GREMLIN Database
FPG - Formamidopyrimidine-DNA glycosylase
UniProt: P05523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10329
Length: 269 (264)
Sequences: 5432 (3694)
Seq/√Len: 227.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_Q62_E3.8571.00
185_R194_E3.6421.00
251_I262_F3.0171.00
191_S194_E2.9331.00
167_V172_A2.9071.00
157_W187_A2.8931.00
178_A208_R2.8601.00
154_I181_I2.7761.00
151_K188_S2.6531.00
47_Q65_E2.6061.00
60_L67_W2.5871.00
15_E19_V2.5841.00
235_Q245_R2.4091.00
140_G199_A2.3841.00
147_C157_W2.3461.00
21_A99_N2.3201.00
179_A201_V2.2461.00
27_V96_V2.1321.00
25_H45_S2.1091.00
11_R59_L2.0931.00
239_R245_R2.0731.00
70_I78_L2.0721.00
144_H195_C2.0011.00
70_I114_W1.9931.00
177_F246_V1.9641.00
194_E197_L1.9451.00
185_R189_S1.9391.00
249_T265_R1.9321.00
252_V265_R1.9081.00
11_R15_E1.8981.00
21_A98_S1.8851.00
254_T263_Y1.8791.00
25_H96_V1.8791.00
50_L64_P1.8611.00
15_E51_S1.8601.00
140_G196_E1.8551.00
128_H162_K1.8391.00
184_D254_T1.8371.00
47_Q64_P1.8151.00
215_T234_L1.8011.00
178_A201_V1.7911.00
93_V114_W1.7881.00
144_H192_L1.7801.00
142_Y146_K1.7331.00
152_T160_D1.7191.00
239_R242_E1.7061.00
198_L202_I1.7051.00
51_S62_E1.6971.00
140_G200_R1.6731.00
157_W163_L1.6691.00
21_A101_K1.6681.00
201_V204_A1.6641.00
156_P257_A1.6441.00
30_N110_R1.6231.00
52_V61_L1.5851.00
236_V251_I1.5791.00
23_I63_L1.5761.00
153_A156_P1.5761.00
253_A260_A1.5711.00
24_L98_S1.5711.00
167_V202_I1.5701.00
178_A235_Q1.5371.00
190_L194_E1.5351.00
178_A205_V1.5331.00
249_T266_Q1.5011.00
175_S202_I1.4941.00
147_C195_C1.4821.00
142_Y145_Q1.4711.00
203_K207_L1.4651.00
178_A204_A1.4591.00
8_E54_R1.4581.00
144_H148_A1.4471.00
186_L189_S1.4381.00
208_R233_E1.4381.00
192_L196_E1.4371.00
22_T48_P1.4311.00
167_V175_S1.4111.00
55_R132_E1.4001.00
143_L199_A1.4001.00
152_T157_W1.3841.00
140_G143_L1.3811.00
35_W113_A1.3781.00
62_E67_W1.3741.00
91_D106_T1.3691.00
40_E43_R1.3611.00
8_E12_R1.3411.00
173_S262_F1.3221.00
180_G246_V1.3191.00
207_L211_E1.3131.00
240_K253_A1.2741.00
182_H263_Y1.2611.00
49_V63_L1.2591.00
147_C154_I1.2521.00
141_E192_L1.2431.00
131_P135_S1.2401.00
118_K121_E1.2391.00
19_V51_S1.2301.00
22_T98_S1.2171.00
139_N142_Y1.1971.00
91_D94_D1.1761.00
29_R94_D1.1731.00
150_K157_W1.1681.00
155_K172_A1.1671.00
240_K262_F1.1621.00
264_C267_C1.1601.00
119_E122_G1.1571.00
8_E11_R1.1561.00
56_A161_N1.1521.00
86_P104_R1.1491.00
252_V263_Y1.1491.00
41_I114_W1.1371.00
208_R211_E1.1331.00
141_E145_Q1.1231.00
158_L202_I1.1211.00
212_Q233_E1.1191.00
18_L97_M1.1131.00
49_V61_L1.1091.00
200_R204_A1.1051.00
244_C264_C1.0991.00
175_S198_L1.0781.00
164_V167_V1.0771.00
244_C247_C1.0771.00
152_T156_P1.0711.00
69_I117_T1.0691.00
138_F164_V1.0661.00
177_F235_Q1.0651.00
197_L201_V1.0631.00
244_C267_C1.0471.00
27_V94_D1.0441.00
199_A203_K1.0411.00
133_P138_F1.0341.00
149_K188_S1.0281.00
49_V97_M1.0221.00
50_L62_E1.0151.00
140_G144_H1.0131.00
34_R37_V1.0071.00
229_Y232_Q0.9961.00
179_A197_L0.9921.00
23_I95_L0.9911.00
63_L68_I0.9881.00
26_A44_L0.9861.00
78_L105_Y0.9791.00
48_P64_P0.9771.00
146_K163_L0.9761.00
58_Y69_I0.9741.00
181_I198_L0.9641.00
256_H261_T0.9591.00
247_C264_C0.9591.00
190_L195_C0.9571.00
129_L165_V0.9381.00
70_I105_Y0.9331.00
172_A261_T0.9221.00
196_E200_R0.9191.00
94_D102_V0.9100.99
214_G228_G0.9080.99
91_D104_R0.9060.99
153_A184_D0.9060.99
105_Y114_W0.9040.99
243_P250_P0.8920.99
18_L49_V0.8820.99
28_V93_V0.8760.99
15_E52_V0.8750.99
92_H110_R0.8750.99
243_P249_T0.8750.99
77_S108_P0.8720.99
227_P232_Q0.8700.99
44_L63_L0.8660.99
95_L114_W0.8610.99
82_P85_L0.8600.99
184_D256_H0.8580.99
144_H147_C0.8550.99
144_H196_E0.8540.99
11_R52_V0.8520.99
96_V102_V0.8440.99
159_M173_S0.8420.99
225_G228_G0.8400.99
13_G213_G0.8380.99
12_R15_E0.8350.99
141_E196_E0.8340.99
231_A234_L0.8300.99
148_A195_C0.8270.99
193_A197_L0.8250.99
75_S108_P0.8230.99
167_V206_L0.8210.99
89_K92_H0.8140.99
150_K163_L0.8130.99
61_L68_I0.8110.99
18_L61_L0.8080.99
75_S112_G0.8040.99
119_E123_H0.8030.99
150_K187_A0.8020.99
124_N127_T0.7940.99
253_A262_F0.7940.99
87_P94_D0.7890.99
191_S195_C0.7880.99
204_A208_R0.7860.98
177_F245_R0.7790.98
156_P256_H0.7750.98
69_I126_L0.7720.98
97_M101_K0.7700.98
159_M259_R0.7670.98
170_I215_T0.7660.98
67_W120_L0.7630.98
134_L203_K0.7620.98
55_R60_L0.7600.98
170_I237_Y0.7600.98
154_I187_A0.7560.98
153_A186_L0.7540.98
247_C267_C0.7540.98
29_R92_H0.7520.98
61_L70_I0.7490.98
47_Q66_G0.7480.98
135_S203_K0.7460.98
117_T125_V0.7460.98
26_A41_I0.7450.98
42_Y45_S0.7420.98
115_L125_V0.7410.98
37_V40_E0.7380.98
41_I70_I0.7370.98
37_V93_V0.7360.98
249_T252_V0.7330.98
189_S194_E0.7320.98
12_R211_E0.7320.98
9_T210_I0.7310.98
68_I95_L0.7300.98
151_K186_L0.7300.98
21_A97_M0.7290.98
170_I175_S0.7280.98
98_S101_K0.7270.98
175_S179_A0.7200.97
154_I195_C0.7200.97
208_R235_Q0.7130.97
236_V239_R0.7130.97
153_A257_A0.7130.97
216_T228_G0.7060.97
4_L8_E0.7050.97
87_P91_D0.7040.97
19_V22_T0.7000.97
6_E170_I0.6980.97
208_R212_Q0.6970.97
255_K260_A0.6900.97
146_K149_K0.6850.96
23_I49_V0.6840.96
17_H80_I0.6830.96
120_L123_H0.6790.96
226_K229_Y0.6730.96
156_P258_Q0.6720.96
189_S252_V0.6690.96
81_L104_R0.6690.96
212_Q232_Q0.6680.96
241_G250_P0.6670.96
6_E214_G0.6660.96
23_I97_M0.6660.96
182_H185_R0.6650.96
143_L147_C0.6640.96
195_C199_A0.6600.96
140_G195_C0.6590.96
68_I114_W0.6550.95
47_Q50_L0.6540.95
235_Q246_V0.6530.95
154_I176_L0.6510.95
184_D252_V0.6510.95
158_L167_V0.6490.95
173_S256_H0.6480.95
192_L195_C0.6480.95
130_G165_V0.6480.95
197_L200_R0.6460.95
78_L95_L0.6460.95
177_F180_G0.6460.95
14_I78_L0.6430.95
171_Y206_L0.6420.95
139_N199_A0.6400.95
135_S138_F0.6400.95
57_K76_G0.6390.95
226_K230_F0.6390.95
24_L99_N0.6380.95
88_E106_T0.6370.95
4_L206_L0.6370.95
32_R110_R0.6330.95
215_T231_A0.6320.94
73_G109_R0.6310.94
136_D203_K0.6300.94
13_G80_I0.6290.94
225_G230_F0.6290.94
254_T260_A0.6270.94
44_L68_I0.6260.94
28_V95_L0.6250.94
77_S221_L0.6250.94
131_P164_V0.6250.94
53_Q67_W0.6230.94
255_K258_Q0.6220.94
14_I52_V0.6200.94
229_Y234_L0.6190.94
34_R73_G0.6160.94
8_E210_I0.6110.93
134_L207_L0.6070.93
160_D163_L0.6070.93
73_G111_F0.6050.93
61_L78_L0.6020.93
181_I194_E0.6020.93
37_V41_I0.6020.93
138_F199_A0.5990.93
180_G197_L0.5980.93
145_Q149_K0.5980.93
80_I101_K0.5960.93
240_K250_P0.5960.93
43_R116_W0.5950.92
148_A192_L0.5940.92
153_A183_P0.5920.92
155_K173_S0.5920.92
32_R35_W0.5910.92
134_L206_L0.5910.92
14_I61_L0.5880.92
36_P40_E0.5860.92
4_L9_T0.5850.92
52_V62_E0.5850.92
238_G262_F0.5820.92
131_P165_V0.5820.92
172_A256_H0.5810.92
227_P230_F0.5790.91
250_P265_R0.5790.91
234_L238_G0.5780.91
171_Y209_S0.5760.91
123_H126_L0.5750.91
58_Y115_L0.5750.91
90_H109_R0.5740.91
146_K150_K0.5740.91
246_V249_T0.5730.91
193_A196_E0.5720.91
145_Q192_L0.5710.91
77_S106_T0.5700.91
57_K71_H0.5690.91
230_F234_L0.5680.91
240_K252_V0.5630.90
105_Y112_G0.5610.90
28_V31_G0.5600.90
199_A202_I0.5590.90
81_L87_P0.5580.90
9_T12_R0.5570.90
205_V209_S0.5550.90
256_H260_A0.5550.90
74_M90_H0.5540.90
4_L54_R0.5530.90
147_C187_A0.5520.89
209_S215_T0.5510.89
33_L37_V0.5510.89
24_L96_V0.5500.89
43_R118_K0.5490.89
153_A187_A0.5490.89
176_L187_A0.5480.89
30_N73_G0.5480.89
132_E165_V0.5480.89
35_W115_L0.5470.89
19_V52_V0.5440.89
177_F247_C0.5430.89
28_V37_V0.5430.89
56_A165_V0.5420.89
133_P206_L0.5420.89
71_H76_G0.5390.88
131_P163_L0.5380.88
7_V74_M0.5380.88
146_K164_V0.5320.88
109_R112_G0.5320.88
133_P164_V0.5300.87
6_E112_G0.5300.87
216_T225_G0.5290.87
49_V52_V0.5290.87
227_P231_A0.5270.87
26_A63_L0.5260.87
113_A125_V0.5260.87
241_G252_V0.5250.87
73_G113_A0.5250.87
74_M111_F0.5250.87
117_T120_L0.5240.87
206_L210_I0.5230.87
185_R191_S0.5230.87
190_L198_L0.5220.87
108_P111_F0.5220.87
184_D263_Y0.5220.87
209_S212_Q0.5150.86
146_K157_W0.5150.86
107_D111_F0.5140.86
75_S92_H0.5130.86
254_T261_T0.5110.86
105_Y109_R0.5100.85
29_R87_P0.5090.85
7_V109_R0.5090.85
5_P8_E0.5070.85
30_N33_L0.5050.85
141_E144_H0.5050.85
54_R132_E0.5030.85
179_A205_V0.5010.84
47_Q63_L0.5010.84
10_S79_R0.5010.84
14_I80_I0.5010.84
205_V208_R0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k82A 1 0.9665 100 0.037 Contact Map
3u6pA 1 0.9182 100 0.051 Contact Map
4pd2A 1 0.9888 100 0.055 Contact Map
3twlA 1 0.9182 100 0.086 Contact Map
1ee8A 2 0.9591 100 0.115 Contact Map
3vk8A 1 0.9405 100 0.124 Contact Map
1k3xA 1 0.9108 100 0.139 Contact Map
4mb7A 2 0.8996 100 0.178 Contact Map
3w0fA 1 0.9033 100 0.224 Contact Map
1tdhA 1 0.8736 100 0.229 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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