AROD - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

AROD - 3-dehydroquinate dehydratase

UniProt:	P05194	Sequences: MKTVTVKDLVIGTGAPKIIVSLMAKDIASVKSEALAYREADFDILEWRVDHYADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10076
Length:	252 (229)
Sequences:	1352 (1075)
Seq/√Len:	71.1

ECOLI - AROD
BACSU - AROD
HALSA - AROD
SULSO - AROD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
78_L	139_V	4.458	1.00
226_G	242_L	3.420	1.00
188_T	202_T	3.262	1.00
49_V	79_F	3.227	1.00
19_I	223_A	3.194	1.00
144_D	147_K	3.117	1.00
154_I	171_I	2.946	1.00
175_P	204_S	2.868	1.00
201_I	223_A	2.514	1.00
189_L	193_E	2.243	1.00
151_A	190_E	2.195	1.00
191_M	196_A	2.166	1.00
41_D	75_K	2.101	1.00
225_F	232_S	2.094	1.00
143_H	205_M	2.002	1.00
179_S	189_L	1.914	1.00
81_F	90_Q	1.901	1.00
78_L	112_M	1.879	1.00
245_V	248_I	1.870	1.00
83_S	97_Y	1.861	1.00
205_M	233_A	1.861	1.00
22_L	30_V	1.855	1.00
80_T	143_H	1.818	1.00
93_S	96_A	1.809	1.00
188_T	203_M	1.804	1.00
79_F	104_A	1.804	1.00
172_A	203_M	1.797	1.00
154_I	187_A	1.783	1.00
112_M	139_V	1.776	1.00
145_F	174_M	1.770	1.00
238_S	241_D	1.765	1.00
143_H	233_A	1.765	1.00
102_R	130_Y	1.757	1.00
169_P	198_R	1.736	1.00
233_A	236_Q	1.714	1.00
207_K	210_V	1.693	1.00
151_A	186_A	1.690	1.00
145_F	205_M	1.679	1.00
44_I	223_A	1.657	1.00
117_L	140_M	1.652	0.99
175_P	181_V	1.652	0.99
181_V	204_S	1.651	0.99
241_D	244_T	1.645	0.99
34_A	71_T	1.630	0.99
162_Q	191_M	1.597	0.99
162_Q	198_R	1.577	0.99
158_L	202_T	1.577	0.99
137_K	167_D	1.561	0.99
151_A	183_T	1.558	0.99
181_V	212_S	1.546	0.99
27_I	67_I	1.533	0.99
155_I	187_A	1.531	0.99
143_H	236_Q	1.508	0.99
162_Q	196_A	1.498	0.99
26_D	29_S	1.490	0.99
80_T	114_D	1.486	0.99
140_M	166_A	1.478	0.99
114_D	143_H	1.478	0.99
175_P	208_T	1.457	0.99
143_H	213_R	1.448	0.99
102_R	126_E	1.408	0.98
216_G	221_S	1.406	0.98
33_E	229_K	1.392	0.98
24_A	29_S	1.390	0.98
142_N	157_R	1.388	0.98
86_E	118_F	1.373	0.98
80_T	205_M	1.364	0.98
37_Y	42_F	1.362	0.98
24_A	33_E	1.352	0.98
154_I	173_L	1.346	0.98
69_R	111_D	1.345	0.98
188_T	200_I	1.341	0.98
94_T	120_G	1.323	0.98
184_L	204_S	1.314	0.97
95_E	99_A	1.309	0.97
186_A	190_E	1.280	0.97
173_L	184_L	1.271	0.97
79_F	110_V	1.263	0.97
15_A	247_T	1.259	0.97
182_L	189_L	1.252	0.97
42_F	239_V	1.245	0.96
172_A	205_M	1.224	0.96
155_I	190_E	1.203	0.96
51_H	89_E	1.199	0.96
20_V	228_V	1.197	0.96
184_L	202_T	1.191	0.95
47_W	65_A	1.189	0.95
112_M	168_I	1.189	0.95
132_H	167_D	1.188	0.95
26_D	53_A	1.182	0.95
204_S	212_S	1.179	0.95
184_L	212_S	1.178	0.95
42_F	75_K	1.177	0.95
80_T	116_E	1.174	0.95
52_Y	64_A	1.174	0.95
48_R	80_T	1.173	0.95
27_I	52_Y	1.166	0.95
105_I	115_L	1.147	0.94
214_L	245_V	1.140	0.94
49_V	101_N	1.138	0.94
76_P	168_I	1.125	0.94
154_I	158_L	1.115	0.93
27_I	64_A	1.112	0.93
213_R	233_A	1.109	0.93
41_D	243_R	1.097	0.93
84_A	89_E	1.096	0.93
114_D	233_A	1.093	0.93
65_A	107_S	1.090	0.93
23_M	232_S	1.088	0.93
65_A	104_A	1.083	0.92
27_I	31_K	1.078	0.92
101_N	113_I	1.072	0.92
84_A	91_A	1.071	0.92
104_A	113_I	1.070	0.92
216_G	232_S	1.068	0.92
150_E	153_E	1.058	0.92
174_M	205_M	1.057	0.92
117_L	161_M	1.053	0.91
55_L	81_F	1.052	0.91
94_T	97_Y	1.038	0.91
17_K	97_Y	1.036	0.91
112_M	137_K	1.034	0.91
185_L	219_F	1.033	0.91
145_F	172_A	1.032	0.91
140_M	161_M	1.030	0.90
33_E	37_Y	1.018	0.90
104_A	108_G	1.018	0.90
167_D	199_P	0.995	0.89
142_N	171_I	0.992	0.89
188_T	221_S	0.991	0.89
105_I	134_H	0.977	0.88
121_D	160_K	0.973	0.88
237_I	242_L	0.959	0.87
23_M	51_H	0.956	0.87
20_V	239_V	0.955	0.87
143_H	170_K	0.952	0.87
92_I	96_A	0.952	0.87
205_M	213_R	0.948	0.86
121_D	125_K	0.942	0.86
80_T	233_A	0.936	0.86
42_F	243_R	0.926	0.85
98_I	123_Q	0.919	0.85
97_Y	119_T	0.917	0.85
103_A	106_D	0.914	0.84
120_G	123_Q	0.914	0.84
114_D	236_Q	0.905	0.84
58_V	62_M	0.902	0.84
42_F	228_V	0.902	0.84
20_V	37_Y	0.901	0.83
21_S	225_F	0.899	0.83
44_I	76_P	0.897	0.83
210_V	214_L	0.896	0.83
160_K	179_S	0.896	0.83
17_K	51_H	0.884	0.82
172_A	233_A	0.883	0.82
21_S	232_S	0.876	0.82
47_W	52_Y	0.872	0.81
76_P	199_P	0.871	0.81
128_V	138_V	0.865	0.81
211_I	215_A	0.863	0.81
48_R	116_E	0.860	0.81
94_T	98_I	0.839	0.79
214_L	237_I	0.831	0.78
166_A	199_P	0.831	0.78
116_E	143_H	0.830	0.78
110_V	136_V	0.828	0.78
35_L	71_T	0.827	0.78
102_R	106_D	0.824	0.78
139_V	201_I	0.820	0.77
205_M	235_G	0.818	0.77
244_T	248_I	0.814	0.77
80_T	213_R	0.811	0.76
155_I	159_R	0.808	0.76
40_A	228_V	0.800	0.75
213_R	236_Q	0.798	0.75
148_T	180_D	0.798	0.75
96_A	99_A	0.792	0.75
58_V	103_A	0.790	0.75
180_D	183_T	0.790	0.75
88_G	116_E	0.786	0.74
25_K	53_A	0.784	0.74
22_L	34_A	0.784	0.74
87_G	116_E	0.783	0.74
97_Y	101_N	0.783	0.74
115_L	124_V	0.779	0.74
48_R	82_R	0.774	0.73
182_L	218_V	0.773	0.73
86_E	142_N	0.772	0.73
79_F	101_N	0.766	0.72
99_A	103_A	0.764	0.72
33_E	36_A	0.763	0.72
38_R	75_K	0.762	0.72
82_R	116_E	0.762	0.72
144_D	157_R	0.757	0.71
144_D	205_M	0.756	0.71
28_A	32_S	0.753	0.71
179_S	193_E	0.752	0.71
77_L	191_M	0.750	0.71
181_V	187_A	0.741	0.70
18_I	242_L	0.739	0.70
94_T	122_D	0.735	0.69
186_A	189_L	0.731	0.69
83_S	86_E	0.729	0.69
153_E	156_A	0.726	0.68
185_L	188_T	0.726	0.68
159_R	162_Q	0.725	0.68
81_F	100_L	0.716	0.67
215_A	246_L	0.713	0.67
47_W	232_S	0.711	0.67
168_I	221_S	0.710	0.66
154_I	183_T	0.708	0.66
104_A	107_S	0.705	0.66
66_K	69_R	0.693	0.65
62_M	103_A	0.692	0.64
20_V	42_F	0.688	0.64
145_F	233_A	0.685	0.64
23_M	119_T	0.679	0.63
118_F	157_R	0.675	0.63
128_V	140_M	0.674	0.62
30_V	47_W	0.672	0.62
114_D	205_M	0.671	0.62
169_P	196_A	0.671	0.62
106_D	130_Y	0.667	0.62
177_S	208_T	0.663	0.61
128_V	239_V	0.662	0.61
102_R	127_T	0.659	0.61
162_Q	169_P	0.659	0.61
173_L	188_T	0.659	0.61
175_P	180_D	0.656	0.60
18_I	239_V	0.654	0.60
191_M	198_R	0.653	0.60
104_A	110_V	0.650	0.60
219_F	238_S	0.648	0.59
181_V	208_T	0.648	0.59
37_Y	41_D	0.647	0.59
217_E	246_L	0.644	0.59
188_T	219_F	0.641	0.59
224_T	233_A	0.637	0.58
43_D	76_P	0.636	0.58
152_E	163_S	0.635	0.58
145_F	234_P	0.635	0.58
147_K	163_S	0.634	0.58
35_L	38_R	0.632	0.58
145_F	236_Q	0.630	0.57
16_P	224_T	0.628	0.57
26_D	35_L	0.628	0.57
159_R	194_Q	0.626	0.57
34_A	45_L	0.624	0.57
172_A	175_P	0.623	0.56
53_A	240_N	0.621	0.56
143_H	203_M	0.620	0.56
148_T	204_S	0.617	0.56
48_R	114_D	0.615	0.55
76_P	232_S	0.614	0.55
145_F	148_T	0.611	0.55
31_K	35_L	0.608	0.55
60_S	63_A	0.608	0.55
66_K	126_E	0.605	0.54
179_S	243_R	0.604	0.54
68_L	227_A	0.604	0.54
89_E	212_S	0.602	0.54
56_S	96_A	0.598	0.53
184_L	203_M	0.597	0.53
192_Q	196_A	0.593	0.53
205_M	236_Q	0.592	0.53
117_L	160_K	0.590	0.52
180_D	209_G	0.589	0.52
126_E	130_Y	0.585	0.52
156_A	159_R	0.584	0.52
26_D	192_Q	0.583	0.52
19_I	44_I	0.583	0.52
19_I	24_A	0.582	0.51
239_V	243_R	0.580	0.51
32_S	240_N	0.580	0.51
84_A	241_D	0.578	0.51
107_S	168_I	0.577	0.51
240_N	245_V	0.576	0.51
98_I	102_R	0.575	0.51
148_T	205_M	0.574	0.50
173_L	204_S	0.573	0.50
113_I	177_S	0.573	0.50
171_I	219_F	0.569	0.50
157_R	161_M	0.569	0.50
172_A	216_G	0.568	0.50
169_P	201_I	0.568	0.50
22_L	37_Y	0.568	0.50
200_I	216_G	0.565	0.49
35_L	66_K	0.564	0.49
141_S	169_P	0.560	0.49
129_A	133_A	0.559	0.49
21_S	42_F	0.558	0.49
20_V	45_L	0.557	0.48
158_L	187_A	0.555	0.48
210_V	249_L	0.553	0.48
171_I	226_G	0.550	0.48
123_Q	127_T	0.549	0.47
59_E	62_M	0.548	0.47
174_M	224_T	0.543	0.47
22_L	45_L	0.543	0.47
44_I	129_A	0.543	0.47
143_H	235_G	0.543	0.47
205_M	234_P	0.543	0.47
36_A	163_S	0.542	0.47
77_L	230_K	0.541	0.46
171_I	183_T	0.540	0.46
80_T	236_Q	0.538	0.46
173_L	181_V	0.538	0.46
22_L	133_A	0.538	0.46
43_D	86_E	0.538	0.46
25_K	51_H	0.537	0.46
244_T	247_T	0.535	0.46
58_V	61_V	0.535	0.46
26_D	60_S	0.533	0.45
106_D	134_H	0.533	0.45
88_G	114_D	0.532	0.45
86_E	140_M	0.532	0.45
84_A	230_K	0.532	0.45
104_A	136_V	0.531	0.45
46_E	170_K	0.530	0.45
139_V	218_V	0.529	0.45
83_S	87_G	0.528	0.45
22_L	27_I	0.528	0.45
215_A	218_V	0.526	0.45
125_K	133_A	0.524	0.44
214_L	248_I	0.520	0.44
78_L	169_P	0.518	0.44
35_L	67_I	0.516	0.43
151_A	187_A	0.515	0.43
28_A	135_D	0.515	0.43
181_V	211_I	0.515	0.43
82_R	114_D	0.513	0.43
182_L	185_L	0.513	0.43
60_S	73_P	0.513	0.43
16_P	217_E	0.512	0.43
185_L	216_G	0.512	0.43
149_P	180_D	0.510	0.43
97_Y	161_M	0.509	0.43
81_F	101_N	0.509	0.43
159_R	163_S	0.508	0.42
81_F	97_Y	0.507	0.42
101_N	105_I	0.506	0.42
95_E	123_Q	0.505	0.42
35_L	59_E	0.503	0.42
17_K	217_E	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cnnA	2	0.9802	100	0.056	Contact Map
4ph6A	2	0.9524	100	0.065	Contact Map
4h3dA	2	1	100	0.08	Contact Map
3l9cA	1	0.8889	100	0.155	Contact Map
2yr1A	2	0.9921	100	0.167	Contact Map
1sflA	2	0.9167	100	0.172	Contact Map
2oczA	2	0.8651	100	0.177	Contact Map
2o7sA	2	0.9087	100	0.213	Contact Map
2egzA	1	0.8571	100	0.229	Contact Map
2ox1A	2	0.7738	100	0.26	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.