ILVD - ECOLI - GREMLIN Contacts

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ILVD - Dihydroxy-acid dehydratase

UniProt:	P05791	Sequences: MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDSQSDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQTLEQYDVMLTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDTLDDDRANGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGLIEDGDLIAIDIPNRGIQLQVSDAELAARREAQDARGDKAWTPKNRERQVSFALRAYASLATSADKGAVRDKSKLGG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10496
Length:	616 (540)
Sequences:	1810 (708)
Seq/√Len:	30.5

ECOLI - ILVD YAGF YJHG EDD
BACSU - ILVD
SULSO - ILVD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
449_T	548_A	5.659	1.00
41_N	73_E	4.482	1.00
40_V	107_M	4.143	1.00
130_L	288_A	4.042	1.00
115_A	239_I	3.879	1.00
220_S	323_M	3.689	1.00
53_L	121_N	3.677	1.00
263_A	346_N	3.442	1.00
273_I	304_L	3.437	1.00
548_A	559_Q	3.435	1.00
40_V	116_M	3.340	1.00
141_I	352_V	3.233	1.00
177_S	180_Q	3.178	1.00
455_Y	464_A	3.169	1.00
208_T	214_S	3.020	1.00
141_I	239_I	2.998	1.00
104_V	132_A	2.960	1.00
260_A	265_F	2.953	1.00
452_A	541_I	2.878	1.00
234_N	237_K	2.854	1.00
64_I	69_G	2.798	1.00
550_D	553_N	2.797	1.00
436_V	549_I	2.778	1.00
170_Q	175_K	2.722	1.00
302_D	306_R	2.697	1.00
457_S	460_D	2.653	1.00
149_E	191_T	2.652	1.00
449_T	559_Q	2.634	1.00
87_H	111_H	2.625	1.00
347_R	358_P	2.620	1.00
54_R	58_K	2.598	1.00
141_I	238_R	2.591	1.00
210_A	271_L	2.586	1.00
454_V	541_I	2.514	0.99
54_R	61_A	2.488	0.99
269_M	296_F	2.461	0.99
453_K	474_D	2.423	0.99
266_E	346_N	2.414	0.99
118_C	140_V	2.391	0.99
496_T	516_F	2.337	0.99
271_L	332_V	2.326	0.99
64_I	236_G	2.316	0.99
238_R	241_E	2.314	0.99
270_T	308_V	2.313	0.99
152_K	184_V	2.305	0.99
349_V	357_L	2.298	0.99
561_S	564_E	2.290	0.99
446_L	552_P	2.285	0.99
452_A	547_I	2.274	0.99
484_K	534_S	2.264	0.99
453_K	543_D	2.257	0.99
548_A	557_Q	2.217	0.99
69_G	240_V	2.208	0.99
542_E	571_A	2.121	0.98
454_V	543_D	2.116	0.98
63_Q	66_A	2.093	0.98
37_I	64_I	2.086	0.98
117_V	143_V	2.082	0.98
340_D	347_R	2.078	0.98
472_A	506_K	2.074	0.98
262_K	294_I	2.052	0.98
558_L	565_L	2.040	0.98
263_A	348_D	2.038	0.98
445_I	448_F	2.035	0.97
37_I	239_I	2.034	0.97
541_I	547_I	2.033	0.97
176_V	180_Q	2.029	0.97
283_L	286_L	2.029	0.97
468_G	502_M	2.016	0.97
37_I	115_A	2.012	0.97
461_A	476_V	2.010	0.97
259_I	264_A	2.005	0.97
475_V	547_I	1.981	0.97
341_R	358_P	1.979	0.97
143_V	235_A	1.972	0.97
436_V	551_I	1.972	0.97
321_Y	408_C	1.968	0.97
349_V	356_T	1.945	0.97
511_I	528_V	1.932	0.97
471_V	506_K	1.928	0.96
434_C	556_I	1.925	0.96
170_Q	173_D	1.867	0.96
356_T	359_Q	1.854	0.96
560_V	564_E	1.846	0.95
475_V	549_I	1.826	0.95
429_F	541_I	1.825	0.95
210_A	332_V	1.812	0.95
449_T	546_L	1.809	0.95
214_S	218_N	1.804	0.95
59_L	233_L	1.799	0.95
282_V	435_I	1.787	0.95
229_K	233_L	1.775	0.94
538_I	541_I	1.767	0.94
365_D	379_R	1.742	0.94
453_K	464_A	1.739	0.94
447_K	550_D	1.713	0.93
51_V	192_C	1.710	0.93
587_R	591_F	1.708	0.93
342_A	412_L	1.704	0.93
210_A	345_L	1.702	0.93
266_E	303_K	1.701	0.93
564_E	567_A	1.685	0.93
456_E	460_D	1.682	0.93
453_K	472_A	1.673	0.92
537_S	558_L	1.669	0.92
39_V	64_I	1.664	0.92
355_L	359_Q	1.654	0.92
546_L	559_Q	1.640	0.92
66_A	237_K	1.618	0.91
541_I	558_L	1.615	0.91
447_K	548_A	1.612	0.91
121_N	145_G	1.604	0.91
442_D	445_I	1.594	0.90
88_G	588_Q	1.591	0.90
460_D	463_E	1.572	0.90
562_D	565_L	1.562	0.89
131_M	291_E	1.560	0.89
290_Q	605_K	1.550	0.89
166_D	170_Q	1.537	0.89
602_S	605_K	1.532	0.89
480_Y	571_A	1.521	0.88
565_L	568_R	1.521	0.88
429_F	537_S	1.510	0.88
39_V	61_A	1.506	0.88
149_E	222_L	1.500	0.87
38_A	41_N	1.496	0.87
59_L	229_K	1.492	0.87
63_Q	67_A	1.492	0.87
117_V	239_I	1.480	0.87
595_A	599_L	1.474	0.87
417_S	446_L	1.473	0.86
471_V	504_L	1.470	0.86
463_E	467_G	1.467	0.86
465_I	501_S	1.463	0.86
69_G	236_G	1.461	0.86
431_E	604_D	1.455	0.86
464_A	470_V	1.454	0.86
539_G	570_E	1.453	0.86
453_K	469_K	1.448	0.86
523_L	604_D	1.445	0.85
406_N	414_H	1.428	0.85
35_P	69_G	1.423	0.85
580_W	583_K	1.408	0.84
265_F	288_A	1.402	0.84
64_I	71_A	1.382	0.83
173_D	504_L	1.382	0.83
410_R	414_H	1.378	0.83
208_T	288_A	1.374	0.82
338_E	341_R	1.374	0.82
243_T	249_Q	1.359	0.82
39_V	116_M	1.358	0.82
183_Q	187_S	1.357	0.82
170_Q	180_Q	1.351	0.81
60_V	117_V	1.342	0.81
244_K	249_Q	1.340	0.81
572_Q	579_A	1.339	0.81
453_K	471_V	1.338	0.81
540_L	569_R	1.334	0.80
528_V	538_I	1.333	0.80
478_I	520_T	1.330	0.80
333_I	381_G	1.325	0.80
541_I	560_V	1.321	0.80
134_L	292_A	1.310	0.79
532_A	538_I	1.304	0.79
269_M	301_I	1.302	0.79
408_C	416_Y	1.293	0.78
87_H	188_A	1.287	0.78
310_Q	317_S	1.287	0.78
95_P	600_A	1.287	0.78
359_Q	362_E	1.284	0.78
542_E	564_E	1.279	0.77
564_E	568_R	1.269	0.77
511_I	556_I	1.267	0.77
537_S	541_I	1.267	0.77
411_S	414_H	1.266	0.77
321_Y	416_Y	1.257	0.76
56_L	224_T	1.256	0.76
529_S	602_S	1.255	0.76
242_L	252_E	1.252	0.76
178_D	363_Q	1.251	0.76
356_T	360_T	1.241	0.75
56_L	59_L	1.231	0.75
474_D	543_D	1.224	0.74
306_R	423_A	1.223	0.74
456_E	479_R	1.217	0.74
367_M	379_R	1.216	0.74
579_A	582_P	1.213	0.74
63_Q	237_K	1.206	0.73
452_A	475_V	1.195	0.72
334_G	409_I	1.190	0.72
365_D	377_M	1.187	0.72
431_E	537_S	1.180	0.71
55_D	229_K	1.180	0.71
61_A	236_G	1.176	0.71
350_K	355_L	1.176	0.71
53_L	73_E	1.172	0.71
263_A	266_E	1.168	0.71
432_N	604_D	1.167	0.71
271_L	336_L	1.162	0.70
41_N	53_L	1.159	0.70
290_Q	295_D	1.157	0.70
230_Q	233_L	1.154	0.70
560_V	565_L	1.149	0.69
511_I	547_I	1.146	0.69
242_L	259_I	1.135	0.68
282_V	298_M	1.131	0.68
258_N	350_K	1.129	0.68
299_S	431_E	1.128	0.68
210_A	336_L	1.126	0.68
259_I	350_K	1.110	0.67
560_V	568_R	1.104	0.66
579_A	583_K	1.095	0.66
150_A	153_T	1.093	0.65
347_R	356_T	1.092	0.65
268_A	335_I	1.090	0.65
325_D	408_C	1.090	0.65
118_C	142_F	1.089	0.65
498_F	501_S	1.088	0.65
562_D	566_A	1.088	0.65
444_S	507_A	1.087	0.65
238_R	242_L	1.083	0.65
273_I	308_V	1.073	0.64
134_L	260_A	1.071	0.64
38_A	73_E	1.069	0.64
443_D	446_L	1.068	0.64
453_K	470_V	1.068	0.64
353_L	356_T	1.065	0.63
337_G	361_L	1.062	0.63
462_V	498_F	1.059	0.63
111_H	588_Q	1.058	0.63
341_R	413_E	1.057	0.63
215_Q	219_G	1.056	0.63
299_S	303_K	1.056	0.63
265_F	268_A	1.052	0.62
563_A	567_A	1.052	0.62
539_G	580_W	1.050	0.62
456_E	538_I	1.050	0.62
318_T	408_C	1.049	0.62
268_A	349_V	1.045	0.62
358_P	361_L	1.044	0.62
238_R	252_E	1.040	0.62
302_D	423_A	1.038	0.61
474_D	506_K	1.036	0.61
116_M	140_V	1.036	0.61
261_S	294_I	1.036	0.61
242_L	254_A	1.036	0.61
62_E	66_A	1.034	0.61
149_E	225_H	1.032	0.61
132_A	256_P	1.031	0.61
64_I	240_V	1.023	0.60
299_S	426_Y	1.020	0.60
130_L	265_F	1.018	0.60
594_R	598_S	1.006	0.59
75_N	107_M	1.004	0.59
254_A	350_K	1.004	0.59
442_D	506_K	1.003	0.59
328_R	363_Q	1.003	0.59
353_L	360_T	1.003	0.59
465_I	504_L	1.001	0.59
99_L	106_Y	0.998	0.58
58_K	62_E	0.997	0.58
174_P	502_M	0.995	0.58
88_G	586_E	0.993	0.58
207_L	268_A	0.990	0.58
349_V	359_Q	0.988	0.58
406_N	411_S	0.988	0.58
345_L	357_L	0.986	0.57
207_L	422_L	0.984	0.57
318_T	321_Y	0.983	0.57
550_D	555_G	0.981	0.57
565_L	569_R	0.979	0.57
457_S	463_E	0.979	0.57
31_D	69_G	0.974	0.56
448_F	507_A	0.973	0.56
130_L	256_P	0.973	0.56
59_L	62_E	0.972	0.56
108_V	113_A	0.972	0.56
461_A	474_D	0.971	0.56
537_S	540_L	0.970	0.56
207_L	323_M	0.969	0.56
265_F	296_F	0.969	0.56
471_V	474_D	0.967	0.56
62_E	65_E	0.965	0.56
452_A	546_L	0.963	0.56
455_Y	478_I	0.962	0.55
463_E	469_K	0.962	0.55
98_E	239_I	0.957	0.55
311_L	335_I	0.957	0.55
453_K	468_G	0.957	0.55
88_G	111_H	0.953	0.55
55_D	224_T	0.952	0.55
353_L	359_Q	0.952	0.55
285_L	296_F	0.948	0.54
188_A	282_V	0.941	0.54
206_C	275_M	0.941	0.54
130_L	208_T	0.939	0.54
63_Q	233_L	0.936	0.53
263_A	349_V	0.936	0.53
429_F	558_L	0.935	0.53
436_V	441_V	0.931	0.53
36_I	70_V	0.931	0.53
561_S	565_L	0.930	0.53
98_E	600_A	0.925	0.53
156_S	166_D	0.924	0.52
462_V	494_Y	0.921	0.52
62_E	233_L	0.920	0.52
337_G	341_R	0.917	0.52
472_A	507_A	0.916	0.52
354_G	357_L	0.908	0.51
243_T	255_L	0.908	0.51
298_M	604_D	0.906	0.51
537_S	565_L	0.906	0.51
338_E	412_L	0.904	0.51
338_E	413_E	0.899	0.50
432_N	538_I	0.899	0.50
302_D	419_D	0.899	0.50
451_P	546_L	0.899	0.50
453_K	467_G	0.897	0.50
150_A	325_D	0.894	0.50
53_L	236_G	0.890	0.50
242_L	251_D	0.889	0.50
153_T	156_S	0.888	0.50
87_H	132_A	0.887	0.50
112_C	188_A	0.887	0.50
358_P	362_E	0.884	0.49
459_D	463_E	0.880	0.49
563_A	566_A	0.875	0.49
169_I	503_G	0.866	0.48
104_V	118_C	0.864	0.48
464_A	543_D	0.863	0.48
297_T	604_D	0.862	0.48
117_V	236_G	0.861	0.47
460_D	464_A	0.860	0.47
367_M	370_Q	0.860	0.47
153_T	184_V	0.860	0.47
540_L	565_L	0.859	0.47
557_Q	562_D	0.856	0.47
351_N	356_T	0.854	0.47
234_N	241_E	0.848	0.46
254_A	349_V	0.846	0.46
219_G	222_L	0.846	0.46
65_E	71_A	0.845	0.46
314_V	326_V	0.844	0.46
460_D	469_K	0.844	0.46
356_T	361_L	0.839	0.46
99_L	153_T	0.836	0.45
600_A	604_D	0.832	0.45
53_L	332_V	0.831	0.45
501_S	504_L	0.830	0.45
243_T	253_S	0.830	0.45
460_D	543_D	0.829	0.45
301_I	604_D	0.827	0.45
351_N	360_T	0.825	0.45
180_Q	496_T	0.822	0.44
64_I	239_I	0.820	0.44
423_A	552_P	0.820	0.44
150_A	326_V	0.815	0.44
282_V	442_D	0.815	0.44
169_I	500_K	0.814	0.44
149_E	224_T	0.812	0.44
601_T	604_D	0.808	0.43
449_T	557_Q	0.806	0.43
176_V	332_V	0.804	0.43
88_G	584_N	0.804	0.43
262_K	266_E	0.804	0.43
214_S	219_G	0.804	0.43
263_A	347_R	0.803	0.43
314_V	436_V	0.802	0.43
332_V	461_A	0.800	0.43
270_T	304_L	0.799	0.43
429_F	479_R	0.796	0.42
91_L	487_P	0.796	0.42
88_G	595_A	0.796	0.42
419_D	423_A	0.794	0.42
442_D	446_L	0.794	0.42
103_S	107_M	0.793	0.42
31_D	34_K	0.791	0.42
297_T	431_E	0.790	0.42
480_Y	539_G	0.789	0.42
334_G	411_S	0.788	0.42
429_F	538_I	0.782	0.41
454_V	558_L	0.778	0.41
153_T	166_D	0.778	0.41
333_I	361_L	0.775	0.41
441_V	446_L	0.767	0.40
239_I	242_L	0.767	0.40
152_K	167_A	0.767	0.40
349_V	358_P	0.766	0.40
529_S	604_D	0.765	0.40
535_G	539_G	0.764	0.40
61_A	71_A	0.762	0.40
290_Q	604_D	0.762	0.40
69_G	208_T	0.761	0.40
362_E	537_S	0.759	0.39
572_Q	580_W	0.756	0.39
34_K	70_V	0.755	0.39
260_A	296_F	0.750	0.39
170_Q	176_V	0.749	0.39
132_A	138_I	0.749	0.39
443_D	552_P	0.749	0.39
441_V	551_I	0.748	0.39
111_H	236_G	0.747	0.39
600_A	607_A	0.744	0.38
167_A	184_V	0.744	0.38
261_S	484_K	0.743	0.38
411_S	567_A	0.741	0.38
494_Y	498_F	0.740	0.38
207_L	210_A	0.740	0.38
211_L	268_A	0.739	0.38
424_V	435_I	0.734	0.38
455_Y	460_D	0.734	0.38
460_D	538_I	0.733	0.37
166_D	188_A	0.733	0.37
581_T	584_N	0.732	0.37
38_A	107_M	0.731	0.37
297_T	300_D	0.728	0.37
564_E	569_R	0.727	0.37
264_A	285_L	0.725	0.37
104_V	107_M	0.725	0.37
528_V	556_I	0.723	0.37
455_Y	470_V	0.723	0.37
283_L	297_T	0.722	0.37
560_V	566_A	0.721	0.37
250_N	255_L	0.720	0.36
134_L	256_P	0.720	0.36
429_F	511_I	0.719	0.36
219_G	335_I	0.718	0.36
306_R	419_D	0.717	0.36
191_T	218_N	0.717	0.36
62_E	237_K	0.714	0.36
173_D	494_Y	0.713	0.36
37_I	141_I	0.711	0.36
532_A	539_G	0.709	0.36
429_F	451_P	0.709	0.36
301_I	419_D	0.708	0.36
140_V	256_P	0.708	0.36
203_S	260_A	0.708	0.36
425_L	436_V	0.706	0.35
561_S	567_A	0.704	0.35
542_E	569_R	0.702	0.35
357_L	360_T	0.702	0.35
178_D	328_R	0.702	0.35
155_L	180_Q	0.701	0.35
230_Q	237_K	0.699	0.35
176_V	596_Y	0.698	0.35
249_Q	253_S	0.698	0.35
299_S	320_K	0.696	0.35
179_S	241_E	0.696	0.35
222_L	596_Y	0.695	0.35
268_A	356_T	0.693	0.35
111_H	263_A	0.692	0.34
236_G	308_V	0.691	0.34
66_A	233_L	0.690	0.34
145_G	187_S	0.689	0.34
141_I	203_S	0.686	0.34
268_A	359_Q	0.686	0.34
135_R	268_A	0.685	0.34
337_G	380_A	0.685	0.34
59_L	63_Q	0.684	0.34
240_V	243_T	0.682	0.34
342_A	413_E	0.682	0.34
332_V	335_I	0.682	0.34
251_D	538_I	0.681	0.34
41_N	56_L	0.680	0.34
222_L	225_H	0.674	0.33
259_I	268_A	0.674	0.33
41_N	65_E	0.670	0.33
251_D	283_L	0.667	0.33
35_P	207_L	0.666	0.33
269_M	297_T	0.665	0.33
87_H	459_D	0.663	0.32
210_A	218_N	0.662	0.32
244_K	250_N	0.662	0.32
108_V	138_I	0.660	0.32
580_W	584_N	0.660	0.32
345_L	529_S	0.660	0.32
56_L	60_V	0.659	0.32
155_L	166_D	0.658	0.32
449_T	511_I	0.658	0.32
43_F	58_K	0.657	0.32
103_S	106_Y	0.657	0.32
357_L	361_L	0.656	0.32
419_D	446_L	0.653	0.32
461_A	498_F	0.652	0.32
60_V	236_G	0.651	0.32
282_V	301_I	0.651	0.32
454_V	477_V	0.650	0.31
477_V	528_V	0.650	0.31
221_L	335_I	0.649	0.31
423_A	540_L	0.649	0.31
337_G	365_D	0.649	0.31
528_V	557_Q	0.648	0.31
381_G	399_T	0.647	0.31
243_T	250_N	0.646	0.31
41_N	206_C	0.645	0.31
470_V	506_K	0.644	0.31
314_V	335_I	0.643	0.31
155_L	320_K	0.642	0.31
186_R	408_C	0.641	0.31
565_L	572_Q	0.641	0.31
254_A	356_T	0.640	0.31
540_L	570_E	0.640	0.31
112_C	186_R	0.640	0.31
176_V	179_S	0.639	0.31
153_T	188_A	0.638	0.31
102_D	516_F	0.638	0.31
537_S	542_E	0.637	0.31
155_L	158_Q	0.637	0.31
271_L	538_I	0.637	0.31
222_L	332_V	0.636	0.31
362_E	380_A	0.635	0.30
283_L	302_D	0.634	0.30
37_I	117_V	0.632	0.30
154_K	157_D	0.632	0.30
459_D	584_N	0.632	0.30
566_A	570_E	0.631	0.30
135_R	596_Y	0.630	0.30
54_R	59_L	0.630	0.30
51_V	224_T	0.629	0.30
534_S	604_D	0.629	0.30
130_L	260_A	0.626	0.30
354_G	360_T	0.626	0.30
86_G	316_P	0.625	0.30
47_V	78_A	0.625	0.30
69_G	351_N	0.625	0.30
66_A	294_I	0.625	0.30
58_K	61_A	0.624	0.30
451_P	475_V	0.623	0.30
314_V	327_H	0.623	0.30
210_A	335_I	0.623	0.30
283_L	299_S	0.623	0.30
470_V	543_D	0.622	0.30
58_K	467_G	0.622	0.30
38_A	187_S	0.622	0.30
132_A	135_R	0.622	0.30
496_T	523_L	0.621	0.30
80_D	85_M	0.619	0.29
310_Q	417_S	0.618	0.29
170_Q	184_V	0.617	0.29
596_Y	609_R	0.616	0.29
219_G	361_L	0.616	0.29
462_V	478_I	0.616	0.29
250_N	253_S	0.615	0.29
560_V	563_A	0.613	0.29
130_L	134_L	0.613	0.29
470_V	474_D	0.612	0.29
92_Y	136_L	0.612	0.29
352_V	356_T	0.612	0.29
428_N	558_L	0.611	0.29
53_L	218_N	0.610	0.29
412_L	582_P	0.610	0.29
255_L	258_N	0.610	0.29
470_V	476_V	0.609	0.29
34_K	37_I	0.609	0.29
360_T	364_Y	0.609	0.29
447_K	549_I	0.608	0.29
436_V	552_P	0.607	0.29
130_L	294_I	0.607	0.29
99_L	102_D	0.606	0.29
35_P	500_K	0.606	0.29
325_D	363_Q	0.606	0.29
81_D	89_G	0.605	0.28
118_C	207_L	0.605	0.28
191_T	407_G	0.604	0.28
449_T	555_G	0.604	0.28
173_D	500_K	0.604	0.28
295_D	424_V	0.602	0.28
320_K	406_N	0.602	0.28
269_M	285_L	0.602	0.28
341_R	472_A	0.602	0.28
283_L	586_E	0.596	0.28
341_R	361_L	0.594	0.28
325_D	328_R	0.594	0.28
361_L	381_G	0.593	0.28
302_D	554_R	0.593	0.28
340_D	345_L	0.592	0.28
166_D	169_I	0.591	0.28
542_E	572_Q	0.590	0.27
67_A	236_G	0.590	0.27
349_V	353_L	0.590	0.27
179_S	352_V	0.589	0.27
35_P	534_S	0.588	0.27
262_K	303_K	0.588	0.27
252_E	255_L	0.588	0.27
532_A	558_L	0.587	0.27
242_L	594_R	0.587	0.27
520_T	524_S	0.587	0.27
538_I	547_I	0.586	0.27
562_D	570_E	0.586	0.27
69_G	117_V	0.586	0.27
318_T	416_Y	0.586	0.27
569_R	572_Q	0.586	0.27
273_I	282_V	0.586	0.27
533_A	600_A	0.585	0.27
304_L	436_V	0.585	0.27
572_Q	578_K	0.584	0.27
87_H	424_V	0.583	0.27
114_D	550_D	0.582	0.27
548_A	555_G	0.582	0.27
447_K	553_N	0.582	0.27
262_K	346_N	0.580	0.27
143_V	264_A	0.580	0.27
43_F	168_M	0.580	0.27
547_I	566_A	0.578	0.27
436_V	475_V	0.578	0.27
426_Y	431_E	0.578	0.27
177_S	480_Y	0.578	0.27
461_A	478_I	0.577	0.27
432_N	605_K	0.577	0.27
341_R	347_R	0.576	0.27
562_D	571_A	0.575	0.27
283_L	453_K	0.575	0.27
80_D	205_N	0.575	0.27
61_A	115_A	0.574	0.26
32_F	240_V	0.574	0.26
406_N	410_R	0.573	0.26
142_F	208_T	0.569	0.26
334_G	378_F	0.569	0.26
290_Q	424_V	0.568	0.26
332_V	345_L	0.568	0.26
572_Q	581_T	0.568	0.26
525_I	549_I	0.567	0.26
230_Q	234_N	0.567	0.26
34_K	141_I	0.566	0.26
179_S	467_G	0.565	0.26
215_Q	335_I	0.565	0.26
253_S	258_N	0.565	0.26
61_A	73_E	0.565	0.26
270_T	342_A	0.565	0.26
155_L	442_D	0.565	0.26
121_N	236_G	0.565	0.26
557_Q	560_V	0.565	0.26
455_Y	543_D	0.563	0.26
266_E	270_T	0.562	0.26
462_V	466_L	0.562	0.26
135_R	299_S	0.562	0.26
282_V	503_G	0.562	0.26
341_R	401_D	0.561	0.26
583_K	586_E	0.560	0.26
465_I	516_F	0.560	0.26
235_A	260_A	0.559	0.26
221_L	327_H	0.559	0.26
133_S	140_V	0.557	0.25
103_S	539_G	0.557	0.25
285_L	538_I	0.557	0.25
350_K	359_Q	0.557	0.25
153_T	381_G	0.557	0.25
56_L	73_E	0.556	0.25
582_P	585_R	0.556	0.25
334_G	337_G	0.555	0.25
182_D	186_R	0.555	0.25
35_P	240_V	0.555	0.25
233_L	237_K	0.555	0.25
44_T	107_M	0.554	0.25
333_I	378_F	0.554	0.25
254_A	359_Q	0.554	0.25
563_A	568_R	0.554	0.25
459_D	478_I	0.554	0.25
233_L	542_E	0.554	0.25
259_I	425_L	0.553	0.25
55_D	59_L	0.552	0.25
303_K	307_K	0.552	0.25
67_A	70_V	0.551	0.25
442_D	520_T	0.551	0.25
429_F	548_A	0.551	0.25
552_P	555_G	0.551	0.25
185_E	421_G	0.550	0.25
553_N	557_Q	0.550	0.25
114_D	142_F	0.550	0.25
453_K	460_D	0.550	0.25
273_I	305_S	0.550	0.25
135_R	283_L	0.550	0.25
539_G	558_L	0.550	0.25
167_A	187_S	0.549	0.25
88_G	137_N	0.549	0.25
135_R	595_A	0.549	0.25
347_R	357_L	0.549	0.25
275_M	335_I	0.548	0.25
116_M	288_A	0.548	0.25
82_G	89_G	0.548	0.25
500_K	503_G	0.547	0.25
511_I	541_I	0.546	0.25
93_S	110_A	0.545	0.25
268_A	361_L	0.545	0.25
168_M	494_Y	0.545	0.25
134_L	288_A	0.544	0.25
297_T	422_L	0.544	0.25
58_K	65_E	0.543	0.25
340_D	368_L	0.543	0.25
333_I	368_L	0.542	0.25
447_K	552_P	0.542	0.25
33_G	251_D	0.542	0.25
80_D	197_G	0.542	0.25
451_P	477_V	0.541	0.24
332_V	336_L	0.541	0.24
134_L	257_R	0.541	0.24
221_L	378_F	0.541	0.24
175_K	379_R	0.541	0.24
241_E	252_E	0.540	0.24
368_L	434_C	0.540	0.24
540_L	581_T	0.540	0.24
595_A	609_R	0.540	0.24
150_A	184_V	0.539	0.24
566_A	569_R	0.539	0.24
342_A	417_S	0.538	0.24
443_D	528_V	0.538	0.24
306_R	409_I	0.538	0.24
368_L	418_K	0.535	0.24
361_L	368_L	0.535	0.24
118_C	210_A	0.535	0.24
207_L	600_A	0.534	0.24
149_E	456_E	0.534	0.24
221_L	332_V	0.534	0.24
179_S	244_K	0.534	0.24
436_V	525_I	0.534	0.24
203_S	265_F	0.533	0.24
436_V	524_S	0.533	0.24
242_L	353_L	0.533	0.24
452_A	474_D	0.533	0.24
54_R	191_T	0.533	0.24
369_T	608_V	0.533	0.24
477_V	558_L	0.533	0.24
271_L	285_L	0.532	0.24
250_N	475_V	0.532	0.24
377_M	380_A	0.532	0.24
270_T	332_V	0.532	0.24
137_N	257_R	0.531	0.24
445_I	502_M	0.531	0.24
67_A	550_D	0.531	0.24
307_K	344_L	0.531	0.24
336_L	596_Y	0.531	0.24
303_K	562_D	0.531	0.24
170_Q	501_S	0.531	0.24
417_S	529_S	0.530	0.24
308_V	409_I	0.530	0.24
307_K	341_R	0.529	0.24
61_A	72_K	0.528	0.24
70_V	208_T	0.528	0.24
460_D	584_N	0.527	0.24
143_V	414_H	0.527	0.24
180_Q	183_Q	0.527	0.24
363_Q	379_R	0.526	0.24
469_K	542_E	0.526	0.24
314_V	332_V	0.526	0.24
485_G	533_A	0.525	0.24
219_G	565_L	0.524	0.23
144_S	205_N	0.524	0.23
352_V	375_K	0.523	0.23
337_G	401_D	0.523	0.23
55_D	58_K	0.523	0.23
507_A	570_E	0.523	0.23
125_I	202_N	0.522	0.23
340_D	361_L	0.522	0.23
459_D	466_L	0.522	0.23
282_V	500_K	0.521	0.23
111_H	474_D	0.521	0.23
34_K	236_G	0.521	0.23
451_P	607_A	0.521	0.23
258_N	294_I	0.520	0.23
333_I	404_R	0.520	0.23
301_I	435_I	0.520	0.23
436_V	556_I	0.520	0.23
140_V	534_S	0.518	0.23
341_R	412_L	0.517	0.23
61_A	70_V	0.517	0.23
313_K	327_H	0.516	0.23
279_T	520_T	0.514	0.23
130_L	210_A	0.514	0.23
452_A	477_V	0.514	0.23
425_L	432_N	0.514	0.23
135_R	256_P	0.514	0.23
251_D	484_K	0.513	0.23
259_I	596_Y	0.513	0.23
281_T	304_L	0.513	0.23
172_A	317_S	0.512	0.23
180_Q	402_D	0.512	0.23
86_G	496_T	0.511	0.23
501_S	538_I	0.511	0.23
219_G	240_V	0.511	0.23
311_L	457_S	0.511	0.23
317_S	528_V	0.510	0.23
134_L	298_M	0.510	0.23
141_I	234_N	0.510	0.23
192_C	224_T	0.509	0.23
80_D	144_S	0.509	0.23
69_G	241_E	0.509	0.23
69_G	320_K	0.508	0.23
104_V	134_L	0.508	0.23
350_K	358_P	0.507	0.23
322_H	520_T	0.507	0.23
112_C	283_L	0.507	0.23
218_N	231_L	0.507	0.23
72_K	351_N	0.506	0.22
132_A	298_M	0.506	0.22
224_T	235_A	0.506	0.22
283_L	487_P	0.505	0.22
90_M	276_G	0.505	0.22
333_I	380_A	0.505	0.22
264_A	539_G	0.505	0.22
42_S	203_S	0.504	0.22
381_G	411_S	0.503	0.22
336_L	361_L	0.503	0.22
79_V	110_A	0.503	0.22
175_K	188_A	0.503	0.22
81_D	94_L	0.502	0.22
286_L	299_S	0.502	0.22
311_L	338_E	0.502	0.22
479_R	539_G	0.501	0.22
81_D	86_G	0.500	0.22
150_A	322_H	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gp4A	2	0.8084	100	0.166	Contact Map
2b99A	3	0.211	72.5	0.983	Contact Map
1c41A	6	0.2078	59	0.984	Contact Map
3rfqA	5	0.2127	56.8	0.985	Contact Map
1q5xA	3	0.224	51.9	0.985	Contact Map
4xcwA	3	0.25	48.4	0.985	Contact Map
4nwoA	3	0.2256	44.7	0.986	Contact Map
4wzzA	1	0.4627	41.6	0.986	Contact Map
2is8A	3	0.2159	39.8	0.986	Contact Map
4lhbA	4	0.2192	39.2	0.986	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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