GREMLIN Database
PTHA - Glucitol/sorbitol-specific phosphotransferase enzyme IIA component
UniProt: P05706 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10970
Length: 123 (115)
Sequences: 433 (333)
Seq/√Len: 31.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_L102_V6.3161.00
61_G114_S3.4851.00
11_R37_E3.3061.00
74_A100_V2.9641.00
77_N84_V2.9421.00
89_D101_H2.6581.00
14_A38_E2.3450.99
84_V100_V2.3180.99
69_A94_A2.2630.99
57_Q64_R2.1010.98
43_H118_F2.0880.98
25_L110_I2.0510.98
56_L67_V2.0060.97
19_A23_Q1.9880.97
8_T115_V1.9770.97
6_Q117_K1.9670.97
26_I39_Y1.8930.96
27_T116_L1.8240.95
59_S117_K1.8090.95
27_T86_L1.6240.92
52_L74_A1.6020.91
59_S64_R1.5400.89
68_T90_G1.4960.88
30_E44_C1.4880.88
8_T64_R1.4160.85
39_Y85_T1.3800.83
40_C81_L1.3740.83
29_R43_H1.3560.82
39_Y89_D1.3420.81
15_S38_E1.3420.81
87_R99_T1.3310.81
74_A84_V1.3170.80
66_P103_A1.3100.80
101_H104_G1.3050.80
31_G42_I1.3040.80
22_D85_T1.3020.79
19_A22_D1.2920.79
73_V77_N1.2460.76
9_I114_S1.1730.72
78_L100_V1.1490.70
14_A67_V1.1400.70
65_Y101_H1.1330.69
16_A41_F1.1320.69
32_A42_I1.1100.68
22_D36_L1.0980.67
60_L86_L1.0770.65
12_I65_Y1.0770.65
76_D80_E1.0390.62
62_Q110_I1.0280.61
98_G118_F1.0150.60
43_H48_L1.0150.60
86_L97_P0.9880.58
70_V75_E0.9880.58
69_A90_G0.9870.58
33_P98_G0.9800.58
27_T84_V0.9620.56
52_L100_V0.9380.54
56_L102_V0.9300.54
65_Y99_T0.9190.53
96_F99_T0.9110.52
73_V89_D0.9060.52
23_Q104_G0.9000.51
29_R52_L0.8980.51
19_A26_I0.8850.50
82_G98_G0.8790.50
88_F102_V0.8770.49
58_F109_D0.8750.49
9_I25_L0.8710.49
9_I116_L0.8680.49
43_H98_G0.8580.48
23_Q86_L0.8490.47
29_R108_D0.8470.47
44_C79_R0.8450.47
57_Q62_Q0.8400.46
90_G94_A0.8390.46
39_Y107_P0.8360.46
73_V101_H0.8180.45
58_F78_L0.7980.43
40_C77_N0.7920.43
77_N101_H0.7920.43
46_G56_L0.7900.42
4_I9_I0.7820.42
22_D107_P0.7790.42
49_K62_Q0.7740.41
5_Y52_L0.7730.41
67_V118_F0.7680.41
29_R81_L0.7640.40
54_P92_N0.7600.40
29_R77_N0.7590.40
11_R60_L0.7490.39
24_M39_Y0.7490.39
68_T103_A0.7480.39
54_P70_V0.7460.39
12_I103_A0.7400.39
52_L106_V0.7330.38
12_I112_P0.7320.38
27_T77_N0.7270.38
48_L79_R0.7150.37
19_A36_L0.7120.36
52_L75_E0.7100.36
22_D39_Y0.7070.36
22_D35_D0.7010.36
6_Q76_D0.7000.36
28_F32_A0.6990.36
10_T43_H0.6940.35
4_I56_L0.6920.35
15_S25_L0.6900.35
46_G67_V0.6880.35
59_S110_I0.6830.34
63_H108_D0.6760.34
16_A21_S0.6760.34
9_I110_I0.6750.34
16_A93_E0.6730.34
68_T89_D0.6720.34
90_G99_T0.6620.33
10_T41_F0.6570.32
41_F56_L0.6560.32
66_P100_V0.6490.32
40_C84_V0.6490.32
4_I75_E0.6420.31
44_C49_K0.6360.31
51_A75_E0.6330.31
54_P115_V0.6270.30
57_Q115_V0.6260.30
20_L94_A0.6240.30
76_D91_L0.6170.30
57_Q66_P0.6100.29
5_Y46_G0.6060.29
43_H82_G0.6050.29
27_T96_F0.6040.29
58_F118_F0.5980.28
47_E115_V0.5880.28
6_Q115_V0.5840.28
8_T117_K0.5790.27
20_L67_V0.5760.27
40_C102_V0.5730.27
31_G52_L0.5700.27
21_S112_P0.5670.26
59_S94_A0.5660.26
9_I111_A0.5650.26
85_T99_T0.5640.26
52_L78_L0.5630.26
51_A113_G0.5600.26
84_V99_T0.5600.26
21_S49_K0.5590.26
39_Y73_V0.5550.26
7_T43_H0.5530.26
51_A102_V0.5500.25
82_G97_P0.5480.25
35_D73_V0.5450.25
106_V111_A0.5370.25
24_M114_S0.5370.25
68_T94_A0.5350.24
90_G98_G0.5340.24
21_S64_R0.5320.24
30_E60_L0.5310.24
38_E85_T0.5270.24
33_P43_H0.5260.24
26_I32_A0.5180.23
10_T63_H0.5180.23
11_R112_P0.5180.23
77_N81_L0.5140.23
61_G113_G0.5140.23
34_A38_E0.5110.23
58_F106_V0.5110.23
4_I40_C0.5110.23
82_G85_T0.5100.23
34_A37_E0.5100.23
35_D85_T0.5070.23
65_Y108_D0.5050.23
80_E115_V0.5010.22
77_N99_T0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f9hA 2 0.9512 100 0.094 Contact Map
3uvjA 1 0.9106 24.9 0.931 Contact Map
3et6A 2 0.9024 22.2 0.933 Contact Map
4p2fA 1 0.8943 19.9 0.934 Contact Map
3mr7A 2 0.8537 18.4 0.935 Contact Map
4ni2A 1 0.9106 18.3 0.935 Contact Map
2fhdA 5 0.5854 15 0.938 Contact Map
3vbaA 2 0.9593 13.1 0.939 Contact Map
1ybtA 2 0.8699 12.4 0.94 Contact Map
3rrlB 1 0.9187 12.1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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