PNP - ECOLI - GREMLIN Contacts

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PNP - Polyribonucleotide nucleotidyltransferase

UniProt:	P05055	Sequences: MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQDFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLIARLIDRPIRPLFPEGFVNEVQVIATVVSVNPQVNPDIVAMIGASAALSLSGIPFNGPIGAARVGYINDQYVLNPTQDELKESKLDLVVAGTEAAVLMVESEAQLLSEDQMLGAVVFGHEQQQVVIQNINELVKEAGKPRWDWQPEPVNEALNARVAALAEARLSDAYRITDKQERYAQVDVIKSETIATLLAEDETLDENELGEILHAIEKNVVRSRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTARDAQVLDELMGERTDTFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRGVLAVMPDMDKFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNYVVLSDILGDEDHLGDMDFKVAGSRDGISALQMDIKIEGITKEIMQVALNQAKGARLHILGVMEQAINAPRGDISEFAPRIHTIKINPDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVKIAATDGEKAKHAIRRIEEITAEIEVGRVYTGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQEVPVKVLEVDRQGRIRLSIKEATEQSQPAAAPEAPAAEQGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10743
Length:	711 (688)
Sequences:	2515 (1144)
Seq/√Len:	43.6

ECOLI - PNP
BACSU - PNP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
253_R	276_E	5.141	1.00
183_E	220_N	4.700	1.00
560_I	568_V	4.691	1.00
354_A	449_A	4.633	1.00
536_V	539_Q	4.592	1.00
320_E	323_M	4.356	1.00
654_I	666_L	4.069	1.00
22_M	330_R	3.983	1.00
459_A	500_D	3.813	1.00
628_K	671_E	3.618	1.00
322_D	528_G	3.571	1.00
350_A	431_I	3.442	1.00
42_V	115_A	3.211	1.00
626_T	673_P	3.185	1.00
626_T	671_E	3.155	1.00
247_A	303_N	3.113	1.00
156_Y	174_K	3.101	1.00
161_Y	203_G	3.087	1.00
332_G	452_D	2.902	1.00
479_S	529_A	2.885	1.00
42_V	133_G	2.867	1.00
327_L	536_V	2.840	1.00
311_A	474_N	2.780	1.00
499_R	538_E	2.748	1.00
211_Q	214_V	2.702	1.00
597_I	609_I	2.700	1.00
166_T	169_E	2.668	1.00
8_K	15_T	2.640	1.00
464_I	479_S	2.637	1.00
499_R	535_G	2.627	1.00
571_K	574_S	2.592	1.00
244_A	248_A	2.557	1.00
157_I	162_V	2.512	1.00
250_A	277_T	2.498	1.00
649_V	654_I	2.492	1.00
254_L	270_V	2.465	1.00
158_N	172_E	2.455	1.00
324_I	479_S	2.390	1.00
156_Y	200_Q	2.368	1.00
556_H	605_A	2.364	1.00
415_M	425_V	2.360	1.00
630_T	646_E	2.346	1.00
543_A	546_G	2.328	1.00
262_D	265_E	2.322	1.00
374_D	408_K	2.319	1.00
139_S	223_V	2.301	1.00
411_V	446_A	2.284	1.00
610_R	614_E	2.253	1.00
7_R	225_E	2.236	1.00
352_V	445_G	2.235	1.00
620_E	623_R	2.222	1.00
578_A	582_E	2.205	1.00
114_I	393_V	2.201	1.00
417_D	420_K	2.188	1.00
689_I	693_T	2.135	1.00
667_Q	670_Q	2.130	1.00
16_V	35_M	2.121	1.00
602_G	606_K	2.107	0.99
630_T	640_A	2.095	0.99
25_R	433_E	2.095	0.99
524_N	528_G	2.093	0.99
245_R	284_E	2.092	0.99
559_K	594_T	2.090	0.99
516_K	520_Q	2.063	0.99
36_D	121_N	2.047	0.99
123_Q	168_D	2.047	0.99
76_S	79_R	2.042	0.99
140_L	226_A	2.032	0.99
217_Q	221_E	2.000	0.99
154_V	163_L	1.983	0.99
609_I	613_E	1.977	0.99
676_V	685_I	1.977	0.99
179_V	208_G	1.971	0.99
558_I	609_I	1.968	0.99
678_E	686_R	1.958	0.99
329_V	540_A	1.943	0.99
527_K	531_L	1.934	0.99
18_L	33_V	1.933	0.99
33_V	133_G	1.910	0.99
582_E	611_R	1.902	0.99
654_I	659_V	1.901	0.99
336_R	551_F	1.901	0.99
447_S	460_A	1.898	0.99
606_K	609_I	1.896	0.99
39_A	335_P	1.893	0.99
18_L	132_I	1.883	0.99
447_S	538_E	1.880	0.99
28_T	142_G	1.874	0.99
475_Y	521_V	1.866	0.99
160_Q	169_E	1.851	0.99
183_E	217_Q	1.850	0.99
116_T	385_Y	1.846	0.99
252_A	256_D	1.839	0.99
619_I	676_V	1.839	0.99
607_H	610_R	1.834	0.99
275_S	279_A	1.831	0.98
310_L	474_N	1.828	0.98
639_V	649_V	1.827	0.98
653_Q	691_E	1.818	0.98
452_D	545_R	1.818	0.98
186_V	205_V	1.806	0.98
584_G	604_K	1.805	0.98
155_G	173_S	1.801	0.98
146_N	512_E	1.800	0.98
249_L	280_T	1.770	0.98
358_T	598_A	1.766	0.98
269_Q	272_V	1.763	0.98
460_A	538_E	1.761	0.98
321_K	476_V	1.753	0.98
414_V	457_I	1.750	0.98
8_K	17_T	1.739	0.98
23_M	432_T	1.738	0.98
197_S	200_Q	1.736	0.98
410_G	504_A	1.727	0.98
7_R	221_E	1.716	0.98
661_K	664_D	1.711	0.98
649_V	666_L	1.686	0.97
307_S	311_A	1.681	0.97
567_D	615_I	1.676	0.97
352_V	427_V	1.670	0.97
10_Q	15_T	1.661	0.97
99_I	138_L	1.657	0.97
154_V	207_F	1.655	0.97
459_A	499_R	1.653	0.97
31_V	136_A	1.651	0.97
156_Y	161_Y	1.649	0.97
354_A	427_V	1.645	0.97
391_G	394_G	1.645	0.97
672_V	689_I	1.642	0.97
206_V	516_K	1.638	0.97
324_I	532_H	1.630	0.97
268_A	272_V	1.627	0.97
132_I	215_V	1.605	0.97
39_A	334_L	1.598	0.96
353_T	430_E	1.598	0.96
554_R	599_A	1.592	0.96
634_D	663_T	1.588	0.96
651_I	662_V	1.579	0.96
272_V	276_E	1.576	0.96
329_V	536_V	1.576	0.96
185_A	513_G	1.573	0.96
18_L	136_A	1.563	0.96
240_E	244_A	1.548	0.96
215_V	219_I	1.547	0.96
153_R	176_D	1.547	0.96
7_R	222_L	1.546	0.96
174_K	194_Q	1.544	0.96
247_A	251_E	1.541	0.96
655_A	689_I	1.537	0.96
556_H	609_I	1.533	0.95
34_S	37_D	1.524	0.95
168_D	171_K	1.523	0.95
127_D	153_R	1.511	0.95
558_I	597_I	1.508	0.95
384_P	393_V	1.499	0.95
590_E	594_T	1.498	0.95
617_A	623_R	1.494	0.95
51_K	54_Q	1.488	0.95
354_A	453_A	1.488	0.95
647_G	687_L	1.487	0.95
46_G	143_I	1.485	0.95
606_K	610_R	1.484	0.95
597_I	612_I	1.481	0.95
656_D	692_A	1.478	0.94
181_G	212_Q	1.477	0.94
470_K	511_I	1.474	0.94
163_L	207_F	1.472	0.94
257_A	273_I	1.456	0.94
599_A	605_A	1.445	0.94
538_E	542_N	1.441	0.94
191_S	505_L	1.440	0.94
9_F	16_V	1.436	0.94
607_H	611_R	1.433	0.93
245_R	249_L	1.427	0.93
328_D	342_L	1.423	0.93
631_R	684_R	1.422	0.93
322_D	525_Q	1.418	0.93
46_G	107_F	1.417	0.93
440_M	443_V	1.414	0.93
242_L	296_I	1.414	0.93
10_Q	13_Q	1.410	0.93
680_D	684_R	1.402	0.93
414_V	461_V	1.402	0.93
324_I	464_I	1.398	0.93
253_R	256_D	1.398	0.93
688_S	691_E	1.398	0.93
6_V	17_T	1.397	0.93
532_H	536_V	1.390	0.92
46_G	231_W	1.380	0.92
131_M	149_I	1.376	0.92
571_K	575_V	1.373	0.92
640_A	646_E	1.372	0.92
136_A	222_L	1.371	0.92
632_I	662_V	1.371	0.92
142_G	231_W	1.355	0.91
641_I	685_I	1.348	0.91
378_F	446_A	1.347	0.91
33_V	129_V	1.344	0.91
575_V	615_I	1.343	0.91
624_V	692_A	1.342	0.91
599_A	604_K	1.339	0.91
107_F	111_V	1.337	0.91
378_F	442_S	1.337	0.91
14_H	35_M	1.328	0.91
115_A	130_A	1.314	0.90
583_T	611_R	1.314	0.90
595_V	612_I	1.314	0.90
139_S	219_I	1.313	0.90
583_T	607_H	1.313	0.90
175_L	196_L	1.313	0.90
107_F	231_W	1.310	0.90
105_E	302_K	1.293	0.89
199_D	520_Q	1.289	0.89
161_Y	200_Q	1.287	0.89
351_L	432_T	1.284	0.89
278_I	294_G	1.265	0.88
536_V	540_A	1.259	0.88
619_I	641_I	1.259	0.88
362_A	373_T	1.255	0.88
197_S	502_I	1.252	0.88
337_T	353_T	1.245	0.87
35_M	129_V	1.245	0.87
316_I	484_D	1.239	0.87
68_Y	428_V	1.238	0.87
32_M	118_V	1.237	0.87
18_L	31_V	1.229	0.87
131_M	151_A	1.228	0.87
239_N	292_E	1.225	0.87
601_D	604_K	1.222	0.86
61_V	95_I	1.213	0.86
376_F	446_A	1.204	0.86
350_A	441_A	1.202	0.86
649_V	692_A	1.201	0.85
120_V	126_P	1.201	0.85
535_G	539_Q	1.198	0.85
631_R	668_M	1.197	0.85
99_I	134_A	1.196	0.85
451_M	457_I	1.193	0.85
17_T	34_S	1.193	0.85
603_E	607_H	1.191	0.85
168_D	172_E	1.191	0.85
28_T	45_V	1.188	0.85
43_T	384_P	1.188	0.85
313_E	474_N	1.185	0.85
568_V	595_V	1.183	0.85
274_K	294_G	1.180	0.84
659_V	664_D	1.179	0.84
350_A	445_G	1.175	0.84
223_V	227_G	1.166	0.84
106_G	233_W	1.166	0.84
229_P	232_D	1.162	0.84
64_Q	88_E	1.157	0.83
267_Y	271_D	1.153	0.83
243_N	247_A	1.153	0.83
580_T	585_T	1.151	0.83
461_V	498_S	1.149	0.83
524_N	527_K	1.144	0.83
250_A	273_I	1.142	0.82
142_G	230_R	1.140	0.82
189_V	507_M	1.139	0.82
106_G	235_P	1.136	0.82
260_I	269_Q	1.134	0.82
151_A	180_A	1.130	0.82
194_Q	413_A	1.127	0.82
640_A	643_G	1.127	0.82
632_I	668_M	1.123	0.81
466_M	477_V	1.121	0.81
46_G	111_V	1.120	0.81
306_R	490_D	1.120	0.81
246_V	277_T	1.119	0.81
651_I	661_K	1.115	0.81
38_T	126_P	1.108	0.80
220_N	224_K	1.107	0.80
385_Y	432_T	1.106	0.80
277_T	297_L	1.106	0.80
174_K	200_Q	1.105	0.80
532_H	535_G	1.104	0.80
142_G	228_K	1.102	0.80
529_A	532_H	1.102	0.80
382_F	386_S	1.097	0.80
18_L	222_L	1.092	0.79
443_V	496_A	1.092	0.79
16_V	132_I	1.091	0.79
603_E	606_K	1.090	0.79
470_K	475_Y	1.088	0.79
199_D	524_N	1.087	0.79
72_R	79_R	1.086	0.79
568_V	571_K	1.084	0.79
273_I	276_E	1.082	0.79
57_F	111_V	1.082	0.79
161_Y	207_F	1.081	0.79
654_I	665_Y	1.079	0.79
429_S	445_G	1.071	0.78
611_R	614_E	1.070	0.78
465_A	477_V	1.069	0.78
87_G	91_I	1.065	0.78
568_V	575_V	1.065	0.78
251_E	255_S	1.064	0.78
249_L	281_L	1.063	0.78
427_V	449_A	1.063	0.78
5_I	225_E	1.062	0.78
201_M	502_I	1.062	0.78
159_D	174_K	1.057	0.77
641_I	676_V	1.057	0.77
199_D	203_G	1.056	0.77
28_T	46_G	1.054	0.77
637_A	666_L	1.054	0.77
255_S	259_R	1.052	0.77
619_I	642_G	1.052	0.77
23_M	342_L	1.048	0.77
457_I	460_A	1.046	0.76
162_V	169_E	1.046	0.76
447_S	451_M	1.044	0.76
195_L	459_A	1.041	0.76
305_V	309_V	1.041	0.76
610_R	613_E	1.039	0.76
375_T	418_M	1.039	0.76
118_V	351_L	1.038	0.76
642_G	645_K	1.036	0.76
20_T	136_A	1.033	0.76
414_V	459_A	1.032	0.75
479_S	532_H	1.030	0.75
19_E	34_S	1.028	0.75
254_L	297_L	1.027	0.75
411_V	450_L	1.026	0.75
30_A	43_T	1.024	0.75
352_V	378_F	1.022	0.75
579_L	611_R	1.022	0.75
357_G	361_D	1.019	0.75
119_S	337_T	1.015	0.74
249_L	277_T	1.013	0.74
254_L	304_V	1.011	0.74
336_R	549_S	1.008	0.74
653_Q	690_K	0.999	0.73
331_T	452_D	0.996	0.73
213_Q	217_Q	0.996	0.73
568_V	612_I	0.994	0.73
448_L	452_D	0.988	0.72
617_A	642_G	0.983	0.72
564_K	618_E	0.983	0.72
310_L	476_V	0.982	0.72
175_L	204_A	0.982	0.72
98_P	180_A	0.982	0.72
54_Q	108_V	0.981	0.72
659_V	666_L	0.980	0.72
304_V	307_S	0.980	0.72
381_N	428_V	0.979	0.72
11_Y	16_V	0.975	0.71
246_V	250_A	0.975	0.71
397_K	400_E	0.973	0.71
18_L	218_N	0.971	0.71
327_L	529_A	0.970	0.71
313_E	476_V	0.970	0.71
547_D	602_G	0.968	0.71
37_D	336_R	0.966	0.71
24_A	41_F	0.964	0.70
40_V	115_A	0.964	0.70
364_V	373_T	0.963	0.70
433_E	438_S	0.963	0.70
333_V	342_L	0.961	0.70
39_A	337_T	0.961	0.70
341_A	431_I	0.960	0.70
654_I	662_V	0.960	0.70
208_G	211_Q	0.958	0.70
32_M	39_A	0.958	0.70
448_L	541_I	0.956	0.70
362_A	424_T	0.955	0.70
359_A	362_A	0.954	0.70
253_R	273_I	0.954	0.70
245_R	248_A	0.953	0.69
259_R	308_R	0.953	0.69
627_G	639_V	0.951	0.69
585_T	604_K	0.950	0.69
555_I	598_A	0.950	0.69
115_A	133_G	0.950	0.69
218_N	222_L	0.949	0.69
632_I	666_L	0.946	0.69
258_Y	304_V	0.945	0.69
289_D	292_E	0.944	0.69
46_G	142_G	0.944	0.69
655_A	659_V	0.941	0.68
110_E	392_M	0.941	0.68
568_V	615_I	0.940	0.68
334_L	353_T	0.939	0.68
54_Q	57_F	0.934	0.68
62_N	89_T	0.932	0.68
115_A	134_A	0.932	0.68
673_P	692_A	0.930	0.68
421_F	456_P	0.930	0.68
579_L	585_T	0.929	0.67
29_A	44_V	0.927	0.67
237_P	240_E	0.924	0.67
195_L	500_D	0.923	0.67
621_V	678_E	0.922	0.67
9_F	218_N	0.922	0.67
541_I	545_R	0.921	0.67
299_A	302_K	0.920	0.67
331_T	541_I	0.915	0.66
633_V	638_F	0.912	0.66
20_T	226_A	0.911	0.66
63_Y	130_A	0.910	0.66
558_I	612_I	0.909	0.66
578_A	611_R	0.909	0.66
192_E	409_R	0.908	0.66
462_A	531_L	0.907	0.66
374_D	405_R	0.906	0.66
156_Y	175_L	0.905	0.65
210_E	213_Q	0.904	0.65
577_R	581_E	0.900	0.65
558_I	595_V	0.899	0.65
66_R	430_E	0.896	0.65
68_Y	430_E	0.896	0.65
649_V	689_I	0.894	0.64
112_Q	390_T	0.893	0.64
313_E	321_K	0.892	0.64
242_L	246_V	0.892	0.64
95_I	115_A	0.886	0.64
567_D	575_V	0.886	0.64
407_A	443_V	0.883	0.64
92_A	616_T	0.881	0.63
23_M	39_A	0.880	0.63
561_N	618_E	0.880	0.63
63_Y	88_E	0.878	0.63
198_E	527_K	0.878	0.63
189_V	465_A	0.877	0.63
27_A	45_V	0.876	0.63
46_G	109_N	0.876	0.63
274_K	297_L	0.876	0.63
195_L	414_V	0.874	0.63
657_K	660_E	0.873	0.63
227_G	230_R	0.872	0.63
238_V	243_N	0.867	0.62
331_T	540_A	0.866	0.62
88_E	378_F	0.864	0.62
44_V	133_G	0.863	0.62
280_T	284_E	0.863	0.62
145_F	148_P	0.862	0.62
240_E	243_N	0.860	0.61
157_I	172_E	0.858	0.61
329_V	448_L	0.858	0.61
517_E	521_V	0.856	0.61
213_Q	216_I	0.850	0.61
245_R	281_L	0.850	0.61
688_S	692_A	0.850	0.61
462_A	538_E	0.850	0.61
386_S	438_S	0.850	0.61
447_S	537_M	0.848	0.60
40_V	95_I	0.848	0.60
627_G	687_L	0.847	0.60
220_N	223_V	0.846	0.60
279_A	282_L	0.846	0.60
127_D	178_V	0.845	0.60
255_S	312_G	0.845	0.60
214_V	217_Q	0.841	0.60
579_L	608_A	0.841	0.60
185_A	189_V	0.839	0.60
427_V	446_A	0.838	0.59
150_G	514_I	0.837	0.59
639_V	654_I	0.836	0.59
387_V	391_G	0.835	0.59
627_G	647_G	0.835	0.59
557_T	594_T	0.835	0.59
141_S	230_R	0.835	0.59
91_I	125_N	0.834	0.59
44_V	137_A	0.834	0.59
247_A	300_I	0.832	0.59
57_F	109_N	0.832	0.59
278_I	282_L	0.831	0.59
83_R	89_T	0.827	0.58
554_R	604_K	0.827	0.58
243_N	296_I	0.826	0.58
666_L	672_V	0.824	0.58
659_V	662_V	0.823	0.58
262_D	347_E	0.823	0.58
640_A	644_G	0.822	0.58
656_D	693_T	0.822	0.58
192_E	405_R	0.822	0.58
272_V	275_S	0.822	0.58
217_Q	220_N	0.821	0.58
327_L	532_H	0.820	0.58
629_V	666_L	0.818	0.58
529_A	536_V	0.818	0.58
37_D	550_E	0.817	0.57
568_V	616_T	0.816	0.57
560_I	587_I	0.815	0.57
452_D	541_I	0.815	0.57
559_K	592_D	0.815	0.57
331_T	545_R	0.808	0.57
676_V	679_V	0.805	0.56
105_E	653_Q	0.804	0.56
161_Y	204_A	0.803	0.56
256_D	269_Q	0.802	0.56
675_K	690_K	0.801	0.56
121_N	124_V	0.801	0.56
298_H	301_E	0.801	0.56
633_V	668_M	0.800	0.56
259_R	312_G	0.799	0.56
352_V	431_I	0.799	0.56
260_I	265_E	0.797	0.56
515_T	518_I	0.796	0.55
14_H	169_E	0.796	0.55
209_H	213_Q	0.795	0.55
384_P	395_S	0.794	0.55
628_K	640_A	0.794	0.55
548_I	554_R	0.793	0.55
261_T	265_E	0.793	0.55
265_E	268_A	0.791	0.55
631_R	686_R	0.791	0.55
73_I	377_L	0.791	0.55
354_A	445_G	0.790	0.55
344_T	433_E	0.790	0.55
364_V	371_E	0.790	0.55
83_R	395_S	0.790	0.55
688_S	693_T	0.789	0.55
200_Q	203_G	0.788	0.55
11_Y	215_V	0.788	0.55
20_T	31_V	0.788	0.55
637_A	662_V	0.787	0.55
377_L	415_M	0.784	0.54
420_K	458_K	0.784	0.54
42_V	134_A	0.783	0.54
206_V	520_Q	0.782	0.54
128_I	132_I	0.781	0.54
177_L	196_L	0.779	0.54
376_F	412_L	0.779	0.54
309_V	469_V	0.778	0.54
31_V	222_L	0.776	0.54
45_V	112_Q	0.773	0.53
150_G	207_F	0.772	0.53
44_V	143_I	0.769	0.53
352_V	376_F	0.768	0.53
250_A	281_L	0.767	0.53
649_V	672_V	0.767	0.53
62_N	92_A	0.764	0.52
14_H	124_V	0.764	0.52
561_N	567_D	0.764	0.52
221_E	225_E	0.761	0.52
22_M	32_M	0.760	0.52
327_L	535_G	0.755	0.52
579_L	583_T	0.754	0.51
105_E	298_H	0.754	0.51
279_A	283_A	0.754	0.51
635_F	648_L	0.753	0.51
111_V	231_W	0.749	0.51
421_F	455_V	0.748	0.51
341_A	448_L	0.747	0.51
250_A	253_R	0.747	0.51
405_R	408_K	0.744	0.51
248_A	252_A	0.744	0.51
267_Y	387_V	0.742	0.50
135_S	148_P	0.742	0.50
276_E	280_T	0.742	0.50
33_V	40_V	0.742	0.50
26_Q	433_E	0.741	0.50
160_Q	232_D	0.739	0.50
64_Q	114_I	0.739	0.50
57_F	108_V	0.739	0.50
359_A	424_T	0.738	0.50
255_S	304_V	0.737	0.50
635_F	646_E	0.736	0.50
415_M	450_L	0.736	0.50
25_R	344_T	0.733	0.49
457_I	682_Q	0.731	0.49
239_N	289_D	0.730	0.49
206_V	210_E	0.728	0.49
30_A	41_F	0.728	0.49
565_I	589_I	0.728	0.49
521_V	525_Q	0.726	0.49
23_M	351_L	0.726	0.49
184_A	512_E	0.726	0.49
427_V	457_I	0.726	0.49
153_R	440_M	0.726	0.49
407_A	440_M	0.725	0.49
285_D	293_L	0.724	0.49
448_L	584_G	0.723	0.49
12_G	16_V	0.722	0.48
678_E	681_R	0.721	0.48
47_Q	54_Q	0.721	0.48
276_E	279_A	0.721	0.48
571_K	595_V	0.719	0.48
118_V	430_E	0.719	0.48
257_A	270_V	0.718	0.48
205_V	519_M	0.718	0.48
350_A	378_F	0.718	0.48
564_K	567_D	0.717	0.48
452_D	583_T	0.717	0.48
475_Y	517_E	0.716	0.48
265_E	269_Q	0.716	0.48
50_A	109_N	0.715	0.48
87_G	125_N	0.714	0.48
210_E	516_K	0.714	0.48
466_M	507_M	0.713	0.48
77_F	364_V	0.713	0.48
635_F	638_F	0.712	0.47
653_Q	677_L	0.711	0.47
587_I	612_I	0.711	0.47
558_I	616_T	0.709	0.47
295_E	298_H	0.709	0.47
585_T	599_A	0.707	0.47
50_A	54_Q	0.706	0.47
33_V	132_I	0.706	0.47
43_T	114_I	0.705	0.47
244_A	247_A	0.705	0.47
189_V	505_L	0.704	0.47
451_M	541_I	0.703	0.47
198_E	530_R	0.703	0.47
92_A	397_K	0.702	0.47
35_M	124_V	0.701	0.46
20_T	222_L	0.701	0.46
556_H	597_I	0.701	0.46
152_A	215_V	0.701	0.46
36_D	124_V	0.701	0.46
298_H	487_H	0.699	0.46
447_S	457_I	0.699	0.46
77_F	366_D	0.697	0.46
78_F	86_E	0.696	0.46
627_G	646_E	0.696	0.46
662_V	665_Y	0.696	0.46
212_Q	216_I	0.695	0.46
64_Q	396_P	0.695	0.46
79_R	85_S	0.693	0.46
274_K	298_H	0.693	0.46
324_I	536_V	0.693	0.46
10_Q	14_H	0.693	0.46
450_L	455_V	0.690	0.45
475_Y	518_I	0.690	0.45
465_A	488_L	0.689	0.45
466_M	526_A	0.688	0.45
308_R	312_G	0.687	0.45
654_I	672_V	0.687	0.45
243_N	299_A	0.687	0.45
152_A	163_L	0.686	0.45
283_A	286_E	0.686	0.45
427_V	450_L	0.685	0.45
91_I	127_D	0.682	0.45
153_R	178_V	0.682	0.45
292_E	296_I	0.682	0.45
362_A	418_M	0.681	0.45
140_L	143_I	0.680	0.44
202_L	523_L	0.679	0.44
195_L	498_S	0.678	0.44
583_T	587_I	0.677	0.44
309_V	316_I	0.676	0.44
112_Q	393_V	0.675	0.44
556_H	606_K	0.675	0.44
255_S	308_R	0.674	0.44
114_I	384_P	0.674	0.44
149_I	273_I	0.673	0.44
136_A	219_I	0.673	0.44
614_E	617_A	0.673	0.44
677_L	686_R	0.671	0.44
375_T	424_T	0.671	0.44
580_T	595_V	0.670	0.43
44_V	134_A	0.669	0.43
627_G	651_I	0.669	0.43
495_V	522_A	0.669	0.43
132_I	136_A	0.669	0.43
620_E	625_Y	0.667	0.43
250_A	254_L	0.667	0.43
63_Y	126_P	0.667	0.43
241_A	244_A	0.667	0.43
575_V	578_A	0.666	0.43
499_R	531_L	0.665	0.43
151_A	205_V	0.663	0.43
624_V	675_K	0.663	0.43
112_Q	392_M	0.663	0.43
658_R	664_D	0.662	0.43
72_R	77_F	0.661	0.43
451_M	545_R	0.660	0.43
149_I	180_A	0.658	0.42
106_G	292_E	0.658	0.42
560_I	565_I	0.657	0.42
466_M	525_Q	0.656	0.42
16_V	218_N	0.656	0.42
555_I	596_K	0.656	0.42
273_I	297_L	0.654	0.42
377_L	424_T	0.654	0.42
84_P	395_S	0.654	0.42
358_T	554_R	0.653	0.42
566_K	571_K	0.653	0.42
62_N	407_A	0.653	0.42
615_I	619_I	0.652	0.42
637_A	664_D	0.651	0.42
604_K	607_H	0.651	0.42
9_F	214_V	0.650	0.42
585_T	611_R	0.649	0.42
477_V	521_V	0.648	0.41
204_A	208_G	0.648	0.41
64_Q	378_F	0.648	0.41
268_A	271_D	0.648	0.41
49_K	294_G	0.647	0.41
333_V	351_L	0.646	0.41
95_I	130_A	0.645	0.41
31_V	137_A	0.644	0.41
390_T	394_G	0.643	0.41
382_F	387_V	0.642	0.41
624_V	673_P	0.642	0.41
384_P	390_T	0.641	0.41
352_V	447_S	0.641	0.41
637_A	665_Y	0.641	0.41
16_V	124_V	0.641	0.41
256_D	259_R	0.640	0.41
82_G	396_P	0.640	0.41
29_A	228_K	0.640	0.41
601_D	606_K	0.639	0.41
440_M	496_A	0.639	0.41
28_T	231_W	0.639	0.41
142_G	227_G	0.638	0.41
509_I	518_I	0.638	0.41
160_Q	203_G	0.638	0.41
313_E	322_D	0.637	0.40
673_P	689_I	0.637	0.40
296_I	300_I	0.635	0.40
196_L	200_Q	0.635	0.40
617_A	625_Y	0.634	0.40
604_K	608_A	0.633	0.40
205_V	208_G	0.632	0.40
105_E	487_H	0.631	0.40
7_R	218_N	0.631	0.40
583_T	608_A	0.630	0.40
62_N	397_K	0.629	0.40
412_L	415_M	0.628	0.40
128_I	178_V	0.628	0.40
55_D	487_H	0.628	0.40
352_V	446_A	0.628	0.40
157_I	173_S	0.627	0.39
132_I	150_G	0.626	0.39
623_R	645_K	0.626	0.39
599_A	602_G	0.625	0.39
156_Y	196_L	0.625	0.39
170_L	176_D	0.625	0.39
631_R	634_D	0.624	0.39
145_F	219_I	0.624	0.39
152_A	181_G	0.624	0.39
32_M	41_F	0.623	0.39
158_N	171_K	0.623	0.39
520_Q	524_N	0.622	0.39
637_A	658_R	0.621	0.39
515_T	519_M	0.620	0.39
78_F	367_E	0.620	0.39
535_G	538_E	0.619	0.39
175_L	200_Q	0.618	0.39
189_V	488_L	0.617	0.39
62_N	392_M	0.617	0.39
73_I	76_S	0.617	0.39
316_I	482_L	0.617	0.39
212_Q	215_V	0.617	0.39
189_V	466_M	0.617	0.39
259_R	314_P	0.616	0.38
111_V	143_I	0.616	0.38
64_Q	116_T	0.616	0.38
495_V	526_A	0.614	0.38
72_R	76_S	0.613	0.38
29_A	137_A	0.612	0.38
655_A	665_Y	0.612	0.38
384_P	391_G	0.609	0.38
614_E	642_G	0.608	0.38
666_L	692_A	0.608	0.38
87_G	92_A	0.608	0.38
264_Q	267_Y	0.607	0.38
600_T	605_A	0.606	0.38
357_G	424_T	0.606	0.38
675_K	688_S	0.606	0.38
563_D	566_K	0.606	0.38
183_E	213_Q	0.605	0.38
632_I	651_I	0.605	0.38
45_V	114_I	0.605	0.38
271_D	275_S	0.604	0.37
29_A	140_L	0.604	0.37
395_S	671_E	0.604	0.37
78_F	686_R	0.604	0.37
40_V	128_I	0.603	0.37
22_M	333_V	0.602	0.37
580_T	588_E	0.601	0.37
675_K	691_E	0.600	0.37
281_L	285_D	0.600	0.37
549_S	552_A	0.599	0.37
114_I	385_Y	0.599	0.37
109_N	231_W	0.599	0.37
689_I	692_A	0.599	0.37
631_R	676_V	0.598	0.37
136_A	140_L	0.598	0.37
219_I	225_E	0.597	0.37
62_N	395_S	0.596	0.37
117_V	387_V	0.594	0.37
646_E	676_V	0.594	0.37
598_A	605_A	0.593	0.36
392_M	682_Q	0.592	0.36
203_G	516_K	0.592	0.36
378_F	431_I	0.591	0.36
410_G	503_S	0.591	0.36
575_V	616_T	0.591	0.36
524_N	531_L	0.590	0.36
110_E	525_Q	0.590	0.36
517_E	520_Q	0.590	0.36
134_A	149_I	0.589	0.36
12_G	211_Q	0.588	0.36
487_H	514_I	0.587	0.36
135_S	150_G	0.587	0.36
116_T	430_E	0.585	0.36
77_F	118_V	0.584	0.36
396_P	401_I	0.583	0.36
179_V	205_V	0.583	0.36
228_K	624_V	0.583	0.36
614_E	643_G	0.582	0.35
411_V	415_M	0.581	0.35
252_A	255_S	0.581	0.35
221_E	224_K	0.580	0.35
48_K	271_D	0.580	0.35
140_L	229_P	0.580	0.35
550_E	554_R	0.580	0.35
332_G	445_G	0.579	0.35
136_A	218_N	0.579	0.35
451_M	538_E	0.579	0.35
250_A	297_L	0.579	0.35
431_I	438_S	0.578	0.35
410_G	496_A	0.577	0.35
26_Q	438_S	0.576	0.35
655_A	685_I	0.576	0.35
641_I	646_E	0.575	0.35
201_M	204_A	0.575	0.35
13_Q	169_E	0.575	0.35
488_L	511_I	0.575	0.35
45_V	442_S	0.575	0.35
242_L	293_L	0.574	0.35
191_S	484_D	0.574	0.35
584_G	599_A	0.573	0.35
613_E	617_A	0.573	0.35
641_I	687_L	0.573	0.35
179_V	409_R	0.572	0.35
251_E	304_V	0.572	0.35
270_V	559_K	0.571	0.35
509_I	515_T	0.571	0.35
441_A	462_A	0.571	0.35
414_V	498_S	0.570	0.34
5_I	221_E	0.569	0.34
267_Y	347_E	0.569	0.34
671_E	686_R	0.568	0.34
243_N	246_V	0.568	0.34
258_Y	305_V	0.568	0.34
39_A	118_V	0.567	0.34
70_A	122_P	0.566	0.34
525_Q	528_G	0.564	0.34
296_I	299_A	0.564	0.34
238_V	299_A	0.564	0.34
341_A	378_F	0.563	0.34
68_Y	353_T	0.562	0.34
179_V	189_V	0.562	0.34
245_R	285_D	0.562	0.34
531_L	535_G	0.562	0.34
16_V	215_V	0.561	0.34
254_L	273_I	0.561	0.34
44_V	89_T	0.561	0.34
630_T	638_F	0.560	0.34
41_F	116_T	0.557	0.33
619_I	645_K	0.557	0.33
324_I	462_A	0.556	0.33
222_L	225_E	0.556	0.33
51_K	105_E	0.556	0.33
277_T	281_L	0.555	0.33
347_E	435_N	0.555	0.33
657_K	665_Y	0.555	0.33
410_G	640_A	0.555	0.33
427_V	453_A	0.555	0.33
204_A	438_S	0.554	0.33
632_I	635_F	0.553	0.33
99_I	149_I	0.553	0.33
637_A	651_I	0.553	0.33
142_G	258_Y	0.553	0.33
280_T	385_Y	0.552	0.33
470_K	473_D	0.552	0.33
300_I	304_V	0.552	0.33
11_Y	152_A	0.551	0.33
313_E	475_Y	0.551	0.33
68_Y	381_N	0.551	0.33
646_E	684_R	0.550	0.33
666_L	670_Q	0.550	0.33
170_L	173_S	0.550	0.33
192_E	412_L	0.549	0.33
305_V	316_I	0.548	0.33
11_Y	132_I	0.548	0.33
313_E	521_V	0.548	0.33
623_R	641_I	0.546	0.32
119_S	562_P	0.546	0.32
634_D	678_E	0.546	0.32
585_T	612_I	0.545	0.32
42_V	92_A	0.545	0.32
67_T	368_L	0.545	0.32
40_V	684_R	0.544	0.32
28_T	43_T	0.544	0.32
631_R	638_F	0.544	0.32
579_L	607_H	0.544	0.32
77_F	628_K	0.543	0.32
447_S	541_I	0.543	0.32
327_L	441_A	0.543	0.32
440_M	554_R	0.543	0.32
258_Y	316_I	0.543	0.32
386_S	565_I	0.542	0.32
376_F	449_A	0.541	0.32
358_T	584_G	0.541	0.32
88_E	92_A	0.541	0.32
341_A	445_G	0.541	0.32
74_P	368_L	0.540	0.32
375_T	415_M	0.540	0.32
326_G	529_A	0.539	0.32
625_Y	648_L	0.539	0.32
327_L	464_I	0.539	0.32
465_A	525_Q	0.539	0.32
298_H	302_K	0.539	0.32
207_F	211_Q	0.539	0.32
152_A	212_Q	0.539	0.32
159_D	200_Q	0.538	0.32
568_V	587_I	0.538	0.32
350_A	429_S	0.538	0.32
70_A	368_L	0.538	0.32
185_A	488_L	0.538	0.32
91_I	149_I	0.538	0.32
156_Y	203_G	0.537	0.32
154_V	161_Y	0.537	0.32
282_L	286_E	0.537	0.32
544_P	548_I	0.537	0.32
663_T	667_Q	0.536	0.32
328_D	536_V	0.535	0.31
89_T	185_A	0.534	0.31
558_I	613_E	0.534	0.31
378_F	433_E	0.534	0.31
23_M	32_M	0.534	0.31
440_M	577_R	0.533	0.31
408_K	412_L	0.533	0.31
376_F	433_E	0.532	0.31
532_H	539_Q	0.532	0.31
677_L	688_S	0.531	0.31
246_V	249_L	0.531	0.31
405_R	412_L	0.530	0.31
525_Q	529_A	0.530	0.31
45_V	116_T	0.530	0.31
258_Y	270_V	0.529	0.31
159_D	575_V	0.529	0.31
89_T	438_S	0.529	0.31
574_S	578_A	0.529	0.31
629_V	637_A	0.528	0.31
251_E	300_I	0.528	0.31
107_F	145_F	0.527	0.31
445_G	448_L	0.526	0.31
76_S	367_E	0.526	0.31
125_N	281_L	0.526	0.31
189_V	519_M	0.526	0.31
598_A	615_I	0.526	0.31
247_A	250_A	0.525	0.31
653_Q	686_R	0.525	0.31
322_D	521_V	0.525	0.31
484_D	686_R	0.525	0.31
136_A	149_I	0.524	0.31
654_I	692_A	0.524	0.31
603_E	610_R	0.524	0.31
529_A	556_H	0.524	0.31
182_T	514_I	0.524	0.31
369_M	372_R	0.523	0.30
582_E	607_H	0.522	0.30
562_P	580_T	0.522	0.30
161_Y	174_K	0.522	0.30
651_I	658_R	0.521	0.30
623_R	692_A	0.521	0.30
241_A	245_R	0.521	0.30
359_A	418_M	0.520	0.30
60_T	110_E	0.520	0.30
277_T	293_L	0.520	0.30
62_N	583_T	0.520	0.30
318_G	479_S	0.519	0.30
117_V	549_S	0.519	0.30
555_I	609_I	0.519	0.30
358_T	424_T	0.518	0.30
88_E	686_R	0.518	0.30
198_E	531_L	0.517	0.30
360_R	588_E	0.516	0.30
277_T	280_T	0.516	0.30
324_I	537_M	0.516	0.30
83_R	419_D	0.515	0.30
438_S	692_A	0.515	0.30
514_I	519_M	0.515	0.30
224_K	272_V	0.515	0.30
392_M	630_T	0.515	0.30
471_E	474_N	0.514	0.30
15_T	36_D	0.514	0.30
246_V	265_E	0.514	0.30
378_F	438_S	0.514	0.30
88_E	352_V	0.513	0.30
139_S	220_N	0.513	0.30
653_Q	688_S	0.512	0.30
139_S	147_G	0.512	0.30
30_A	118_V	0.511	0.30
27_A	30_A	0.510	0.29
146_N	227_G	0.510	0.29
411_V	427_V	0.510	0.29
341_A	354_A	0.510	0.29
316_I	577_R	0.509	0.29
360_R	586_T	0.509	0.29
24_A	43_T	0.509	0.29
266_R	482_L	0.508	0.29
185_A	466_M	0.508	0.29
460_A	499_R	0.507	0.29
189_V	470_K	0.507	0.29
579_L	599_A	0.507	0.29
239_N	242_L	0.507	0.29
679_V	685_I	0.507	0.29
185_A	209_H	0.506	0.29
347_E	484_D	0.506	0.29
131_M	377_L	0.506	0.29
20_T	23_M	0.506	0.29
112_Q	391_G	0.506	0.29
321_K	469_V	0.506	0.29
577_R	615_I	0.506	0.29
134_A	153_R	0.505	0.29
632_I	670_Q	0.505	0.29
477_V	507_M	0.504	0.29
327_L	465_A	0.504	0.29
132_I	218_N	0.504	0.29
181_G	519_M	0.503	0.29
242_L	245_R	0.503	0.29
567_D	616_T	0.503	0.29
113_V	245_R	0.503	0.29
106_G	234_Q	0.503	0.29
115_A	387_V	0.502	0.29
88_E	370_G	0.502	0.29
323_M	613_E	0.502	0.29
502_I	531_L	0.501	0.29
466_M	488_L	0.501	0.29
34_S	39_A	0.501	0.29
67_T	376_F	0.501	0.29
254_L	554_R	0.500	0.29
482_L	488_L	0.500	0.29
507_M	522_A	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4nbqA	3	0.955	100	0.295	Contact Map
3cdiA	3	0.7257	100	0.295	Contact Map
1e3pA	3	0.8692	100	0.325	Contact Map
4aidA	3	0.7975	100	0.334	Contact Map
3u1kA	3	0.8551	100	0.409	Contact Map
3gmeA	3	0.6779	100	0.434	Contact Map
2nn6A	1	0.3797	100	0.799	Contact Map
2nn6B	1	0.3263	100	0.831	Contact Map
2je6B	2	0.3249	100	0.833	Contact Map
2po1A	1	0.3277	100	0.835	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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