GREMLIN Database
3MG1 - DNA-3-methyladenine glycosylase 1
UniProt: P05100 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10986
Length: 187 (181)
Sequences: 2856 (1812)
Seq/√Len: 134.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_H71_M3.8641.00
15_A19_N3.2641.00
143_D159_T3.2531.00
75_D78_R3.0161.00
26_T113_V3.0031.00
138_S143_D2.7081.00
97_G155_K2.5121.00
115_F148_A2.4651.00
40_Q56_Y2.3141.00
49_V86_I2.2191.00
55_N84_G2.1971.00
23_V181_C2.1821.00
89_R93_Q2.1071.00
166_M171_L2.0991.00
72_Q75_D2.0281.00
47_I51_K1.9561.00
52_K86_I1.9491.00
138_S159_T1.8941.00
20_E53_R1.8461.00
148_A152_R1.8381.00
76_V96_I1.7971.00
33_E57_R1.7871.00
108_N152_R1.7391.00
66_V103_L1.7071.00
13_Y47_I1.6991.00
34_M169_C1.6891.00
36_C95_I1.6581.00
145_L162_C1.6511.00
97_G101_A1.6181.00
119_F148_A1.6161.00
76_V93_Q1.6101.00
25_E30_K1.6071.00
60_F95_I1.5891.00
65_P103_L1.5791.00
102_Y112_F1.5721.00
10_D47_I1.5431.00
73_E93_Q1.5111.00
104_Q107_Q1.4921.00
101_A104_Q1.4761.00
115_F119_F1.4681.00
120_V124_P1.4581.00
177_V182_Y1.4161.00
40_Q95_I1.4091.00
141_A144_A1.3951.00
28_S111_P1.3731.00
65_P102_Y1.3661.00
7_V13_Y1.3651.00
148_A151_K1.3601.00
139_T172_V1.3581.00
11_P14_I1.3481.00
58_A82_D1.3471.00
58_A84_G1.3401.00
131_T134_E1.3391.00
55_N59_C1.3381.00
167_Q174_D1.3361.00
5_G132_L1.3291.00
10_D51_K1.3041.00
90_G93_Q1.3021.00
141_A145_L1.2781.00
66_V106_E1.2741.00
61_H75_D1.2671.00
73_E77_E1.2551.00
30_K34_M1.2451.00
125_Q141_A1.2391.00
73_E96_I1.2361.00
94_A155_K1.2351.00
101_A154_F1.2341.00
85_I92_I1.2321.00
109_G152_R1.2301.00
105_M109_G1.2281.00
5_G176_V1.2181.00
130_T134_E1.2131.00
33_E53_R1.2121.00
165_F169_C1.2091.00
11_P15_A1.1961.00
71_M75_D1.1951.00
79_L85_I1.1890.99
140_S143_D1.1850.99
80_V92_I1.1810.99
34_M38_E1.1620.99
4_C17_H1.1570.99
3_R14_I1.1410.99
3_R180_C1.1360.99
39_G157_V1.1330.99
59_C79_L1.1260.99
8_S14_I1.1260.99
146_S157_V1.1180.99
54_E57_R1.0890.99
20_E33_E1.0870.99
55_N58_A1.0820.99
31_L165_F1.0620.99
126_V173_N1.0570.99
132_L176_V1.0550.99
32_F95_I1.0520.99
68_V95_I1.0440.99
3_R18_D1.0290.99
25_E34_M1.0280.99
59_C84_G1.0120.98
56_Y95_I1.0050.98
49_V52_K1.0050.98
24_P117_W1.0040.98
61_H67_K1.0020.98
173_N182_Y0.9990.98
115_F152_R0.9920.98
29_K64_D0.9880.98
31_L169_C0.9820.98
9_Q14_I0.9800.98
17_H179_C0.9790.98
36_C39_G0.9640.98
28_S106_E0.9610.98
112_F116_V0.9590.98
59_C82_D0.9520.98
4_C179_C0.9280.97
135_I176_V0.9240.97
77_E81_Q0.9060.97
80_V88_H0.9010.97
39_G161_I0.8840.96
129_A134_E0.8710.96
138_S142_S0.8680.96
68_V71_M0.8660.96
12_L51_K0.8640.96
120_V171_L0.8560.95
28_S110_E0.8540.95
82_D87_R0.8440.95
116_V169_C0.8350.95
141_A166_M0.8230.94
116_V145_L0.8220.94
78_R82_D0.8220.94
116_V165_F0.8180.94
113_V117_W0.8140.94
163_Y174_D0.8110.94
72_Q96_I0.8110.94
105_M154_F0.8110.94
126_V182_Y0.8060.94
121_N141_A0.8030.94
157_V162_C0.8020.93
27_D30_K0.8010.93
53_R57_R0.7960.93
142_S159_T0.7950.93
175_H179_C0.7950.93
173_N183_P0.7840.93
128_Q182_Y0.7830.93
32_F35_I0.7820.93
80_V89_R0.7740.92
26_T114_D0.7730.92
10_D13_Y0.7720.92
8_S47_I0.7710.92
157_V161_I0.7660.92
129_A176_V0.7640.92
20_E57_R0.7610.92
65_P106_E0.7560.91
140_S144_A0.7550.91
55_N82_D0.7540.91
128_Q177_V0.7500.91
31_L171_L0.7470.91
7_V181_C0.7460.91
68_V96_I0.7410.91
77_E89_R0.7410.91
65_P68_V0.7350.90
105_M110_E0.7340.90
28_S112_F0.7320.90
93_Q155_K0.7310.90
25_E169_C0.7260.90
102_Y105_M0.7260.90
166_M172_V0.7230.89
130_T177_V0.7220.89
67_K70_A0.7080.88
35_I116_V0.7070.88
68_V102_Y0.7040.88
29_K62_Q0.7020.88
101_A105_M0.7020.88
106_E111_P0.6950.87
7_V14_I0.6910.87
149_L157_V0.6900.87
34_M165_F0.6890.87
27_D113_V0.6840.87
90_G155_K0.6820.86
13_Y51_K0.6820.86
132_L135_I0.6820.86
56_Y85_I0.6790.86
127_T139_T0.6780.86
8_S11_P0.6730.86
31_L113_V0.6710.86
66_V70_A0.6700.86
34_M168_A0.6650.85
60_F68_V0.6650.85
115_F149_L0.6650.85
105_M112_F0.6640.85
69_A103_L0.6640.85
129_A135_I0.6600.85
102_Y106_E0.6580.84
111_P114_D0.6510.84
106_E109_G0.6450.83
109_G115_F0.6450.83
77_E80_V0.6400.83
7_V10_D0.6400.83
71_M79_L0.6390.83
109_G148_A0.6340.82
93_Q96_I0.6340.82
105_M111_P0.6290.82
162_C165_F0.6270.82
39_G42_A0.6250.81
88_H156_F0.6220.81
163_Y172_V0.6200.81
112_F115_F0.6200.81
39_G94_A0.6190.81
139_T142_S0.6180.81
5_G178_G0.6170.81
144_A148_A0.6140.80
103_L107_Q0.6140.80
69_A100_R0.6130.80
4_C175_H0.6100.80
79_L92_I0.6100.80
137_T142_S0.6080.80
17_H175_H0.6060.79
28_S102_Y0.6060.79
75_D79_L0.6050.79
79_L82_D0.6050.79
83_A87_R0.6030.79
137_T167_Q0.6020.79
71_M96_I0.5940.78
12_L47_I0.5920.78
38_E161_I0.5880.77
116_V171_L0.5840.77
38_E164_S0.5840.77
80_V90_G0.5810.76
52_K55_N0.5770.76
36_C40_Q0.5760.76
100_R104_Q0.5740.76
32_F99_A0.5720.75
118_S145_L0.5670.75
80_V93_Q0.5670.75
55_N85_I0.5650.74
61_H72_Q0.5650.74
106_E110_E0.5650.74
163_Y167_Q0.5650.74
119_F152_R0.5630.74
110_E152_R0.5560.73
117_W171_L0.5490.72
67_K71_M0.5490.72
103_L106_E0.5460.72
54_E58_A0.5460.72
174_D179_C0.5430.72
8_S13_Y0.5430.72
26_T117_W0.5330.70
114_D122_H0.5330.70
97_G100_R0.5300.70
160_T164_S0.5280.69
56_Y86_I0.5270.69
72_Q78_R0.5260.69
94_A97_G0.5250.69
117_W120_V0.5250.69
136_P139_T0.5240.69
48_T52_K0.5210.68
32_F36_C0.5200.68
167_Q179_C0.5180.68
129_A136_P0.5160.68
32_F88_H0.5160.68
42_A161_I0.5160.68
94_A98_N0.5130.67
74_E77_E0.5130.67
49_V55_N0.5110.67
3_R8_S0.5100.67
7_V176_V0.5070.66
54_E62_Q0.5060.66
139_T166_M0.5060.66
129_A177_V0.5060.66
44_L91_K0.5050.66
23_V182_Y0.5010.65
129_A132_L0.5010.65
76_V89_R0.5010.65
105_M115_F0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jg6A 1 0.9947 100 0.011 Contact Map
2ofkA 1 0.9786 100 0.026 Contact Map
3n0uA 1 0.7594 93.4 0.932 Contact Map
1kg2A 1 0.7701 91.3 0.936 Contact Map
4unfA 1 0.8128 90.5 0.938 Contact Map
1ornA 1 0.7807 90.2 0.938 Contact Map
1pu6A 1 0.7647 90.1 0.938 Contact Map
4ofaA 1 0.6524 89.8 0.938 Contact Map
2yg9A 1 0.8235 89.5 0.939 Contact Map
2abkA 1 0.7754 89.4 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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