GREMLIN Database
AROD - 3-dehydroquinate dehydratase
UniProt: P05194 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10076
Length: 252 (229)
Sequences: 1352 (1075)
Seq/√Len: 71.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_L139_V4.4581.00
226_G242_L3.4201.00
188_T202_T3.2621.00
49_V79_F3.2271.00
19_I223_A3.1941.00
144_D147_K3.1171.00
154_I171_I2.9461.00
175_P204_S2.8681.00
201_I223_A2.5141.00
189_L193_E2.2431.00
151_A190_E2.1951.00
191_M196_A2.1661.00
41_D75_K2.1011.00
225_F232_S2.0941.00
143_H205_M2.0021.00
179_S189_L1.9141.00
81_F90_Q1.9011.00
78_L112_M1.8791.00
245_V248_I1.8701.00
83_S97_Y1.8611.00
205_M233_A1.8611.00
22_L30_V1.8551.00
80_T143_H1.8181.00
93_S96_A1.8091.00
188_T203_M1.8041.00
79_F104_A1.8041.00
172_A203_M1.7971.00
154_I187_A1.7831.00
112_M139_V1.7761.00
145_F174_M1.7701.00
238_S241_D1.7651.00
143_H233_A1.7651.00
102_R130_Y1.7571.00
169_P198_R1.7361.00
233_A236_Q1.7141.00
207_K210_V1.6931.00
151_A186_A1.6901.00
145_F205_M1.6791.00
44_I223_A1.6571.00
117_L140_M1.6520.99
175_P181_V1.6520.99
181_V204_S1.6510.99
241_D244_T1.6450.99
34_A71_T1.6300.99
162_Q191_M1.5970.99
162_Q198_R1.5770.99
158_L202_T1.5770.99
137_K167_D1.5610.99
151_A183_T1.5580.99
181_V212_S1.5460.99
27_I67_I1.5330.99
155_I187_A1.5310.99
143_H236_Q1.5080.99
162_Q196_A1.4980.99
26_D29_S1.4900.99
80_T114_D1.4860.99
140_M166_A1.4780.99
114_D143_H1.4780.99
175_P208_T1.4570.99
143_H213_R1.4480.99
102_R126_E1.4080.98
216_G221_S1.4060.98
33_E229_K1.3920.98
24_A29_S1.3900.98
142_N157_R1.3880.98
86_E118_F1.3730.98
80_T205_M1.3640.98
37_Y42_F1.3620.98
24_A33_E1.3520.98
154_I173_L1.3460.98
69_R111_D1.3450.98
188_T200_I1.3410.98
94_T120_G1.3230.98
184_L204_S1.3140.97
95_E99_A1.3090.97
186_A190_E1.2800.97
173_L184_L1.2710.97
79_F110_V1.2630.97
15_A247_T1.2590.97
182_L189_L1.2520.97
42_F239_V1.2450.96
172_A205_M1.2240.96
155_I190_E1.2030.96
51_H89_E1.1990.96
20_V228_V1.1970.96
184_L202_T1.1910.95
47_W65_A1.1890.95
112_M168_I1.1890.95
132_H167_D1.1880.95
26_D53_A1.1820.95
204_S212_S1.1790.95
184_L212_S1.1780.95
42_F75_K1.1770.95
80_T116_E1.1740.95
52_Y64_A1.1740.95
48_R80_T1.1730.95
27_I52_Y1.1660.95
105_I115_L1.1470.94
214_L245_V1.1400.94
49_V101_N1.1380.94
76_P168_I1.1250.94
154_I158_L1.1150.93
27_I64_A1.1120.93
213_R233_A1.1090.93
41_D243_R1.0970.93
84_A89_E1.0960.93
114_D233_A1.0930.93
65_A107_S1.0900.93
23_M232_S1.0880.93
65_A104_A1.0830.92
27_I31_K1.0780.92
101_N113_I1.0720.92
84_A91_A1.0710.92
104_A113_I1.0700.92
216_G232_S1.0680.92
150_E153_E1.0580.92
174_M205_M1.0570.92
117_L161_M1.0530.91
55_L81_F1.0520.91
94_T97_Y1.0380.91
17_K97_Y1.0360.91
112_M137_K1.0340.91
185_L219_F1.0330.91
145_F172_A1.0320.91
140_M161_M1.0300.90
33_E37_Y1.0180.90
104_A108_G1.0180.90
167_D199_P0.9950.89
142_N171_I0.9920.89
188_T221_S0.9910.89
105_I134_H0.9770.88
121_D160_K0.9730.88
237_I242_L0.9590.87
23_M51_H0.9560.87
20_V239_V0.9550.87
143_H170_K0.9520.87
92_I96_A0.9520.87
205_M213_R0.9480.86
121_D125_K0.9420.86
80_T233_A0.9360.86
42_F243_R0.9260.85
98_I123_Q0.9190.85
97_Y119_T0.9170.85
103_A106_D0.9140.84
120_G123_Q0.9140.84
114_D236_Q0.9050.84
58_V62_M0.9020.84
42_F228_V0.9020.84
20_V37_Y0.9010.83
21_S225_F0.8990.83
44_I76_P0.8970.83
210_V214_L0.8960.83
160_K179_S0.8960.83
17_K51_H0.8840.82
172_A233_A0.8830.82
21_S232_S0.8760.82
47_W52_Y0.8720.81
76_P199_P0.8710.81
128_V138_V0.8650.81
211_I215_A0.8630.81
48_R116_E0.8600.81
94_T98_I0.8390.79
214_L237_I0.8310.78
166_A199_P0.8310.78
116_E143_H0.8300.78
110_V136_V0.8280.78
35_L71_T0.8270.78
102_R106_D0.8240.78
139_V201_I0.8200.77
205_M235_G0.8180.77
244_T248_I0.8140.77
80_T213_R0.8110.76
155_I159_R0.8080.76
40_A228_V0.8000.75
213_R236_Q0.7980.75
148_T180_D0.7980.75
96_A99_A0.7920.75
58_V103_A0.7900.75
180_D183_T0.7900.75
88_G116_E0.7860.74
25_K53_A0.7840.74
22_L34_A0.7840.74
87_G116_E0.7830.74
97_Y101_N0.7830.74
115_L124_V0.7790.74
48_R82_R0.7740.73
182_L218_V0.7730.73
86_E142_N0.7720.73
79_F101_N0.7660.72
99_A103_A0.7640.72
33_E36_A0.7630.72
38_R75_K0.7620.72
82_R116_E0.7620.72
144_D157_R0.7570.71
144_D205_M0.7560.71
28_A32_S0.7530.71
179_S193_E0.7520.71
77_L191_M0.7500.71
181_V187_A0.7410.70
18_I242_L0.7390.70
94_T122_D0.7350.69
186_A189_L0.7310.69
83_S86_E0.7290.69
153_E156_A0.7260.68
185_L188_T0.7260.68
159_R162_Q0.7250.68
81_F100_L0.7160.67
215_A246_L0.7130.67
47_W232_S0.7110.67
168_I221_S0.7100.66
154_I183_T0.7080.66
104_A107_S0.7050.66
66_K69_R0.6930.65
62_M103_A0.6920.64
20_V42_F0.6880.64
145_F233_A0.6850.64
23_M119_T0.6790.63
118_F157_R0.6750.63
128_V140_M0.6740.62
30_V47_W0.6720.62
114_D205_M0.6710.62
169_P196_A0.6710.62
106_D130_Y0.6670.62
177_S208_T0.6630.61
128_V239_V0.6620.61
102_R127_T0.6590.61
162_Q169_P0.6590.61
173_L188_T0.6590.61
175_P180_D0.6560.60
18_I239_V0.6540.60
191_M198_R0.6530.60
104_A110_V0.6500.60
219_F238_S0.6480.59
181_V208_T0.6480.59
37_Y41_D0.6470.59
217_E246_L0.6440.59
188_T219_F0.6410.59
224_T233_A0.6370.58
43_D76_P0.6360.58
152_E163_S0.6350.58
145_F234_P0.6350.58
147_K163_S0.6340.58
35_L38_R0.6320.58
145_F236_Q0.6300.57
16_P224_T0.6280.57
26_D35_L0.6280.57
159_R194_Q0.6260.57
34_A45_L0.6240.57
172_A175_P0.6230.56
53_A240_N0.6210.56
143_H203_M0.6200.56
148_T204_S0.6170.56
48_R114_D0.6150.55
76_P232_S0.6140.55
145_F148_T0.6110.55
31_K35_L0.6080.55
60_S63_A0.6080.55
66_K126_E0.6050.54
179_S243_R0.6040.54
68_L227_A0.6040.54
89_E212_S0.6020.54
56_S96_A0.5980.53
184_L203_M0.5970.53
192_Q196_A0.5930.53
205_M236_Q0.5920.53
117_L160_K0.5900.52
180_D209_G0.5890.52
126_E130_Y0.5850.52
156_A159_R0.5840.52
26_D192_Q0.5830.52
19_I44_I0.5830.52
19_I24_A0.5820.51
239_V243_R0.5800.51
32_S240_N0.5800.51
84_A241_D0.5780.51
107_S168_I0.5770.51
240_N245_V0.5760.51
98_I102_R0.5750.51
148_T205_M0.5740.50
173_L204_S0.5730.50
113_I177_S0.5730.50
171_I219_F0.5690.50
157_R161_M0.5690.50
172_A216_G0.5680.50
169_P201_I0.5680.50
22_L37_Y0.5680.50
200_I216_G0.5650.49
35_L66_K0.5640.49
141_S169_P0.5600.49
129_A133_A0.5590.49
21_S42_F0.5580.49
20_V45_L0.5570.48
158_L187_A0.5550.48
210_V249_L0.5530.48
171_I226_G0.5500.48
123_Q127_T0.5490.47
59_E62_M0.5480.47
174_M224_T0.5430.47
22_L45_L0.5430.47
44_I129_A0.5430.47
143_H235_G0.5430.47
205_M234_P0.5430.47
36_A163_S0.5420.47
77_L230_K0.5410.46
171_I183_T0.5400.46
80_T236_Q0.5380.46
173_L181_V0.5380.46
22_L133_A0.5380.46
43_D86_E0.5380.46
25_K51_H0.5370.46
244_T247_T0.5350.46
58_V61_V0.5350.46
26_D60_S0.5330.45
106_D134_H0.5330.45
88_G114_D0.5320.45
86_E140_M0.5320.45
84_A230_K0.5320.45
104_A136_V0.5310.45
46_E170_K0.5300.45
139_V218_V0.5290.45
83_S87_G0.5280.45
22_L27_I0.5280.45
215_A218_V0.5260.45
125_K133_A0.5240.44
214_L248_I0.5200.44
78_L169_P0.5180.44
35_L67_I0.5160.43
151_A187_A0.5150.43
28_A135_D0.5150.43
181_V211_I0.5150.43
82_R114_D0.5130.43
182_L185_L0.5130.43
60_S73_P0.5130.43
16_P217_E0.5120.43
185_L216_G0.5120.43
149_P180_D0.5100.43
97_Y161_M0.5090.43
81_F101_N0.5090.43
159_R163_S0.5080.42
81_F97_Y0.5070.42
101_N105_I0.5060.42
95_E123_Q0.5050.42
35_L59_E0.5030.42
17_K217_E0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cnnA 2 0.9802 100 0.056 Contact Map
4ph6A 2 0.9524 100 0.065 Contact Map
4h3dA 2 1 100 0.08 Contact Map
3l9cA 1 0.8889 100 0.155 Contact Map
2yr1A 2 0.9921 100 0.167 Contact Map
1sflA 2 0.9167 100 0.172 Contact Map
2oczA 2 0.8651 100 0.177 Contact Map
2o7sA 2 0.9087 100 0.213 Contact Map
2egzA 1 0.8571 100 0.229 Contact Map
2ox1A 2 0.7738 100 0.26 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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