GREMLIN Database
KDSB - 3-deoxy-manno-octulosonate cytidylyltransferase
UniProt: P04951 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10519
Length: 248 (236)
Sequences: 2387 (1586)
Seq/√Len: 103.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_R64_E4.0061.00
27_K35_E3.9351.00
58_V63_G3.4051.00
52_E56_R3.1821.00
31_V35_E2.9871.00
11_Y18_G2.8271.00
55_A59_E2.7851.00
36_R39_E2.7401.00
123_M214_V2.6771.00
147_D151_Y2.6691.00
23_D244_R2.5641.00
31_V61_A2.5441.00
103_M243_V2.5251.00
34_L63_G2.4081.00
127_A223_V2.2751.00
28_P57_A2.2441.00
151_Y222_H2.2331.00
201_S216_W2.1981.00
72_H81_E2.1981.00
5_V97_V2.1771.00
32_H36_R2.1551.00
125_T223_V2.1371.00
179_L225_V2.0451.00
37_A97_V2.0381.00
151_Y220_K1.9511.00
127_A179_L1.9251.00
237_P241_E1.9181.00
55_A65_V1.9151.00
69_R81_E1.8901.00
241_E244_R1.8881.00
47_V58_V1.8781.00
24_I29_M1.8731.00
16_L22_V1.8591.00
5_V42_A1.8511.00
22_V240_L1.8421.00
153_L215_L1.8291.00
41_G110_R1.7951.00
156_S160_I1.7591.00
55_A67_M1.7501.00
136_A178_F1.7451.00
18_G53_D1.7331.00
84_E193_R1.7181.00
198_W219_E1.6581.00
234_V243_V1.6491.00
240_L244_R1.6261.00
23_D26_G1.6221.00
146_L179_L1.5901.00
6_I82_V1.5821.00
56_R59_E1.5731.00
47_V63_G1.5571.00
74_S77_E1.5541.00
127_A146_L1.5461.00
11_Y53_D1.5341.00
191_F219_E1.5331.00
191_F214_V1.5291.00
194_R219_E1.5291.00
127_A144_V1.5151.00
28_P32_H1.4411.00
22_V237_P1.4361.00
40_S110_R1.4031.00
200_P205_H1.3971.00
28_P31_V1.3761.00
69_R72_H1.3510.99
34_L61_A1.3410.99
46_I66_C1.3320.99
52_E55_A1.3230.99
49_T54_V1.3140.99
165_D208_M1.3080.99
241_E245_A1.3010.99
57_A60_A1.2940.99
46_I86_C1.2870.99
189_A193_R1.2870.99
115_N222_H1.2860.99
127_A225_V1.2590.99
16_L237_P1.2560.99
203_L216_W1.2310.99
198_W217_Y1.2280.99
147_D220_K1.2250.99
104_I109_I1.2120.99
122_G219_E1.2000.99
20_P54_V1.1960.99
16_L244_R1.1870.99
112_V184_I1.1860.99
90_D193_R1.1840.99
77_E195_Y1.1790.99
56_R60_A1.1750.98
108_I126_L1.1660.98
30_I58_V1.1640.98
115_N224_A1.1630.98
34_L38_R1.1560.98
25_N103_M1.1270.98
6_I46_I1.1220.98
58_V61_A1.1160.98
129_P225_V1.1130.98
80_A193_R1.1000.98
137_F159_T1.0980.98
4_V46_I1.0930.98
4_V91_D1.0930.98
46_I82_V1.0800.97
124_A186_G1.0790.97
236_T240_L1.0740.97
31_V34_L1.0730.97
42_A97_V1.0700.97
144_V223_V1.0700.97
114_D117_A1.0680.97
26_G32_H1.0640.97
153_L203_L1.0630.97
133_A137_F1.0330.97
101_E233_G1.0180.96
66_C85_K1.0130.96
95_V186_G1.0120.96
129_P177_N1.0110.96
59_E64_E1.0090.96
103_M234_V1.0070.96
115_N124_A1.0070.96
80_A84_E1.0050.96
126_L224_A1.0050.96
32_H247_M0.9950.96
66_C82_V0.9940.96
118_Q222_H0.9830.95
75_G210_E0.9830.95
29_M234_V0.9820.95
132_N135_E0.9740.95
125_T181_H0.9670.95
146_L225_V0.9670.95
5_V40_S0.9640.95
20_P29_M0.9600.95
145_V154_Y0.9590.95
214_V219_E0.9530.95
24_I243_V0.9520.95
140_N236_T0.9520.95
93_V186_G0.9510.95
59_E65_V0.9480.94
89_S92_T0.9450.94
97_V104_I0.9350.94
145_V153_L0.9320.94
136_A159_T0.9230.94
83_V189_A0.9190.93
4_V44_R0.9180.93
49_T55_A0.9050.93
105_P231_G0.9010.93
96_N185_Y0.9010.93
204_E213_R0.8980.93
4_V92_T0.8970.93
36_R106_A0.8970.93
111_Q226_A0.8930.92
18_G51_H0.8920.92
108_I226_A0.8820.92
75_G185_Y0.8720.92
46_I64_E0.8700.91
20_P33_V0.8610.91
195_Y214_V0.8600.91
191_F195_Y0.8590.91
36_R104_I0.8520.91
201_S217_Y0.8500.90
123_M191_F0.8500.90
112_V116_L0.8490.90
49_T67_M0.8480.90
48_A68_T0.8470.90
125_T211_Q0.8470.90
6_I48_A0.8430.90
116_L124_A0.8410.90
50_D67_M0.8290.89
116_L121_V0.8280.89
146_L150_G0.8270.89
75_G96_N0.8250.89
27_K31_V0.8220.89
97_V109_I0.8200.89
116_L188_R0.8160.89
161_P207_E0.8140.89
3_F43_E0.8120.88
146_L223_V0.8100.88
130_I141_A0.8100.88
185_Y210_E0.8070.88
128_V182_L0.8070.88
134_E138_N0.8020.88
181_H209_L0.8010.88
23_D32_H0.7910.87
163_D166_R0.7900.87
93_V116_L0.7900.87
31_V57_A0.7840.87
232_T242_R0.7810.86
137_F163_D0.7780.86
11_Y20_P0.7770.86
38_R45_I0.7760.86
122_G220_K0.7740.86
128_V180_R0.7700.86
95_V113_A0.7690.86
73_Q77_E0.7670.85
31_V63_G0.7650.85
34_L47_V0.7630.85
152_A155_F0.7620.85
11_Y51_H0.7620.85
95_V112_V0.7590.85
52_E67_M0.7540.84
23_D28_P0.7540.84
139_P162_W0.7490.84
112_V186_G0.7490.84
74_S195_Y0.7460.84
70_A73_Q0.7440.84
152_A223_V0.7420.83
155_F181_H0.7380.83
163_D178_F0.7380.83
125_T209_L0.7370.83
107_T228_E0.7340.83
6_I79_L0.7300.82
181_H211_Q0.7270.82
80_A196_V0.7270.82
148_A216_W0.7240.82
3_F42_A0.7200.82
42_A109_I0.7160.81
24_I247_M0.7160.81
226_A229_V0.7150.81
39_E106_A0.7060.80
87_A189_A0.7050.80
69_R84_E0.7050.80
154_Y212_L0.7030.80
142_V155_F0.7020.80
145_V160_I0.7020.80
20_P99_G0.6920.79
155_F209_L0.6920.79
121_V222_H0.6910.79
24_I234_V0.6880.79
20_P30_I0.6840.78
83_V192_I0.6790.78
111_Q114_D0.6770.77
72_H77_E0.6760.77
47_V61_A0.6750.77
77_E196_V0.6740.77
138_N238_E0.6740.77
105_P226_A0.6700.77
25_N244_R0.6650.76
145_V156_S0.6650.76
209_L212_L0.6640.76
198_W214_V0.6610.76
96_N210_E0.6580.75
86_C91_D0.6570.75
47_V54_V0.6560.75
128_V230_P0.6560.75
133_A136_A0.6550.75
202_P216_W0.6540.75
52_E59_E0.6530.75
155_F211_Q0.6520.75
194_R197_N0.6520.75
154_Y160_I0.6510.75
148_A199_Q0.6510.75
35_E38_R0.6510.75
83_V94_I0.6510.75
122_G214_V0.6490.74
77_E192_I0.6490.74
81_E85_K0.6440.74
94_I189_A0.6430.74
51_H54_V0.6420.74
135_E138_N0.6420.74
44_R86_C0.6380.73
232_T243_V0.6360.73
205_H208_M0.6360.73
31_V58_V0.6350.73
24_I240_L0.6270.72
156_S161_P0.6260.72
111_Q126_L0.6230.71
148_A217_Y0.6210.71
91_D94_I0.6180.71
142_V157_R0.6160.71
25_N243_V0.6150.70
130_I159_T0.6150.70
112_V124_A0.6130.70
154_Y207_E0.6110.70
107_T111_Q0.6110.70
62_G65_V0.6110.70
122_G194_R0.6100.70
154_Y203_L0.6070.69
51_H70_A0.6000.69
242_R245_A0.5990.68
180_R231_G0.5980.68
23_D241_E0.5980.68
181_H185_Y0.5940.68
137_F167_F0.5940.68
72_H79_L0.5940.68
240_L243_V0.5910.67
141_A180_R0.5910.67
185_Y211_Q0.5900.67
5_V45_I0.5880.67
105_P108_I0.5870.67
58_V62_G0.5870.67
75_G181_H0.5860.67
239_D242_R0.5820.66
118_Q188_R0.5800.66
101_E157_R0.5760.65
199_Q217_Y0.5750.65
110_R114_D0.5750.65
40_S113_A0.5700.65
156_S207_E0.5690.65
202_P205_H0.5680.64
142_V183_G0.5670.64
76_T195_Y0.5660.64
143_K157_R0.5650.64
121_V151_Y0.5640.64
3_F113_A0.5630.64
148_A202_P0.5630.64
147_D153_L0.5630.64
96_N181_H0.5620.64
22_V244_R0.5610.63
108_I182_L0.5610.63
79_L187_Y0.5600.63
66_C86_C0.5600.63
205_H238_E0.5550.63
9_A30_I0.5540.62
75_G98_Q0.5540.62
183_G211_Q0.5540.62
78_R100_D0.5500.62
185_Y209_L0.5470.61
112_V126_L0.5470.61
202_P217_Y0.5460.61
87_A90_D0.5400.61
150_G225_V0.5390.60
23_D29_M0.5390.60
29_M244_R0.5390.60
244_R247_M0.5370.60
16_L140_N0.5370.60
5_V43_E0.5360.60
27_K32_H0.5350.60
128_V231_G0.5350.60
12_A18_G0.5330.60
179_L216_W0.5310.59
16_L236_T0.5270.59
47_V62_G0.5250.58
33_V36_R0.5240.58
142_V181_H0.5230.58
49_T70_A0.5230.58
74_S201_S0.5220.58
232_T246_E0.5220.58
20_P53_D0.5210.58
195_Y216_W0.5210.58
30_I34_L0.5210.58
6_I83_V0.5210.58
164_R233_G0.5200.58
53_D57_A0.5180.57
16_L25_N0.5180.57
75_G209_L0.5150.57
42_A113_A0.5140.57
3_F93_V0.5130.57
9_A13_S0.5130.57
159_T162_W0.5100.56
82_V195_Y0.5070.56
75_G211_Q0.5070.56
11_Y49_T0.5050.55
82_V87_A0.5040.55
202_P206_I0.5030.55
108_I115_N0.5030.55
125_T155_F0.5030.55
119_R188_R0.5020.55
101_E143_K0.5010.55
59_E148_A0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k8dA 2 0.9919 100 0.54 Contact Map
1vicA 2 0.996 100 0.55 Contact Map
3oamA 2 1 100 0.554 Contact Map
4xwiA 2 1 100 0.563 Contact Map
1h7eA 2 0.9516 100 0.564 Contact Map
3tqdA 2 0.9718 100 0.57 Contact Map
4fcuA 2 0.9919 100 0.579 Contact Map
2y6pA 2 0.9315 100 0.584 Contact Map
1eziA 2 0.8669 100 0.642 Contact Map
4g3qA 3 0.9315 100 0.664 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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