GREMLIN Database
PDXB - Erythronate-4-phosphate dehydrogenase
UniProt: P05459 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10692
Length: 378 (295)
Sequences: 4413 (2708)
Seq/√Len: 157.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_D193_L5.0851.00
213_D216_A4.5781.00
191_E219_T4.0651.00
199_P225_Q3.3641.00
162_D196_S3.2681.00
160_S163_E3.1111.00
119_V135_L2.9851.00
118_T141_K2.7821.00
187_H235_E2.6441.00
201_A226_K2.5411.00
51_E55_A2.5071.00
107_A170_I2.4781.00
189_A194_I2.4611.00
120_G164_L2.4341.00
51_E79_Q2.4111.00
222_N247_K2.2941.00
100_F138_L2.2761.00
178_F184_K2.2631.00
54_L62_V2.2421.00
166_Q196_S2.2271.00
118_T143_L2.1991.00
165_V193_L2.1931.00
218_L247_K2.1421.00
194_I203_L2.1221.00
4_L38_A2.0991.00
28_R52_S2.0861.00
191_E195_R2.0771.00
10_P14_D2.0271.00
187_H213_D1.9891.00
2_K21_E1.9161.00
194_I220_C1.9081.00
202_I227_L1.8591.00
177_L186_L1.8431.00
120_G168_A1.8101.00
143_L167_R1.7501.00
100_F135_L1.7321.00
219_T223_E1.7231.00
173_F211_V1.7201.00
218_L222_N1.7081.00
106_L228_S1.6951.00
98_Y256_A1.6941.00
197_L201_A1.6931.00
163_E167_R1.6931.00
189_A193_L1.6921.00
41_L49_V1.6781.00
23_T38_A1.6761.00
164_L168_A1.6511.00
177_L210_A1.6511.00
76_W79_Q1.6411.00
37_D58_P1.6381.00
119_V140_I1.6271.00
131_L172_T1.6201.00
195_R225_Q1.6061.00
169_D198_K1.6041.00
14_D18_R1.5941.00
55_A80_A1.5861.00
194_I197_L1.5841.00
39_D60_K1.5751.00
72_V84_F1.5751.00
179_K186_L1.5681.00
124_V144_L1.5541.00
192_K196_S1.5301.00
117_R261_E1.5111.00
276_K281_E1.5091.00
165_V189_A1.5071.00
28_R50_N1.4991.00
28_R32_V1.4981.00
63_G270_V1.4601.00
99_V131_L1.4531.00
202_I228_S1.4311.00
222_N246_K1.4301.00
135_L140_I1.4291.00
23_T34_Q1.4271.00
195_R223_E1.4171.00
51_E76_W1.3991.00
32_V52_S1.3861.00
121_I132_Q1.3811.00
165_V171_L1.3731.00
118_T168_A1.3651.00
171_L201_A1.3601.00
64_T72_V1.3561.00
159_R163_E1.3511.00
162_D193_L1.3501.00
77_L84_F1.3481.00
217_L229_V1.3431.00
106_L230_V1.3371.00
141_K167_R1.3201.00
220_C226_K1.3191.00
122_V173_F1.3081.00
191_E216_A1.2991.00
115_Y139_G1.2901.00
50_N53_L1.2881.00
121_I172_T1.2781.00
215_T243_E1.2721.00
234_W251_G1.2661.00
40_A61_F1.2611.00
203_L212_V1.2601.00
106_L202_I1.2481.00
39_D58_P1.2361.00
200_G226_K1.2271.00
13_R17_S1.2251.00
198_K201_A1.2201.00
141_K157_D1.1991.00
11_Y264_A1.1941.00
43_V72_V1.1891.00
61_F85_S1.1821.00
32_V53_L1.1811.00
54_L80_A1.1781.00
97_E134_R1.1701.00
130_R133_A1.1701.00
40_A274_Y1.1681.00
194_I225_Q1.1681.00
143_L168_A1.1601.00
83_G286_L1.1591.00
76_W80_A1.1531.00
121_I128_G1.1521.00
170_I202_I1.1461.00
2_K37_D1.1351.00
14_D17_S1.1271.00
190_D216_A1.1261.00
15_L271_F1.1261.00
176_P185_T1.1201.00
222_N243_E1.1181.00
72_V77_L1.1151.00
159_R164_L1.1071.00
35_L57_K1.0960.99
200_G225_Q1.0850.99
221_L249_D1.0790.99
189_A203_L1.0780.99
277_F283_H1.0770.99
74_E78_K1.0750.99
121_I131_L1.0730.99
207_C211_V1.0670.99
179_K184_K1.0630.99
192_K195_R1.0620.99
75_A79_Q1.0590.99
157_D167_R1.0570.99
104_L138_L1.0500.99
143_L159_R1.0440.99
171_L197_L1.0380.99
54_L82_I1.0380.99
203_L226_K1.0370.99
175_T211_V1.0340.99
175_T207_C1.0310.99
91_N257_G1.0270.99
151_D155_E1.0260.99
275_S279_G1.0240.99
57_K80_A1.0050.99
276_K284_V1.0050.99
99_V206_A1.0040.99
61_F274_Y1.0030.99
55_A76_W1.0030.99
15_L275_S0.9980.99
92_A130_R0.9960.99
200_G223_E0.9940.99
187_H190_D0.9910.99
217_L226_K0.9890.99
106_L250_I0.9820.99
19_L275_S0.9730.99
159_R167_R0.9680.99
61_F277_F0.9670.99
165_V201_A0.9660.99
161_L193_L0.9650.99
62_V77_L0.9570.99
190_D213_D0.9530.99
2_K23_T0.9520.99
33_A36_A0.9520.99
188_L211_V0.9520.99
73_D76_W0.9510.99
36_A57_K0.9510.99
175_T188_L0.9450.98
130_R134_R0.9430.98
122_V189_A0.9380.98
221_L229_V0.9370.98
217_L231_L0.9370.98
162_D192_K0.9280.98
140_I170_I0.9270.98
215_T219_T0.9210.98
93_I97_E0.9210.98
40_A270_V0.9210.98
93_I134_R0.9190.98
29_P52_S0.9160.98
268_T272_E0.9070.98
218_L243_E0.9070.98
174_H206_A0.9060.98
19_L279_G0.9050.98
66_T71_H0.9020.98
173_F203_L0.8930.98
54_L76_W0.8910.98
172_T206_A0.8880.98
98_Y102_S0.8830.98
221_L247_K0.8780.98
51_E80_A0.8770.98
219_T222_N0.8770.98
239_E242_V0.8770.98
30_I33_A0.8750.97
133_A139_G0.8650.97
37_D57_K0.8640.97
131_L174_H0.8610.97
129_R153_G0.8600.97
165_V197_L0.8550.97
193_L196_S0.8530.97
177_L185_T0.8520.97
102_S230_V0.8500.97
122_V175_T0.8440.97
10_P17_S0.8440.97
25_V34_Q0.8430.97
218_L246_K0.8420.97
93_I115_Y0.8420.97
122_V171_L0.8380.97
168_A171_L0.8350.97
118_T167_R0.8340.97
90_C266_G0.8330.97
103_L170_I0.8320.97
214_N235_E0.8300.97
35_L56_G0.8300.97
201_A225_Q0.8300.97
187_H210_A0.8290.96
98_Y252_T0.8280.96
218_L231_L0.8270.96
276_K280_H0.8240.96
64_T71_H0.8220.96
101_S104_L0.8210.96
222_N249_D0.8160.96
78_K288_T0.8140.96
15_L272_E0.8120.96
5_V12_A0.8090.96
203_L217_L0.8050.96
112_F202_I0.8020.96
3_I16_F0.8010.96
5_V16_F0.8010.96
122_V161_L0.7930.95
89_G126_N0.7890.95
152_R155_E0.7880.95
106_L204_I0.7810.95
162_D166_Q0.7800.95
186_L210_A0.7740.95
193_L197_L0.7640.94
150_A153_G0.7630.94
258_Y263_K0.7610.94
112_F117_R0.7600.94
124_V129_R0.7580.94
208_R254_H0.7580.94
161_L165_V0.7580.94
113_S265_R0.7570.94
112_F260_L0.7560.94
171_L203_L0.7550.94
89_G92_A0.7530.94
112_F170_I0.7520.94
165_V196_S0.7470.94
34_Q38_A0.7420.94
56_G59_I0.7400.94
11_Y14_D0.7390.93
143_L164_L0.7390.93
30_I34_Q0.7380.93
245_L251_G0.7360.93
96_V134_R0.7360.93
94_A262_G0.7350.93
272_E276_K0.7340.93
218_L251_G0.7330.93
13_R24_A0.7300.93
98_Y255_I0.7270.93
93_I130_R0.7250.93
4_L25_V0.7250.93
54_L77_L0.7230.93
122_V188_L0.7180.92
146_D174_H0.7170.92
94_A113_S0.7130.92
161_L189_A0.7120.92
42_M270_V0.7070.92
114_L170_I0.7060.92
215_T235_E0.7050.92
16_F271_F0.7040.92
214_N241_N0.7010.92
49_V53_L0.7010.92
98_Y101_S0.6990.91
40_A278_I0.6950.91
296_G300_L0.6940.91
34_Q37_D0.6940.91
230_V250_I0.6930.91
221_L226_K0.6920.91
197_L225_Q0.6920.91
269_Q285_A0.6910.91
103_L119_V0.6890.91
200_G227_L0.6890.91
93_I133_A0.6860.91
70_D177_L0.6840.91
220_C225_Q0.6810.90
163_E166_Q0.6810.90
150_A154_D0.6780.90
164_L171_L0.6780.90
43_V49_V0.6770.90
297_R300_L0.6750.90
86_A287_D0.6720.90
83_G283_H0.6690.90
173_F189_A0.6670.89
15_L268_T0.6640.89
20_G275_S0.6630.89
35_L41_L0.6610.89
149_R158_F0.6610.89
87_A266_G0.6600.89
151_D154_D0.6590.89
32_V36_A0.6550.89
149_R153_G0.6550.89
93_I113_S0.6550.89
95_V256_A0.6500.88
49_V54_L0.6490.88
87_A90_C0.6450.88
96_V130_R0.6420.88
265_R268_T0.6410.88
44_R91_N0.6410.88
202_I230_V0.6390.87
48_K70_D0.6360.87
8_N46_V0.6360.87
201_A220_C0.6340.87
52_S55_A0.6330.87
111_G259_T0.6310.87
257_G263_K0.6310.87
295_F300_L0.6300.87
159_R168_A0.6300.87
90_C257_G0.6290.87
107_A202_I0.6270.86
25_V30_I0.6220.86
131_L135_L0.6210.86
114_L138_L0.6210.86
212_V217_L0.6190.86
236_G240_L0.6160.85
102_S206_A0.6130.85
12_A267_T0.6090.85
175_T185_T0.6080.85
67_A126_N0.6080.85
68_G254_H0.6070.85
293_P296_G0.6070.85
188_L193_L0.6060.84
145_C161_L0.6040.84
61_F278_I0.6020.84
283_H286_L0.6020.84
295_F298_I0.6010.84
161_L188_L0.6010.84
215_T242_V0.6000.84
89_G269_Q0.5990.84
149_R154_D0.5990.84
119_V131_L0.5950.83
91_N94_A0.5950.83
100_F131_L0.5940.83
51_E73_D0.5940.83
113_S259_T0.5930.83
107_A114_L0.5930.83
29_P33_A0.5910.83
212_V229_V0.5910.83
218_L241_N0.5890.83
103_L204_I0.5880.83
194_I217_L0.5880.83
144_L158_F0.5840.82
96_V185_T0.5830.82
32_V35_L0.5830.82
61_F83_G0.5810.82
296_G299_T0.5800.82
83_G289_L0.5800.82
243_E246_K0.5790.82
12_A271_F0.5780.82
240_L243_E0.5780.82
132_Q142_T0.5780.82
103_L202_I0.5780.82
117_R140_I0.5770.81
119_V172_T0.5760.81
277_F280_H0.5750.81
102_S250_I0.5740.81
173_F194_I0.5730.81
7_E47_T0.5700.81
6_D43_V0.5660.80
67_A89_G0.5650.80
63_G85_S0.5640.80
214_N236_G0.5620.80
121_I142_T0.5620.80
60_K278_I0.5610.80
280_H283_H0.5580.79
49_V52_S0.5570.79
62_V82_I0.5570.79
44_R64_T0.5570.79
27_G34_Q0.5560.79
239_E245_L0.5560.79
201_A227_L0.5540.79
6_D47_T0.5530.79
87_A270_V0.5520.79
16_F42_M0.5520.79
99_V172_T0.5490.78
135_L142_T0.5480.78
273_A285_A0.5480.78
100_F134_R0.5470.78
103_L131_L0.5460.78
63_G274_Y0.5450.78
272_E284_V0.5450.78
35_L53_L0.5420.77
7_E46_V0.5420.77
9_M42_M0.5420.77
102_S105_M0.5400.77
5_V13_R0.5370.77
109_R249_D0.5340.76
173_F207_C0.5330.76
118_T198_K0.5330.76
243_E247_K0.5320.76
35_L38_A0.5310.76
56_G80_A0.5280.75
6_D41_L0.5260.75
105_M250_I0.5220.75
95_V100_F0.5220.75
274_Y278_I0.5220.75
104_L137_A0.5220.75
214_N242_V0.5190.74
100_F119_V0.5190.74
165_V188_L0.5190.74
112_F227_L0.5180.74
144_L154_D0.5170.74
42_M274_Y0.5160.74
220_C229_V0.5150.74
172_T207_C0.5150.74
187_H216_A0.5140.74
108_E256_A0.5140.74
17_S24_A0.5140.74
96_V131_L0.5130.73
147_P178_F0.5130.73
85_S285_A0.5130.73
44_R65_A0.5130.73
6_D46_V0.5130.73
40_A63_G0.5120.73
95_V234_W0.5120.73
11_Y268_T0.5110.73
271_F275_S0.5110.73
136_E142_T0.5100.73
189_A197_L0.5090.73
68_G208_R0.5090.73
3_I20_G0.5090.73
124_V149_R0.5080.73
90_C262_G0.5070.73
152_R156_G0.5070.73
95_V99_V0.5070.73
91_N95_V0.5060.72
134_R138_L0.5030.72
44_R47_T0.5020.72
35_L54_L0.5010.72
44_R257_G0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oetA 2 0.9974 100 0.229 Contact Map
2o4cA 2 0.9868 100 0.23 Contact Map
1sc6A 4 0.9365 100 0.395 Contact Map
3k5pA 3 0.955 100 0.406 Contact Map
1ygyA 4 0.9735 100 0.423 Contact Map
2g76A 2 0.7249 100 0.434 Contact Map
1dxyA 5 0.754 100 0.436 Contact Map
4g2nA 3 0.7513 100 0.437 Contact Map
3ba1A 2 0.7513 100 0.44 Contact Map
2yq5A 4 0.7513 100 0.446 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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