GREMLIN Database
ILVA - L-threonine dehydratase biosynthetic IlvA
UniProt: P04968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10493
Length: 514 (399)
Sequences: 1362 (719)
Seq/√Len: 36.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_V200_I6.5771.00
141_K144_E5.3471.00
193_A259_L5.1841.00
74_T77_Q4.1801.00
250_E253_R4.1021.00
69_M159_H4.0291.00
221_K225_D3.8201.00
173_L311_A3.5721.00
106_L127_E3.2941.00
98_S105_A3.2231.00
214_A242_V3.1721.00
218_A222_A2.8061.00
144_E148_Q2.7811.00
47_V309_R2.7541.00
186_P315_S2.7431.00
104_K127_E2.7271.00
218_A264_T2.7231.00
341_L396_L2.6821.00
187_V220_L2.6711.00
170_A196_V2.6611.00
204_M207_I2.6571.00
220_L247_I2.6371.00
72_G161_M2.6091.00
215_E266_D2.6081.00
185_V196_V2.5461.00
48_I300_I2.4891.00
219_C223_A2.4841.00
180_L311_A2.4741.00
231_D246_R2.4311.00
193_A255_C2.3611.00
269_A298_K2.3350.99
197_A258_Y2.3320.99
75_E78_K2.3150.99
220_L262_I2.2950.99
196_V313_I2.1740.99
242_V288_S2.1640.99
141_K145_L2.1570.99
285_A314_L2.1460.99
254_L258_Y2.1420.99
180_L207_I2.1040.99
49_L309_R2.1010.99
266_D269_A2.0980.99
31_V175_Q2.0120.98
104_K151_F2.0110.98
143_I146_S1.9990.98
33_P55_R1.9950.98
75_E79_A1.9860.98
48_I296_M1.9820.98
187_V262_I1.9770.98
358_L402_G1.9630.98
293_L296_M1.9580.98
99_A105_A1.9370.98
224_L262_I1.9190.98
158_D249_D1.8930.98
221_K262_I1.8690.97
274_M288_S1.8610.97
50_V312_H1.8560.97
216_D236_G1.8520.97
221_K264_T1.8410.97
19_A161_M1.8260.97
397_Q401_D1.7920.97
181_D308_E1.7870.97
173_L180_L1.7610.96
201_K260_D1.7590.96
239_A270_I1.7500.96
210_I261_D1.7310.96
229_P249_D1.7250.96
242_V291_L1.7060.96
77_Q152_T1.7010.96
36_K47_V1.6990.96
183_V196_V1.6860.95
77_Q80_H1.6730.95
106_L151_F1.6690.95
223_A285_A1.6410.95
135_F139_K1.6330.94
108_V145_L1.6290.94
274_M319_V1.6260.94
255_C259_L1.6080.94
139_K143_I1.6010.94
170_A173_L1.5970.94
170_A200_I1.5820.93
409_L412_D1.5790.93
226_A230_V1.5750.93
17_L202_Q1.5750.93
246_R249_D1.5680.93
76_E80_H1.5670.93
218_A221_K1.5650.93
348_E354_K1.5640.93
78_K103_V1.5610.93
215_E264_T1.5550.93
24_P68_A1.5470.93
46_N308_E1.5350.92
31_V176_Q1.5230.92
171_L199_L1.5180.92
186_P242_V1.4960.91
145_L149_Q1.4930.91
229_P246_R1.4690.91
277_L285_A1.4660.91
99_A126_G1.4650.90
208_K261_D1.4520.90
214_A217_S1.4400.90
129_L141_K1.4020.88
219_C247_I1.3980.88
83_I151_F1.3940.88
145_L151_F1.3890.88
216_D267_S1.3820.88
99_A124_F1.3700.87
84_T155_P1.3660.87
228_H249_D1.3520.87
174_L200_I1.3470.86
44_L300_I1.3340.86
296_M300_I1.3250.85
74_T78_K1.3250.85
196_V200_I1.3220.85
157_F246_R1.3150.85
185_V209_V1.3070.85
134_N137_E1.2880.84
181_D309_R1.2870.84
85_A135_F1.2850.84
155_P159_H1.2810.83
222_A230_V1.2650.83
183_V209_V1.2610.82
393_K397_Q1.2530.82
274_M327_V1.2530.82
261_D302_L1.2530.82
333_L410_S1.2450.82
193_A209_V1.2280.81
359_L381_V1.2160.80
36_K49_L1.2140.80
220_L255_C1.2130.80
223_A247_I1.2120.80
44_L48_I1.2110.80
70_M94_V1.2040.79
227_G256_Q1.1990.79
25_V28_A1.1970.79
104_K149_Q1.1960.79
181_D307_G1.1910.79
70_M101_L1.1870.78
385_L388_G1.1720.77
70_M103_V1.1620.77
169_L196_V1.1480.76
239_A288_S1.1480.76
131_H141_K1.1470.76
160_P250_E1.1440.76
69_M155_P1.1410.76
113_T156_P1.1410.76
113_T116_I1.1340.75
34_L177_D1.1310.75
142_A153_W1.1220.74
332_E337_R1.1180.74
94_V103_V1.1160.74
119_D122_R1.1140.74
300_I310_L1.1100.73
193_A211_A1.1100.73
135_F155_P1.1060.73
48_I305_I1.1060.73
40_L50_V1.0970.73
400_N405_S1.0920.72
182_R208_K1.0900.72
139_K153_W1.0900.72
46_N305_I1.0850.72
279_E337_R1.0820.72
276_D297_K1.0800.71
239_A242_V1.0700.71
222_A226_A1.0700.71
219_C222_A1.0680.71
349_K412_D1.0560.70
134_N245_K1.0500.69
42_S123_G1.0500.69
209_V254_L1.0290.68
112_A364_V1.0200.67
68_A72_G1.0190.67
25_V60_S1.0160.67
84_T153_W1.0160.67
108_V138_A1.0160.67
184_F299_Y1.0150.67
139_K155_P1.0090.66
47_V307_G1.0030.66
106_L149_Q0.9940.65
319_V327_V0.9940.65
115_D119_D0.9850.64
171_L175_Q0.9820.64
83_I152_T0.9800.64
240_E293_L0.9780.64
240_E312_H0.9770.64
292_A312_H0.9750.63
396_L406_V0.9740.63
182_R308_E0.9730.63
412_D415_A0.9690.63
363_S384_R0.9660.63
84_T259_L0.9620.62
279_E314_L0.9600.62
222_A225_D0.9480.61
222_A264_T0.9460.61
351_S354_K0.9460.61
198_V254_L0.9440.61
211_A220_L0.9390.60
305_I308_E0.9380.60
40_L293_L0.9300.60
224_L255_C0.9290.60
105_A162_V0.9260.59
173_L183_V0.9220.59
209_V259_L0.9220.59
219_C285_A0.9210.59
157_F414_M0.9190.59
109_M130_L0.9180.59
253_R256_Q0.9170.59
278_F284_V0.9170.59
111_T133_A0.9150.58
341_L399_L0.9090.58
273_A297_K0.9090.58
136_D217_S0.9080.58
249_D361_G0.9070.58
180_L309_R0.9020.57
295_G315_S0.9010.57
362_R391_E0.9000.57
344_T405_S0.8990.57
21_L31_V0.8980.57
174_L204_M0.8960.57
34_L311_A0.8920.56
186_P262_I0.8880.56
355_F381_V0.8760.55
213_E217_S0.8750.55
49_L177_D0.8730.55
349_K371_F0.8710.55
73_L77_Q0.8710.55
179_H206_Q0.8680.54
17_L21_L0.8670.54
133_A214_A0.8660.54
32_T97_S0.8650.54
105_A126_G0.8640.54
116_I371_F0.8550.53
174_L183_V0.8520.53
25_V67_Y0.8500.53
393_K400_N0.8500.53
28_A67_Y0.8490.53
219_C264_T0.8490.53
215_E218_A0.8440.52
103_V319_V0.8430.52
25_V29_A0.8430.52
78_K104_K0.8420.52
125_G315_S0.8410.52
261_D303_H0.8400.52
113_T240_E0.8300.51
385_L391_E0.8300.51
214_A270_I0.8290.51
40_L44_L0.8290.51
198_V258_Y0.8280.51
157_F314_L0.8270.51
127_E149_Q0.8240.51
223_A246_R0.8210.50
396_L400_N0.8200.50
83_I146_S0.8190.50
183_V311_A0.8190.50
118_V136_D0.8180.50
187_V193_A0.8150.50
214_A239_A0.8150.50
187_V255_C0.8140.50
211_A259_L0.8130.50
46_N181_D0.8120.50
213_E223_A0.8090.49
155_P251_T0.8080.49
336_Q411_D0.8070.49
362_R398_M0.8070.49
61_F120_A0.8070.49
352_F367_F0.8040.49
251_T254_L0.8010.49
261_D401_D0.8000.48
400_N406_V0.7980.48
146_S153_W0.7970.48
185_V292_A0.7960.48
277_L314_L0.7950.48
126_G143_I0.7940.48
255_C262_I0.7930.48
344_T376_N0.7930.48
296_M312_H0.7920.48
208_K308_E0.7920.48
48_I301_A0.7920.48
345_I351_S0.7890.48
120_A404_Y0.7890.48
29_A35_Q0.7870.47
136_D213_E0.7870.47
157_F251_T0.7850.47
163_I254_L0.7810.47
25_V71_A0.7770.46
274_M283_A0.7750.46
186_P288_S0.7730.46
108_V141_K0.7710.46
186_P197_A0.7700.46
354_K402_G0.7690.46
46_N300_I0.7690.46
217_S414_M0.7690.46
349_K399_L0.7680.46
345_I352_F0.7670.46
84_T126_G0.7660.46
324_L341_L0.7630.45
116_I315_S0.7620.45
230_V252_F0.7610.45
213_E221_K0.7600.45
216_D235_V0.7590.45
126_G349_K0.7580.45
325_R328_S0.7570.45
148_Q395_I0.7570.45
50_V240_E0.7550.45
296_M310_L0.7530.44
113_T170_A0.7510.44
181_D207_I0.7490.44
179_H204_M0.7490.44
362_R395_I0.7420.43
211_A262_I0.7390.43
348_E375_K0.7390.43
77_Q226_A0.7350.43
129_L145_L0.7320.43
187_V211_A0.7320.43
42_S208_K0.7310.43
267_S384_R0.7280.42
29_A56_Q0.7250.42
20_V23_A0.7250.42
43_R297_K0.7230.42
209_V306_R0.7210.42
45_D150_G0.7200.42
173_L200_I0.7180.41
45_D306_R0.7180.41
20_V199_L0.7180.41
46_N304_N0.7170.41
322_H328_S0.7170.41
389_L393_K0.7160.41
136_D157_F0.7140.41
23_A96_F0.7130.41
38_E42_S0.7130.41
234_R242_V0.7130.41
32_T327_V0.7130.41
220_L224_L0.7120.41
141_K209_V0.7110.41
202_Q258_Y0.7050.40
285_A319_V0.7040.40
332_E384_R0.7020.40
397_Q400_N0.7000.40
284_V319_V0.6990.40
252_F256_Q0.6970.40
18_R202_Q0.6960.40
170_A405_S0.6950.40
277_L293_L0.6930.39
238_F267_S0.6920.39
213_E242_V0.6910.39
143_I147_Q0.6900.39
45_D76_E0.6900.39
348_E364_V0.6880.39
42_S45_D0.6880.39
256_Q348_E0.6880.39
218_A223_A0.6880.39
21_L175_Q0.6860.39
179_H309_R0.6850.39
33_P324_L0.6840.39
84_T107_I0.6820.38
126_G385_L0.6820.38
351_S404_Y0.6790.38
45_D100_R0.6790.38
96_F100_R0.6780.38
63_L97_S0.6760.38
355_F379_I0.6760.38
170_A298_K0.6730.38
126_G146_S0.6730.38
356_C404_Y0.6730.38
180_L194_A0.6730.38
178_A204_M0.6720.38
154_V307_G0.6700.37
73_L81_G0.6680.37
76_E228_H0.6680.37
20_V167_G0.6680.37
76_E257_E0.6670.37
34_L173_L0.6660.37
40_L101_L0.6660.37
63_L224_L0.6660.37
389_L397_Q0.6650.37
209_V385_L0.6650.37
217_S232_L0.6620.37
130_L138_A0.6620.37
19_A139_K0.6610.37
146_S337_R0.6610.37
345_I367_F0.6590.37
256_Q401_D0.6580.36
358_L398_M0.6580.36
354_K397_Q0.6580.36
178_A206_Q0.6560.36
336_Q389_L0.6560.36
253_R257_E0.6550.36
147_Q228_H0.6540.36
136_D240_E0.6540.36
333_L351_S0.6530.36
332_E382_G0.6520.36
122_R401_D0.6510.36
169_L192_L0.6500.36
210_I263_I0.6460.36
275_K321_F0.6450.35
32_T383_V0.6420.35
368_N380_F0.6400.35
209_V401_D0.6380.35
336_Q392_R0.6360.35
147_Q306_R0.6340.35
142_A154_V0.6340.35
328_S340_L0.6340.35
324_L364_V0.6340.35
157_F215_E0.6320.34
392_R406_V0.6310.34
180_L204_M0.6300.34
170_A209_V0.6270.34
175_Q319_V0.6270.34
116_I284_V0.6260.34
198_V203_L0.6250.34
293_L314_L0.6240.34
216_D271_C0.6230.34
80_H150_G0.6220.34
140_A211_A0.6210.34
353_L357_Q0.6200.33
131_H397_Q0.6180.33
181_D310_L0.6170.33
124_F149_Q0.6160.33
70_M216_D0.6160.33
358_L395_I0.6150.33
47_V390_E0.6140.33
22_R175_Q0.6130.33
254_L257_E0.6130.33
279_E388_G0.6100.33
69_M77_Q0.6080.33
379_I384_R0.6060.32
213_E239_A0.6060.32
186_P291_L0.6060.32
29_A120_A0.6030.32
310_L314_L0.6030.32
111_T349_K0.6020.32
112_A240_E0.6000.32
101_L194_A0.6000.32
131_H136_D0.5990.32
70_M314_L0.5990.32
259_L293_L0.5980.32
217_S235_V0.5980.32
394_E401_D0.5970.32
157_F265_V0.5950.32
25_V61_F0.5940.31
217_S242_V0.5920.31
131_H138_A0.5910.31
71_A402_G0.5910.31
208_K375_K0.5910.31
43_R276_D0.5900.31
255_C379_I0.5900.31
213_E295_G0.5880.31
18_R293_L0.5880.31
59_H267_S0.5870.31
169_L210_I0.5870.31
368_N382_G0.5860.31
202_Q406_V0.5860.31
163_I250_E0.5860.31
103_V298_K0.5860.31
128_V340_L0.5850.31
242_V270_I0.5850.31
69_M72_G0.5850.31
131_H313_I0.5840.31
75_E99_A0.5830.31
197_A201_K0.5830.31
293_L312_H0.5820.31
114_A162_V0.5820.31
187_V213_E0.5810.31
186_P313_I0.5800.30
136_D140_A0.5790.30
17_L22_R0.5770.30
80_H152_T0.5760.30
39_K280_D0.5750.30
300_I305_I0.5740.30
58_V270_I0.5730.30
73_L78_K0.5720.30
59_H323_G0.5720.30
301_A336_Q0.5700.30
59_H182_R0.5700.30
196_V398_M0.5700.30
150_G222_A0.5700.30
76_E79_A0.5690.30
160_P164_A0.5680.30
18_R177_D0.5640.29
213_E224_L0.5640.29
78_K101_L0.5640.29
44_L390_E0.5640.29
67_Y281_V0.5640.29
386_S395_I0.5640.29
268_D334_G0.5630.29
37_M288_S0.5620.29
103_V108_V0.5610.29
338_E370_R0.5610.29
272_A334_G0.5600.29
52_R321_F0.5600.29
284_V364_V0.5600.29
365_T370_R0.5590.29
270_I291_L0.5590.29
68_A168_T0.5580.29
84_T175_Q0.5570.29
158_D229_P0.5550.29
255_C258_Y0.5530.28
194_A256_Q0.5520.28
197_A257_E0.5520.28
151_F307_G0.5520.28
225_D264_T0.5510.28
399_L404_Y0.5500.28
176_Q395_I0.5500.28
148_Q225_D0.5490.28
133_A138_A0.5490.28
67_Y377_A0.5480.28
183_V207_I0.5480.28
83_I141_K0.5480.28
399_L414_M0.5470.28
113_T130_L0.5450.28
271_C287_P0.5440.28
333_L413_E0.5440.28
24_P159_H0.5430.28
106_L111_T0.5420.28
322_H331_C0.5420.28
19_A228_H0.5410.28
139_K146_S0.5410.28
35_Q120_A0.5400.28
121_V126_G0.5400.28
107_I366_E0.5400.28
136_D245_K0.5390.28
103_V142_A0.5390.28
275_K279_E0.5380.27
238_F365_T0.5380.27
84_T314_L0.5370.27
297_K335_E0.5370.27
225_D306_R0.5360.27
134_N327_V0.5340.27
83_I153_W0.5340.27
275_K282_R0.5330.27
115_D126_G0.5330.27
154_V291_L0.5310.27
74_T152_T0.5290.27
147_Q348_E0.5290.27
108_V131_H0.5280.27
158_D248_G0.5280.27
115_D135_F0.5280.27
271_C330_R0.5270.27
335_E367_F0.5270.27
268_D275_K0.5260.27
148_Q258_Y0.5260.27
287_P367_F0.5250.27
249_D311_A0.5230.26
126_G142_A0.5230.26
128_V199_L0.5220.26
390_E393_K0.5220.26
263_I291_L0.5210.26
354_K357_Q0.5210.26
36_K39_K0.5190.26
185_V214_A0.5190.26
200_I204_M0.5190.26
201_K209_V0.5190.26
112_A214_A0.5180.26
171_L384_R0.5180.26
59_H412_D0.5180.26
383_V392_R0.5160.26
394_E397_Q0.5160.26
211_A247_I0.5160.26
157_F364_V0.5150.26
299_Y305_I0.5150.26
169_L313_I0.5140.26
338_E365_T0.5140.26
57_P96_F0.5140.26
228_H256_Q0.5130.26
50_V285_A0.5130.26
106_L129_L0.5130.26
137_E146_S0.5120.26
232_L235_V0.5120.26
22_R296_M0.5120.26
113_T169_L0.5120.26
347_E371_F0.5110.26
214_A414_M0.5100.26
109_M191_G0.5100.26
74_T390_E0.5090.25
83_I319_V0.5090.25
56_Q399_L0.5080.25
193_A196_V0.5080.25
92_Q166_Q0.5070.25
181_D204_M0.5070.25
111_T157_F0.5060.25
140_A400_N0.5060.25
120_A142_A0.5050.25
70_M305_I0.5050.25
272_A276_D0.5040.25
24_P71_A0.5040.25
85_A122_R0.5040.25
187_V247_I0.5040.25
111_T131_H0.5030.25
84_T240_E0.5030.25
287_P325_R0.5020.25
31_V171_L0.5020.25
174_L207_I0.5010.25
80_H104_K0.5010.25
377_A382_G0.5010.25
47_V147_Q0.5000.25
329_E365_T0.5000.25
135_F219_C0.5000.25
113_T366_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tdjA 2 0.9611 100 0.255 Contact Map
3iauA 1 0.6498 100 0.648 Contact Map
2gn0A 2 0.6362 100 0.65 Contact Map
3ss7X 1 0.644 100 0.659 Contact Map
1v71A 2 0.6187 100 0.66 Contact Map
1ve5A 3 0.5895 100 0.673 Contact Map
3l6bA 2 0.6206 100 0.674 Contact Map
2rkbA 2 0.5992 100 0.674 Contact Map
4h27A 1 0.5973 100 0.68 Contact Map
4d9iA 2 0.6381 100 0.686 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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