GREMLIN Database
NLPA - Lipoprotein 28
UniProt: P04846 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10657
Length: 272 (259)
Sequences: 3629 (2506)
Seq/√Len: 155.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_T173_D3.6081.00
254_P258_K3.3031.00
35_K65_V3.2081.00
133_T181_M3.1271.00
103_K236_E3.1021.00
235_R238_N3.0141.00
135_A197_V2.9831.00
132_A198_D2.9401.00
37_G82_L2.8961.00
258_K262_T2.8701.00
90_R94_E2.7991.00
53_V255_E2.6031.00
33_H61_D2.4931.00
95_Q99_A2.4851.00
130_E177_H2.4831.00
133_T179_Q2.4391.00
120_K193_D2.4351.00
122_I129_K2.3691.00
107_V244_V2.3421.00
58_Y246_E2.3271.00
108_G248_L2.3051.00
238_N241_A2.1461.00
49_V256_V2.0831.00
33_H63_E2.0801.00
123_K127_Q2.0741.00
129_K132_A2.0671.00
55_K61_D2.0641.00
136_I143_L2.0591.00
35_K63_E2.0471.00
168_A182_E2.0411.00
134_V199_V2.0191.00
137_P146_A2.0091.00
105_V236_E2.0071.00
78_N103_K1.9991.00
97_N102_Y1.9981.00
96_D102_Y1.9891.00
58_Y249_Q1.9681.00
148_L151_Q1.9221.00
213_S216_H1.8351.00
104_L233_V1.8111.00
258_K261_E1.7901.00
84_A234_A1.7841.00
117_G199_V1.7811.00
134_V178_L1.7561.00
153_E220_F1.6921.00
128_I199_V1.6581.00
155_L178_L1.6561.00
212_L217_D1.6461.00
242_E246_E1.6421.00
152_K223_D1.6141.00
80_G235_R1.6141.00
75_D79_H1.5811.00
48_E51_K1.5801.00
122_I198_D1.5581.00
254_P257_A1.5521.00
109_N229_V1.5281.00
90_R106_A1.5191.00
236_E239_K1.5121.00
84_A247_F1.5081.00
60_L246_E1.5081.00
45_D263_I1.4411.00
136_I180_I1.4371.00
213_S217_D1.4251.00
245_K249_Q1.4211.00
157_T172_T1.4031.00
53_V57_K1.3961.00
116_A218_S1.3831.00
159_K172_T1.3761.00
49_V53_V1.3701.00
171_I180_I1.3601.00
116_A221_I1.3521.00
248_L252_Q1.3401.00
128_I132_A1.3361.00
75_D96_D1.3281.00
105_V239_K1.3211.00
159_K170_D1.3201.00
130_E176_R1.3201.00
53_V256_V1.3201.00
71_L92_F1.3041.00
32_K243_N1.2921.00
162_K166_P1.2871.00
232_L248_L1.2831.00
49_V52_K1.2791.00
240_N245_K1.2781.00
259_A263_I1.2781.00
135_A191_V1.2671.00
78_N102_Y1.2631.00
241_A244_V1.2501.00
90_R231_I1.2491.00
34_I243_N1.2141.00
124_T127_Q1.2111.00
50_A53_V1.2071.00
51_K55_K1.2051.00
125_V220_F1.1991.00
44_Q66_G1.1871.00
48_E64_L1.1811.00
45_D264_F1.1791.00
139_D142_N1.1771.00
75_D100_H1.1751.00
60_L243_N1.1711.00
17_A20_L1.1551.00
77_T82_L1.1521.00
197_V200_A1.1431.00
158_L172_T1.1271.00
121_K198_D1.1241.00
107_V248_L1.1211.00
37_G77_T1.1181.00
106_A231_I1.1121.00
97_N236_E1.1091.00
49_V259_A1.0980.99
38_V47_A1.0820.99
122_I132_A1.0810.99
52_K55_K1.0790.99
97_N103_K1.0700.99
53_V250_S1.0690.99
117_G201_I1.0580.99
90_R109_N1.0550.99
188_L200_A1.0520.99
234_A238_N1.0400.99
34_I60_L1.0380.99
43_E111_F1.0370.99
21_L24_C1.0360.99
183_L191_V1.0330.99
151_Q157_T1.0330.99
80_G237_D1.0300.99
94_E98_Q1.0280.99
125_V128_I1.0260.99
77_T235_R1.0140.99
97_N104_L1.0040.99
234_A237_D1.0020.99
86_V110_T1.0010.99
72_L75_D0.9990.99
74_N88_Q0.9940.99
144_G166_P0.9920.99
49_V255_E0.9870.99
84_A244_V0.9790.99
37_G67_F0.9740.99
58_Y250_S0.9640.99
35_K83_D0.9610.99
246_E249_Q0.9550.99
199_V219_V0.9480.98
108_G232_L0.9420.98
151_Q155_L0.9390.98
159_K162_K0.9360.98
38_V44_Q0.9360.98
16_L19_I0.9300.98
95_Q98_Q0.9260.98
36_V47_A0.9260.98
93_L97_N0.9250.98
107_V234_A0.9170.98
70_S185_G0.9160.98
85_N88_Q0.9130.98
93_L231_I0.9130.98
174_N178_L0.9110.98
97_N105_V0.9070.98
67_F76_A0.9010.98
143_L168_A0.9010.98
115_M201_I0.8980.98
183_L188_L0.8950.98
20_L23_G0.8950.98
31_A61_D0.8940.98
93_L233_V0.8930.98
54_A250_S0.8840.98
117_G125_V0.8780.97
51_K61_D0.8730.97
34_I247_F0.8670.97
45_D48_E0.8660.97
15_L18_G0.8610.97
108_G252_Q0.8590.97
237_D241_A0.8560.97
69_G72_L0.8550.97
229_V271_G0.8490.97
16_L20_L0.8470.97
86_V251_Y0.8470.97
75_D78_N0.8410.97
96_D100_H0.8360.97
246_E250_S0.8350.97
43_E113_F0.8340.96
86_V111_F0.8310.96
213_S265_N0.8290.96
122_I199_V0.8280.96
106_A109_N0.8170.96
113_F205_T0.8170.96
95_Q141_T0.8060.96
15_L19_I0.8000.96
49_V250_S0.7970.95
189_P210_T0.7960.95
110_T251_Y0.7930.95
119_S122_I0.7930.95
128_I155_L0.7850.95
35_K77_T0.7820.95
218_S221_I0.7810.95
74_N87_F0.7810.95
53_V253_S0.7750.95
207_I212_L0.7750.95
24_C27_S0.7730.95
257_A261_E0.7710.95
192_L200_A0.7700.95
53_V58_Y0.7680.94
54_A60_L0.7670.94
31_A243_N0.7660.94
47_A86_V0.7650.94
187_Q191_V0.7600.94
96_D104_L0.7510.94
67_F82_L0.7500.94
143_L182_E0.7480.94
203_S230_N0.7470.94
135_A188_L0.7450.94
167_T170_D0.7440.93
74_N85_N0.7440.93
77_T238_N0.7410.93
47_A62_V0.7350.93
261_E270_P0.7350.93
110_T248_L0.7330.93
48_E52_K0.7300.93
106_A248_L0.7290.93
190_R193_D0.7290.93
29_S32_K0.7250.93
43_E86_V0.7250.93
214_P221_I0.7240.93
87_F92_F0.7220.92
139_D185_G0.7200.92
144_G148_L0.7200.92
223_D226_S0.7170.92
185_G203_S0.7110.92
168_A180_I0.7090.92
14_L18_G0.7090.92
131_G177_H0.7080.92
10_T20_L0.7080.92
191_V194_D0.7070.92
160_E163_G0.7040.91
70_S73_P0.7020.91
13_A17_A0.7020.91
174_N177_H0.7000.91
75_D102_Y0.6990.91
106_A233_V0.6950.91
44_Q48_E0.6900.91
146_A201_I0.6880.91
168_A172_T0.6870.90
18_G22_A0.6860.90
86_V113_F0.6860.90
32_K60_L0.6850.90
213_S218_S0.6840.90
172_T175_P0.6830.90
110_T252_Q0.6830.90
89_H141_T0.6810.90
70_S77_T0.6800.90
50_A250_S0.6790.90
163_G166_P0.6750.90
128_I198_D0.6740.90
113_F268_A0.6710.89
187_Q190_R0.6710.89
149_L153_E0.6700.89
215_V218_S0.6620.89
232_L251_Y0.6610.89
105_V234_A0.6600.89
41_G264_F0.6590.89
128_I134_V0.6570.88
205_T209_Q0.6560.88
123_K217_D0.6520.88
65_V77_T0.6470.88
91_P227_P0.6460.88
54_A62_V0.6450.88
24_C30_D0.6440.87
107_V233_V0.6380.87
186_A206_Y0.6380.87
51_K64_L0.6360.87
254_P261_E0.6360.87
117_G220_F0.6330.87
148_L152_K0.6330.87
70_S203_S0.6290.86
156_I180_I0.6290.86
28_S31_A0.6280.86
40_N66_G0.6260.86
192_L197_V0.6250.86
214_P218_S0.6240.86
135_A183_L0.6210.85
147_L156_I0.6200.85
155_L199_V0.6180.85
192_L212_L0.6160.85
47_A251_Y0.6140.85
24_C28_S0.6100.84
51_K54_A0.6090.84
259_A262_T0.6070.84
122_I128_I0.6050.84
204_T267_G0.6040.84
15_L20_L0.6030.84
262_T265_N0.6030.84
234_A241_A0.6000.83
22_A25_D0.6000.83
151_Q163_G0.5980.83
89_H93_L0.5970.83
37_G76_A0.5960.83
119_S127_Q0.5950.83
10_T22_A0.5950.83
70_S230_N0.5940.83
13_A16_L0.5940.83
149_L222_E0.5920.83
89_H139_D0.5920.83
178_L199_V0.5900.82
41_G45_D0.5900.82
73_P77_T0.5850.82
148_L166_P0.5840.82
43_E47_A0.5840.82
14_L20_L0.5830.82
138_N184_E0.5800.81
115_M204_T0.5770.81
125_V219_V0.5760.81
142_N146_A0.5750.81
137_P185_G0.5730.81
50_A54_A0.5700.80
241_A245_K0.5690.80
148_L164_L0.5640.80
147_L158_L0.5620.79
185_G189_P0.5610.79
189_P206_Y0.5600.79
126_A153_E0.5600.79
259_A264_F0.5590.79
93_L104_L0.5550.78
32_K61_D0.5550.78
117_G128_I0.5550.78
92_F96_D0.5550.78
132_A174_N0.5540.78
234_A239_K0.5530.78
114_P203_S0.5530.78
137_P201_I0.5500.78
78_N96_D0.5490.78
168_A179_Q0.5480.78
94_E97_N0.5480.78
57_K249_Q0.5460.77
151_Q160_E0.5460.77
70_S139_D0.5460.77
89_H231_I0.5450.77
136_I182_E0.5440.77
13_A19_I0.5440.77
214_P217_D0.5430.77
192_L202_I0.5420.77
46_V259_A0.5410.77
89_H142_N0.5350.76
85_N92_F0.5340.76
143_L167_T0.5330.76
48_E66_G0.5320.76
249_Q252_Q0.5310.75
137_P142_N0.5290.75
50_A256_V0.5290.75
184_E189_P0.5290.75
113_F204_T0.5280.75
151_Q161_G0.5270.75
154_K157_T0.5270.75
110_T113_F0.5270.75
220_F223_D0.5250.75
36_V63_E0.5250.75
98_Q165_L0.5250.75
123_K157_T0.5250.75
12_A15_L0.5250.75
76_A81_E0.5240.74
139_D146_A0.5240.74
69_G73_P0.5230.74
71_L75_D0.5220.74
107_V239_K0.5210.74
181_M197_V0.5210.74
122_I125_V0.5200.74
143_L185_G0.5200.74
238_N244_V0.5190.74
123_K159_K0.5190.74
92_F209_Q0.5190.74
34_I244_V0.5170.73
62_V247_F0.5170.73
234_A244_V0.5150.73
13_A20_L0.5150.73
113_F230_N0.5140.73
34_I84_A0.5130.73
123_K126_A0.5120.73
67_F70_S0.5120.73
260_A270_P0.5110.73
150_L201_I0.5110.73
11_G14_L0.5100.72
10_T16_L0.5080.72
205_T208_Q0.5070.72
47_A64_L0.5070.72
115_M203_S0.5060.72
138_N182_E0.5060.72
128_I178_L0.5060.72
174_N180_I0.5050.72
257_A270_P0.5020.71
189_P202_I0.5010.71
34_I62_V0.5010.71
96_D101_G0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qhqA 1 0.875 100 0.401 Contact Map
3ir1A 3 0.8713 100 0.464 Contact Map
4ntlA 1 0.8787 100 0.48 Contact Map
3up9A 1 0.8676 100 0.483 Contact Map
4oteA 4 0.8824 100 0.486 Contact Map
1xs5A 1 0.8787 100 0.506 Contact Map
3gxaA 3 0.8713 100 0.507 Contact Map
4k3fA 1 0.8824 100 0.508 Contact Map
3tqwA 1 0.864 100 0.51 Contact Map
4q5tA 1 0.8934 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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