MCP3 - ECOLI - GREMLIN Contacts

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MCP3 - Methyl-accepting chemotaxis protein III

UniProt:	P05704	Sequences: MNTTPSQRLGFLHHIRLVPLFACILGGILVLFALSSALAGYFLWQADRDQRDVTAEIEIRTGLANSSDFLRSARINMIQAGAASRIAEMEAMKRNIAQAESEIKQSQQGYRAYQNRPVKTPADEALDTELNQRFQAYITGMQPMLKYAKNGMFEAIINHESEQIRPLDNAYTDILNKAVKIRSTRANQLAELAHQRTRLGGMFMIGAFVLALVMTLITFMVLRRIVIRPLQHAAQRIEKIASGDLTMNDEPAGRNEIGRLSRHLQQMQHSLGMTVGTVRQGAEEIYRGTSEISAGNADLSSRTEEQAAAIEQTAASMEQLTATVKQNADNAHHASKLAQEASIKASDGGQTVSGVVKTMGAISTSSKKISEITAVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRTLASRSAQAAKEIEGLISESVRLIDLGSDEVATAGKTMSTIVDAVASVTHIMQEIAAASDEQSRGITQVSQAISEMDKVTQQNASLVEEASAAAVSLEEQAARLTEAVDVFRLHKHSVSAEPRGAGEPVSFATV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11018
Length:	546 (503)
Sequences:	20034 (17171)
Seq/√Len:	765.6

ECOLI - MCP3 MCP2 MCP1 MCP4 AER
BACSU - TLPA YOAH YVAQ TLPB MCPB MCPA MCPC TLPC HEMAT
HALSA - HTR4 HTR2 Q9HRA1 COST Q9HQX8 HMAT HTR9 Q9HR88 HTR7 Q9HPA2 Q9HP10 Q9HS86 Q9HRN6 Q9HQT5 Q9HPQ5 HTR1 Q9HPW6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
253_G	258_G	3.731	1.00
16_R	19_P	3.437	1.00
239_K	244_D	3.335	1.00
345_A	348_G	3.217	1.00
37_A	41_Y	3.157	1.00
239_K	247_M	2.661	1.00
361_A	435_L	2.614	1.00
248_N	272_G	2.415	1.00
234_A	259_R	2.313	1.00
365_S	435_L	2.302	1.00
343_I	347_D	2.282	1.00
20_L	255_N	2.281	1.00
265_Q	268_Q	2.272	1.00
202_M	206_G	2.255	1.00
238_E	259_R	2.240	1.00
152_M	155_A	2.207	1.00
277_T	515_R	2.195	1.00
224_R	228_R	2.179	1.00
233_A	261_S	2.116	1.00
326_Q	329_D	2.107	1.00
238_E	266_Q	2.089	1.00
368_K	371_E	2.082	1.00
350_Q	354_G	2.054	1.00
364_T	367_K	2.039	1.00
199_L	203_F	2.024	1.00
365_S	431_E	2.008	1.00
234_A	263_H	1.991	1.00
437_D	441_D	1.957	1.00
223_R	227_I	1.924	1.00
36_S	208_F	1.902	1.00
238_E	242_S	1.896	1.00
146_K	150_N	1.891	1.00
198_R	202_M	1.870	1.00
101_S	105_Q	1.862	1.00
340_E	343_I	1.856	1.00
374_A	378_S	1.835	1.00
128_T	132_Q	1.827	1.00
176_N	180_K	1.824	1.00
237_I	264_L	1.813	1.00
338_A	348_G	1.810	1.00
363_S	440_S	1.807	1.00
265_Q	269_H	1.795	1.00
255_N	258_G	1.792	1.00
237_I	267_M	1.788	1.00
180_K	184_T	1.788	1.00
39_A	204_M	1.784	1.00
453_I	464_M	1.774	1.00
240_I	268_Q	1.767	1.00
459_S	462_H	1.766	1.00
124_E	128_T	1.757	1.00
240_I	267_M	1.754	1.00
426_E	430_S	1.752	1.00
371_E	374_A	1.728	1.00
143_P	146_K	1.719	1.00
297_A	301_S	1.719	1.00
370_S	433_V	1.715	1.00
508_S	511_E	1.697	1.00
487_E	490_K	1.693	1.00
20_L	225_I	1.685	1.00
125_A	129_E	1.680	1.00
448_K	452_T	1.676	1.00
41_Y	45_Q	1.667	1.00
259_R	262_R	1.661	1.00
344_K	452_T	1.652	1.00
361_A	364_T	1.651	1.00
90_E	94_R	1.642	1.00
458_A	462_H	1.639	1.00
441_D	445_T	1.633	1.00
511_E	515_R	1.626	1.00
357_K	360_G	1.625	1.00
333_H	336_K	1.625	1.00
205_I	209_V	1.614	1.00
480_Q	483_Q	1.612	1.00
104_K	108_Q	1.606	1.00
350_Q	353_S	1.602	1.00
142_Q	146_K	1.600	1.00
248_N	265_Q	1.597	1.00
336_K	339_Q	1.592	1.00
336_K	340_E	1.590	1.00
413_T	416_S	1.584	1.00
420_Q	424_E	1.581	1.00
238_E	263_H	1.575	1.00
206_G	210_L	1.564	1.00
450_M	453_I	1.561	1.00
418_S	422_A	1.556	1.00
108_Q	112_A	1.554	1.00
191_E	195_Q	1.543	1.00
430_S	434_R	1.543	1.00
248_N	269_H	1.538	1.00
273_M	277_T	1.530	1.00
173_D	177_K	1.525	1.00
515_R	518_E	1.518	1.00
105_Q	109_G	1.517	1.00
364_T	368_K	1.514	1.00
287_R	291_E	1.509	1.00
237_I	263_H	1.509	1.00
272_G	276_G	1.504	1.00
298_D	301_S	1.491	1.00
368_K	424_E	1.487	1.00
121_P	124_E	1.483	1.00
339_Q	343_I	1.482	1.00
452_T	455_D	1.475	1.00
233_A	260_L	1.466	1.00
28_I	215_T	1.458	1.00
448_K	451_S	1.456	1.00
517_T	521_D	1.453	1.00
122_A	125_A	1.453	1.00
501_E	504_A	1.451	1.00
423_K	427_G	1.450	1.00
140_G	143_P	1.442	1.00
248_N	268_Q	1.430	1.00
97_A	101_S	1.415	1.00
460_V	464_M	1.409	1.00
231_Q	234_A	1.409	1.00
416_S	420_Q	1.403	1.00
514_A	518_E	1.401	1.00
270_S	522_V	1.400	1.00
332_H	336_K	1.398	1.00
100_E	104_K	1.397	1.00
455_D	459_S	1.396	1.00
78_I	82_A	1.395	1.00
18_V	22_A	1.388	1.00
198_R	201_G	1.388	1.00
377_N	426_E	1.387	1.00
277_T	519_A	1.387	1.00
308_A	312_Q	1.385	1.00
177_K	180_K	1.380	1.00
312_Q	315_A	1.379	1.00
201_G	205_I	1.364	1.00
102_E	105_Q	1.361	1.00
244_D	247_M	1.353	1.00
42_F	45_Q	1.352	1.00
197_T	201_G	1.351	1.00
162_E	166_P	1.348	1.00
135_Q	139_T	1.347	1.00
366_S	436_I	1.344	1.00
358_T	438_L	1.343	1.00
123_D	126_L	1.336	1.00
479_T	483_Q	1.335	1.00
294_A	298_D	1.333	1.00
308_A	311_E	1.330	1.00
93_K	97_A	1.327	1.00
365_S	368_K	1.326	1.00
342_S	346_S	1.325	1.00
453_I	460_V	1.315	1.00
176_N	179_V	1.307	1.00
237_I	260_L	1.306	1.00
94_R	98_Q	1.300	1.00
107_Q	111_R	1.299	1.00
472_D	476_R	1.298	1.00
325_K	329_D	1.297	1.00
219_F	223_R	1.294	1.00
363_S	437_D	1.292	1.00
497_S	500_E	1.291	1.00
420_Q	423_K	1.291	1.00
434_R	438_L	1.289	1.00
234_A	238_E	1.286	1.00
74_R	78_I	1.285	1.00
490_K	494_Q	1.284	1.00
497_S	501_E	1.282	1.00
233_A	264_L	1.281	1.00
500_E	504_A	1.278	1.00
318_E	322_A	1.278	1.00
108_Q	111_R	1.272	1.00
446_A	450_M	1.270	1.00
129_E	133_R	1.269	1.00
190_A	194_H	1.269	1.00
409_S	412_R	1.268	1.00
143_P	147_Y	1.267	1.00
329_D	333_H	1.262	1.00
441_D	444_A	1.262	1.00
279_R	283_E	1.260	1.00
269_H	273_M	1.259	1.00
451_S	455_D	1.259	1.00
519_A	522_V	1.247	1.00
34_L	38_L	1.246	1.00
367_K	437_D	1.243	1.00
134_F	138_I	1.243	1.00
360_G	444_A	1.241	1.00
232_H	250_E	1.234	1.00
122_A	126_L	1.231	1.00
490_K	493_Q	1.230	1.00
235_Q	238_E	1.229	1.00
360_G	364_T	1.228	1.00
270_S	273_M	1.224	1.00
16_R	259_R	1.224	1.00
368_K	431_E	1.223	1.00
239_K	242_S	1.219	1.00
280_Q	284_E	1.217	1.00
111_R	131_N	1.216	1.00
349_G	353_S	1.214	1.00
203_F	206_G	1.210	1.00
98_Q	101_S	1.210	1.00
391_A	409_S	1.208	1.00
424_E	427_G	1.205	1.00
129_E	132_Q	1.203	1.00
476_R	480_Q	1.200	1.00
146_K	149_K	1.195	1.00
363_S	367_K	1.195	1.00
18_V	224_R	1.194	1.00
309_A	487_E	1.194	1.00
109_G	112_A	1.190	1.00
202_M	205_I	1.189	1.00
47_D	197_T	1.189	1.00
139_T	142_Q	1.187	1.00
302_R	491_V	1.184	1.00
231_Q	235_Q	1.181	1.00
95_N	98_Q	1.181	1.00
18_V	223_R	1.180	1.00
38_L	42_F	1.180	1.00
358_T	439_G	1.179	1.00
15_I	19_P	1.179	1.00
236_R	249_D	1.175	1.00
251_P	261_S	1.173	1.00
301_S	304_E	1.173	1.00
361_A	365_S	1.172	1.00
139_T	143_P	1.164	1.00
290_S	294_A	1.163	1.00
359_M	439_G	1.159	1.00
343_I	346_S	1.150	1.00
249_D	265_Q	1.149	1.00
99_A	102_E	1.149	1.00
319_Q	322_A	1.147	1.00
268_Q	272_G	1.144	1.00
375_V	421_A	1.144	1.00
145_L	149_K	1.142	1.00
301_S	305_E	1.140	1.00
423_K	426_E	1.127	1.00
232_H	235_Q	1.126	1.00
242_S	266_Q	1.124	1.00
67_S	71_R	1.123	1.00
104_K	107_Q	1.121	1.00
283_E	517_T	1.120	1.00
317_M	320_L	1.119	1.00
486_S	490_K	1.111	1.00
280_Q	283_E	1.111	1.00
483_Q	487_E	1.111	1.00
347_D	350_Q	1.109	1.00
98_Q	102_E	1.107	1.00
62_G	65_N	1.103	1.00
91_A	95_N	1.100	1.00
334_A	464_M	1.098	1.00
507_V	511_E	1.098	1.00
131_N	135_Q	1.094	1.00
105_Q	108_Q	1.093	1.00
233_A	237_I	1.093	1.00
353_S	357_K	1.091	1.00
344_K	347_D	1.091	1.00
51_R	55_A	1.089	1.00
251_P	265_Q	1.086	1.00
362_I	439_G	1.084	1.00
477_G	481_V	1.084	1.00
427_G	431_E	1.081	1.00
431_E	435_L	1.077	1.00
494_Q	497_S	1.076	1.00
278_V	520_V	1.073	1.00
438_L	441_D	1.072	1.00
351_T	356_V	1.071	1.00
357_K	361_A	1.070	1.00
344_K	348_G	1.067	1.00
377_N	422_A	1.066	1.00
356_V	447_G	1.066	1.00
305_E	308_A	1.065	1.00
128_T	131_N	1.061	1.00
189_L	192_L	1.055	1.00
68_D	71_R	1.050	1.00
195_Q	199_L	1.050	1.00
511_E	514_A	1.049	1.00
126_L	129_E	1.047	1.00
79_Q	82_A	1.046	1.00
209_V	213_V	1.044	1.00
331_A	334_A	1.044	1.00
518_E	522_V	1.044	1.00
94_R	97_A	1.043	1.00
493_Q	497_S	1.043	1.00
491_V	495_N	1.041	1.00
166_P	170_A	1.039	1.00
232_H	236_R	1.039	1.00
476_R	479_T	1.036	1.00
17_L	257_I	1.035	1.00
334_A	348_G	1.031	1.00
286_Y	290_S	1.030	1.00
514_A	517_T	1.030	1.00
291_E	294_A	1.028	1.00
244_D	524_R	1.027	1.00
354_G	357_K	1.025	1.00
306_Q	316_S	1.013	1.00
44_W	201_G	1.013	1.00
220_M	224_R	1.012	1.00
25_L	219_F	1.012	1.00
29_L	215_T	1.007	1.00
217_I	221_V	1.007	1.00
121_P	125_A	1.004	1.00
234_A	260_L	1.004	1.00
138_I	142_Q	1.003	1.00
167_L	170_A	1.001	1.00
75_I	79_Q	1.000	1.00
69_F	73_A	0.997	1.00
251_P	262_R	0.997	1.00
377_N	381_F	0.996	1.00
32_F	35_S	0.994	1.00
125_A	128_T	0.993	1.00
18_V	227_I	0.991	1.00
417_R	420_Q	0.990	1.00
33_A	37_A	0.990	1.00
419_A	423_K	0.990	1.00
180_K	183_S	0.988	1.00
101_S	104_K	0.987	1.00
473_E	476_R	0.983	1.00
391_A	412_R	0.980	1.00
235_Q	239_K	0.979	1.00
177_K	181_I	0.978	1.00
31_L	211_A	0.978	1.00
132_Q	136_A	0.977	1.00
483_Q	486_S	0.975	1.00
216_L	220_M	0.975	1.00
103_I	106_S	0.974	1.00
304_E	308_A	0.973	1.00
163_Q	166_P	0.972	1.00
79_Q	83_A	0.970	1.00
504_A	508_S	0.967	1.00
518_E	521_D	0.967	1.00
287_R	290_S	0.965	1.00
230_L	257_I	0.964	1.00
262_R	265_Q	0.963	1.00
329_D	332_H	0.962	1.00
133_R	136_A	0.960	1.00
341_A	348_G	0.960	1.00
327_N	471_S	0.959	1.00
368_K	428_L	0.958	1.00
372_I	428_L	0.956	1.00
276_G	280_Q	0.956	1.00
261_S	265_Q	0.955	1.00
194_H	198_R	0.955	1.00
346_S	350_Q	0.953	1.00
44_W	48_R	0.949	1.00
351_T	445_T	0.948	1.00
61_T	64_A	0.947	1.00
277_T	280_Q	0.947	1.00
447_G	451_S	0.947	1.00
43_L	200_G	0.946	1.00
334_A	338_A	0.946	1.00
249_D	261_S	0.945	1.00
509_L	523_F	0.942	1.00
469_A	473_E	0.938	1.00
446_A	453_I	0.938	1.00
76_N	79_Q	0.937	1.00
283_E	287_R	0.933	1.00
266_Q	269_H	0.932	1.00
434_R	437_D	0.930	1.00
41_Y	44_W	0.929	1.00
322_A	326_Q	0.927	1.00
427_G	430_S	0.926	1.00
332_H	472_D	0.923	1.00
236_R	247_M	0.922	1.00
22_A	26_G	0.920	1.00
164_I	168_D	0.917	1.00
338_A	341_A	0.914	1.00
86_I	90_E	0.909	1.00
320_L	331_A	0.909	1.00
358_T	442_E	0.908	1.00
109_G	113_Y	0.907	1.00
335_S	339_Q	0.907	1.00
199_L	202_M	0.906	1.00
362_I	432_S	0.906	1.00
221_V	224_R	0.905	1.00
266_Q	270_S	0.905	1.00
111_R	114_Q	0.903	1.00
38_L	41_Y	0.903	1.00
240_I	264_L	0.901	1.00
250_E	265_Q	0.901	1.00
229_P	253_G	0.900	1.00
50_Q	53_V	0.898	1.00
311_E	315_A	0.898	1.00
469_A	472_D	0.894	1.00
36_S	40_G	0.893	1.00
99_A	103_I	0.890	1.00
228_R	232_H	0.890	1.00
294_A	297_A	0.889	1.00
325_K	479_T	0.888	1.00
254_R	258_G	0.888	1.00
136_A	139_T	0.886	1.00
351_T	354_G	0.886	1.00
349_G	356_V	0.884	1.00
455_D	458_A	0.884	1.00
120_T	123_D	0.881	1.00
340_E	344_K	0.878	1.00
48_R	51_R	0.876	1.00
230_L	260_L	0.872	1.00
103_I	107_Q	0.871	1.00
148_A	151_G	0.870	1.00
40_G	201_G	0.868	1.00
225_I	229_P	0.867	1.00
257_I	261_S	0.867	1.00
337_L	341_A	0.864	1.00
510_E	514_A	0.864	1.00
361_A	438_L	0.863	1.00
179_V	183_S	0.862	1.00
80_A	148_A	0.860	1.00
236_R	239_K	0.858	1.00
141_M	144_M	0.857	1.00
106_S	109_G	0.857	1.00
96_I	103_I	0.856	1.00
96_I	100_E	0.853	1.00
290_S	510_E	0.853	1.00
239_K	267_M	0.850	1.00
305_E	309_A	0.847	1.00
378_S	417_R	0.847	1.00
245_L	271_L	0.847	1.00
80_A	84_S	0.846	1.00
284_E	508_S	0.842	1.00
247_M	268_Q	0.840	1.00
298_D	302_R	0.840	1.00
144_M	148_A	0.837	1.00
171_Y	175_L	0.836	1.00
43_L	47_D	0.834	1.00
175_L	178_A	0.830	1.00
47_D	51_R	0.829	1.00
182_R	185_R	0.826	1.00
93_K	149_K	0.824	1.00
88_E	91_A	0.824	1.00
186_A	189_L	0.820	1.00
289_T	506_A	0.820	1.00
90_E	93_K	0.819	1.00
231_Q	259_R	0.819	1.00
309_A	316_S	0.818	1.00
52_D	56_E	0.817	1.00
161_S	165_R	0.814	1.00
378_S	381_F	0.813	1.00
69_F	72_S	0.813	1.00
91_A	94_R	0.810	1.00
56_E	60_R	0.808	1.00
516_L	523_F	0.807	1.00
35_S	39_A	0.805	1.00
15_I	23_C	0.803	1.00
87_A	90_E	0.799	1.00
286_Y	517_T	0.799	1.00
141_M	145_L	0.798	1.00
447_G	450_M	0.798	1.00
346_S	458_A	0.797	1.00
147_Y	150_N	0.797	1.00
409_S	413_T	0.796	1.00
70_L	73_A	0.794	1.00
42_F	200_G	0.794	1.00
203_F	207_A	0.794	1.00
377_N	423_K	0.793	1.00
54_T	57_I	0.792	1.00
296_N	499_V	0.792	1.00
158_N	162_E	0.790	1.00
241_A	266_Q	0.787	1.00
24_I	31_L	0.786	1.00
173_D	176_N	0.786	1.00
465_Q	469_A	0.784	1.00
338_A	345_A	0.782	1.00
157_I	160_E	0.780	1.00
48_R	52_D	0.780	1.00
92_M	95_N	0.779	1.00
236_R	264_L	0.778	1.00
73_A	76_N	0.776	1.00
480_Q	484_A	0.775	1.00
504_A	507_V	0.775	1.00
315_A	318_E	0.774	1.00
334_A	345_A	0.773	1.00
64_A	68_D	0.772	1.00
155_A	159_H	0.770	1.00
228_R	231_Q	0.770	1.00
174_I	177_K	0.768	1.00
246_T	525_L	0.767	1.00
192_L	196_R	0.766	1.00
367_K	371_E	0.765	1.00
63_L	66_S	0.761	1.00
25_L	28_I	0.760	1.00
462_H	465_Q	0.758	1.00
143_P	163_Q	0.757	1.00
489_D	493_Q	0.756	1.00
135_Q	138_I	0.755	1.00
50_Q	54_T	0.755	1.00
227_I	231_Q	0.754	1.00
80_A	83_A	0.752	1.00
320_L	334_A	0.750	1.00
318_E	482_S	0.749	1.00
450_M	464_M	0.748	1.00
154_E	157_I	0.748	1.00
371_E	375_V	0.745	1.00
102_E	106_S	0.740	1.00
267_M	271_L	0.738	1.00
43_L	46_A	0.738	1.00
309_A	484_A	0.736	1.00
172_T	176_N	0.736	1.00
417_R	424_E	0.735	1.00
264_L	268_Q	0.734	1.00
373_T	426_E	0.734	1.00
36_S	204_M	0.733	1.00
495_N	499_V	0.732	1.00
65_N	68_D	0.731	1.00
512_Q	515_R	0.731	1.00
165_R	169_N	0.729	1.00
315_A	319_Q	0.729	1.00
226_V	229_P	0.729	1.00
157_I	161_S	0.727	1.00
178_A	182_R	0.726	1.00
366_S	432_S	0.726	1.00
73_A	77_M	0.726	1.00
276_G	279_R	0.724	1.00
466_E	469_A	0.724	1.00
64_A	67_S	0.724	1.00
169_N	173_D	0.723	1.00
223_R	226_V	0.722	1.00
251_P	255_N	0.720	1.00
352_V	356_V	0.720	1.00
513_A	523_F	0.720	1.00
46_A	50_Q	0.720	1.00
345_A	454_V	0.719	1.00
133_R	174_I	0.719	1.00
174_I	181_I	0.718	1.00
24_I	28_I	0.716	1.00
110_Y	113_Y	0.714	1.00
306_Q	313_T	0.713	1.00
89_M	93_K	0.712	1.00
515_R	519_A	0.712	1.00
229_P	257_I	0.711	1.00
359_M	443_V	0.710	1.00
49_D	52_D	0.708	1.00
72_S	75_I	0.707	1.00
126_L	130_L	0.705	1.00
479_T	482_S	0.702	1.00
496_A	499_V	0.701	1.00
71_R	74_R	0.700	1.00
316_S	319_Q	0.700	1.00
264_L	267_M	0.699	1.00
334_A	341_A	0.699	1.00
237_I	240_I	0.696	1.00
246_T	524_R	0.694	1.00
373_T	377_N	0.694	1.00
85_R	88_E	0.693	1.00
97_A	100_E	0.691	1.00
276_G	525_L	0.689	1.00
75_I	78_I	0.686	1.00
19_P	23_C	0.684	1.00
65_N	69_F	0.683	1.00
179_V	182_R	0.683	1.00
433_V	437_D	0.682	1.00
278_V	516_L	0.682	1.00
184_T	189_L	0.680	1.00
110_Y	114_Q	0.679	1.00
196_R	199_L	0.678	1.00
285_I	509_L	0.677	1.00
507_V	510_E	0.677	1.00
107_Q	110_Y	0.676	1.00
132_Q	135_Q	0.675	1.00
19_P	22_A	0.675	1.00
306_Q	320_L	0.674	1.00
431_E	434_R	0.674	1.00
77_M	80_A	0.673	1.00
147_Y	152_M	0.672	1.00
348_G	453_I	0.671	1.00
352_V	355_V	0.671	1.00
96_I	99_A	0.670	1.00
170_A	173_D	0.670	1.00
191_E	194_H	0.667	1.00
328_A	331_A	0.664	1.00
124_E	127_D	0.664	1.00
446_A	449_T	0.664	1.00
279_R	521_D	0.663	1.00
17_L	230_L	0.663	1.00
462_H	466_E	0.662	1.00
131_N	134_F	0.659	1.00
342_S	345_A	0.657	1.00
138_I	141_M	0.657	1.00
45_Q	49_D	0.656	1.00
154_E	158_N	0.656	1.00
430_S	433_V	0.653	1.00
106_S	111_R	0.652	1.00
30_V	33_A	0.651	1.00
155_A	158_N	0.650	1.00
436_I	439_G	0.648	1.00
193_A	197_T	0.646	1.00
71_R	75_I	0.646	1.00
242_S	270_S	0.643	1.00
59_I	62_G	0.642	1.00
62_G	109_G	0.642	1.00
371_E	424_E	0.641	1.00
40_G	44_W	0.641	1.00
159_H	162_E	0.640	1.00
53_V	57_I	0.639	1.00
22_A	223_R	0.639	1.00
279_R	525_L	0.639	1.00
471_S	474_Q	0.638	1.00
92_M	96_I	0.637	1.00
47_D	55_A	0.637	1.00
275_V	525_L	0.634	1.00
482_S	486_S	0.632	1.00
61_T	65_N	0.632	1.00
306_Q	309_A	0.632	1.00
497_S	504_A	0.630	1.00
181_I	184_T	0.629	1.00
324_V	327_N	0.627	1.00
45_Q	48_R	0.626	1.00
54_T	59_I	0.626	1.00
473_E	477_G	0.625	1.00
44_W	47_D	0.625	1.00
354_G	445_T	0.624	1.00
309_A	312_Q	0.624	1.00
106_S	110_Y	0.624	1.00
342_S	461_T	0.624	1.00
461_T	465_Q	0.623	1.00
39_A	43_L	0.621	1.00
126_L	181_I	0.620	1.00
310_I	313_T	0.618	1.00
439_G	443_V	0.617	1.00
327_N	334_A	0.617	1.00
127_D	131_N	0.617	1.00
241_A	263_H	0.615	1.00
159_H	163_Q	0.615	1.00
136_A	140_G	0.614	1.00
210_L	214_M	0.614	1.00
299_L	303_T	0.613	1.00
279_R	517_T	0.613	1.00
285_I	512_Q	0.612	1.00
181_I	185_R	0.612	1.00
355_V	443_V	0.611	1.00
273_M	276_G	0.611	1.00
320_L	324_V	0.609	1.00
227_I	257_I	0.609	1.00
327_N	331_A	0.608	1.00
474_Q	481_V	0.606	1.00
291_E	501_E	0.606	1.00
299_L	302_R	0.606	1.00
175_L	179_V	0.604	1.00
374_A	377_N	0.604	1.00
435_L	438_L	0.603	1.00
520_V	523_F	0.602	1.00
284_E	287_R	0.601	1.00
360_G	363_S	0.600	1.00
354_G	358_T	0.600	1.00
213_V	217_I	0.599	1.00
349_G	454_V	0.597	1.00
171_Y	174_I	0.593	1.00
29_L	219_F	0.592	1.00
185_R	189_L	0.590	1.00
51_R	54_T	0.590	1.00
347_D	452_T	0.589	1.00
320_L	327_N	0.588	1.00
454_V	458_A	0.586	1.00
81_G	84_S	0.586	1.00
240_I	271_L	0.584	1.00
298_D	494_Q	0.583	1.00
449_T	453_I	0.582	1.00
482_S	485_I	0.582	1.00
58_E	186_A	0.580	1.00
215_T	219_F	0.580	1.00
344_K	456_A	0.579	1.00
251_P	258_G	0.577	1.00
381_F	392_V	0.576	1.00
385_I	392_V	0.573	1.00
92_M	99_A	0.573	1.00
372_I	421_A	0.573	1.00
77_M	81_G	0.573	1.00
484_A	487_E	0.572	1.00
229_P	256_E	0.572	1.00
253_G	257_I	0.572	1.00
356_V	360_G	0.572	1.00
130_L	134_F	0.571	1.00
196_R	200_G	0.571	1.00
236_R	240_I	0.571	1.00
174_I	178_A	0.569	1.00
372_I	429_I	0.569	1.00
349_G	355_V	0.569	1.00
381_F	419_A	0.568	1.00
127_D	130_L	0.568	1.00
165_R	168_D	0.568	1.00
359_M	440_S	0.567	1.00
160_E	163_Q	0.567	1.00
194_H	197_T	0.565	1.00
165_R	170_A	0.565	1.00
282_A	286_Y	0.564	1.00
123_D	127_D	0.563	1.00
51_R	194_H	0.563	1.00
87_A	91_A	0.562	1.00
137_Y	140_G	0.562	1.00
322_A	325_K	0.560	1.00
314_A	317_M	0.557	1.00
457_V	464_M	0.556	1.00
100_E	107_Q	0.556	1.00
502_A	505_A	0.555	1.00
44_W	197_T	0.553	1.00
342_S	458_A	0.552	1.00
129_E	174_I	0.552	1.00
50_Q	193_A	0.552	1.00
286_Y	510_E	0.551	1.00
418_S	428_L	0.549	1.00
238_E	241_A	0.548	1.00
134_F	137_Y	0.548	1.00
78_I	83_A	0.546	1.00
312_Q	480_Q	0.546	1.00
52_D	55_A	0.546	1.00
107_Q	113_Y	0.545	1.00
344_K	449_T	0.545	1.00
225_I	228_R	0.544	1.00
358_T	435_L	0.544	1.00
137_Y	141_M	0.542	1.00
337_L	459_S	0.541	1.00
161_S	164_I	0.541	1.00
100_E	106_S	0.540	1.00
432_S	436_I	0.540	1.00
192_L	195_Q	0.539	1.00
217_I	220_M	0.539	1.00
384_N	412_R	0.536	1.00
331_A	335_S	0.535	1.00
171_Y	178_A	0.535	1.00
327_N	330_N	0.534	1.00
258_G	262_R	0.534	1.00
362_I	436_I	0.534	1.00
174_I	179_V	0.534	1.00
166_P	169_N	0.533	1.00
335_S	338_A	0.531	1.00
106_S	114_Q	0.530	1.00
83_A	88_E	0.528	1.00
501_E	505_A	0.528	1.00
415_A	418_S	0.525	1.00
293_S	510_E	0.525	1.00
47_D	194_H	0.523	1.00
170_A	174_I	0.523	1.00
158_N	161_S	0.523	1.00
272_G	525_L	0.522	1.00
40_G	197_T	0.522	1.00
68_D	72_S	0.522	1.00
367_K	370_S	0.522	1.00
46_A	49_D	0.521	1.00
164_I	170_A	0.521	1.00
156_I	159_H	0.520	1.00
206_G	209_V	0.519	1.00
56_E	59_I	0.518	1.00
29_L	212_L	0.516	1.00
509_L	513_A	0.515	1.00
499_V	506_A	0.512	1.00
353_S	451_S	0.512	1.00
47_D	53_V	0.511	1.00
459_S	463_I	0.511	1.00
160_E	164_I	0.510	1.00
100_E	103_I	0.509	1.00
310_I	488_M	0.508	1.00
349_G	451_S	0.508	1.00
366_S	372_I	0.508	1.00
18_V	231_Q	0.508	1.00
388_L	396_R	0.506	1.00
372_I	418_S	0.506	1.00
243_G	267_M	0.505	1.00
63_L	67_S	0.504	1.00
498_L	501_E	0.504	1.00
503_S	507_V	0.502	1.00
82_A	85_R	0.501	1.00
296_N	506_A	0.501	1.00
281_G	284_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.5549	100	0.37	Contact Map
1qu7A	2	0.4158	100	0.506	Contact Map
2ch7A	2	0.5147	100	0.545	Contact Map
3g67A	2	0.3901	100	0.593	Contact Map
4i3mA	2	0.2692	99.9	0.739	Contact Map
4cq4A	4	0.1575	99.6	0.826	Contact Map
2f95B	2	0.0952	99.4	0.844	Contact Map
4gycB	2	0.1117	99.3	0.856	Contact Map
3zccA	2	0.1923	98.9	0.875	Contact Map
4i5sA	2	0.5092	98.7	0.886	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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