GREMLIN Database
APAH - Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]
UniProt: P05637 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10048
Length: 280 (262)
Sequences: 1356 (971)
Seq/√Len: 60.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_G47_D5.4071.00
14_D44_G4.5011.00
257_R260_D3.7911.00
39_V70_L3.1401.00
50_R92_A3.1361.00
34_L52_V3.0061.00
9_V48_V2.9361.00
23_V255_C2.8021.00
87_T91_E2.7871.00
50_R94_D2.7251.00
74_F99_L2.6541.00
33_W118_M2.5871.00
60_R109_Q2.5441.00
128_D131_T2.5111.00
13_Y17_I2.4481.00
40_A85_R2.4451.00
31_T60_R2.4391.00
9_V16_L2.4301.00
161_N191_Q2.3401.00
241_Y256_L2.2461.00
151_F177_T2.2421.00
108_L132_A2.1831.00
245_T254_T2.1611.00
138_D172_R2.1461.00
103_R148_Y2.1391.00
16_L34_L2.1391.00
17_I51_Y2.0951.00
9_V34_L2.0921.00
257_R264_F2.0871.00
55_L59_V2.0591.00
71_L99_L2.0591.00
108_L117_V2.0401.00
108_L133_K2.0301.00
53_K97_E2.0261.00
187_F191_Q2.0141.00
56_G59_V2.0131.00
224_A256_L1.9861.00
137_R140_E1.9691.00
52_V59_V1.9501.00
34_L59_V1.9161.00
61_L105_Q1.8801.00
33_W109_Q1.8531.00
131_T135_C1.8491.00
50_R98_L1.8471.00
110_I133_K1.8341.00
25_F30_D1.8331.00
260_D264_F1.7890.99
148_Y152_L1.7420.99
53_K56_G1.7320.99
17_I21_H1.6710.99
69_H156_Y1.6300.99
104_R144_S1.6250.99
47_D88_P1.6220.99
123_I132_A1.6180.99
3_T259_E1.5990.99
16_L51_Y1.5960.99
124_T175_F1.5960.99
154_A170_L1.5830.99
124_T179_A1.5820.99
68_L155_M1.5630.99
139_V177_T1.5320.98
193_D207_L1.5090.98
185_F203_A1.4790.98
13_Y47_D1.4510.98
5_L224_A1.4510.98
92_A98_L1.4470.98
53_K59_V1.4300.97
138_D176_I1.4250.97
13_Y51_Y1.4010.97
52_V61_L1.3880.97
6_I255_C1.3800.97
175_F179_A1.3720.97
12_C248_C1.3510.96
222_S261_K1.3370.96
169_G172_R1.3310.96
4_Y23_V1.3220.96
49_L98_L1.3140.96
229_A248_C1.3100.96
132_A180_F1.3080.96
38_L61_L1.2970.95
75_A148_Y1.2830.95
142_V173_L1.2710.95
116_L258_W1.2670.95
157_G160_P1.2660.95
183_M192_L1.2620.95
60_R105_Q1.2600.95
53_K98_L1.2440.94
172_R176_I1.2320.94
94_D98_L1.2300.94
117_V123_I1.2270.94
185_F200_P1.2270.94
110_I114_K1.2070.93
6_I34_L1.1880.93
135_C176_I1.1870.93
18_A21_H1.1830.93
35_T253_L1.1800.92
5_L118_M1.1730.92
35_T62_V1.1710.92
229_A235_G1.1700.92
119_A223_I1.1650.92
51_Y55_L1.1580.92
63_L68_L1.1520.91
135_C138_D1.1330.91
82_P85_R1.1190.90
10_H248_C1.1080.90
136_A143_L1.1070.90
222_S241_Y1.1050.90
163_W167_L1.1020.90
109_Q118_M1.0920.89
243_L248_C1.0740.88
208_K214_P1.0720.88
34_L255_C1.0610.88
128_D135_C1.0560.87
52_V55_L1.0530.87
15_E44_G1.0470.87
176_I180_F1.0440.87
75_A149_P1.0390.87
23_V264_F1.0320.86
160_P174_R1.0280.86
10_H35_T1.0270.86
25_F34_L1.0250.86
138_D169_G1.0240.86
5_L116_L1.0220.86
9_V52_V1.0070.85
252_T265_V1.0020.85
110_I117_V0.9930.84
185_F230_S0.9810.83
6_I23_V0.9740.83
229_A246_G0.9720.83
13_Y48_V0.9710.83
225_F240_I0.9690.83
74_F95_A0.9660.82
138_D143_L0.9630.82
139_V142_V0.9470.81
51_Y54_S0.9450.81
255_C266_Q0.9450.81
7_G11_G0.9440.81
16_L59_V0.9440.81
35_T61_L0.9420.81
169_G176_I0.9370.80
10_H39_V0.9270.80
24_E28_G0.9260.80
185_F196_S0.9240.79
22_K264_F0.9230.79
201_E204_P0.9160.79
235_G241_Y0.9120.79
136_A140_E0.9100.78
4_Y25_F0.9100.78
208_K212_A0.9030.78
103_R152_L0.9010.78
193_D196_S0.8970.77
252_T267_P0.8920.77
70_L89_L0.8900.77
26_T29_K0.8850.76
8_D11_G0.8780.76
80_N87_T0.8770.76
162_N191_Q0.8760.76
131_T165_P0.8690.75
35_T238_E0.8690.75
46_L98_L0.8650.75
15_E18_A0.8600.74
39_V67_D0.8590.74
100_N104_R0.8590.74
220_E239_G0.8560.74
110_I221_Y0.8540.74
108_L136_A0.8470.73
106_P140_E0.8420.73
6_I16_L0.8390.72
17_I47_D0.8290.72
229_A251_G0.8290.72
5_L256_L0.8190.71
150_F153_D0.8170.70
124_T135_C0.8150.70
227_H244_D0.8120.70
40_A229_A0.8100.70
108_L129_L0.8050.69
208_K213_I0.8050.69
236_T240_I0.8030.69
4_Y30_D0.7990.69
62_V118_M0.7990.69
235_G240_I0.7950.68
225_F242_A0.7930.68
142_V146_D0.7910.68
212_A237_P0.7890.68
15_E247_C0.7860.67
62_V106_P0.7840.67
3_T31_T0.7760.66
38_L48_V0.7750.66
28_G58_S0.7750.66
21_H24_E0.7750.66
18_A266_Q0.7730.66
162_N189_N0.7720.66
131_T134_E0.7660.65
96_D100_N0.7650.65
150_F154_A0.7590.65
224_A236_T0.7580.65
6_I253_L0.7530.64
115_K221_Y0.7520.64
89_L95_A0.7520.64
4_Y264_F0.7480.64
130_Q134_E0.7470.64
5_L109_Q0.7470.64
159_M164_S0.7450.63
117_V129_L0.7410.63
5_L258_W0.7400.63
8_D37_D0.7370.62
188_P208_K0.7350.62
68_L160_P0.7330.62
117_V132_A0.7320.62
19_L255_C0.7320.62
47_D51_Y0.7320.62
159_M166_E0.7310.62
213_I217_V0.7300.62
107_L139_V0.7290.62
119_A124_T0.7290.62
29_K58_S0.7190.61
196_S202_E0.7170.60
123_I183_M0.7170.60
124_T180_F0.7160.60
142_V145_S0.7150.60
12_C247_C0.7110.60
196_S204_P0.7080.59
226_G244_D0.7010.59
141_A220_E0.7010.59
136_A139_V0.6990.58
157_G174_R0.6910.58
39_V89_L0.6910.58
46_L49_L0.6870.57
229_A234_K0.6850.57
254_T263_Y0.6830.57
186_C213_I0.6830.57
33_W60_R0.6820.57
106_P109_Q0.6780.56
68_L156_Y0.6770.56
199_S230_S0.6750.56
23_V253_L0.6740.56
25_F58_S0.6730.56
81_K229_A0.6680.55
15_E175_F0.6680.55
24_E51_Y0.6670.55
66_H226_G0.6660.55
59_V257_R0.6650.55
117_V133_K0.6620.54
48_V52_V0.6590.54
257_R262_Q0.6580.54
86_L89_L0.6510.53
119_A219_E0.6490.53
75_A99_L0.6490.53
175_F192_L0.6480.53
62_V259_E0.6480.53
123_I180_F0.6460.53
157_G178_N0.6450.52
139_V143_L0.6430.52
119_A183_M0.6420.52
35_T224_A0.6410.52
179_A183_M0.6400.52
26_T30_D0.6380.52
107_L180_F0.6360.51
77_I149_P0.6340.51
116_L256_L0.6320.51
68_L181_T0.6310.51
117_V221_Y0.6310.51
73_V81_K0.6300.51
93_P220_E0.6290.51
126_Q179_A0.6270.50
21_H26_T0.6260.50
256_L263_Y0.6260.50
119_A126_Q0.6250.50
73_V84_D0.6240.50
259_E262_Q0.6220.50
137_R144_S0.6170.49
256_L261_K0.6160.49
5_L40_A0.6140.49
86_L233_G0.6140.49
72_A156_Y0.6130.49
110_I129_L0.6120.49
9_V116_L0.6100.48
7_G19_L0.6080.48
178_N182_R0.6070.48
123_I218_A0.6070.48
163_W172_R0.6050.48
101_W143_L0.6030.48
37_D65_N0.6030.48
69_H245_T0.6020.48
21_H97_E0.6020.48
12_C184_R0.6020.48
147_S150_F0.6010.47
237_P240_I0.6000.47
174_R249_W0.5940.47
46_L89_L0.5930.47
35_T118_M0.5920.46
14_D18_A0.5900.46
136_A144_S0.5870.46
114_K221_Y0.5860.46
83_K119_A0.5850.46
37_D227_H0.5840.46
108_L123_I0.5840.46
109_Q186_C0.5820.45
158_D185_F0.5820.45
65_N120_H0.5810.45
210_W250_G0.5800.45
37_D244_D0.5790.45
35_T243_L0.5790.45
193_D251_G0.5780.45
24_E82_P0.5770.45
255_C258_W0.5760.45
80_N89_L0.5720.44
17_I54_S0.5700.44
34_L67_D0.5700.44
85_R88_P0.5690.44
139_V155_M0.5680.44
164_S259_E0.5670.44
243_L256_L0.5670.44
199_S202_E0.5660.44
142_V147_S0.5650.43
27_P58_S0.5650.43
231_L249_W0.5650.43
50_R54_S0.5630.43
21_H28_G0.5630.43
49_L94_D0.5630.43
71_L143_L0.5610.43
9_V13_Y0.5610.43
137_R141_A0.5590.43
129_L133_K0.5590.43
169_G173_L0.5590.43
173_L177_T0.5570.43
240_I256_L0.5550.42
135_C172_R0.5550.42
40_A45_S0.5540.42
179_A194_M0.5530.42
24_E29_K0.5530.42
66_H182_R0.5530.42
196_S229_A0.5530.42
108_L180_F0.5520.42
16_L193_D0.5500.42
136_A180_F0.5490.42
193_D245_T0.5480.42
67_D160_P0.5460.41
45_S85_R0.5460.41
25_F32_L0.5450.41
134_E141_A0.5420.41
229_A242_A0.5420.41
124_T192_L0.5400.41
15_E259_E0.5390.41
16_L54_S0.5380.41
104_R130_Q0.5380.41
40_A69_H0.5380.41
126_Q190_G0.5360.40
66_H227_H0.5360.40
116_L222_S0.5340.40
31_T113_E0.5320.40
128_D217_V0.5320.40
88_P91_E0.5320.40
184_R231_L0.5290.40
185_F199_S0.5270.39
222_S240_I0.5250.39
35_T260_D0.5230.39
224_A258_W0.5230.39
38_L52_V0.5210.39
67_D158_D0.5200.39
83_K87_T0.5190.38
248_C251_G0.5190.38
76_G84_D0.5180.38
53_K94_D0.5170.38
199_S239_G0.5170.38
264_F267_P0.5170.38
10_H40_A0.5150.38
65_N227_H0.5150.38
155_M160_P0.5140.38
54_S105_Q0.5140.38
25_F224_A0.5140.38
65_N244_D0.5140.38
9_V15_E0.5120.38
215_G218_A0.5120.38
225_F231_L0.5120.38
241_Y261_K0.5120.38
116_L239_G0.5110.38
26_T58_S0.5110.38
6_I17_I0.5100.38
179_A192_L0.5100.38
13_Y21_H0.5080.37
75_A152_L0.5050.37
183_M230_S0.5050.37
167_L178_N0.5040.37
49_L53_K0.5040.37
69_H155_M0.5040.37
110_I113_E0.5040.37
127_W174_R0.5040.37
155_M181_T0.5040.37
18_A100_N0.5010.37
21_H54_S0.5010.37
236_T256_L0.5000.36
225_F229_A0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dfjA 2 0.9536 100 0.378 Contact Map
2qjcA 1 0.7464 100 0.545 Contact Map
4j6oA 1 0.7964 100 0.619 Contact Map
2z72A 1 0.8679 100 0.638 Contact Map
1g5bA 4 0.7071 100 0.697 Contact Map
3icfA 2 0.8429 99.9 0.703 Contact Map
1fjmA 1 0.825 99.9 0.707 Contact Map
4il1A 1 0.8821 99.9 0.708 Contact Map
4i5lC 1 0.8429 99.9 0.713 Contact Map
1auiA 1 0.8786 99.9 0.721 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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