GREMLIN Database
RBSD - D-ribose pyranase
UniProt: P04982 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10817
Length: 139 (131)
Sequences: 860 (540)
Seq/√Len: 47.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_V116_S4.3341.00
11_I120_I3.2911.00
56_G87_H3.2311.00
81_H103_Y2.6911.00
66_A102_R2.6271.00
50_S53_Q2.5871.00
68_I134_C2.5691.00
13_S38_T2.4661.00
18_L62_M2.4281.00
44_L48_V2.2841.00
48_V53_Q2.1211.00
45_T57_V2.0631.00
2_K61_E2.0621.00
10_D38_T2.0160.99
66_A134_C1.9870.99
67_A88_L1.8630.99
80_L129_A1.8610.99
13_S17_R1.8420.99
69_I103_Y1.8170.99
14_V118_A1.7530.98
69_I73_I1.7220.98
65_E134_C1.6640.98
9_S39_R1.6360.98
33_I39_R1.5990.97
44_L54_V1.5620.97
67_A101_I1.5500.97
29_A125_C1.5440.97
22_D117_Q1.5150.96
55_L133_L1.5070.96
26_V58_V1.4930.96
12_S16_S1.4920.96
25_V109_F1.4820.96
23_T134_C1.4780.96
23_T68_I1.4300.95
2_K12_S1.4210.94
59_T64_V1.3720.93
104_T112_Q1.3100.92
74_K103_Y1.3050.92
63_Q138_T1.2610.90
73_I77_N1.2520.90
25_V113_T1.2520.90
24_L118_A1.2430.89
73_I103_Y1.2280.89
111_Q114_A1.2230.89
71_E75_H1.2080.88
31_L109_F1.2040.88
25_V31_L1.1970.88
82_E86_T1.1940.87
73_I84_L1.1840.87
45_T56_G1.1750.87
35_K117_Q1.1590.86
14_V40_I1.1360.85
108_Q111_Q1.1200.84
11_I42_M1.1110.83
15_I58_V1.0900.82
36_S114_A1.0870.82
18_L24_L1.0710.81
62_M135_A1.0580.80
10_D13_S1.0560.80
51_F124_E1.0450.79
21_T65_E1.0430.79
33_I119_V1.0230.78
15_I61_E1.0220.78
46_Q125_C1.0120.77
55_L84_L1.0100.77
24_L58_V1.0100.77
9_S17_R1.0000.76
17_R39_R0.9910.76
55_L131_I0.9900.75
46_Q138_T0.9880.75
68_I104_T0.9770.74
5_T60_N0.9730.74
71_E74_K0.9590.73
110_K128_Y0.9500.72
68_I112_Q0.9440.72
23_T132_I0.9380.71
4_G60_N0.9370.71
63_Q136_G0.9350.71
113_T119_V0.9300.71
24_L62_M0.9290.71
52_M83_T0.9270.71
27_C31_L0.9180.70
85_L103_Y0.9180.70
21_T31_L0.9160.70
44_L57_V0.9080.69
100_E114_A0.9030.68
53_Q56_G0.9030.68
23_T112_Q0.8710.66
57_V60_N0.8690.66
52_M80_L0.8560.64
9_S12_S0.8530.64
31_L113_T0.8400.63
85_L101_I0.8390.63
24_L40_I0.8390.63
58_V120_I0.8290.62
19_G33_I0.8240.61
29_A138_T0.8220.61
40_I118_A0.8070.60
14_V24_L0.8020.59
79_Q82_E0.7870.58
73_I81_H0.7850.58
80_L83_T0.7780.57
69_I131_I0.7730.56
65_E119_V0.7510.54
31_L119_V0.7480.54
9_S43_A0.7450.54
71_E103_Y0.7410.53
77_N126_S0.7390.53
9_S13_S0.7350.53
10_D40_I0.7310.52
2_K16_S0.7280.52
52_M87_H0.7250.52
54_V122_S0.7240.52
120_I138_T0.7220.51
29_A46_Q0.7160.51
67_A131_I0.7040.50
45_T48_V0.6990.49
13_S39_R0.6970.49
44_L122_S0.6960.49
13_S40_I0.6920.48
77_N83_T0.6750.47
17_R117_Q0.6720.46
18_L135_A0.6600.45
52_M56_G0.6540.45
19_G136_G0.6480.44
72_E106_H0.6470.44
84_L131_I0.6430.44
56_G83_T0.6410.43
81_H85_L0.6400.43
19_G43_A0.6400.43
59_T97_N0.6390.43
6_V15_I0.6380.43
11_I15_I0.6380.43
8_N43_A0.6370.43
39_R43_A0.6350.43
50_S56_G0.6280.42
65_E136_G0.6230.42
31_L129_A0.6230.42
15_I137_V0.6200.41
12_S43_A0.6170.41
72_E110_K0.6150.41
2_K8_N0.6140.41
39_R67_A0.6130.41
27_C129_A0.6120.41
19_G127_P0.6080.40
8_N49_P0.6060.40
56_G88_L0.6050.40
55_L59_T0.6040.40
3_K12_S0.6020.40
79_Q98_T0.6010.39
24_L120_I0.5990.39
47_G124_E0.5940.39
21_T134_C0.5920.39
25_V119_V0.5890.38
3_K63_Q0.5880.38
61_E64_V0.5840.38
45_T53_Q0.5840.38
74_K79_Q0.5790.37
69_I81_H0.5760.37
69_I84_L0.5750.37
114_A117_Q0.5730.37
6_V138_T0.5710.37
11_I138_T0.5700.37
104_T115_E0.5680.36
57_V61_E0.5610.36
66_A100_E0.5600.36
4_G61_E0.5600.36
19_G27_C0.5570.35
70_A106_H0.5550.35
31_L124_E0.5550.35
23_T115_E0.5540.35
64_V88_L0.5530.35
86_T100_E0.5520.35
31_L65_E0.5510.35
16_S58_V0.5510.35
9_S16_S0.5500.35
102_R112_Q0.5390.34
79_Q120_I0.5330.33
30_G130_N0.5320.33
18_L120_I0.5290.33
67_A99_I0.5270.33
33_I36_S0.5220.32
15_I138_T0.5220.32
15_I62_M0.5200.32
32_P127_P0.5200.32
39_R80_L0.5180.32
7_L29_A0.5170.32
125_C138_T0.5160.32
48_V61_E0.5140.32
70_A139_F0.5110.31
104_T114_A0.5100.31
109_F113_T0.5070.31
100_E105_T0.5040.31
75_H111_Q0.5040.31
106_H110_K0.5030.31
113_T116_S0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e7nA 6 1 100 0.168 Contact Map
1ogdA 5 0.9424 100 0.18 Contact Map
3p12A 2 0.9209 100 0.191 Contact Map
2ob5A 2 0.9712 100 0.247 Contact Map
3mvkA 5 0.9496 100 0.278 Contact Map
4a34A 5 0.9424 100 0.28 Contact Map
2wcvA 7 0.9281 100 0.314 Contact Map
2wcuA 2 0.9424 100 0.331 Contact Map
3oy2A 2 0.9712 21.1 0.948 Contact Map
1wzuA 1 0.4101 15.9 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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