GREMLIN Database
AMPN - Aminopeptidase N
UniProt: P04825 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10696
Length: 870 (764)
Sequences: 4978 (3499)
Seq/√Len: 126.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_D231_K3.9991.00
26_T146_I3.7721.00
410_R427_D3.6521.00
142_T178_D3.6301.00
22_D140_R3.6211.00
228_T232_N3.6061.00
198_R212_E3.3751.00
24_D142_T3.3351.00
149_K166_E3.2691.00
131_Y141_F3.1921.00
411_H424_A3.0891.00
235_K239_E3.0491.00
120_C128_I2.9741.00
406_L427_D2.8881.00
146_I173_W2.8401.00
144_K175_Q2.7931.00
406_L410_R2.6991.00
147_A174_V2.6901.00
21_T43_V2.6821.00
196_V212_E2.6581.00
92_L102_A2.6381.00
60_K99_S2.6041.00
729_D733_Q2.6011.00
704_F734_E2.5941.00
147_A155_L2.5671.00
92_L100_P2.5431.00
448_V483_I2.5381.00
165_G173_W2.5241.00
19_Q45_H2.5091.00
98_I102_A2.5071.00
399_N429_S2.4841.00
63_S97_E2.4731.00
240_R401_Q2.4311.00
448_V465_I2.4311.00
140_R178_D2.4111.00
149_K170_G2.4031.00
205_S244_E2.3921.00
633_D637_I2.3851.00
143_T187_F2.3511.00
30_D33_K2.3381.00
90_F100_P2.3041.00
20_I132_L2.2931.00
547_S550_Q2.2721.00
28_D146_I2.2591.00
634_P637_I2.2391.00
94_I100_P2.2271.00
92_L98_I2.2171.00
401_Q405_Q2.1981.00
160_N248_D2.1691.00
145_I189_L2.1351.00
198_R210_A2.1191.00
99_S102_A2.1171.00
243_L408_F2.1121.00
42_A54_L2.1061.00
242_G409_E2.1031.00
465_I485_F2.1031.00
90_F102_A2.0731.00
162_V177_Q2.0591.00
164_Q172_H2.0381.00
466_S516_E2.0361.00
450_V465_I2.0321.00
28_D171_R2.0311.00
62_V99_S2.0131.00
161_R164_Q2.0111.00
364_I387_V2.0111.00
90_F98_I2.0101.00
469_T481_L2.0071.00
140_R181_P1.9921.00
402_K405_Q1.9901.00
395_L399_N1.9831.00
311_R417_T1.9821.00
26_T144_K1.9781.00
190_V268_L1.9751.00
129_T187_F1.9741.00
96_N100_P1.9731.00
702_K706_E1.9721.00
693_T696_A1.9661.00
481_L488_E1.9591.00
392_H397_E1.9591.00
156_L268_L1.9531.00
86_L89_R1.9521.00
510_L519_F1.9511.00
149_K172_H1.9501.00
195_D220_L1.9271.00
66_I94_I1.9261.00
163_A175_Q1.9111.00
395_L425_M1.9071.00
325_F392_H1.9061.00
53_R80_A1.9011.00
159_G248_D1.8971.00
90_F96_N1.8771.00
167_L173_W1.8761.00
514_Q517_Q1.8701.00
195_D217_R1.8701.00
45_H91_T1.8681.00
554_L557_H1.8671.00
197_L223_A1.8651.00
22_D142_T1.8631.00
464_T516_E1.8411.00
23_I139_A1.8391.00
252_I271_F1.8321.00
145_I155_L1.8281.00
65_H95_I1.8211.00
67_N92_L1.8211.00
21_T45_H1.8191.00
94_I98_I1.8181.00
483_I488_E1.8121.00
275_Y290_D1.8071.00
161_R174_V1.7961.00
329_E337_R1.7941.00
733_Q737_D1.7861.00
141_F184_C1.7801.00
462_T518_T1.7761.00
659_I663_N1.7751.00
448_V512_V1.7711.00
432_D435_H1.7521.00
39_V97_E1.7401.00
131_Y184_C1.7341.00
94_I102_A1.7261.00
197_L224_P1.7251.00
452_D461_Y1.7241.00
689_A700_V1.7211.00
41_Q95_I1.7101.00
546_W550_Q1.7081.00
233_S296_G1.7041.00
701_S705_H1.7001.00
771_H774_F1.6951.00
212_E251_M1.6931.00
606_E609_D1.6921.00
637_I640_V1.6901.00
449_T466_S1.6901.00
62_V97_E1.6881.00
57_E79_G1.6781.00
193_D217_R1.6731.00
703_Q706_E1.6721.00
406_L428_A1.6681.00
256_D273_S1.6661.00
242_G405_Q1.6621.00
43_V91_T1.6591.00
41_Q93_K1.6491.00
431_V511_N1.6321.00
635_I639_E1.6191.00
140_R177_Q1.6171.00
22_D178_D1.6121.00
484_P488_E1.6091.00
632_I637_I1.6071.00
411_H420_D1.6061.00
43_V93_K1.5991.00
399_N402_K1.5961.00
289_L343_N1.5931.00
736_D746_M1.5891.00
409_E412_D1.5761.00
319_K376_Y1.5671.00
92_L96_N1.5621.00
211_L230_L1.5561.00
329_E392_H1.5541.00
39_V95_I1.5521.00
461_Y530_P1.5501.00
576_I579_N1.5411.00
226_A295_I1.5391.00
459_E524_V1.5331.00
86_L90_F1.5321.00
361_A443_S1.5321.00
437_R441_S1.5321.00
455_N459_E1.5321.00
240_R397_E1.5261.00
136_D311_R1.5241.00
632_I636_A1.5171.00
405_Q409_E1.5161.00
144_K173_W1.5141.00
403_G425_M1.5061.00
449_T543_E1.5051.00
215_V223_A1.5051.00
694_H698_V1.4981.00
659_I662_A1.4961.00
633_D636_A1.4951.00
481_L484_P1.4921.00
224_P228_T1.4761.00
686_R722_A1.4731.00
700_V716_A1.4721.00
128_I189_L1.4691.00
411_H414_S1.4661.00
36_V100_P1.4631.00
720_A731_L1.4611.00
90_F94_I1.4561.00
213_L226_A1.4461.00
190_V253_V1.4451.00
351_L378_L1.4441.00
658_A662_A1.4441.00
472_T478_K1.4361.00
160_N177_Q1.4211.00
681_R703_Q1.4131.00
636_A639_E1.4121.00
196_V214_Y1.4121.00
632_I635_I1.4111.00
546_W549_Q1.4101.00
26_T39_V1.4091.00
483_I490_Y1.4071.00
410_R424_A1.4001.00
96_N102_A1.4001.00
635_I638_A1.3981.00
533_L542_L1.3951.00
253_V268_L1.3941.00
298_E301_H1.3921.00
465_I512_V1.3861.00
362_H377_T1.3841.00
553_F557_H1.3801.00
63_S70_P1.3801.00
105_A127_H1.3791.00
403_G424_A1.3771.00
199_D227_M1.3691.00
251_M267_G1.3681.00
423_Q426_E1.3641.00
450_V532_L1.3621.00
213_L227_M1.3591.00
190_V194_F1.3591.00
243_L412_D1.3551.00
575_Y578_L1.3531.00
454_Y524_V1.3481.00
150_I193_D1.3481.00
634_P638_A1.3471.00
447_I541_K1.3441.00
293_R327_D1.3411.00
215_V220_L1.3381.00
742_N745_V1.3381.00
216_D219_N1.3381.00
230_L252_I1.3341.00
297_H301_H1.3341.00
143_T157_S1.3311.00
419_D434_S1.3301.00
448_V533_L1.3291.00
464_T518_T1.3281.00
340_N344_N1.3271.00
221_D279_R1.3271.00
155_L174_V1.3271.00
297_H381_Y1.3221.00
60_K97_E1.3191.00
301_H381_Y1.3151.00
225_W229_S1.3111.00
262_A294_V1.3061.00
125_F131_Y1.2981.00
609_D612_L1.2981.00
219_N222_R1.2961.00
624_E628_L1.2951.00
109_L116_L1.2931.00
479_Q483_I1.2891.00
112_S257_F1.2871.00
188_A268_L1.2851.00
142_T175_Q1.2841.00
654_D658_A1.2791.00
480_P484_P1.2751.00
576_I580_V1.2721.00
283_A287_D1.2721.00
483_I489_L1.2671.00
237_D330_F1.2671.00
766_R770_Q1.2641.00
605_D608_I1.2611.00
225_W335_G1.2591.00
698_V701_S1.2551.00
513_T517_Q1.2551.00
577_K580_V1.2531.00
636_A640_V1.2531.00
481_L490_Y1.2531.00
24_D144_K1.2521.00
608_I613_A1.2501.00
264_E297_H1.2491.00
24_D175_Q1.2481.00
310_C415_A1.2481.00
447_I543_E1.2471.00
38_A130_Y1.2451.00
438_R479_Q1.2391.00
451_K466_S1.2361.00
423_Q427_D1.2361.00
264_E298_E1.2341.00
275_Y294_V1.2341.00
26_T173_W1.2280.99
264_E301_H1.2240.99
455_N458_T1.2210.99
702_K705_H1.2200.99
633_D638_A1.2150.99
494_G498_P1.2110.99
243_L405_Q1.2110.99
480_P483_I1.2090.99
235_K238_E1.2090.99
19_Q46_G1.2080.99
698_V702_K1.2080.99
75_K78_E1.2060.99
163_A173_W1.2040.99
344_N385_A1.2040.99
142_T162_V1.2020.99
154_F196_V1.1960.99
119_Q260_M1.1940.99
767_G771_H1.1940.99
481_L489_L1.1900.99
365_R441_S1.1890.99
138_L183_P1.1870.99
751_I788_A1.1830.99
453_D462_T1.1830.99
491_D495_K1.1820.99
472_T475_Q1.1820.99
535_E560_N1.1720.99
485_F532_L1.1700.99
424_A428_A1.1690.99
260_M319_K1.1690.99
119_Q122_A1.1660.99
195_D218_G1.1660.99
530_P546_W1.1650.99
454_Y459_E1.1620.99
460_Q520_V1.1620.99
298_E381_Y1.1580.99
561_D571_L1.1580.99
250_Y299_Y1.1570.99
243_L409_E1.1480.99
681_R712_D1.1480.99
322_L404_M1.1470.99
484_P490_Y1.1450.99
44_R94_I1.1410.99
75_K80_A1.1390.99
308_V408_F1.1380.99
236_W329_E1.1360.99
182_K186_L1.1360.99
391_I422_V1.1310.99
65_H70_P1.1280.99
641_R645_T1.1250.99
269_N299_Y1.1190.99
301_H320_E1.1180.99
304_T322_L1.1160.99
57_E127_H1.1100.99
117_C255_V1.1040.99
219_N273_S1.1020.99
148_D171_R1.1000.99
111_Q116_L1.0980.99
495_K498_P1.0970.99
25_L143_T1.0950.99
424_A427_D1.0950.99
633_D640_V1.0940.99
482_H488_E1.0940.99
165_G175_Q1.0920.99
119_Q124_G1.0910.99
575_Y579_N1.0900.99
488_E534_C1.0870.99
426_E432_D1.0860.99
689_A723_A1.0840.99
27_F189_L1.0800.99
24_D41_Q1.0790.99
606_E612_L1.0780.99
532_L544_Y1.0750.99
713_A739_W1.0750.99
451_K464_T1.0750.99
481_L486_A1.0740.99
264_E381_Y1.0700.99
613_A617_L1.0690.99
75_K79_G1.0680.99
324_V327_D1.0640.99
657_L661_N1.0610.98
58_D76_E1.0600.98
59_L100_P1.0590.98
211_L231_K1.0580.98
765_V769_L1.0560.98
610_P613_A1.0560.98
459_E523_N1.0560.98
766_R769_L1.0550.98
321_G388_I1.0520.98
53_R82_V1.0510.98
476_A479_Q1.0500.98
612_L616_I1.0490.98
75_K82_V1.0480.98
694_H730_A1.0480.98
321_G384_G1.0450.98
156_L253_V1.0430.98
36_V98_I1.0430.98
229_S292_E1.0420.98
460_Q522_D1.0420.98
479_Q488_E1.0410.98
119_Q265_N1.0410.98
124_G127_H1.0400.98
630_D633_D1.0390.98
492_N526_F1.0380.98
51_P84_S1.0360.98
555_M568_A1.0360.98
637_I641_R1.0350.98
623_N627_E1.0320.98
63_S95_I1.0310.98
786_I790_A1.0290.98
167_L171_R1.0260.98
484_P487_I1.0260.98
366_P375_F1.0250.98
782_I790_A1.0250.98
420_D423_Q1.0240.98
378_L382_E1.0190.98
402_K406_L1.0190.98
247_L266_K1.0170.98
404_M408_F1.0170.98
713_A738_K1.0150.98
482_H511_N1.0130.98
166_E172_H1.0110.98
465_I468_R1.0110.98
55_N80_A1.0110.98
406_L424_A1.0110.98
399_N428_A1.0100.98
438_R481_L1.0100.98
764_T767_G1.0080.98
448_V540_V1.0070.98
225_W292_E1.0060.98
74_W81_L1.0050.98
438_R482_H1.0050.98
600_R655_E1.0050.98
543_E549_Q1.0040.98
291_I294_V1.0040.98
696_A699_L1.0010.98
142_T177_Q0.9940.98
29_L109_L0.9940.98
548_D574_T0.9920.98
254_A277_L0.9890.98
635_I640_V0.9880.98
623_N626_A0.9870.98
258_F261_G0.9860.98
633_D641_R0.9860.98
19_Q181_P0.9840.98
150_I172_H0.9830.98
161_R212_E0.9820.98
408_F416_A0.9810.97
479_Q484_P0.9810.97
21_T91_T0.9770.97
483_I487_I0.9750.97
450_V463_L0.9740.97
367_D441_S0.9730.97
263_M301_H0.9710.97
77_E80_A0.9700.97
81_L85_N0.9670.97
18_Y88_E0.9670.97
320_E381_Y0.9660.97
22_D43_V0.9640.97
297_H320_E0.9620.97
237_D300_F0.9620.97
632_I641_R0.9610.97
236_W333_D0.9600.97
578_L581_A0.9590.97
496_V559_R0.9540.97
768_L775_T0.9510.97
768_L772_R0.9480.97
560_N563_S0.9480.97
746_M750_F0.9480.97
51_P82_V0.9470.97
633_D639_E0.9470.97
290_D294_V0.9470.97
146_I171_R0.9460.97
442_Q479_Q0.9460.97
304_T308_V0.9420.97
368_M371_E0.9420.97
300_F326_R0.9410.97
122_A373_N0.9380.97
621_S625_M0.9380.97
87_P90_F0.9360.97
721_V752_L0.9350.97
649_A656_L0.9350.97
607_K613_A0.9310.97
204_R239_E0.9300.97
478_K481_L0.9280.96
459_E525_Y0.9270.96
707_A712_D0.9270.96
66_I71_W0.9260.96
110_Y258_F0.9260.96
452_D527_Q0.9250.96
405_Q408_F0.9250.96
38_A100_P0.9230.96
481_L487_I0.9220.96
121_E319_K0.9220.96
274_K290_D0.9200.96
236_W330_F0.9190.96
132_L137_V0.9170.96
682_N703_Q0.9160.96
661_N664_Y0.9150.96
422_V437_R0.9130.96
488_E496_V0.9120.96
263_M297_H0.9110.96
402_K428_A0.9100.96
551_L567_A0.9100.96
454_Y526_F0.9090.96
479_Q482_H0.9080.96
200_T210_A0.9070.96
484_P489_L0.9070.96
162_V175_Q0.9070.96
393_T537_S0.9060.96
315_Q365_R0.9050.96
182_K266_K0.9020.96
695_L699_L0.9020.96
473_P478_K0.8980.96
65_H93_K0.8980.96
177_Q248_D0.8960.96
475_Q478_K0.8950.96
333_D397_E0.8940.96
736_D773_S0.8930.96
102_A116_L0.8890.96
756_S759_A0.8870.95
85_N88_E0.8850.95
221_D224_P0.8850.95
204_R235_K0.8840.95
263_M298_E0.8830.95
263_M381_Y0.8830.95
553_F556_R0.8820.95
77_E82_V0.8820.95
20_I42_A0.8810.95
466_S515_A0.8810.95
264_E320_E0.8800.95
482_H513_T0.8790.95
35_V99_S0.8780.95
452_D545_K0.8780.95
451_K462_T0.8770.95
110_Y257_F0.8770.95
491_D528_P0.8760.95
540_V544_Y0.8750.95
262_A381_Y0.8720.95
634_P639_E0.8720.95
426_E437_R0.8690.95
608_I612_L0.8680.95
80_A83_I0.8670.95
318_L407_Y0.8670.95
216_D273_S0.8660.95
606_E611_A0.8650.95
56_G100_P0.8610.95
298_E320_E0.8590.95
545_K548_D0.8580.95
156_L214_Y0.8570.95
159_G179_P0.8550.94
773_S777_S0.8550.94
58_D105_A0.8540.94
630_D637_I0.8520.94
533_L540_V0.8510.94
468_R567_A0.8500.94
138_L309_T0.8490.94
56_G59_L0.8480.94
494_G497_I0.8480.94
463_L485_F0.8470.94
345_V389_R0.8470.94
649_A691_G0.8410.94
28_D37_T0.8400.94
748_K752_L0.8380.94
329_E397_E0.8380.94
308_V424_A0.8370.94
784_S788_A0.8370.94
403_G428_A0.8350.94
23_I42_A0.8350.94
435_H513_T0.8340.94
481_L485_F0.8340.94
37_T97_E0.8320.94
697_D731_L0.8320.94
167_L170_G0.8310.94
120_C125_F0.8300.94
655_E658_A0.8300.94
737_D740_H0.8300.94
480_P488_E0.8290.94
258_F272_N0.8280.93
699_L703_Q0.8270.93
29_L116_L0.8240.93
261_G381_Y0.8230.93
485_F512_V0.8230.93
331_S340_N0.8200.93
217_R220_L0.8190.93
698_V730_A0.8180.93
192_G253_V0.8170.93
376_Y380_V0.8140.93
656_L687_F0.8140.93
737_D741_Q0.8130.93
704_F731_L0.8120.93
316_L362_H0.8120.93
695_L698_V0.8100.93
64_V83_I0.8090.93
474_D478_K0.8090.93
10_R367_D0.8080.93
434_S437_R0.8070.93
304_T404_M0.8050.93
66_I92_L0.8050.93
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654_D662_A0.5010.63
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573_A624_E0.5000.63
48_S88_E0.5000.63
263_M376_Y0.5000.63
666_S674_D0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yd0A 1 0.9322 100 0.19 Contact Map
4jbsA 1 0.9402 100 0.194 Contact Map
4kx7A 1 0.9368 100 0.198 Contact Map
4fkeA 1 0.9391 100 0.198 Contact Map
4pj6A 2 0.9299 100 0.208 Contact Map
4wz9A 2 0.9356 100 0.211 Contact Map
1z5hA 3 0.8736 100 0.264 Contact Map
4x2uA 1 0.9805 100 0.339 Contact Map
4qhpA 1 0.9874 100 0.347 Contact Map
3b34A 1 0.9885 100 0.347 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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