GREMLIN Database
PABB - Aminodeoxychorismate synthase component 1
UniProt: P05041 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10683
Length: 453 (433)
Sequences: 5652 (3862)
Seq/√Len: 185.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
318_A346_A4.6691.00
319_V347_Q4.2381.00
84_Q353_H4.2331.00
367_I391_C4.0421.00
190_R194_G3.4981.00
277_L292_K3.4471.00
319_V350_E3.3611.00
326_P345_T3.1891.00
267_E345_T3.1701.00
203_Y208_D3.1041.00
276_T337_V2.9361.00
432_Q435_A2.9051.00
203_Y381_E2.8641.00
219_H418_Q2.8081.00
327_E330_V2.7931.00
194_G434_E2.6131.00
374_R377_E2.6091.00
32_M50_V2.6081.00
193_Y425_G2.5981.00
190_R434_E2.5241.00
395_G405_T2.5201.00
189_T192_Q2.5081.00
78_D81_Q2.5061.00
202_E206_S2.4041.00
324_K345_T2.3951.00
78_D359_R2.3821.00
209_C212_V2.3761.00
287_S291_V2.3651.00
349_P352_L2.3251.00
291_V295_N2.3091.00
290_A333_P2.3051.00
279_R286_D2.3021.00
364_G407_I2.2791.00
219_H420_F2.2631.00
188_M196_K2.2561.00
352_L356_D2.2281.00
221_T418_Q2.2001.00
226_E251_A2.1951.00
112_Y376_M2.1691.00
266_S347_Q2.1271.00
287_S290_A2.1181.00
333_P338_H2.1011.00
200_V212_V2.0921.00
252_I389_A2.0881.00
195_E198_R2.0731.00
243_A394_I2.0371.00
267_E347_Q1.9581.00
314_I318_A1.9581.00
280_L285_E1.9461.00
45_R146_D1.9401.00
259_R404_D1.9341.00
378_I382_L1.9301.00
317_V360_A1.9261.00
331_V340_L1.8991.00
270_T310_M1.8821.00
198_R201_Q1.8761.00
285_E288_K1.8661.00
32_M107_L1.8371.00
211_Q426_G1.8361.00
294_A340_L1.8261.00
243_A254_S1.8261.00
296_S299_D1.8251.00
160_V163_R1.8241.00
22_F31_A1.8041.00
253_L414_A1.7851.00
48_I144_I1.7821.00
283_P287_S1.7811.00
225_D228_Q1.7771.00
414_A419_I1.7461.00
273_I341_V1.7131.00
163_R166_W1.7111.00
332_E341_V1.7081.00
280_L289_Q1.6971.00
434_E438_Q1.6941.00
202_E205_H1.6861.00
271_R332_E1.6781.00
190_R437_Y1.6531.00
21_Y145_V1.6501.00
200_V214_L1.6341.00
106_A138_I1.6291.00
246_R251_A1.6251.00
187_N385_Q1.6041.00
281_P285_E1.5821.00
389_A408_T1.5711.00
209_C375_A1.5491.00
198_R433_E1.5341.00
110_F114_L1.5331.00
216_Q440_T1.5191.00
438_Q442_D1.5181.00
288_K292_K1.5171.00
319_V349_P1.5171.00
358_L397_L1.5111.00
282_D285_E1.5041.00
289_Q292_K1.4931.00
203_Y374_R1.4921.00
197_F433_E1.4791.00
113_D380_D1.4611.00
222_Y414_A1.4511.00
290_A331_V1.4361.00
214_L425_G1.4361.00
437_Y441_F1.4321.00
314_I346_A1.3991.00
199_Q381_E1.3951.00
315_G321_G1.3941.00
203_Y378_I1.3891.00
127_Q130_V1.3881.00
435_A438_Q1.3841.00
254_S406_S1.3831.00
58_T65_V1.3581.00
192_Q384_P1.3561.00
192_Q195_E1.3511.00
304_L329_F1.3491.00
412_L419_I1.3491.00
194_G198_R1.3451.00
264_D402_N1.3441.00
79_P134_M1.3371.00
269_Q345_T1.3351.00
197_F427_I1.3341.00
438_Q441_F1.3241.00
184_W220_A1.3231.00
244_F251_A1.3091.00
199_Q202_E1.3041.00
358_L405_T1.3021.00
23_S231_L1.3021.00
217_R420_F1.2991.00
124_I380_D1.2941.00
271_R327_E1.2931.00
226_E414_A1.2931.00
190_R438_Q1.2841.00
348_L357_L1.2831.00
18_A145_V1.2801.00
243_A252_I1.2681.00
268_I318_A1.2681.00
241_F259_R1.2661.00
220_A419_I1.2651.00
229_A414_A1.2651.00
30_W56_T1.2631.00
194_G433_E1.2591.00
113_D386_R1.2541.00
412_L447_I1.2511.00
185_Q221_T1.2481.00
215_A422_S1.2461.00
396_Y404_D1.2461.00
423_A444_V1.2401.00
398_S402_N1.2321.00
304_L328_L1.2241.00
268_I314_I1.2131.00
374_R381_E1.2081.00
102_F107_L1.2001.00
229_A412_L1.1941.00
425_G440_T1.1921.00
84_Q88_D1.1791.00
35_H234_N1.1771.00
263_C268_I1.1731.00
213_N424_G1.1721.00
284_Q288_K1.1691.00
192_Q196_K1.1641.00
326_P343_T1.1641.00
199_Q203_Y1.1631.00
214_L427_I1.1561.00
269_Q343_T1.1561.00
191_E195_E1.1541.00
212_V379_I1.1501.00
394_I408_T1.1441.00
229_A253_L1.1381.00
221_T417_G1.1361.00
47_D147_H1.1321.00
136_V405_T1.1301.00
263_C357_L1.1251.00
198_R202_E1.1191.00
216_Q441_F1.1181.00
127_Q386_R1.1171.00
263_C348_L1.1171.00
166_W169_S1.1141.00
79_P117_R1.1121.00
208_D374_R1.1111.00
266_S350_E1.1101.00
144_I155_L1.1091.00
226_E244_F1.1051.00
186_S216_Q1.1021.00
131_L413_T1.1021.00
227_W244_F1.1001.00
82_V85_Q1.0991.00
119_E373_V1.0981.00
216_Q437_Y1.0941.00
205_H429_A1.0931.00
237_N255_L1.0891.00
277_L289_Q1.0871.00
145_V152_V1.0831.00
300_R329_F1.0821.00
195_E199_Q1.0811.00
84_Q356_D1.0771.00
290_A338_H1.0691.00
138_I399_F1.0631.00
81_Q85_Q1.0601.00
389_A413_T1.0601.00
201_Q429_A1.0591.00
393_S405_T1.0581.00
81_Q84_Q1.0571.00
355_S397_L1.0561.00
285_E289_Q1.0541.00
307_V328_L1.0531.00
277_L299_D1.0511.00
288_K291_V1.0471.00
274_K366_S1.0471.00
421_C444_V1.0411.00
102_F105_G1.0301.00
294_A331_V1.0281.00
143_L152_V1.0211.00
271_R343_T1.0060.99
222_Y419_I1.0050.99
254_S394_I1.0030.99
54_I140_D1.0030.99
200_V209_C1.0000.99
212_V378_I0.9990.99
291_V294_A0.9990.99
88_D353_H0.9980.99
222_Y229_A0.9940.99
209_C378_I0.9940.99
201_Q205_H0.9930.99
230_F234_N0.9910.99
380_D386_R0.9870.99
160_V167_L0.9850.99
200_V427_I0.9850.99
260_F361_A0.9840.99
159_D163_R0.9840.99
239_A242_S0.9840.99
28_L52_E0.9840.99
142_A155_L0.9820.99
274_K303_N0.9810.99
165_A169_S0.9770.99
164_R167_L0.9750.99
421_C448_L0.9720.99
135_A247_L0.9700.99
116_R380_D0.9690.99
188_M384_P0.9640.99
296_S435_A0.9640.99
78_D117_R0.9630.99
243_A406_S0.9580.99
237_N336_A0.9570.99
141_W156_S0.9560.99
319_V322_S0.9540.99
306_I366_S0.9520.99
260_F270_T0.9520.99
268_I357_L0.9510.99
263_C354_A0.9500.99
21_Y25_L0.9470.99
68_E71_K0.9460.99
84_Q359_R0.9460.99
437_Y440_T0.9420.99
213_N368_T0.9400.99
277_L442_D0.9380.99
53_P139_Y0.9340.99
314_I361_A0.9330.99
118_F362_F0.9290.99
274_K306_I0.9270.99
185_Q219_H0.9260.99
294_A300_R0.9240.99
278_P442_D0.9220.99
110_F397_L0.9180.99
110_F358_L0.9140.99
114_L134_M0.9130.99
259_R269_Q0.9110.99
251_A414_A0.9100.99
252_I394_I0.9090.99
109_L389_A0.9050.99
412_L421_C0.9010.99
445_N449_K0.9010.99
67_S70_E0.8970.99
249_Q415_I0.8970.99
213_N391_C0.8960.99
266_S319_V0.8950.99
129_I420_F0.8940.99
200_V382_L0.8890.99
239_A336_A0.8880.99
303_N306_I0.8880.99
60_F63_E0.8840.99
215_A440_T0.8830.99
54_I138_I0.8820.99
58_T135_A0.8670.98
265_N402_N0.8620.98
278_P289_Q0.8600.98
50_V107_L0.8580.98
121_L377_E0.8580.98
242_S255_L0.8560.98
56_T135_A0.8550.98
374_R378_I0.8550.98
353_H356_D0.8540.98
59_T64_T0.8530.98
17_A20_F0.8530.98
115_G376_M0.8520.98
213_N367_I0.8520.98
110_F134_M0.8490.98
164_R168_E0.8480.98
55_C86_V0.8470.98
364_G406_S0.8470.98
184_W448_L0.8440.98
182_S221_T0.8430.98
160_V164_R0.8400.98
32_M139_Y0.8380.98
83_L136_V0.8370.98
122_P377_E0.8360.98
159_D162_A0.8360.98
218_F448_L0.8340.98
367_I409_I0.8300.98
20_F24_R0.8300.98
114_L117_R0.8300.98
128_D385_Q0.8290.98
327_E343_T0.8280.98
110_F136_V0.8230.98
197_F201_Q0.8220.98
191_E194_G0.8220.98
196_K384_P0.8220.98
204_L429_A0.8200.98
299_D435_A0.8190.98
212_V375_A0.8170.98
163_R167_L0.8170.98
218_F441_F0.8160.98
80_L114_L0.8160.98
165_A168_E0.8150.98
52_E141_W0.8030.97
48_I142_A0.7940.97
198_R205_H0.7930.97
194_G432_Q0.7900.97
217_R422_S0.7890.97
194_G197_F0.7890.97
335_P446_R0.7870.97
113_D116_R0.7830.97
230_F253_L0.7830.97
86_V89_R0.7830.97
96_H100_L0.7820.97
334_F341_V0.7790.97
315_G320_A0.7790.97
22_F25_L0.7740.97
260_F274_K0.7720.97
55_C66_V0.7710.97
270_T361_A0.7710.97
123_E380_D0.7710.97
310_M364_G0.7700.97
324_K347_Q0.7690.97
196_K214_L0.7680.97
300_R328_L0.7650.97
125_A380_D0.7650.97
303_N391_C0.7630.97
397_L403_M0.7620.96
218_F423_A0.7610.96
278_P435_A0.7560.96
263_C266_S0.7520.96
330_V343_T0.7520.96
26_S246_R0.7480.96
74_T77_D0.7470.96
35_H230_F0.7470.96
196_K200_V0.7450.96
131_L250_G0.7440.96
262_L269_Q0.7440.96
186_S440_T0.7420.96
292_K295_N0.7420.96
245_L394_I0.7410.96
57_L82_V0.7400.96
45_R148_Q0.7370.96
116_R123_E0.7350.96
18_A21_Y0.7350.96
308_D311_R0.7350.96
278_P281_P0.7340.96
97_N100_L0.7340.96
46_F144_I0.7310.96
163_R170_Q0.7300.96
259_R271_R0.7290.95
303_N366_S0.7270.95
107_L245_L0.7240.95
309_L365_G0.7220.95
303_N310_M0.7190.95
284_Q287_S0.7190.95
111_G133_D0.7180.95
250_G415_I0.7170.95
22_F227_W0.7160.95
115_G118_F0.7140.95
367_I407_I0.7130.95
105_G399_F0.7090.95
425_G435_A0.7080.95
160_V166_W0.7050.95
364_G391_C0.7050.95
312_N316_R0.7040.95
378_I381_E0.7040.95
63_E74_T0.7020.94
282_D288_K0.7000.94
69_S72_R0.6990.94
268_I346_A0.6990.94
260_F303_N0.6990.94
301_A430_D0.6990.94
188_M216_Q0.6990.94
59_T134_M0.6990.94
116_R122_P0.6990.94
354_A403_M0.6980.94
130_V415_I0.6970.94
28_L246_R0.6960.94
60_F133_D0.6960.94
261_I361_A0.6940.94
135_A250_G0.6930.94
60_F65_V0.6920.94
37_G40_D0.6900.94
200_V379_I0.6880.94
58_T67_S0.6870.94
278_P438_Q0.6870.94
293_L331_V0.6870.94
263_C403_M0.6870.94
336_A446_R0.6860.94
278_P285_E0.6850.94
290_A294_A0.6850.94
358_L403_M0.6850.94
414_A417_G0.6850.94
77_D81_Q0.6850.94
187_N219_H0.6840.94
217_R385_Q0.6810.94
115_G380_D0.6790.93
54_I106_A0.6780.93
116_R133_D0.6770.93
51_A141_W0.6770.93
188_M192_Q0.6770.93
295_N300_R0.6760.93
110_F405_T0.6750.93
325_V328_L0.6750.93
20_F23_S0.6740.93
118_F359_R0.6740.93
252_I411_T0.6740.93
373_V377_E0.6720.93
21_Y143_L0.6710.93
356_D360_A0.6710.93
260_F310_M0.6700.93
303_N338_H0.6680.93
260_F306_I0.6680.93
327_E332_E0.6680.93
215_A424_G0.6670.93
117_R133_D0.6650.93
373_V376_M0.6580.92
203_Y377_E0.6570.92
300_R304_L0.6570.92
311_R370_A0.6560.92
261_I403_M0.6520.92
123_E386_R0.6510.92
162_A166_W0.6510.92
237_N446_R0.6500.92
110_F395_G0.6500.92
292_K296_S0.6490.92
229_A419_I0.6480.92
159_D167_L0.6470.92
59_T79_P0.6420.91
65_V72_R0.6420.91
391_C406_S0.6420.91
48_I107_L0.6410.91
26_S225_D0.6390.91
266_S348_L0.6380.91
119_E316_R0.6380.91
28_L51_A0.6380.91
364_G367_I0.6370.91
18_A22_F0.6370.91
329_F340_L0.6360.91
385_Q422_S0.6360.91
102_F404_D0.6340.91
187_N216_Q0.6320.91
270_T314_I0.6320.91
268_I348_L0.6280.91
213_N406_S0.6280.91
331_V338_H0.6250.90
127_Q217_R0.6250.90
236_A449_K0.6240.90
347_Q350_E0.6240.90
129_I386_R0.6220.90
158_N167_L0.6210.90
88_D91_D0.6210.90
132_P250_G0.6200.90
310_M391_C0.6200.90
247_L250_G0.6190.90
441_F445_N0.6170.90
85_Q88_D0.6170.90
308_D313_D0.6150.90
143_L154_L0.6130.89
22_F49_V0.6120.89
270_T344_I0.6110.89
303_N307_V0.6110.89
141_W154_L0.6080.89
201_Q433_E0.6070.89
390_W425_G0.6060.89
227_W231_L0.6030.89
157_H399_F0.6010.89
125_A128_D0.5990.88
211_Q428_V0.5990.88
243_A411_T0.5990.88
63_E76_T0.5970.88
254_S408_T0.5970.88
17_A24_R0.5960.88
18_A25_L0.5960.88
112_Y368_T0.5960.88
39_A44_S0.5950.88
93_R97_N0.5950.88
240_P334_F0.5940.88
271_R330_V0.5930.88
64_T82_V0.5930.88
35_H242_S0.5920.88
303_N342_S0.5910.88
444_V448_L0.5910.88
187_N217_R0.5900.88
301_A311_R0.5900.88
210_Y312_N0.5900.88
210_Y368_T0.5890.88
223_S417_G0.5890.88
19_E231_L0.5880.87
159_D166_W0.5880.87
277_L338_H0.5870.87
252_I408_T0.5860.87
213_N375_A0.5840.87
213_N364_G0.5840.87
17_A231_L0.5840.87
297_A300_R0.5840.87
68_E73_T0.5790.87
194_G437_Y0.5770.86
139_Y142_A0.5760.86
197_F425_G0.5750.86
127_Q415_I0.5750.86
213_N254_S0.5730.86
413_T420_F0.5730.86
77_D85_Q0.5720.86
316_R373_V0.5720.86
255_L447_I0.5720.86
364_G375_A0.5700.86
22_F244_F0.5700.86
186_S218_F0.5680.86
254_S364_G0.5680.86
203_Y209_C0.5660.85
233_L255_L0.5650.85
243_A364_G0.5650.85
163_R168_E0.5640.85
238_R255_L0.5630.85
65_V68_E0.5610.85
260_F366_S0.5610.85
238_R335_P0.5610.85
279_R333_P0.5590.85
299_D366_S0.5590.85
267_E326_P0.5580.85
131_L389_A0.5580.85
213_N243_A0.5570.84
415_I418_Q0.5570.84
104_G142_A0.5560.84
129_I388_N0.5530.84
210_Y311_R0.5530.84
442_D445_N0.5530.84
211_Q306_I0.5530.84
29_P248_E0.5520.84
31_A246_R0.5520.84
27_H246_R0.5510.84
224_G229_A0.5500.84
280_L286_D0.5500.84
273_I409_I0.5490.84
254_S391_C0.5490.84
120_S377_E0.5490.84
84_Q355_S0.5480.84
367_I408_T0.5470.83
75_T79_P0.5470.83
305_M308_D0.5470.83
103_Q398_S0.5460.83
90_A399_F0.5460.83
67_S72_R0.5460.83
161_N165_A0.5450.83
200_V213_N0.5450.83
366_S425_G0.5450.83
336_A449_K0.5440.83
85_Q89_R0.5430.83
133_D386_R0.5430.83
261_I357_L0.5420.83
305_M311_R0.5420.83
271_R334_F0.5420.83
136_V395_G0.5410.83
384_P422_S0.5400.83
308_D312_N0.5390.83
274_K428_V0.5390.83
103_Q400_C0.5390.83
296_S367_I0.5380.82
274_K425_G0.5380.82
228_Q231_L0.5380.82
100_L153_S0.5360.82
305_M313_D0.5360.82
186_S423_A0.5350.82
213_N310_M0.5340.82
201_Q428_V0.5340.82
196_K382_L0.5330.82
377_E381_E0.5330.82
83_L90_A0.5320.82
125_A384_P0.5320.82
197_F214_L0.5310.82
214_L382_L0.5310.82
441_F448_L0.5310.82
294_A297_A0.5300.81
367_I447_I0.5300.81
303_N329_F0.5290.81
318_A323_V0.5290.81
395_G403_M0.5280.81
286_D338_H0.5280.81
164_R170_Q0.5260.81
284_Q350_E0.5260.81
310_M366_S0.5240.81
236_A336_A0.5240.81
19_E227_W0.5240.81
317_V357_L0.5230.81
86_V90_A0.5230.81
195_E202_E0.5220.80
259_R364_G0.5220.80
55_C68_E0.5220.80
308_D370_A0.5210.80
280_L283_P0.5200.80
339_H367_I0.5190.80
59_T117_R0.5190.80
57_L64_T0.5180.80
66_V75_T0.5180.80
188_M214_L0.5170.80
64_T74_T0.5170.80
184_W451_L0.5160.80
226_E253_L0.5160.80
162_A165_A0.5150.80
193_Y440_T0.5150.80
299_D428_V0.5150.80
125_A386_R0.5140.79
178_F224_G0.5130.79
54_I59_T0.5120.79
301_A305_M0.5120.79
115_G366_S0.5110.79
54_I399_F0.5100.79
203_Y382_L0.5100.79
119_E376_M0.5100.79
306_I310_M0.5090.79
259_R396_Y0.5080.79
375_A426_G0.5080.79
108_G136_V0.5070.79
218_F444_V0.5070.79
61_G65_V0.5060.78
357_L361_A0.5050.78
56_T137_G0.5050.78
253_L412_L0.5050.78
146_D151_T0.5050.78
17_A25_L0.5050.78
226_E246_R0.5040.78
49_V143_L0.5030.78
203_Y206_S0.5030.78
200_V378_I0.5030.78
25_L49_V0.5020.78
63_E67_S0.5020.78
305_M312_N0.5020.78
362_F391_C0.5010.78
341_V408_T0.5010.78
313_D370_A0.5000.78
239_A335_P0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k0eA 1 0.9691 100 0.111 Contact Map
1i1qA 2 0.9823 100 0.144 Contact Map
4grhA 1 0.936 100 0.149 Contact Map
1qdlA 1 0.9095 100 0.152 Contact Map
3logA 1 0.9448 100 0.198 Contact Map
3h9mA 1 0.8653 100 0.208 Contact Map
2fn0A 2 0.894 100 0.25 Contact Map
3gseA 1 0.8587 100 0.303 Contact Map
3bzmA 1 0.883 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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