GREMLIN Database
EX1 - Exodeoxyribonuclease I
UniProt: P04995 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10926
Length: 475 (462)
Sequences: 668 (429)
Seq/√Len: 20.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_L33_A6.4601.00
85_A115_I5.8861.00
275_D278_T5.1791.00
208_L308_V4.5631.00
12_L47_E3.9281.00
37_D41_N3.8201.00
301_V309_L3.7781.00
92_F99_I3.7101.00
42_V188_Y3.6621.00
316_R319_D3.5901.00
246_V261_M3.5651.00
73_E77_K3.5271.00
319_D322_R3.2941.00
258_A300_L3.2891.00
372_F380_M3.2861.00
114_N367_L3.1971.00
11_F100_L3.1831.00
141_M197_V3.1781.00
211_H217_L3.1671.00
55_D431_R3.1500.99
221_I229_L3.0000.99
85_A116_F2.9240.99
62_G446_E2.8980.99
457_D460_K2.8570.99
175_I185_A2.8500.99
237_G242_N2.8460.99
53_P75_R2.7700.99
165_R168_H2.7120.98
125_A129_Q2.6450.98
16_Y112_T2.6440.98
137_L140_V2.5330.98
11_F205_F2.5030.97
428_L431_R2.4900.97
50_Y73_E2.4570.97
451_V468_W2.4450.97
116_F121_Y2.4340.97
143_A308_V2.3760.96
117_Y366_Q2.3620.96
287_K295_A2.3380.96
152_I196_L2.3270.96
197_V200_R2.3000.96
16_Y28_P2.2990.96
22_H25_L2.2900.95
19_F29_A2.2710.95
64_V463_L2.1750.94
49_F87_R2.1490.94
140_V208_L2.1470.94
179_N185_A2.1420.93
11_F209_F2.1100.93
170_T176_E2.0730.92
216_K219_A2.0730.92
279_L296_V2.0610.92
217_L309_L2.0570.92
279_L350_I2.0340.92
274_L282_R2.0230.91
247_A334_L2.0010.91
143_A208_L1.9940.91
196_L200_R1.9870.91
13_F100_L1.9860.90
44_G94_V1.9490.90
384_L410_Y1.9450.90
157_N168_H1.9440.90
217_L303_I1.9170.89
232_V243_T1.8820.88
408_F411_R1.8660.87
157_N161_L1.8250.86
372_F403_I1.8080.86
112_T116_F1.8060.86
12_L92_F1.7950.85
164_F242_N1.7910.85
446_E449_M1.7870.85
53_P74_A1.7770.85
40_F100_L1.7730.85
82_A414_N1.7570.84
163_S168_H1.7540.84
362_N409_N1.7480.84
145_Y162_P1.7350.83
206_D210_T1.7050.82
386_T394_L1.7050.82
451_V465_K1.7000.82
176_E185_A1.6770.81
138_L363_V1.6670.81
161_L239_W1.6570.80
229_L309_L1.6550.80
11_F40_F1.6550.80
276_S350_I1.6510.80
369_N406_L1.6430.80
34_I42_V1.6420.80
117_Y311_Q1.6310.79
443_Y446_E1.6230.79
14_H111_V1.6140.78
269_S336_I1.6010.78
47_E91_L1.6010.78
120_F380_M1.5860.77
268_I333_N1.5710.76
33_A92_F1.5660.76
39_E198_K1.5650.76
28_P112_T1.5630.76
334_L338_R1.5590.76
106_R139_D1.5320.75
14_H28_P1.5090.73
411_R418_T1.5060.73
237_G240_R1.5050.73
18_T107_F1.5010.73
220_L309_L1.4980.73
48_V184_M1.4800.72
407_L411_R1.4650.71
18_T111_V1.4530.70
269_S273_E1.4520.70
299_K302_H1.4490.70
366_Q369_N1.4460.70
38_S209_F1.4320.69
161_L237_G1.4040.68
105_V306_C1.3900.67
34_I48_V1.3880.67
40_F195_K1.3760.66
144_C197_V1.3610.65
96_K99_I1.3600.65
240_R265_A1.3560.65
19_F57_Y1.3420.64
42_V195_K1.3110.62
267_D270_P1.3090.62
195_K198_K1.3090.62
458_K461_V1.3040.62
137_L234_G1.2970.61
373_S399_V1.2940.61
69_I74_A1.2880.61
389_R417_G1.2840.61
262_V268_I1.2750.60
245_W327_R1.2640.59
54_A364_D1.2590.59
448_Q465_K1.2510.59
140_V308_V1.2480.58
51_C305_K1.2450.58
327_R334_L1.2360.58
168_H171_K1.2360.58
247_A337_L1.2310.57
415_F470_Y1.2250.57
218_M303_I1.2220.57
279_L283_L1.2170.56
175_I179_N1.2110.56
137_L197_V1.2110.56
445_D449_M1.2110.56
120_F383_V1.2030.56
328_Q332_D1.2020.55
468_W472_E1.2020.55
226_M338_R1.1990.55
34_I47_E1.1930.55
132_N262_V1.1890.55
98_C132_N1.1870.55
270_P296_V1.1850.54
286_A289_D1.1790.54
312_A334_L1.1720.54
287_K293_N1.1630.53
222_D309_L1.1620.53
379_A399_V1.1550.52
270_P273_E1.1470.52
31_F88_I1.1440.52
329_H333_N1.1430.52
96_K195_K1.1400.51
278_T281_E1.1360.51
383_V407_L1.1330.51
37_D267_D1.1330.51
106_R299_K1.1290.51
430_H434_V1.1250.51
262_V266_G1.1220.50
366_Q406_L1.1190.50
240_R263_D1.1170.50
245_W312_A1.1090.49
33_A50_Y1.1060.49
138_L234_G1.1040.49
153_N156_E1.1030.49
302_H305_K1.1030.49
236_F300_L1.1000.49
272_L340_N1.0940.49
38_S42_V1.0890.48
364_D414_N1.0870.48
363_V406_L1.0850.48
424_Q428_L1.0740.47
170_T175_I1.0730.47
167_E171_K1.0710.47
236_F261_M1.0680.47
170_T192_A1.0630.47
28_P111_V1.0620.46
60_Q446_E1.0580.46
289_D293_N1.0580.46
267_D274_L1.0510.46
139_D231_H1.0510.46
60_Q63_A1.0460.45
34_I188_Y1.0440.45
465_K468_W1.0430.45
284_Y300_L1.0430.45
364_D406_L1.0410.45
13_F127_S1.0370.45
51_C84_F1.0310.44
110_E113_R1.0270.44
243_T323_L1.0270.44
221_I251_W1.0270.44
377_R381_K1.0270.44
16_Y53_P1.0140.43
105_V130_H1.0120.43
446_E450_L1.0110.43
377_R380_M1.0100.43
117_Y372_F1.0060.43
161_L242_N1.0050.43
33_A47_E1.0020.43
14_H112_T0.9980.42
44_G49_F0.9960.42
49_F91_L0.9950.42
99_I104_N0.9890.42
170_T177_H0.9860.42
336_I339_E0.9830.41
60_Q138_L0.9830.41
87_R91_L0.9830.41
11_F38_S0.9810.41
236_F244_S0.9780.41
245_W331_L0.9760.41
332_D335_K0.9700.41
20_G26_D0.9700.41
408_F426_R0.9650.40
316_R322_R0.9640.40
277_D280_R0.9620.40
285_T290_L0.9610.40
137_L193_M0.9600.40
83_A203_R0.9540.40
465_K472_E0.9470.39
453_Q456_D0.9460.39
383_V386_T0.9450.39
412_A423_E0.9440.39
157_N163_S0.9440.39
188_Y195_K0.9440.39
25_L365_A0.9420.39
312_A331_L0.9420.39
444_A471_A0.9390.39
13_F64_V0.9370.39
262_V347_V0.9370.39
296_V350_I0.9360.38
38_S347_V0.9260.38
105_V215_H0.9220.38
124_Y368_Y0.9200.38
120_F407_L0.9160.37
99_I126_W0.9150.37
133_S212_R0.9150.37
258_A284_Y0.9130.37
320_A325_I0.9110.37
28_P84_F0.9100.37
364_D386_T0.9090.37
463_L466_A0.9090.37
50_Y77_K0.9050.37
231_H299_K0.9000.36
282_R297_P0.8960.36
327_R331_L0.8940.36
104_N111_V0.8940.36
100_L209_F0.8930.36
321_D358_T0.8910.36
346_K350_I0.8880.36
91_L94_V0.8860.35
12_L48_V0.8850.35
81_E118_R0.8840.35
314_T320_A0.8820.35
29_A57_Y0.8810.35
44_G91_L0.8810.35
336_I340_N0.8760.35
89_H121_Y0.8750.35
257_N303_I0.8740.35
85_A89_H0.8720.35
291_G295_A0.8640.34
203_R343_V0.8630.34
122_D377_R0.8610.34
16_Y111_V0.8510.33
232_V310_A0.8510.33
31_F467_L0.8460.33
391_L407_L0.8440.33
301_V387_E0.8440.33
215_H218_M0.8430.33
162_P323_L0.8410.33
429_E433_Q0.8370.33
21_T165_R0.8350.33
376_D400_D0.8350.33
338_R401_K0.8340.32
387_E390_N0.8340.32
341_P378_A0.8330.32
298_V311_Q0.8320.32
390_N393_A0.8310.32
165_R220_L0.8300.32
57_Y208_L0.8280.32
235_M299_K0.8270.32
20_G61_P0.8240.32
236_F319_D0.8230.32
210_T216_K0.8180.32
345_E349_A0.8180.32
117_Y132_N0.8180.32
435_F440_L0.8170.31
254_E352_A0.8150.31
205_F209_F0.8130.31
448_Q468_W0.8060.31
363_V369_N0.8040.31
132_N220_L0.8020.31
13_F126_W0.8000.31
93_T184_M0.8000.31
11_F85_A0.7990.30
80_N83_A0.7990.30
134_R180_A0.7980.30
140_V143_A0.7970.30
10_T43_I0.7950.30
161_L221_I0.7940.30
411_R423_E0.7940.30
193_M239_W0.7930.30
222_D225_Q0.7920.30
245_W330_C0.7890.30
240_R316_R0.7860.30
120_F410_Y0.7860.30
44_G76_A0.7850.30
48_V74_A0.7830.30
170_T203_R0.7820.30
14_H99_I0.7820.30
98_C346_K0.7810.30
205_F255_N0.7810.30
447_L467_L0.7730.29
14_H320_A0.7680.29
15_D18_T0.7660.29
213_N216_K0.7660.29
262_V298_V0.7650.29
458_K466_A0.7630.29
204_L228_P0.7600.28
132_N208_L0.7600.28
139_D299_K0.7580.28
13_F138_L0.7580.28
175_I192_A0.7560.28
296_V324_G0.7550.28
37_D213_N0.7540.28
404_E438_E0.7530.28
98_C323_L0.7510.28
10_T14_H0.7500.28
138_L235_M0.7490.28
456_D460_K0.7490.28
22_H236_F0.7480.28
62_G443_Y0.7470.28
314_T319_D0.7460.28
241_G314_T0.7410.27
245_W325_I0.7390.27
230_V314_T0.7390.27
12_L49_F0.7390.27
98_C117_Y0.7380.27
65_L463_L0.7370.27
126_W138_L0.7360.27
230_V243_T0.7350.27
144_C310_A0.7310.27
158_D459_E0.7300.27
236_F246_V0.7300.27
181_H186_D0.7280.27
120_F377_R0.7280.27
56_D109_D0.7280.27
291_G294_A0.7270.27
51_C79_E0.7270.27
276_S349_A0.7260.27
170_T193_M0.7230.26
125_A377_R0.7210.26
451_V469_Q0.7210.26
291_G353_E0.7200.26
144_C456_D0.7180.26
241_G319_D0.7180.26
363_V366_Q0.7170.26
317_P380_M0.7170.26
327_R330_C0.7160.26
391_L411_R0.7160.26
64_V99_I0.7140.26
138_L365_A0.7120.26
82_A121_Y0.7120.26
266_G294_A0.7120.26
57_Y470_Y0.7110.26
444_A448_Q0.7100.26
145_Y209_F0.7100.26
237_G295_A0.7090.26
444_A451_V0.7090.26
195_K358_T0.7080.26
70_T463_L0.7060.26
78_G81_E0.7060.26
132_N309_L0.7020.25
81_E154_W0.7010.25
443_Y471_A0.7000.25
47_E92_F0.6990.25
372_F402_R0.6960.25
102_Y364_D0.6960.25
114_N347_V0.6940.25
458_K468_W0.6940.25
388_P391_L0.6930.25
206_D219_A0.6930.25
138_L142_R0.6930.25
161_L235_M0.6930.25
331_L334_L0.6930.25
394_L447_L0.6920.25
145_Y241_G0.6910.25
447_L462_A0.6880.25
280_R353_E0.6870.25
152_I200_R0.6870.25
23_P111_V0.6850.25
90_S279_L0.6850.25
29_A63_A0.6820.24
287_K291_G0.6820.24
40_F198_K0.6800.24
165_R211_H0.6780.24
333_N336_I0.6770.24
392_P411_R0.6770.24
89_H92_F0.6740.24
11_F31_F0.6740.24
245_W334_L0.6730.24
274_L350_I0.6720.24
199_T294_A0.6700.24
56_D81_E0.6680.24
285_T306_C0.6660.24
211_H220_L0.6650.24
461_V466_A0.6640.24
383_V394_L0.6630.24
230_V245_W0.6630.24
105_V421_Y0.6630.24
410_Y415_F0.6630.24
223_V226_M0.6630.24
185_A196_L0.6600.23
148_R151_G0.6590.23
34_I245_W0.6590.23
195_K434_V0.6570.23
177_H189_A0.6570.23
50_Y184_M0.6530.23
127_S138_L0.6530.23
92_F285_T0.6510.23
302_H350_I0.6490.23
201_Q310_A0.6490.23
234_G237_G0.6470.23
94_V383_V0.6460.23
288_T345_E0.6450.23
82_A415_F0.6450.23
251_W424_Q0.6430.23
12_L91_L0.6430.23
260_I301_V0.6430.23
434_V438_E0.6420.23
81_E97_T0.6420.23
285_T305_K0.6420.23
203_R440_L0.6420.23
217_L301_V0.6400.23
330_C334_L0.6400.23
35_R97_T0.6370.22
56_D413_R0.6350.22
104_N306_C0.6350.22
232_V315_L0.6340.22
27_R54_A0.6310.22
139_D142_R0.6300.22
44_G330_C0.6290.22
229_L246_V0.6290.22
268_I274_L0.6270.22
265_A333_N0.6260.22
29_A111_V0.6250.22
284_Y295_A0.6240.22
113_R134_R0.6230.22
137_L240_R0.6220.22
301_V305_K0.6210.22
62_G66_I0.6200.22
63_A278_T0.6190.22
207_Y250_A0.6190.22
375_A379_A0.6190.22
114_N365_A0.6180.22
289_D395_D0.6180.22
345_E441_Q0.6180.22
286_A356_P0.6180.22
60_Q259_V0.6170.21
221_I275_D0.6160.21
241_G316_R0.6150.21
15_D20_G0.6150.21
329_H332_D0.6150.21
154_W413_R0.6140.21
317_P437_P0.6130.21
260_I300_L0.6120.21
466_A469_Q0.6120.21
317_P344_R0.6120.21
298_V337_L0.6120.21
144_C208_L0.6110.21
394_L421_Y0.6100.21
17_E181_H0.6100.21
72_Q163_S0.6100.21
175_I442_G0.6090.21
198_K415_F0.6090.21
278_T360_S0.6080.21
221_I332_D0.6070.21
54_A82_A0.6070.21
281_E291_G0.6060.21
98_C209_F0.6050.21
289_D356_P0.6050.21
374_D380_M0.6040.21
177_H185_A0.6040.21
221_I301_V0.6040.21
272_L296_V0.6030.21
420_D445_D0.6030.21
81_E119_N0.6030.21
285_T288_T0.6020.21
14_H165_R0.6020.21
25_L431_R0.6010.21
319_D323_L0.6010.21
99_I127_S0.5980.21
66_I288_T0.5970.21
407_L418_T0.5970.21
335_K339_E0.5960.21
108_D166_L0.5960.21
107_F111_V0.5950.21
287_K382_I0.5950.21
66_I93_T0.5950.21
110_E134_R0.5950.21
372_F406_L0.5940.20
160_G447_L0.5940.20
176_E309_L0.5940.20
28_P255_N0.5930.20
284_Y346_K0.5920.20
430_H438_E0.5920.20
128_W261_M0.5920.20
245_W300_L0.5910.20
56_D118_R0.5900.20
233_S252_H0.5900.20
117_Y443_Y0.5890.20
458_K472_E0.5880.20
97_T109_D0.5880.20
78_G413_R0.5870.20
435_F471_A0.5870.20
460_K466_A0.5860.20
56_D78_G0.5860.20
84_F177_H0.5850.20
47_E88_I0.5850.20
458_K464_L0.5830.20
303_I317_P0.5830.20
33_A48_V0.5820.20
463_L471_A0.5820.20
207_Y244_S0.5820.20
265_A330_C0.5820.20
428_L473_E0.5810.20
81_E109_D0.5810.20
157_N364_D0.5810.20
65_L446_E0.5810.20
289_D351_F0.5780.20
199_T383_V0.5780.20
34_I191_I0.5780.20
451_V461_V0.5770.20
255_N258_A0.5760.20
234_G252_H0.5760.20
288_T418_T0.5740.20
164_F218_M0.5740.20
10_T100_L0.5740.20
167_E309_L0.5740.20
279_L374_D0.5740.20
19_F69_I0.5720.20
321_D381_K0.5720.20
30_Q67_T0.5720.20
55_D470_Y0.5690.19
33_A73_E0.5690.19
193_M409_N0.5690.19
40_F126_W0.5680.19
52_K210_T0.5680.19
397_T457_D0.5670.19
235_M466_A0.5670.19
17_E186_D0.5670.19
46_P148_R0.5670.19
116_F399_V0.5670.19
114_N284_Y0.5670.19
316_R434_V0.5660.19
42_V192_A0.5660.19
104_N127_S0.5630.19
243_T314_T0.5630.19
262_V380_M0.5620.19
312_A338_R0.5590.19
420_D431_R0.5590.19
109_D118_R0.5580.19
226_M247_A0.5580.19
337_L386_T0.5570.19
157_N237_G0.5570.19
39_E131_D0.5570.19
324_G329_H0.5560.19
32_A35_R0.5550.19
114_N364_D0.5530.19
275_D279_L0.5530.19
205_F299_K0.5530.19
108_D186_D0.5530.19
49_F153_N0.5530.19
117_Y365_A0.5520.19
84_F119_N0.5500.19
103_N181_H0.5480.19
324_G330_C0.5470.19
79_E301_V0.5460.19
10_T35_R0.5460.19
312_A327_R0.5450.19
398_F403_I0.5450.19
24_A114_N0.5450.19
53_P236_F0.5450.19
117_Y310_A0.5440.18
21_T256_R0.5440.18
366_Q438_E0.5440.18
420_D456_D0.5440.18
76_A165_R0.5440.18
122_D125_A0.5440.18
92_F389_R0.5440.18
108_D181_H0.5430.18
342_Q349_A0.5430.18
412_A419_L0.5430.18
58_L391_L0.5430.18
140_V196_L0.5430.18
222_D226_M0.5420.18
245_W319_D0.5410.18
42_V197_V0.5400.18
104_N137_L0.5400.18
108_D183_A0.5390.18
76_A470_Y0.5380.18
298_V347_V0.5380.18
286_A473_E0.5380.18
267_D275_D0.5370.18
261_M398_F0.5360.18
378_A382_I0.5360.18
246_V309_L0.5340.18
31_F72_Q0.5340.18
139_D167_E0.5330.18
209_F396_I0.5330.18
244_S265_A0.5330.18
382_I390_N0.5330.18
12_L34_I0.5320.18
47_E87_R0.5310.18
22_H144_C0.5310.18
247_A262_V0.5310.18
168_H364_D0.5300.18
207_Y362_N0.5290.18
445_D448_Q0.5280.18
13_F36_T0.5270.18
158_D168_H0.5270.18
105_V291_G0.5260.18
175_I213_N0.5260.18
347_V447_L0.5260.18
231_H302_H0.5260.18
91_L443_Y0.5260.18
34_I51_C0.5250.18
208_L300_L0.5250.18
224_P309_L0.5250.18
310_A314_T0.5250.18
211_H242_N0.5250.18
126_W295_A0.5250.18
41_N246_V0.5240.18
76_A463_L0.5240.18
275_D325_I0.5240.18
171_K192_A0.5240.18
379_A397_T0.5230.18
195_K445_D0.5230.18
54_A75_R0.5230.18
240_R319_D0.5210.18
277_D428_L0.5210.18
102_Y124_Y0.5200.18
319_D335_K0.5190.18
99_I165_R0.5180.17
391_L410_Y0.5180.17
119_N154_W0.5180.17
272_L336_I0.5180.17
40_F48_V0.5180.17
208_L306_C0.5170.17
121_Y384_L0.5170.17
388_P418_T0.5160.17
278_T350_I0.5160.17
16_Y84_F0.5160.17
112_T410_Y0.5150.17
296_V343_V0.5140.17
31_F74_A0.5140.17
254_E260_I0.5130.17
206_D267_D0.5130.17
11_F19_F0.5120.17
318_E390_N0.5120.17
79_E417_G0.5120.17
456_D461_V0.5110.17
52_K417_G0.5100.17
100_L126_W0.5100.17
74_A386_T0.5090.17
388_P411_R0.5090.17
377_R384_L0.5090.17
12_L467_L0.5090.17
103_N186_D0.5080.17
377_R403_I0.5080.17
46_P151_G0.5080.17
78_G154_W0.5060.17
450_L463_L0.5060.17
9_S38_S0.5060.17
165_R377_R0.5060.17
288_T292_D0.5050.17
11_F115_I0.5050.17
104_N171_K0.5030.17
52_K121_Y0.5030.17
261_M301_V0.5030.17
96_K227_K0.5030.17
249_L347_V0.5030.17
249_L333_N0.5030.17
330_C333_N0.5030.17
234_G240_R0.5020.17
364_D415_F0.5010.17
224_P273_E0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qxfA 1 0.9074 100 0.322 Contact Map
4rg8A 1 0.9663 100 0.332 Contact Map
3u3yB 2 0.4126 100 0.815 Contact Map
3mxmB 2 0.4211 99.9 0.867 Contact Map
1y97A 2 0.4147 99.9 0.87 Contact Map
2guiA 1 0.3558 99.9 0.874 Contact Map
2f96A 2 0.3895 99.9 0.874 Contact Map
1w0hA 1 0.3937 99.9 0.875 Contact Map
2xriA 1 0.3958 99.9 0.875 Contact Map
2gbzA 2 0.3579 99.9 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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