FUMC - ECOLI - GREMLIN Contacts

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FUMC - Fumarate hydratase class II

UniProt:	P05042	Sequences: MNTVRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQMVGSMKAGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10358
Length:	467 (403)
Sequences:	10916 (5797)
Seq/√Len:	288.8

ECOLI - FUMC ASPA ARLY PUR8
BACSU - ASPA FUMC ARLY PUR8
HALSA - FUMC ARLY Q9HS42
SULSO - FUMC Q980P8 ARLY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
60_E	70_A	3.885	1.00
69_K	133_D	3.472	1.00
61_D	249_E	3.361	1.00
53_R	78_D	3.342	1.00
397_R	400_Q	3.272	1.00
57_K	74_R	3.224	1.00
165_K	212_L	2.903	1.00
47_A	154_L	2.878	1.00
57_K	253_I	2.846	1.00
285_A	340_V	2.772	1.00
446_S	449_E	2.770	1.00
168_T	209_E	2.759	1.00
161_I	216_E	2.665	1.00
399_N	403_N	2.646	1.00
170_T	389_V	2.642	1.00
156_L	277_A	2.636	1.00
43_S	374_R	2.605	1.00
113_R	117_L	2.528	1.00
197_L	393_P	2.512	1.00
343_N	372_S	2.503	1.00
221_H	276_Q	2.492	1.00
161_I	212_L	2.426	1.00
249_E	252_V	2.395	1.00
174_K	177_A	2.336	1.00
336_L	379_G	2.321	1.00
282_K	344_D	2.290	1.00
66_S	69_K	2.259	1.00
60_E	67_E	2.251	1.00
153_L	223_A	2.247	1.00
158_K	219_L	2.172	1.00
180_D	395_R	2.167	1.00
223_A	257_P	2.167	1.00
165_K	216_E	2.096	1.00
400_Q	404_E	2.092	1.00
163_Q	381_E	2.052	1.00
339_Q	368_N	2.047	1.00
310_S	392_E	2.044	1.00
168_T	212_L	2.024	1.00
433_L	441_A	2.012	1.00
67_E	71_S	2.007	1.00
170_T	384_N	1.997	1.00
166_T	385_K	1.992	1.00
173_E	389_V	1.973	1.00
79_E	117_L	1.971	1.00
397_R	401_L	1.932	1.00
292_A	333_L	1.915	1.00
212_L	216_E	1.909	1.00
170_T	388_A	1.903	1.00
249_E	253_I	1.902	1.00
286_A	341_M	1.897	1.00
173_E	177_A	1.896	1.00
217_Y	221_H	1.870	1.00
50_L	154_L	1.852	1.00
214_H	276_Q	1.826	1.00
71_S	75_Q	1.825	1.00
427_K	431_E	1.803	1.00
164_L	284_L	1.787	1.00
225_L	251_A	1.779	1.00
217_Y	220_P	1.762	1.00
399_N	457_E	1.748	1.00
172_N	209_E	1.739	1.00
427_K	442_L	1.739	1.00
449_E	452_S	1.732	1.00
53_R	74_R	1.708	1.00
261_A	267_A	1.705	1.00
288_L	333_L	1.694	1.00
178_F	181_I	1.693	1.00
455_R	458_Q	1.693	1.00
420_K	423_E	1.675	1.00
436_K	451_D	1.674	1.00
395_R	399_N	1.674	1.00
224_E	259_V	1.668	1.00
168_T	205_V	1.667	1.00
384_N	389_V	1.660	1.00
70_A	74_R	1.657	1.00
447_E	451_D	1.635	1.00
211_N	287_S	1.625	1.00
275_V	351_G	1.622	1.00
210_H	266_E	1.612	1.00
57_K	249_E	1.610	1.00
248_D	252_V	1.590	1.00
227_L	246_V	1.575	1.00
440_L	447_E	1.567	1.00
166_T	384_N	1.539	1.00
448_A	451_D	1.522	1.00
433_L	438_A	1.506	1.00
58_V	249_E	1.506	1.00
53_R	81_L	1.495	1.00
346_A	364_M	1.490	1.00
163_Q	377_A	1.486	1.00
175_S	205_V	1.481	1.00
72_A	118_L	1.479	1.00
174_K	178_F	1.463	1.00
229_G	267_A	1.461	1.00
220_P	257_P	1.461	1.00
282_K	348_N	1.459	1.00
345_V	349_M	1.443	1.00
218_S	280_A	1.422	1.00
155_A	377_A	1.402	1.00
385_K	389_V	1.397	1.00
330_C	387_C	1.376	1.00
210_H	272_D	1.370	1.00
78_D	82_A	1.368	1.00
278_H	347_I	1.364	1.00
394_N	397_R	1.361	1.00
113_R	116_E	1.357	1.00
271_C	362_R	1.347	1.00
396_E	400_Q	1.345	1.00
213_K	221_H	1.337	1.00
38_E	371_Q	1.326	1.00
46_H	50_L	1.325	1.00
433_L	437_A	1.323	1.00
434_T	437_A	1.322	1.00
292_A	383_F	1.318	1.00
297_W	355_N	1.311	1.00
168_T	208_L	1.309	1.00
53_R	57_K	1.301	1.00
152_A	277_A	1.301	1.00
286_A	351_G	1.289	1.00
420_K	444_Y	1.288	1.00
201_I	204_W	1.286	1.00
43_S	155_A	1.284	1.00
172_N	176_R	1.283	1.00
83_G	117_L	1.281	1.00
161_I	219_L	1.280	1.00
170_T	173_E	1.277	1.00
279_G	283_G	1.271	1.00
197_L	201_I	1.265	1.00
275_V	283_G	1.264	1.00
48_L	143_V	1.262	1.00
166_T	389_V	1.253	1.00
56_A	65_L	1.253	1.00
79_E	84_Q	1.246	1.00
204_W	357_E	1.245	1.00
341_M	349_M	1.244	1.00
181_I	395_R	1.243	1.00
339_Q	371_Q	1.227	1.00
49_A	81_L	1.218	1.00
106_M	110_L	1.209	1.00
137_S	238_T	1.208	1.00
49_A	106_M	1.207	1.00
79_E	113_R	1.204	1.00
415_H	449_E	1.201	1.00
72_A	75_Q	1.200	1.00
176_R	179_A	1.198	1.00
308_E	392_E	1.197	1.00
46_H	81_L	1.190	1.00
64_L	136_K	1.187	1.00
164_L	208_L	1.186	1.00
308_E	394_N	1.182	1.00
342_G	346_A	1.179	1.00
251_A	257_P	1.152	1.00
443_G	446_S	1.150	1.00
347_I	369_F	1.150	1.00
197_L	398_I	1.147	1.00
49_A	80_V	1.137	1.00
178_F	395_R	1.135	1.00
152_A	369_F	1.132	1.00
107_N	111_A	1.131	1.00
333_L	379_G	1.131	1.00
163_Q	166_T	1.130	1.00
344_D	348_N	1.126	1.00
172_N	205_V	1.122	1.00
295_V	330_C	1.121	1.00
163_Q	384_N	1.121	1.00
96_T	104_M	1.120	1.00
191_D	302_P	1.116	1.00
54_A	253_I	1.111	1.00
165_K	169_Q	1.110	1.00
204_W	291_I	1.102	1.00
71_S	74_R	1.093	1.00
215_I	284_L	1.092	1.00
137_S	239_H	1.089	1.00
161_I	165_K	1.088	1.00
46_H	85_H	1.085	1.00
416_I	421_A	1.081	1.00
167_L	208_L	1.081	1.00
179_A	198_G	1.077	1.00
153_L	256_A	1.076	1.00
171_L	291_I	1.074	1.00
72_A	76_A	1.070	1.00
337_C	341_M	1.070	1.00
180_D	198_G	1.060	1.00
274_L	369_F	1.057	1.00
174_K	201_I	1.056	1.00
155_A	159_Q	1.055	1.00
78_D	81_L	1.055	1.00
202_S	263_N	1.052	1.00
166_T	381_E	1.051	1.00
146_T	225_L	1.047	1.00
61_D	253_I	1.046	1.00
51_T	143_V	1.044	1.00
167_L	388_A	1.040	1.00
194_P	402_L	1.038	1.00
183_K	398_I	1.034	1.00
159_Q	377_A	1.028	1.00
74_R	78_D	1.025	1.00
156_L	219_L	1.025	1.00
431_E	438_A	1.024	1.00
67_E	70_A	1.021	1.00
289_M	334_T	1.017	1.00
213_K	220_P	1.014	1.00
47_A	150_V	1.014	1.00
148_M	366_I	1.003	1.00
181_I	398_I	1.002	1.00
223_A	256_A	0.998	1.00
288_L	380_M	0.998	1.00
50_L	253_I	0.996	1.00
148_M	274_L	0.994	1.00
195_L	232_V	0.994	1.00
295_V	391_I	0.992	1.00
46_H	154_L	0.992	1.00
174_K	388_A	0.991	1.00
179_A	196_T	0.991	1.00
191_D	301_G	0.988	1.00
225_L	250_L	0.986	1.00
277_A	369_F	0.984	1.00
417_G	420_K	0.984	1.00
185_G	195_L	0.984	1.00
188_H	331_E	0.983	1.00
433_L	442_L	0.976	1.00
79_E	85_H	0.976	1.00
280_A	284_L	0.973	1.00
415_H	453_W	0.971	1.00
62_L	239_H	0.965	1.00
42_T	86_D	0.963	1.00
310_S	394_N	0.961	1.00
196_T	460_V	0.955	1.00
206_A	210_H	0.953	1.00
153_L	219_L	0.952	1.00
448_A	452_S	0.950	1.00
75_Q	79_E	0.950	1.00
297_W	356_F	0.949	1.00
164_L	212_L	0.948	1.00
219_L	223_A	0.946	1.00
90_P	93_I	0.940	1.00
156_L	215_I	0.939	1.00
213_K	217_Y	0.936	1.00
437_A	441_A	0.935	1.00
79_E	83_G	0.935	1.00
414_T	449_E	0.933	1.00
217_Y	276_Q	0.932	1.00
48_L	106_M	0.930	1.00
75_Q	117_L	0.920	1.00
42_T	46_H	0.918	1.00
60_E	71_S	0.917	1.00
309_I	391_I	0.917	1.00
88_E	92_A	0.914	1.00
427_K	438_A	0.914	1.00
72_A	130_P	0.913	1.00
171_L	201_I	0.900	1.00
46_H	86_D	0.900	1.00
247_A	251_A	0.897	1.00
51_T	146_T	0.896	1.00
186_R	191_D	0.892	1.00
402_L	456_P	0.891	1.00
66_S	133_D	0.891	1.00
58_V	246_V	0.890	1.00
339_Q	367_H	0.889	1.00
43_S	154_L	0.888	1.00
195_L	265_F	0.888	1.00
279_G	344_D	0.887	1.00
50_L	81_L	0.885	1.00
175_S	202_S	0.885	1.00
278_H	369_F	0.885	1.00
58_V	62_L	0.883	1.00
206_A	262_P	0.876	1.00
48_L	51_T	0.876	1.00
438_A	442_L	0.871	1.00
278_H	344_D	0.865	1.00
168_T	172_N	0.863	1.00
154_L	158_K	0.863	1.00
68_E	71_S	0.858	1.00
170_T	174_K	0.857	1.00
129_H	132_D	0.857	1.00
47_A	151_A	0.856	1.00
199_Q	264_K	0.850	1.00
171_L	205_V	0.850	1.00
200_E	357_E	0.848	1.00
177_A	392_E	0.847	1.00
205_V	209_E	0.844	1.00
77_A	80_V	0.844	1.00
305_G	397_R	0.843	1.00
436_K	447_E	0.842	1.00
289_M	352_A	0.838	1.00
284_L	380_M	0.836	1.00
169_Q	173_E	0.834	1.00
189_L	297_W	0.834	1.00
182_V	460_V	0.833	1.00
405_S	410_T	0.833	1.00
436_K	440_L	0.832	1.00
279_G	348_N	0.831	1.00
50_L	250_L	0.831	1.00
449_E	453_W	0.828	1.00
181_I	393_P	0.828	1.00
439_A	442_L	0.821	1.00
61_D	67_E	0.821	1.00
56_A	70_A	0.819	1.00
171_L	388_A	0.809	1.00
182_V	402_L	0.808	0.99
367_H	371_Q	0.800	0.99
333_L	383_F	0.798	0.99
148_M	369_F	0.798	0.99
224_E	273_A	0.796	0.99
55_A	138_Q	0.795	0.99
230_T	320_I	0.793	0.99
381_E	385_K	0.792	0.99
111_A	114_A	0.791	0.99
309_I	390_G	0.789	0.99
73_I	130_P	0.789	0.99
286_A	348_N	0.785	0.99
291_I	383_F	0.781	0.99
427_K	441_A	0.779	0.99
200_E	298_L	0.777	0.99
115_S	131_N	0.776	0.99
178_F	393_P	0.775	0.99
423_E	427_K	0.775	0.99
338_C	346_A	0.773	0.99
104_M	107_N	0.772	0.99
186_R	302_P	0.771	0.99
270_T	287_S	0.768	0.99
403_N	436_K	0.767	0.99
69_K	73_I	0.767	0.99
76_A	79_E	0.766	0.99
83_G	113_R	0.765	0.99
405_S	408_L	0.764	0.99
189_L	300_S	0.763	0.99
82_A	86_D	0.762	0.99
85_H	113_R	0.760	0.99
158_K	256_A	0.759	0.99
210_H	224_E	0.759	0.99
343_N	371_Q	0.759	0.99
450_F	454_V	0.753	0.99
339_Q	343_N	0.751	0.99
60_E	65_L	0.749	0.99
276_Q	279_G	0.749	0.99
226_A	267_A	0.748	0.99
227_L	250_L	0.740	0.99
183_K	200_E	0.739	0.99
405_S	411_A	0.736	0.99
177_A	395_R	0.734	0.99
341_M	345_V	0.729	0.99
260_T	264_K	0.729	0.99
437_A	447_E	0.728	0.99
164_L	380_M	0.728	0.99
57_K	61_D	0.727	0.99
223_A	251_A	0.727	0.99
350_G	364_M	0.726	0.99
298_L	356_F	0.725	0.99
83_G	88_E	0.724	0.99
434_T	438_A	0.722	0.99
53_R	253_I	0.721	0.99
61_D	239_H	0.721	0.99
203_G	290_K	0.720	0.99
387_C	391_I	0.719	0.99
181_I	196_T	0.719	0.99
81_L	85_H	0.718	0.99
265_F	357_E	0.717	0.99
269_A	357_E	0.717	0.99
310_S	390_G	0.715	0.99
68_E	72_A	0.713	0.99
277_A	281_L	0.710	0.99
346_A	368_N	0.710	0.99
272_D	287_S	0.710	0.99
224_E	261_A	0.710	0.99
93_I	115_S	0.709	0.99
246_V	250_L	0.709	0.99
259_V	262_P	0.708	0.99
343_N	373_V	0.707	0.99
292_A	330_C	0.707	0.99
338_C	350_G	0.704	0.99
312_P	390_G	0.702	0.99
396_E	399_N	0.700	0.99
54_A	57_K	0.698	0.99
44_L	144_F	0.697	0.99
180_D	457_E	0.695	0.98
169_Q	172_N	0.694	0.98
393_P	398_I	0.693	0.98
266_E	272_D	0.693	0.98
184_I	304_C	0.692	0.98
310_S	313_E	0.692	0.98
201_I	398_I	0.691	0.98
438_A	441_A	0.691	0.98
65_L	136_K	0.690	0.98
156_L	218_S	0.689	0.98
277_A	374_R	0.688	0.98
406_L	409_V	0.686	0.98
105_N	110_L	0.686	0.98
207_M	287_S	0.685	0.98
275_V	347_I	0.683	0.98
208_L	380_M	0.682	0.98
220_P	223_A	0.680	0.98
159_Q	163_Q	0.680	0.98
445_L	453_W	0.679	0.98
339_Q	375_L	0.679	0.98
69_K	130_P	0.679	0.98
73_I	77_A	0.678	0.98
116_E	119_G	0.674	0.98
76_A	118_L	0.671	0.98
173_E	176_R	0.669	0.98
171_L	208_L	0.668	0.98
40_M	367_H	0.667	0.98
149_H	273_A	0.666	0.98
411_A	415_H	0.666	0.98
274_L	347_I	0.665	0.98
208_L	211_N	0.665	0.98
423_E	442_L	0.665	0.98
53_R	70_A	0.664	0.98
160_L	377_A	0.662	0.98
380_M	384_N	0.662	0.98
406_L	410_T	0.662	0.98
160_L	373_V	0.660	0.98
305_G	394_N	0.659	0.98
247_A	260_T	0.658	0.98
62_L	249_E	0.656	0.98
214_H	272_D	0.656	0.98
80_V	110_L	0.656	0.98
207_M	270_T	0.655	0.98
153_L	257_P	0.653	0.98
167_L	384_N	0.652	0.98
181_I	399_N	0.652	0.98
38_E	367_H	0.651	0.98
130_P	133_D	0.647	0.98
291_I	388_A	0.647	0.98
103_N	312_P	0.644	0.98
82_A	85_H	0.643	0.98
250_L	253_I	0.641	0.97
293_N	334_T	0.641	0.97
64_L	239_H	0.641	0.97
112_N	116_E	0.640	0.97
301_G	305_G	0.640	0.97
84_Q	89_F	0.640	0.97
165_K	209_E	0.639	0.97
213_K	216_E	0.639	0.97
211_N	283_G	0.636	0.97
457_E	461_G	0.635	0.97
64_L	137_S	0.635	0.97
284_L	376_L	0.634	0.97
183_K	195_L	0.630	0.97
111_A	115_S	0.629	0.97
275_V	348_N	0.627	0.97
416_I	420_K	0.625	0.97
422_A	426_K	0.625	0.97
266_E	287_S	0.624	0.97
333_L	387_C	0.624	0.97
56_A	73_I	0.623	0.97
410_T	413_N	0.622	0.97
175_S	179_A	0.622	0.97
85_H	88_E	0.620	0.97
178_F	197_L	0.618	0.97
341_M	348_N	0.618	0.97
288_L	384_N	0.618	0.97
155_A	373_V	0.617	0.97
369_F	373_V	0.617	0.97
57_K	70_A	0.617	0.97
452_S	458_Q	0.616	0.97
397_R	404_E	0.615	0.97
345_V	348_N	0.615	0.97
165_K	168_T	0.614	0.97
156_L	222_V	0.614	0.97
69_K	72_A	0.613	0.97
56_A	134_V	0.612	0.97
166_T	170_T	0.612	0.97
70_A	73_I	0.612	0.97
282_K	286_A	0.610	0.97
160_L	281_L	0.610	0.97
60_E	74_R	0.610	0.97
401_L	404_E	0.610	0.97
184_I	402_L	0.608	0.97
105_N	111_A	0.607	0.96
176_R	180_D	0.607	0.96
215_I	280_A	0.607	0.96
151_A	373_V	0.606	0.96
170_T	385_K	0.606	0.96
289_M	353_S	0.606	0.96
329_Q	383_F	0.605	0.96
289_M	349_M	0.605	0.96
207_M	269_A	0.603	0.96
95_Q	109_V	0.602	0.96
445_L	450_F	0.602	0.96
246_V	249_E	0.601	0.96
214_H	217_Y	0.601	0.96
281_L	376_L	0.601	0.96
338_C	349_M	0.600	0.96
156_L	161_I	0.600	0.96
65_L	69_K	0.600	0.96
218_S	222_V	0.599	0.96
307_G	394_N	0.599	0.96
403_N	434_T	0.599	0.96
433_L	439_A	0.598	0.96
275_V	279_G	0.597	0.96
218_S	277_A	0.597	0.96
225_L	260_T	0.596	0.96
174_K	391_I	0.595	0.96
191_D	405_S	0.594	0.96
196_T	461_G	0.593	0.96
167_L	380_M	0.592	0.96
342_G	345_V	0.589	0.96
314_N	390_G	0.589	0.96
213_K	224_E	0.588	0.96
440_L	451_D	0.588	0.96
283_G	351_G	0.587	0.96
162_P	166_T	0.586	0.96
412_L	425_A	0.586	0.96
77_A	110_L	0.585	0.96
405_S	412_L	0.584	0.96
93_I	96_T	0.584	0.96
172_N	175_S	0.582	0.96
88_E	91_L	0.581	0.95
129_H	419_D	0.580	0.95
346_A	365_V	0.579	0.95
412_L	450_F	0.578	0.95
346_A	350_G	0.578	0.95
405_S	409_V	0.577	0.95
214_H	221_H	0.576	0.95
407_M	410_T	0.576	0.95
208_L	284_L	0.576	0.95
167_L	170_T	0.575	0.95
133_D	136_K	0.574	0.95
204_W	207_M	0.574	0.95
65_L	73_I	0.572	0.95
395_R	398_I	0.565	0.95
200_E	294_D	0.564	0.95
90_P	94_W	0.562	0.95
66_S	70_A	0.562	0.95
51_T	147_A	0.560	0.95
458_Q	461_G	0.560	0.95
445_L	449_E	0.560	0.95
427_K	433_L	0.560	0.95
329_Q	387_C	0.559	0.94
277_A	373_V	0.559	0.94
108_E	112_N	0.559	0.94
407_M	411_A	0.558	0.94
440_L	450_F	0.557	0.94
208_L	288_L	0.557	0.94
164_L	215_I	0.555	0.94
160_L	376_L	0.555	0.94
211_N	214_H	0.555	0.94
285_A	376_L	0.555	0.94
334_T	361_F	0.555	0.94
402_L	407_M	0.553	0.94
209_E	213_K	0.552	0.94
368_N	371_Q	0.551	0.94
305_G	309_I	0.551	0.94
411_A	414_T	0.550	0.94
161_I	280_A	0.550	0.94
279_G	282_K	0.549	0.94
314_N	385_K	0.549	0.94
366_I	370_L	0.549	0.94
101_Q	105_N	0.548	0.94
45_I	84_Q	0.546	0.94
107_N	110_L	0.545	0.94
437_A	440_L	0.545	0.94
281_L	284_L	0.545	0.94
80_V	86_D	0.544	0.94
292_A	334_T	0.544	0.94
452_S	455_R	0.544	0.94
220_P	224_E	0.542	0.94
206_A	209_E	0.541	0.93
91_L	94_W	0.538	0.93
424_I	442_L	0.537	0.93
47_A	50_L	0.536	0.93
183_K	298_L	0.536	0.93
276_Q	283_G	0.535	0.93
49_A	77_A	0.534	0.93
152_A	222_V	0.532	0.93
60_E	66_S	0.532	0.93
231_A	320_I	0.531	0.93
43_S	159_Q	0.528	0.93
50_L	54_A	0.528	0.93
336_L	375_L	0.527	0.93
118_L	130_P	0.526	0.93
89_F	109_V	0.526	0.93
201_I	391_I	0.525	0.92
424_I	439_A	0.524	0.92
214_H	283_G	0.523	0.92
51_T	227_L	0.523	0.92
195_L	199_Q	0.521	0.92
182_V	456_P	0.521	0.92
419_D	423_E	0.520	0.92
89_F	94_W	0.519	0.92
431_E	441_A	0.519	0.92
218_S	276_Q	0.517	0.92
89_F	92_A	0.517	0.92
226_A	268_L	0.516	0.92
181_I	198_G	0.516	0.92
50_L	254_T	0.513	0.92
278_H	372_S	0.512	0.91
251_A	256_A	0.512	0.91
297_W	300_S	0.511	0.91
400_Q	403_N	0.511	0.91
56_A	74_R	0.509	0.91
281_L	340_V	0.507	0.91
103_N	107_N	0.506	0.91
92_A	95_Q	0.506	0.91
140_S	226_A	0.506	0.91
216_E	220_P	0.505	0.91
333_L	337_C	0.504	0.91
105_N	109_V	0.503	0.91
188_H	360_V	0.503	0.91
73_I	118_L	0.502	0.91
340_V	377_A	0.501	0.91
55_A	250_L	0.501	0.91
189_L	355_N	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1furA	4	0.9807	100	0.133	Contact Map
1yfmA	4	0.9572	100	0.142	Contact Map
1vdkA	4	0.9786	100	0.144	Contact Map
3r6qA	4	0.9893	100	0.15	Contact Map
4hgvA	4	0.985	100	0.151	Contact Map
3gtdA	4	0.9743	100	0.153	Contact Map
1jswA	4	0.9764	100	0.156	Contact Map
3e04A	4	0.985	100	0.159	Contact Map
3ocfA	4	0.9572	100	0.171	Contact Map
4admA	4	0.97	100	0.174	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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