GREMLIN Database
EX7L - Exodeoxyribonuclease 7 large subunit
UniProt: P04994 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11072
Length: 456 (433)
Sequences: 2090 (1579)
Seq/√Len: 75.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_N228_S5.6751.00
124_E223_R4.5511.00
225_I245_A4.5241.00
131_Y226_F4.4481.00
222_A244_I4.1211.00
175_A184_Q3.8631.00
431_T440_S3.5061.00
423_V438_I3.4251.00
193_N229_R3.3381.00
419_K435_D3.2841.00
141_C168_P3.1901.00
159_V257_S3.1691.00
233_V263_V3.1201.00
429_L440_S3.0701.00
333_Q337_T2.9821.00
181_A215_S2.9761.00
126_L223_R2.9731.00
193_N230_I2.9341.00
36_I39_F2.8451.00
378_Q382_T2.7451.00
225_I232_V2.7331.00
182_P218_D2.7221.00
174_A185_I2.7111.00
144_V156_I2.6581.00
119_A123_A2.6541.00
218_D221_V2.6421.00
74_P102_M2.6411.00
143_G201_L2.6371.00
143_G198_C2.6331.00
186_V221_V2.6301.00
189_I201_L2.6191.00
222_A248_V2.5971.00
156_I204_G2.5951.00
190_E227_T2.5651.00
288_Y292_R2.5261.00
409_T431_T2.5141.00
49_F99_V2.5001.00
186_V220_R2.4161.00
156_I202_I2.3891.00
409_T440_S2.3631.00
115_E119_A2.2701.00
75_Q78_Q2.2111.00
242_V247_F2.1961.00
433_L438_I2.1751.00
19_V88_L2.1701.00
135_L251_L2.1451.00
47_W67_N2.1241.00
185_I221_V2.1231.00
192_A201_L2.1171.00
60_C99_V2.1081.00
420_V435_D2.0821.00
59_R94_D2.0501.00
189_I203_V2.0221.00
317_T320_E2.0181.00
408_V416_V2.0171.00
410_T432_R1.9991.00
204_G235_A1.9821.00
120_K219_E1.8631.00
160_L169_V1.8441.00
39_F47_W1.8431.00
202_I263_V1.8331.00
143_G192_A1.7911.00
174_A188_A1.7811.00
251_L262_V1.7331.00
200_V263_V1.7321.00
172_Y198_C1.7311.00
16_N95_Y1.6921.00
394_E397_S1.6621.00
172_Y195_R1.6591.00
41_Q73_R1.6501.00
61_A96_Q1.6421.00
359_R362_T1.6321.00
36_I80_V1.6321.00
17_Q90_E1.6231.00
417_L423_V1.6201.00
157_L169_V1.6121.00
221_V224_A1.6021.00
337_T340_Q1.6001.00
87_T98_I1.6001.00
186_V189_I1.5970.99
20_R24_E1.5730.99
412_T427_E1.5630.99
181_A185_I1.5620.99
152_A240_T1.5450.99
189_I221_V1.5260.99
18_T26_E1.5180.99
144_V169_V1.5160.99
356_K360_A1.5130.99
429_L442_V1.5110.99
84_A97_I1.5090.99
430_T437_W1.5030.99
141_C170_I1.4930.99
201_L228_S1.4870.99
429_L438_I1.4860.99
162_R261_E1.4850.99
38_N76_H1.4680.99
164_D265_R1.4650.99
85_N100_E1.4340.99
401_T404_R1.4310.99
431_T438_I1.4200.99
189_I232_V1.4200.99
167_L264_S1.4170.99
407_S431_T1.3980.99
112_Q116_Q1.3970.99
116_Q120_K1.3740.98
186_V218_D1.3710.98
142_V200_V1.3700.98
150_G153_L1.3670.98
407_S433_L1.3650.98
360_A363_R1.3570.98
244_I248_V1.3470.98
210_L214_W1.3360.98
152_A204_G1.3360.98
190_E194_Q1.3350.98
219_E223_R1.3290.98
31_W83_R1.3280.98
72_F102_M1.3260.98
204_G236_V1.3240.98
47_W70_V1.3160.98
189_I228_S1.3140.98
122_Q128_D1.3130.98
182_P220_R1.3100.98
141_C198_C1.3040.98
399_L432_R1.3010.98
50_T57_Q1.2910.98
83_R101_S1.2760.98
62_M72_F1.2750.97
24_E87_T1.2730.97
366_Q370_R1.2720.97
428_M443_K1.2690.97
382_T385_R1.2680.97
82_V102_M1.2650.97
109_L113_K1.2550.97
226_F248_V1.2540.97
170_I198_C1.2530.97
133_K229_R1.2530.97
31_W81_L1.2460.97
139_A142_V1.2410.97
189_I225_I1.2370.97
40_T76_H1.2340.97
239_E252_R1.2310.97
33_S79_Q1.2290.97
142_V160_L1.2260.97
417_L429_L1.2130.97
88_L95_Y1.2110.97
180_D183_G1.2010.96
410_T430_T1.1980.96
183_G220_R1.1940.96
203_V235_A1.1900.96
148_K153_L1.1880.96
72_F104_P1.1850.96
124_E219_E1.1800.96
185_I203_V1.1780.96
423_V429_L1.1770.96
61_A98_I1.1740.96
36_I102_M1.1720.96
15_L58_V1.1690.96
10_F18_T1.1640.96
62_M102_M1.1560.96
174_A184_Q1.1560.96
118_K247_F1.1540.95
175_A180_D1.1450.95
58_V84_A1.1360.95
145_I203_V1.1340.95
254_P258_A1.1290.95
136_P200_V1.1230.95
62_M67_N1.1130.94
370_R374_T1.1110.94
373_E377_A1.1110.94
187_R190_E1.1030.94
16_N19_V1.1030.94
10_F15_L1.0960.94
32_I97_I1.0960.94
267_Q271_L1.0890.94
114_Y244_I1.0820.94
115_E118_K1.0760.93
420_V433_L1.0710.93
82_V99_V1.0710.93
18_T27_M1.0680.93
116_Q119_A1.0650.93
415_N422_Q1.0580.93
189_I193_N1.0530.93
408_V432_R1.0450.92
325_R329_A1.0450.92
104_P116_Q1.0370.92
60_C97_I1.0370.92
103_Q109_L1.0350.92
203_V234_S1.0320.92
164_D167_L1.0260.92
377_A380_S1.0250.92
143_G172_Y1.0160.91
39_F74_P1.0080.91
251_L254_P1.0060.91
107_E111_Q1.0040.91
394_E400_S1.0030.91
120_K124_E0.9970.91
39_F67_N0.9960.90
80_V102_M0.9960.90
11_T14_R0.9890.90
423_V427_E0.9860.90
214_W218_D0.9850.90
22_L26_E0.9830.90
143_G170_I0.9710.89
386_F390_V0.9690.89
150_G235_A0.9650.89
339_Q343_R0.9630.89
20_R90_E0.9620.89
363_R367_L0.9550.89
423_V433_L0.9530.88
135_L200_V0.9500.88
388_N391_T0.9490.88
400_S403_A0.9470.88
182_P215_S0.9450.88
172_Y192_A0.9450.88
113_K117_L0.9430.88
332_N335_K0.9380.88
423_V442_V0.9350.87
392_H395_A0.9340.87
321_R328_F0.9330.87
119_A122_Q0.9320.87
201_L230_I0.9300.87
185_I189_I0.9300.87
432_R437_W0.9280.87
38_N50_T0.9270.87
182_P186_V0.9270.87
70_V102_M0.9200.87
114_Y247_F0.9190.87
47_W74_P0.9190.87
344_L347_R0.9180.86
424_K427_E0.9170.86
163_R261_E0.9170.86
62_M99_V0.9160.86
324_K328_F0.9130.86
126_L219_E0.9120.86
152_A156_I0.9050.86
428_M439_E0.9040.86
186_V190_E0.9030.86
58_V95_Y0.9010.85
394_E399_L0.9010.85
19_V58_V0.9000.85
397_S401_T0.8970.85
294_R297_T0.8970.85
159_V240_T0.8950.85
114_Y118_K0.8950.85
160_L264_S0.8940.85
62_M70_V0.8920.85
203_V221_V0.8910.85
140_H168_P0.8880.85
355_P359_R0.8870.85
310_L313_A0.8860.84
42_P149_T0.8860.84
58_V97_I0.8850.84
174_A192_A0.8840.84
19_V23_L0.8840.84
148_K154_H0.8810.84
110_L214_W0.8770.84
144_V153_L0.8730.84
133_K226_F0.8720.84
36_I60_C0.8670.83
130_Q226_F0.8640.83
104_P112_Q0.8630.83
228_S232_V0.8620.83
174_A221_V0.8620.83
214_W217_N0.8600.83
44_S64_R0.8590.83
394_E403_A0.8590.83
418_K422_Q0.8570.82
113_K116_Q0.8550.82
197_E230_I0.8500.82
273_Q277_T0.8470.82
13_S55_T0.8460.82
37_S50_T0.8440.81
292_R295_R0.8360.81
40_T149_T0.8360.81
266_N269_E0.8360.81
145_I174_A0.8350.81
367_L370_R0.8340.81
410_T416_V0.8330.81
218_D224_A0.8320.81
223_R227_T0.8300.80
86_I95_Y0.8280.80
157_L171_I0.8250.80
95_Y149_T0.8240.80
162_R258_A0.8230.80
49_F62_M0.8220.80
16_N88_L0.8200.80
361_Q365_Q0.8190.80
154_H158_H0.8180.79
19_V95_Y0.8170.79
117_L120_K0.8160.79
145_I188_A0.8130.79
51_L82_V0.8120.79
89_Y92_R0.8120.79
426_G441_E0.8100.79
158_H254_P0.8070.79
65_N68_R0.8060.78
148_K173_P0.8030.78
332_N336_R0.8030.78
283_M287_Y0.8030.78
234_S245_A0.7980.78
34_G60_C0.7980.78
111_Q257_S0.7960.78
158_H162_R0.7950.77
15_L86_I0.7940.77
36_I74_P0.7930.77
234_S246_D0.7930.77
21_L25_H0.7910.77
23_L88_L0.7890.77
419_K422_Q0.7880.77
126_L226_F0.7870.77
310_L314_R0.7870.77
412_T428_M0.7810.76
71_T103_Q0.7810.76
66_S69_R0.7800.76
41_Q47_W0.7800.76
49_F60_C0.7780.76
133_K228_S0.7760.76
10_F14_R0.7750.76
56_A90_E0.7710.75
293_T338_G0.7710.75
71_T113_K0.7690.75
330_L334_L0.7690.75
18_T22_L0.7670.75
375_L379_L0.7650.75
403_A434_E0.7610.74
430_T439_E0.7610.74
395_A401_T0.7600.74
142_V167_L0.7570.74
42_P98_I0.7560.74
409_T433_L0.7540.74
63_F96_Q0.7540.74
64_R68_R0.7530.74
200_V233_V0.7510.73
280_R284_A0.7440.73
14_R18_T0.7430.73
42_P57_Q0.7420.72
341_Q344_L0.7420.72
114_Y217_N0.7410.72
372_A376_R0.7390.72
57_Q92_R0.7380.72
11_T95_Y0.7380.72
198_C230_I0.7380.72
188_A191_L0.7360.72
66_S100_E0.7330.72
13_S56_A0.7300.71
104_P111_Q0.7300.71
44_S316_Q0.7290.71
62_M74_P0.7290.71
23_L86_I0.7290.71
408_V433_L0.7280.71
135_L233_V0.7250.71
195_R198_C0.7240.71
317_T321_R0.7230.71
16_N93_G0.7200.70
321_R325_R0.7190.70
363_R366_Q0.7190.70
111_Q159_V0.7170.70
58_V86_I0.7150.70
438_I442_V0.7120.69
162_R262_V0.7100.69
81_L103_Q0.7090.69
44_S96_Q0.7090.69
15_L32_I0.7080.69
390_V399_L0.7080.69
305_Q310_L0.7080.69
198_C201_L0.7070.69
285_M292_R0.7030.68
192_A198_C0.7030.68
368_E372_A0.7030.68
141_C197_E0.7030.68
154_H157_L0.7020.68
172_Y191_L0.7010.68
74_P78_Q0.7010.68
224_A228_S0.7010.68
354_Q357_I0.7000.68
148_K171_I0.6970.68
242_V249_A0.6970.68
40_T67_N0.6970.68
279_Q283_M0.6950.67
401_T418_K0.6950.67
330_L333_Q0.6940.67
32_I86_I0.6930.67
37_S52_K0.6930.67
176_V216_F0.6920.67
193_N201_L0.6920.67
10_F321_R0.6910.67
401_T408_V0.6890.67
343_R346_Q0.6870.67
385_R389_A0.6840.66
426_G442_V0.6810.66
396_V400_S0.6800.66
164_D264_S0.6790.66
293_T297_T0.6790.66
328_F332_N0.6780.66
40_T60_C0.6770.65
267_Q270_L0.6760.65
204_G240_T0.6710.65
294_R298_Q0.6710.65
9_I81_L0.6700.65
145_I189_I0.6700.65
191_L195_R0.6690.65
139_A200_V0.6660.64
425_A443_K0.6660.64
62_M98_I0.6630.64
186_V224_A0.6620.64
58_V99_V0.6610.64
40_T61_A0.6580.63
393_L397_S0.6560.63
138_P270_L0.6560.63
154_H240_T0.6520.63
152_A157_L0.6520.63
149_T153_L0.6510.62
150_G204_G0.6500.62
193_N232_V0.6480.62
88_L96_Q0.6470.62
428_M441_E0.6470.62
118_K222_A0.6440.62
362_T366_Q0.6430.61
157_L160_L0.6430.61
355_P358_H0.6430.61
356_K383_R0.6420.61
309_Q313_A0.6420.61
235_A257_S0.6390.61
160_L260_A0.6380.61
118_K127_F0.6370.61
16_N22_L0.6370.61
384_E388_N0.6370.61
253_A259_A0.6350.61
143_G191_L0.6340.60
84_A95_Y0.6330.60
158_H257_S0.6330.60
165_P265_R0.6330.60
419_K436_G0.6320.60
190_E224_A0.6310.60
142_V263_V0.6310.60
78_Q104_P0.6300.60
303_L308_P0.6300.60
152_A235_A0.6280.60
64_R92_R0.6260.59
353_P357_I0.6260.59
417_L433_L0.6250.59
196_N229_R0.6250.59
139_A265_R0.6240.59
52_K211_E0.6240.59
318_M322_L0.6210.59
116_Q123_A0.6190.59
170_I197_E0.6180.58
57_Q94_D0.6180.58
335_K339_Q0.6180.58
20_R87_T0.6180.58
132_K250_D0.6170.58
223_R226_F0.6160.58
40_T47_W0.6160.58
114_Y222_A0.6160.58
376_R415_N0.6150.58
47_W62_M0.6150.58
35_E108_G0.6140.58
29_Q84_A0.6130.58
145_I192_A0.6130.58
118_K244_I0.6120.58
37_S76_H0.6110.58
133_K248_V0.6090.57
387_G390_V0.6090.57
171_I204_G0.6090.57
402_L405_G0.6080.57
81_L112_Q0.6080.57
364_I367_L0.6080.57
111_Q114_Y0.6070.57
245_A249_A0.6060.57
14_R22_L0.6050.57
38_N49_F0.6040.57
117_L244_I0.6040.57
390_V397_S0.6030.57
439_E443_K0.6020.56
160_L258_A0.6010.56
172_Y230_I0.6010.56
381_A384_E0.6010.56
254_P257_S0.5980.56
360_A364_I0.5970.56
210_L240_T0.5960.56
121_L222_A0.5950.56
338_G342_Q0.5930.55
188_A192_A0.5920.55
88_L93_G0.5920.55
164_D270_L0.5890.55
19_V86_I0.5890.55
410_T422_Q0.5890.55
321_R324_K0.5880.55
19_V59_R0.5880.55
117_L219_E0.5880.55
59_R92_R0.5870.55
109_L112_Q0.5870.55
133_K232_V0.5860.54
338_G361_Q0.5860.54
420_V434_E0.5840.54
30_V84_A0.5830.54
166_S267_Q0.5820.54
111_Q115_E0.5820.54
203_V236_V0.5820.54
74_P80_V0.5810.54
388_N392_H0.5810.54
114_Y242_V0.5800.54
138_P164_D0.5800.54
172_Y201_L0.5800.54
176_V181_A0.5790.54
336_R339_Q0.5780.53
337_T341_Q0.5780.53
240_T263_V0.5760.53
183_G187_R0.5750.53
397_S403_A0.5750.53
150_G173_P0.5750.53
42_P85_N0.5750.53
153_L157_L0.5740.53
110_L210_L0.5740.53
225_I244_I0.5730.53
286_D290_A0.5720.53
235_A245_A0.5720.53
147_S258_A0.5720.53
50_T59_R0.5720.53
51_L80_V0.5710.53
193_N224_A0.5700.52
165_P266_N0.5690.52
106_G163_R0.5670.52
419_K442_V0.5660.52
92_R212_D0.5660.52
42_P45_G0.5650.52
316_Q338_G0.5640.52
97_I273_Q0.5640.52
196_N230_I0.5630.52
287_Y290_A0.5630.52
8_A14_R0.5620.51
143_G156_I0.5620.51
420_V436_G0.5610.51
36_I99_V0.5610.51
425_A441_E0.5610.51
258_A261_E0.5610.51
402_L407_S0.5600.51
151_A240_T0.5600.51
339_Q342_Q0.5590.51
46_H63_F0.5590.51
31_W107_E0.5590.51
211_E252_R0.5590.51
66_S133_K0.5580.51
159_V162_R0.5580.51
57_Q212_D0.5580.51
45_G64_R0.5560.51
390_V393_L0.5550.51
257_S304_Q0.5550.51
180_D215_S0.5540.50
67_N74_P0.5530.50
143_G232_V0.5530.50
359_R363_R0.5510.50
58_V88_L0.5510.50
121_L223_R0.5510.50
165_P269_E0.5510.50
12_V34_G0.5500.50
167_L263_V0.5500.50
147_S152_A0.5500.50
156_I159_V0.5490.50
316_Q320_E0.5490.50
50_T95_Y0.5480.50
398_P406_Y0.5480.50
420_V424_K0.5480.50
365_Q369_Y0.5470.50
40_T43_A0.5460.49
211_E250_D0.5460.49
179_D183_G0.5440.49
340_Q344_L0.5440.49
84_A88_L0.5440.49
27_M31_W0.5430.49
152_A171_I0.5430.49
298_Q301_H0.5430.49
180_D184_Q0.5420.49
350_Q353_P0.5420.49
104_P174_A0.5400.49
65_N69_R0.5380.48
392_H396_V0.5360.48
379_L383_R0.5350.48
413_D424_K0.5350.48
373_E389_A0.5350.48
113_K120_K0.5350.48
36_I70_V0.5330.48
385_R412_T0.5330.48
361_Q369_Y0.5320.48
112_Q115_E0.5320.48
121_L124_E0.5310.48
42_P50_T0.5310.48
184_Q188_A0.5310.48
292_R299_I0.5300.47
87_T97_I0.5300.47
159_V204_G0.5280.47
382_T386_F0.5270.47
189_I204_G0.5270.47
420_V423_V0.5270.47
311_R315_Q0.5240.47
163_R265_R0.5230.47
357_I378_Q0.5230.47
177_Q212_D0.5230.47
362_T365_Q0.5220.46
415_N430_T0.5220.46
10_F20_R0.5220.46
387_G391_T0.5220.46
45_G96_Q0.5210.46
22_L27_M0.5210.46
188_A200_V0.5200.46
163_R253_A0.5200.46
349_N369_Y0.5200.46
138_P166_S0.5190.46
391_T395_A0.5190.46
78_Q152_A0.5190.46
100_E173_P0.5180.46
369_Y378_Q0.5180.46
296_F300_H0.5170.46
331_E335_K0.5170.46
253_A261_E0.5160.46
42_P175_A0.5150.46
33_S105_A0.5150.46
29_Q83_R0.5140.45
383_R387_G0.5140.45
159_V235_A0.5140.45
272_R276_S0.5140.45
186_V203_V0.5130.45
319_L322_L0.5110.45
172_Y197_E0.5110.45
423_V440_S0.5100.45
138_P410_T0.5100.45
295_R299_I0.5090.45
285_M289_L0.5080.45
111_Q210_L0.5080.45
105_A109_L0.5060.44
43_A149_T0.5060.44
148_K157_L0.5060.44
315_Q319_L0.5050.44
91_P95_Y0.5050.44
44_S92_R0.5050.44
96_Q219_E0.5050.44
153_L235_A0.5050.44
163_R259_A0.5040.44
111_Q158_H0.5040.44
137_S273_Q0.5040.44
160_L167_L0.5040.44
63_F113_K0.5020.44
312_L316_Q0.5010.44
16_N56_A0.5010.44
365_Q372_A0.5010.44
174_A264_S0.5010.44
153_L171_I0.5010.44
189_I224_A0.5010.44
384_E387_G0.5000.44
253_A262_V0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gnxB 1 0.2478 99.5 0.889 Contact Map
4joiA 1 0.2697 98.5 0.927 Contact Map
3kdfD 2 0.2434 97.5 0.942 Contact Map
3au7A 1 0.2917 97.4 0.944 Contact Map
3dm3A 4 0.1864 97 0.948 Contact Map
3e0eA 1 0.182 96.5 0.95 Contact Map
1o7iA 1 0.2259 95.9 0.953 Contact Map
3kf6A 1 0.2741 94.9 0.956 Contact Map
2hpiA 2 0.318 94.6 0.957 Contact Map
1txyA 2 0.1667 93.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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