GREMLIN Database
PYRC - Dihydroorotase
UniProt: P05020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10806
Length: 348 (328)
Sequences: 7288 (4437)
Seq/√Len: 245.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
291_H294_A3.7461.00
319_E340_E3.5451.00
229_N233_Q3.2031.00
229_N232_Q3.1071.00
34_S73_F2.9491.00
324_E337_L2.8971.00
182_K230_I2.8961.00
192_N245_R2.8181.00
199_I203_H2.7791.00
158_I184_A2.7691.00
299_N302_Q2.7641.00
124_M169_L2.6811.00
20_L29_V2.5171.00
322_V341_T2.5061.00
323_A326_I2.4991.00
4_P315_L2.4551.00
288_A291_H2.3701.00
7_V315_L2.3221.00
9_K315_L2.3171.00
129_R132_K2.2951.00
294_A299_N2.2701.00
204_L235_L2.2161.00
320_Q344_W2.1701.00
35_E328_L2.1621.00
155_A183_D2.1471.00
12_R38_G2.1221.00
39_R76_L2.1201.00
189_R241_S2.1001.00
207_N229_N2.0671.00
175_V196_A2.0451.00
162_M187_Y2.0281.00
319_E342_V2.0251.00
200_T203_H2.0091.00
321_Q340_E2.0031.00
189_R243_F1.8841.00
179_I188_V1.8831.00
222_C269_C1.8481.00
162_M195_L1.8431.00
282_V286_M1.8381.00
37_Y275_A1.8181.00
27_K31_P1.7951.00
279_Y292_F1.7771.00
151_F183_D1.7721.00
130_M137_L1.7631.00
8_L289_L1.7561.00
247_F303_F1.7521.00
16_W247_F1.7461.00
10_I316_V1.7421.00
291_H295_F1.7331.00
138_L177_E1.7321.00
127_L172_L1.7051.00
182_K234_A1.7021.00
188_V197_A1.6951.00
13_P276_L1.6911.00
323_A337_L1.6781.00
206_F278_S1.6661.00
318_E344_W1.6651.00
197_A244_N1.6521.00
89_E92_R1.6491.00
228_R231_H1.6451.00
279_Y296_C1.6431.00
181_T184_A1.6151.00
24_D29_V1.6051.00
16_W304_Y1.5931.00
298_V302_Q1.5761.00
10_I293_E1.5741.00
25_M330_D1.5621.00
285_E342_V1.5441.00
207_N210_H1.5341.00
205_M278_S1.5321.00
134_G305_G1.5221.00
307_P310_D1.5111.00
143_V156_R1.5061.00
250_T275_A1.5061.00
194_R303_F1.4711.00
31_P328_L1.4651.00
50_V56_A1.4531.00
185_A238_L1.4471.00
186_D190_D1.4401.00
221_Y265_G1.4231.00
237_E241_S1.4131.00
159_E165_L1.4101.00
281_T285_E1.4031.00
52_T55_A1.4031.00
207_N232_Q1.4011.00
239_V295_F1.3991.00
91_E129_R1.3911.00
270_F331_D1.3881.00
293_E297_S1.3871.00
182_K186_D1.3861.00
7_V317_R1.3831.00
20_L40_A1.3801.00
159_E187_Y1.3681.00
20_L30_V1.3651.00
129_R133_I1.3641.00
41_I78_T1.3601.00
78_T111_T1.3371.00
248_L279_Y1.3311.00
119_S122_A1.3291.00
110_T135_M1.3031.00
294_A298_V1.3021.00
30_V71_H1.2921.00
9_K313_I1.2911.00
14_D301_P1.2901.00
208_R228_R1.2831.00
81_L126_V1.2751.00
257_R261_E1.2651.00
190_D193_E1.2611.00
161_V174_V1.2511.00
130_M135_M1.2501.00
281_T342_V1.2321.00
124_M170_T1.2261.00
322_V327_A1.2241.00
4_P9_K1.2231.00
183_D231_H1.2201.00
236_R282_V1.2091.00
283_F286_M1.2081.00
134_G173_K1.2071.00
97_G135_M1.2011.00
165_L168_R1.1971.00
83_D89_E1.1921.00
10_I314_E1.1921.00
41_I76_L1.1911.00
237_E240_A1.1891.00
275_A296_C1.1871.00
136_P173_K1.1811.00
283_F287_N1.1781.00
25_M28_T1.1731.00
276_L280_A1.1671.00
92_R95_N1.1651.00
173_K305_G1.1641.00
281_T339_G1.1631.00
124_M128_E1.1611.00
233_Q237_E1.1591.00
199_I235_L1.1531.00
13_P296_C1.1481.00
62_R65_D1.1481.00
210_H220_L1.1381.00
16_W300_G1.1351.00
302_Q308_V1.1331.00
248_L295_F1.1261.00
274_T322_V1.1221.00
41_I304_Y1.1211.00
13_P37_Y1.1141.00
53_V57_V1.0981.00
167_Q174_V1.0961.00
292_F296_C1.0921.00
178_H251_D1.0841.00
209_N229_N1.0831.00
277_G320_Q1.0771.00
206_F220_L1.0641.00
10_I13_P1.0531.00
176_F179_I1.0531.00
151_F155_A1.0521.00
120_I143_V1.0521.00
151_F228_R1.0481.00
125_P128_E1.0461.00
186_D189_R1.0441.00
68_P71_H1.0421.00
297_S300_G1.0291.00
152_D169_L1.0271.00
201_P271_N1.0181.00
167_Q194_R1.0171.00
140_H178_H1.0081.00
205_M282_V1.0061.00
206_F226_L1.0041.00
20_L42_V1.0041.00
284_E287_N1.0031.00
171_A194_R1.0031.00
280_A289_L1.0021.00
187_Y190_D1.0001.00
127_L137_L0.9991.00
14_D39_R0.9971.00
30_V72_D0.9931.00
23_G255_H0.9921.00
25_M69_A0.9911.00
173_K194_R0.9901.00
162_M191_G0.9851.00
158_I176_F0.9851.00
240_A291_H0.9791.00
123_I139_V0.9671.00
120_I160_S0.9661.00
27_K72_D0.9661.00
49_P80_Y0.9581.00
91_E133_I0.9581.00
259_R266_C0.9561.00
32_Y270_F0.9561.00
79_C96_E0.9521.00
78_T138_L0.9511.00
191_G195_L0.9511.00
33_T40_A0.9491.00
280_A284_E0.9421.00
232_Q236_R0.9301.00
283_F292_F0.9281.00
185_A244_N0.9281.00
270_F327_A0.9221.00
238_L243_F0.9191.00
91_E132_K0.9101.00
31_P72_D0.9091.00
49_P85_L0.9051.00
282_V287_N0.9051.00
274_T327_A0.8991.00
90_L133_I0.8991.00
39_R74_T0.8981.00
299_N303_F0.8981.00
130_M172_L0.8981.00
242_G295_F0.8971.00
16_W41_I0.8941.00
16_W249_G0.8931.00
192_N243_F0.8931.00
55_A58_A0.8891.00
139_V174_V0.8891.00
239_V244_N0.8851.00
17_H178_H0.8851.00
210_H339_G0.8821.00
202_Q222_C0.8811.00
196_A303_F0.8770.99
177_E198_T0.8700.99
27_K69_A0.8670.99
34_S72_D0.8660.99
23_G259_R0.8650.99
51_T55_A0.8620.99
20_L272_A0.8570.99
54_E58_A0.8550.99
218_P265_G0.8540.99
276_L316_V0.8530.99
234_A238_L0.8510.99
12_R311_T0.8490.99
74_T308_V0.8480.99
202_Q269_C0.8470.99
240_A243_F0.8440.99
13_P275_A0.8430.99
256_A259_R0.8430.99
156_R160_S0.8350.99
14_D300_G0.8340.99
155_A159_E0.8300.99
33_T272_A0.8280.99
185_A197_A0.8270.99
94_F133_I0.8270.99
63_I66_A0.8260.99
324_E327_A0.8260.99
138_L304_Y0.8200.99
121_D125_P0.8200.99
185_A235_L0.8180.99
236_R287_N0.8170.99
21_R255_H0.8170.99
280_A316_V0.8130.99
294_A302_Q0.8040.99
22_D25_M0.8010.99
57_V64_L0.8010.99
179_I244_N0.7990.99
273_P328_L0.7970.99
92_R96_E0.7970.99
22_D58_A0.7970.99
151_F231_H0.7960.99
21_R253_A0.7960.99
39_R312_F0.7960.99
282_V339_G0.7960.99
223_L267_A0.7960.99
62_R66_A0.7930.99
134_G194_R0.7890.99
184_A188_V0.7870.99
298_V308_V0.7860.99
230_I233_Q0.7860.99
204_L279_Y0.7850.99
54_E57_V0.7840.99
50_V55_A0.7760.99
151_F181_T0.7730.99
248_L296_C0.7720.99
106_P161_V0.7680.99
206_F336_F0.7620.99
293_E298_V0.7590.99
317_R343_R0.7590.99
209_N212_L0.7560.98
19_H178_H0.7540.98
19_H251_D0.7530.98
278_S341_T0.7530.98
210_H229_N0.7530.98
128_E131_E0.7490.98
219_H257_R0.7490.98
234_A237_E0.7470.98
131_E171_A0.7440.98
284_E342_V0.7440.98
58_A62_R0.7420.98
185_A243_F0.7420.98
57_V96_E0.7340.98
116_G157_F0.7330.98
326_I337_L0.7330.98
236_R285_E0.7320.98
270_F333_L0.7290.98
127_L170_T0.7270.98
279_Y283_F0.7270.98
22_D62_R0.7250.98
88_N129_R0.7250.98
182_K237_E0.7250.98
30_V40_A0.7240.98
276_L313_I0.7220.98
18_L272_A0.7200.98
211_M220_L0.7200.98
152_D156_R0.7190.98
334_V337_L0.7170.98
231_H234_A0.7160.98
262_S266_C0.7150.98
236_R283_F0.7150.98
154_E184_A0.7140.98
93_G110_T0.7140.98
327_A337_L0.7120.98
284_E292_F0.7100.98
121_D124_M0.7090.98
247_F304_Y0.7090.98
74_T312_F0.7060.98
18_L37_Y0.7050.98
141_G157_F0.7010.98
32_Y273_P0.7010.98
103_K178_H0.6990.97
276_L314_E0.6980.97
233_Q236_R0.6950.97
320_Q345_S0.6910.97
276_L292_F0.6890.97
139_V176_F0.6850.97
137_L172_L0.6840.97
45_N48_P0.6830.97
189_R237_E0.6820.97
155_A181_T0.6810.97
11_R298_V0.6810.97
156_R159_E0.6800.97
65_D69_A0.6790.97
185_A189_R0.6780.97
167_Q172_L0.6730.97
53_V92_R0.6720.97
197_A245_R0.6720.97
236_R286_M0.6710.97
124_M152_D0.6710.97
35_E273_P0.6640.97
91_E96_E0.6630.97
131_E169_L0.6600.96
2_T315_L0.6600.96
139_V161_V0.6600.96
19_H43_M0.6590.96
94_F135_M0.6570.96
158_I179_I0.6570.96
269_C335_P0.6560.96
221_Y267_A0.6550.96
105_Y108_N0.6520.96
277_G344_W0.6490.96
8_L316_V0.6460.96
318_E345_S0.6460.96
39_R301_P0.6450.96
319_E343_R0.6450.96
179_I184_A0.6440.96
182_K231_H0.6440.96
179_I197_A0.6410.96
275_A279_Y0.6400.96
271_N274_T0.6390.96
94_F129_R0.6390.96
219_H261_E0.6350.96
206_F335_P0.6350.96
17_H251_D0.6340.96
178_H253_A0.6300.95
34_S71_H0.6270.95
222_C267_A0.6260.95
85_L115_H0.6240.95
79_C93_G0.6190.95
189_R193_E0.6170.95
166_R170_T0.6170.95
196_A245_R0.6160.95
219_H333_L0.6140.95
104_L126_V0.6130.95
83_D118_T0.6120.95
159_E190_D0.6120.95
127_L174_V0.6110.95
283_F289_L0.6100.95
23_G256_A0.6090.95
82_T122_A0.6080.94
120_I156_R0.6080.94
16_W175_V0.6080.94
276_L296_C0.6080.94
201_P274_T0.6060.94
274_T277_G0.6060.94
186_D234_A0.6020.94
165_L169_L0.6010.94
320_Q341_T0.6010.94
143_V160_S0.6000.94
64_L68_P0.5980.94
217_R220_L0.5980.94
122_A125_P0.5970.94
316_V345_S0.5960.94
44_P85_L0.5960.94
71_H75_P0.5950.94
105_Y109_A0.5950.94
327_A332_T0.5940.94
30_V75_P0.5940.94
51_T82_T0.5940.94
239_V248_L0.5940.94
325_S337_L0.5930.94
32_Y272_A0.5920.94
280_A343_R0.5900.94
80_Y85_L0.5900.94
108_N112_N0.5890.93
17_H43_M0.5890.93
199_I204_L0.5890.93
201_P279_Y0.5880.93
280_A292_F0.5860.93
93_G97_G0.5860.93
327_A334_V0.5860.93
127_L167_Q0.5850.93
142_E223_L0.5840.93
40_A73_F0.5820.93
38_G312_F0.5790.93
302_Q310_D0.5760.93
131_E170_T0.5750.93
45_N80_Y0.5720.92
167_Q170_T0.5710.92
277_G341_T0.5700.92
11_R310_D0.5700.92
247_F295_F0.5690.92
78_T177_E0.5660.92
274_T336_F0.5650.92
295_F299_N0.5640.92
175_V303_F0.5630.92
302_Q307_P0.5630.92
149_D267_A0.5610.92
262_S265_G0.5600.92
41_I138_L0.5590.92
79_C91_E0.5580.92
51_T80_Y0.5580.92
166_R195_L0.5570.91
83_D86_D0.5560.91
17_H198_T0.5550.91
28_T330_D0.5550.91
314_E345_S0.5540.91
11_R293_E0.5540.91
201_P249_G0.5540.91
41_I306_L0.5530.91
183_D186_D0.5510.91
258_H261_E0.5510.91
199_I239_V0.5500.91
84_S87_P0.5490.91
106_P109_A0.5490.91
21_R45_N0.5490.91
30_V73_F0.5480.91
91_E95_N0.5470.91
45_N255_H0.5470.91
182_K238_L0.5470.91
205_M339_G0.5460.91
88_N92_R0.5460.91
133_I136_P0.5450.91
65_D68_P0.5430.90
276_L289_L0.5420.90
200_T249_G0.5410.90
309_N312_F0.5400.90
222_C226_L0.5380.90
53_V89_E0.5380.90
19_H253_A0.5380.90
283_F288_A0.5350.90
56_A77_M0.5340.90
218_P261_E0.5340.90
277_G345_S0.5340.90
32_Y36_I0.5330.90
162_M168_R0.5320.90
105_Y110_T0.5310.89
166_R187_Y0.5280.89
176_F188_V0.5270.89
14_D308_V0.5260.89
131_E172_L0.5240.89
322_V334_V0.5230.89
219_H337_L0.5220.89
341_T344_W0.5190.88
189_R234_A0.5170.88
26_L71_H0.5160.88
127_L130_M0.5160.88
117_V123_I0.5150.88
202_Q251_D0.5140.88
38_G311_T0.5130.88
104_L123_I0.5130.88
125_P129_R0.5130.88
141_G176_F0.5120.88
123_I161_V0.5110.88
18_L252_S0.5100.87
140_H251_D0.5100.87
36_I277_G0.5090.87
4_P313_I0.5080.87
281_T341_T0.5070.87
6_Q317_R0.5060.87
282_V285_E0.5050.87
327_A331_D0.5040.87
301_P308_V0.5030.87
18_L40_A0.5030.87
274_T334_V0.5020.87
318_E321_Q0.5010.87
155_A187_Y0.5010.87
52_T89_E0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z26A 2 0.9655 100 0.35 Contact Map
4lfyA 2 0.9713 100 0.355 Contact Map
3dc8A 3 0.9598 100 0.45 Contact Map
2ftyA 3 0.9626 100 0.452 Contact Map
3pnuA 2 0.9454 100 0.457 Contact Map
4lcqA 3 0.9655 100 0.462 Contact Map
4c6eA 2 0.9023 100 0.465 Contact Map
2ftwA 3 0.9655 100 0.478 Contact Map
3e74A 3 0.9397 100 0.479 Contact Map
3griA 1 0.9483 100 0.489 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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