00
43_L64_L0.5701.00
110_L122_I0.5691.00
223_V228_A0.5681.00
43_L82_I0.5671.00
28_S34_R0.5661.00
45_Q49_V0.5621.00
31_T34_R0.5601.00
182_S187_D0.5581.00
186_P212_N0.5581.00
170_A178_R0.5521.00
101_A105_H0.5511.00
198_Q222_T0.5491.00
108_P112_R0.5451.00
172_A256_N0.5441.00
214_I217_P0.5431.00
91_G119_S0.5411.00
242_L247_L0.5401.00
43_L46_P0.5401.00
203_R209_F0.5381.00
72_L76_Q0.5381.00
72_L75_Y0.5361.00
9_F61_G0.5351.00
8_T36_I0.5351.00
177_V183_V0.5341.00
18_F29_P0.5331.00
169_I240_A0.5301.00
66_V81_T0.5291.00
96_F125_T0.5291.00
201_V205_I0.5281.00
117_H120_V0.5271.00
226_H243_P0.5271.00
173_L178_R0.5251.00
36_I48_F0.5251.00
103_Y225_G0.5251.00
202_R207_L0.5241.00
91_G117_H0.5231.00
18_F50_R0.5211.00
209_F217_P0.5191.00
189_S216_N0.5191.00
134_E140_E0.5181.00
286_I290_W0.5181.00
145_I274_V0.5171.00
171_P175_C0.5171.00
84_Q89_L0.5171.00
68_A75_Y0.5151.00
46_P60_A0.5141.00
67_F82_I0.5131.00
105_H109_I0.5121.00
27_V35_Q0.5101.00
196_A226_H0.5081.00
148_K152_L0.5081.00
8_T21_S0.5071.00
71_T79_R0.5071.00
16_R55_V0.5061.00
210_R213_K0.5031.00
6_L64_L0.5021.00
209_F212_N0.5011.00
257_R260_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fzvA 4 0.9596 100 0.081 Contact Map
1ixcA 4 0.9731 100 0.083 Contact Map
1uthA 2 0.7407 100 0.083 Contact Map
2h98A 2 0.6734 100 0.083 Contact Map
1al3A 1 0.697 100 0.088 Contact Map
2h9bA 2 0.6734 100 0.088 Contact Map
3fxqA 3 0.9798 100 0.089 Contact Map
2esnA 3 0.9798 100 0.091 Contact Map
4x6gA 4 0.9865 100 0.097 Contact Map
3szpA 3 0.9731 100 0.106 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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