AMPN - ECOLI - GREMLIN Contacts

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AMPN - Aminopeptidase N

UniProt:	P04825	Sequences: MTQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10696
Length:	870 (764)
Sequences:	4978 (3499)
Seq/√Len:	126.6

ECOLI - AMPN
SULSO - APE1 APE2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_D	231_K	3.999	1.00
26_T	146_I	3.772	1.00
410_R	427_D	3.652	1.00
142_T	178_D	3.630	1.00
22_D	140_R	3.621	1.00
228_T	232_N	3.606	1.00
198_R	212_E	3.375	1.00
24_D	142_T	3.335	1.00
149_K	166_E	3.269	1.00
131_Y	141_F	3.192	1.00
411_H	424_A	3.089	1.00
235_K	239_E	3.049	1.00
120_C	128_I	2.974	1.00
406_L	427_D	2.888	1.00
146_I	173_W	2.840	1.00
144_K	175_Q	2.793	1.00
406_L	410_R	2.699	1.00
147_A	174_V	2.690	1.00
21_T	43_V	2.682	1.00
196_V	212_E	2.658	1.00
92_L	102_A	2.638	1.00
60_K	99_S	2.604	1.00
729_D	733_Q	2.601	1.00
704_F	734_E	2.594	1.00
147_A	155_L	2.567	1.00
92_L	100_P	2.543	1.00
448_V	483_I	2.538	1.00
165_G	173_W	2.524	1.00
19_Q	45_H	2.509	1.00
98_I	102_A	2.507	1.00
399_N	429_S	2.484	1.00
63_S	97_E	2.473	1.00
240_R	401_Q	2.431	1.00
448_V	465_I	2.431	1.00
140_R	178_D	2.411	1.00
149_K	170_G	2.403	1.00
205_S	244_E	2.392	1.00
633_D	637_I	2.385	1.00
143_T	187_F	2.351	1.00
30_D	33_K	2.338	1.00
90_F	100_P	2.304	1.00
20_I	132_L	2.293	1.00
547_S	550_Q	2.272	1.00
28_D	146_I	2.259	1.00
634_P	637_I	2.239	1.00
94_I	100_P	2.227	1.00
92_L	98_I	2.217	1.00
401_Q	405_Q	2.198	1.00
160_N	248_D	2.169	1.00
145_I	189_L	2.135	1.00
198_R	210_A	2.119	1.00
99_S	102_A	2.117	1.00
243_L	408_F	2.112	1.00
42_A	54_L	2.106	1.00
242_G	409_E	2.103	1.00
465_I	485_F	2.103	1.00
90_F	102_A	2.073	1.00
162_V	177_Q	2.059	1.00
164_Q	172_H	2.038	1.00
466_S	516_E	2.036	1.00
450_V	465_I	2.032	1.00
28_D	171_R	2.031	1.00
62_V	99_S	2.013	1.00
161_R	164_Q	2.011	1.00
364_I	387_V	2.011	1.00
90_F	98_I	2.010	1.00
469_T	481_L	2.007	1.00
140_R	181_P	1.992	1.00
402_K	405_Q	1.990	1.00
395_L	399_N	1.983	1.00
311_R	417_T	1.982	1.00
26_T	144_K	1.978	1.00
190_V	268_L	1.975	1.00
129_T	187_F	1.974	1.00
96_N	100_P	1.973	1.00
702_K	706_E	1.972	1.00
693_T	696_A	1.966	1.00
481_L	488_E	1.959	1.00
392_H	397_E	1.959	1.00
156_L	268_L	1.953	1.00
86_L	89_R	1.952	1.00
510_L	519_F	1.951	1.00
149_K	172_H	1.950	1.00
195_D	220_L	1.927	1.00
66_I	94_I	1.926	1.00
163_A	175_Q	1.911	1.00
395_L	425_M	1.907	1.00
325_F	392_H	1.906	1.00
53_R	80_A	1.901	1.00
159_G	248_D	1.897	1.00
90_F	96_N	1.877	1.00
167_L	173_W	1.876	1.00
514_Q	517_Q	1.870	1.00
195_D	217_R	1.870	1.00
45_H	91_T	1.868	1.00
554_L	557_H	1.867	1.00
197_L	223_A	1.865	1.00
22_D	142_T	1.863	1.00
464_T	516_E	1.841	1.00
23_I	139_A	1.839	1.00
252_I	271_F	1.832	1.00
145_I	155_L	1.828	1.00
65_H	95_I	1.821	1.00
67_N	92_L	1.821	1.00
21_T	45_H	1.819	1.00
94_I	98_I	1.818	1.00
483_I	488_E	1.812	1.00
275_Y	290_D	1.807	1.00
161_R	174_V	1.796	1.00
329_E	337_R	1.794	1.00
733_Q	737_D	1.786	1.00
141_F	184_C	1.780	1.00
462_T	518_T	1.776	1.00
659_I	663_N	1.775	1.00
448_V	512_V	1.771	1.00
432_D	435_H	1.752	1.00
39_V	97_E	1.740	1.00
131_Y	184_C	1.734	1.00
94_I	102_A	1.726	1.00
197_L	224_P	1.725	1.00
452_D	461_Y	1.724	1.00
689_A	700_V	1.721	1.00
41_Q	95_I	1.710	1.00
546_W	550_Q	1.708	1.00
233_S	296_G	1.704	1.00
701_S	705_H	1.700	1.00
771_H	774_F	1.695	1.00
212_E	251_M	1.693	1.00
606_E	609_D	1.692	1.00
637_I	640_V	1.690	1.00
449_T	466_S	1.690	1.00
62_V	97_E	1.688	1.00
57_E	79_G	1.678	1.00
193_D	217_R	1.673	1.00
703_Q	706_E	1.672	1.00
406_L	428_A	1.668	1.00
256_D	273_S	1.666	1.00
242_G	405_Q	1.662	1.00
43_V	91_T	1.659	1.00
41_Q	93_K	1.649	1.00
431_V	511_N	1.632	1.00
635_I	639_E	1.619	1.00
140_R	177_Q	1.617	1.00
22_D	178_D	1.612	1.00
484_P	488_E	1.609	1.00
632_I	637_I	1.607	1.00
411_H	420_D	1.606	1.00
43_V	93_K	1.599	1.00
399_N	402_K	1.596	1.00
289_L	343_N	1.593	1.00
736_D	746_M	1.589	1.00
409_E	412_D	1.576	1.00
319_K	376_Y	1.567	1.00
92_L	96_N	1.562	1.00
211_L	230_L	1.556	1.00
329_E	392_H	1.554	1.00
39_V	95_I	1.552	1.00
461_Y	530_P	1.550	1.00
576_I	579_N	1.541	1.00
226_A	295_I	1.539	1.00
459_E	524_V	1.533	1.00
86_L	90_F	1.532	1.00
361_A	443_S	1.532	1.00
437_R	441_S	1.532	1.00
455_N	459_E	1.532	1.00
240_R	397_E	1.526	1.00
136_D	311_R	1.524	1.00
632_I	636_A	1.517	1.00
405_Q	409_E	1.516	1.00
144_K	173_W	1.514	1.00
403_G	425_M	1.506	1.00
449_T	543_E	1.505	1.00
215_V	223_A	1.505	1.00
694_H	698_V	1.498	1.00
659_I	662_A	1.496	1.00
633_D	636_A	1.495	1.00
481_L	484_P	1.492	1.00
224_P	228_T	1.476	1.00
686_R	722_A	1.473	1.00
700_V	716_A	1.472	1.00
128_I	189_L	1.469	1.00
411_H	414_S	1.466	1.00
36_V	100_P	1.463	1.00
720_A	731_L	1.461	1.00
90_F	94_I	1.456	1.00
213_L	226_A	1.446	1.00
190_V	253_V	1.445	1.00
351_L	378_L	1.444	1.00
658_A	662_A	1.444	1.00
472_T	478_K	1.436	1.00
160_N	177_Q	1.421	1.00
681_R	703_Q	1.413	1.00
636_A	639_E	1.412	1.00
196_V	214_Y	1.412	1.00
632_I	635_I	1.411	1.00
546_W	549_Q	1.410	1.00
26_T	39_V	1.409	1.00
483_I	490_Y	1.407	1.00
410_R	424_A	1.400	1.00
96_N	102_A	1.400	1.00
635_I	638_A	1.398	1.00
533_L	542_L	1.395	1.00
253_V	268_L	1.394	1.00
298_E	301_H	1.392	1.00
465_I	512_V	1.386	1.00
362_H	377_T	1.384	1.00
553_F	557_H	1.380	1.00
63_S	70_P	1.380	1.00
105_A	127_H	1.379	1.00
403_G	424_A	1.377	1.00
199_D	227_M	1.369	1.00
251_M	267_G	1.368	1.00
423_Q	426_E	1.364	1.00
450_V	532_L	1.362	1.00
213_L	227_M	1.359	1.00
190_V	194_F	1.359	1.00
243_L	412_D	1.355	1.00
575_Y	578_L	1.353	1.00
454_Y	524_V	1.348	1.00
150_I	193_D	1.348	1.00
634_P	638_A	1.347	1.00
447_I	541_K	1.344	1.00
293_R	327_D	1.341	1.00
215_V	220_L	1.338	1.00
742_N	745_V	1.338	1.00
216_D	219_N	1.338	1.00
230_L	252_I	1.334	1.00
297_H	301_H	1.334	1.00
143_T	157_S	1.331	1.00
419_D	434_S	1.330	1.00
448_V	533_L	1.329	1.00
464_T	518_T	1.328	1.00
340_N	344_N	1.327	1.00
221_D	279_R	1.327	1.00
155_L	174_V	1.327	1.00
297_H	381_Y	1.322	1.00
60_K	97_E	1.319	1.00
301_H	381_Y	1.315	1.00
225_W	229_S	1.311	1.00
262_A	294_V	1.306	1.00
125_F	131_Y	1.298	1.00
609_D	612_L	1.298	1.00
219_N	222_R	1.296	1.00
624_E	628_L	1.295	1.00
109_L	116_L	1.293	1.00
479_Q	483_I	1.289	1.00
112_S	257_F	1.287	1.00
188_A	268_L	1.285	1.00
142_T	175_Q	1.284	1.00
654_D	658_A	1.279	1.00
480_P	484_P	1.275	1.00
576_I	580_V	1.272	1.00
283_A	287_D	1.272	1.00
483_I	489_L	1.267	1.00
237_D	330_F	1.267	1.00
766_R	770_Q	1.264	1.00
605_D	608_I	1.261	1.00
225_W	335_G	1.259	1.00
698_V	701_S	1.255	1.00
513_T	517_Q	1.255	1.00
577_K	580_V	1.253	1.00
636_A	640_V	1.253	1.00
481_L	490_Y	1.253	1.00
24_D	144_K	1.252	1.00
608_I	613_A	1.250	1.00
264_E	297_H	1.249	1.00
24_D	175_Q	1.248	1.00
310_C	415_A	1.248	1.00
447_I	543_E	1.247	1.00
38_A	130_Y	1.245	1.00
438_R	479_Q	1.239	1.00
451_K	466_S	1.236	1.00
423_Q	427_D	1.236	1.00
264_E	298_E	1.234	1.00
275_Y	294_V	1.234	1.00
26_T	173_W	1.228	0.99
264_E	301_H	1.224	0.99
455_N	458_T	1.221	0.99
702_K	705_H	1.220	0.99
633_D	638_A	1.215	0.99
494_G	498_P	1.211	0.99
243_L	405_Q	1.211	0.99
480_P	483_I	1.209	0.99
235_K	238_E	1.209	0.99
19_Q	46_G	1.208	0.99
698_V	702_K	1.208	0.99
75_K	78_E	1.206	0.99
163_A	173_W	1.204	0.99
344_N	385_A	1.204	0.99
142_T	162_V	1.202	0.99
154_F	196_V	1.196	0.99
119_Q	260_M	1.194	0.99
767_G	771_H	1.194	0.99
481_L	489_L	1.190	0.99
365_R	441_S	1.189	0.99
138_L	183_P	1.187	0.99
751_I	788_A	1.183	0.99
453_D	462_T	1.183	0.99
491_D	495_K	1.182	0.99
472_T	475_Q	1.182	0.99
535_E	560_N	1.172	0.99
485_F	532_L	1.170	0.99
424_A	428_A	1.169	0.99
260_M	319_K	1.169	0.99
119_Q	122_A	1.166	0.99
195_D	218_G	1.166	0.99
530_P	546_W	1.165	0.99
454_Y	459_E	1.162	0.99
460_Q	520_V	1.162	0.99
298_E	381_Y	1.158	0.99
561_D	571_L	1.158	0.99
250_Y	299_Y	1.157	0.99
243_L	409_E	1.148	0.99
681_R	712_D	1.148	0.99
322_L	404_M	1.147	0.99
484_P	490_Y	1.145	0.99
44_R	94_I	1.141	0.99
75_K	80_A	1.139	0.99
308_V	408_F	1.138	0.99
236_W	329_E	1.136	0.99
182_K	186_L	1.136	0.99
391_I	422_V	1.131	0.99
65_H	70_P	1.128	0.99
641_R	645_T	1.125	0.99
269_N	299_Y	1.119	0.99
301_H	320_E	1.118	0.99
304_T	322_L	1.116	0.99
57_E	127_H	1.110	0.99
117_C	255_V	1.104	0.99
219_N	273_S	1.102	0.99
148_D	171_R	1.100	0.99
111_Q	116_L	1.098	0.99
495_K	498_P	1.097	0.99
25_L	143_T	1.095	0.99
424_A	427_D	1.095	0.99
633_D	640_V	1.094	0.99
482_H	488_E	1.094	0.99
165_G	175_Q	1.092	0.99
119_Q	124_G	1.091	0.99
575_Y	579_N	1.090	0.99
488_E	534_C	1.087	0.99
426_E	432_D	1.086	0.99
689_A	723_A	1.084	0.99
27_F	189_L	1.080	0.99
24_D	41_Q	1.079	0.99
606_E	612_L	1.078	0.99
532_L	544_Y	1.075	0.99
713_A	739_W	1.075	0.99
451_K	464_T	1.075	0.99
481_L	486_A	1.074	0.99
264_E	381_Y	1.070	0.99
613_A	617_L	1.069	0.99
75_K	79_G	1.068	0.99
324_V	327_D	1.064	0.99
657_L	661_N	1.061	0.98
58_D	76_E	1.060	0.98
59_L	100_P	1.059	0.98
211_L	231_K	1.058	0.98
765_V	769_L	1.056	0.98
610_P	613_A	1.056	0.98
459_E	523_N	1.056	0.98
766_R	769_L	1.055	0.98
321_G	388_I	1.052	0.98
53_R	82_V	1.051	0.98
476_A	479_Q	1.050	0.98
612_L	616_I	1.049	0.98
75_K	82_V	1.048	0.98
694_H	730_A	1.048	0.98
321_G	384_G	1.045	0.98
156_L	253_V	1.043	0.98
36_V	98_I	1.043	0.98
229_S	292_E	1.042	0.98
460_Q	522_D	1.042	0.98
479_Q	488_E	1.041	0.98
119_Q	265_N	1.041	0.98
124_G	127_H	1.040	0.98
630_D	633_D	1.039	0.98
492_N	526_F	1.038	0.98
51_P	84_S	1.036	0.98
555_M	568_A	1.036	0.98
637_I	641_R	1.035	0.98
623_N	627_E	1.032	0.98
63_S	95_I	1.031	0.98
786_I	790_A	1.029	0.98
167_L	171_R	1.026	0.98
484_P	487_I	1.026	0.98
366_P	375_F	1.025	0.98
782_I	790_A	1.025	0.98
420_D	423_Q	1.024	0.98
378_L	382_E	1.019	0.98
402_K	406_L	1.019	0.98
247_L	266_K	1.017	0.98
404_M	408_F	1.017	0.98
713_A	738_K	1.015	0.98
482_H	511_N	1.013	0.98
166_E	172_H	1.011	0.98
465_I	468_R	1.011	0.98
55_N	80_A	1.011	0.98
406_L	424_A	1.011	0.98
399_N	428_A	1.010	0.98
438_R	481_L	1.010	0.98
764_T	767_G	1.008	0.98
448_V	540_V	1.007	0.98
225_W	292_E	1.006	0.98
74_W	81_L	1.005	0.98
438_R	482_H	1.005	0.98
600_R	655_E	1.005	0.98
543_E	549_Q	1.004	0.98
291_I	294_V	1.004	0.98
696_A	699_L	1.001	0.98
142_T	177_Q	0.994	0.98
29_L	109_L	0.994	0.98
548_D	574_T	0.992	0.98
254_A	277_L	0.989	0.98
635_I	640_V	0.988	0.98
623_N	626_A	0.987	0.98
258_F	261_G	0.986	0.98
633_D	641_R	0.986	0.98
19_Q	181_P	0.984	0.98
150_I	172_H	0.983	0.98
161_R	212_E	0.982	0.98
408_F	416_A	0.981	0.97
479_Q	484_P	0.981	0.97
21_T	91_T	0.977	0.97
483_I	487_I	0.975	0.97
450_V	463_L	0.974	0.97
367_D	441_S	0.973	0.97
263_M	301_H	0.971	0.97
77_E	80_A	0.970	0.97
81_L	85_N	0.967	0.97
18_Y	88_E	0.967	0.97
320_E	381_Y	0.966	0.97
22_D	43_V	0.964	0.97
297_H	320_E	0.962	0.97
237_D	300_F	0.962	0.97
632_I	641_R	0.961	0.97
236_W	333_D	0.960	0.97
578_L	581_A	0.959	0.97
496_V	559_R	0.954	0.97
768_L	775_T	0.951	0.97
768_L	772_R	0.948	0.97
560_N	563_S	0.948	0.97
746_M	750_F	0.948	0.97
51_P	82_V	0.947	0.97
633_D	639_E	0.947	0.97
290_D	294_V	0.947	0.97
146_I	171_R	0.946	0.97
442_Q	479_Q	0.946	0.97
304_T	308_V	0.942	0.97
368_M	371_E	0.942	0.97
300_F	326_R	0.941	0.97
122_A	373_N	0.938	0.97
621_S	625_M	0.938	0.97
87_P	90_F	0.936	0.97
721_V	752_L	0.935	0.97
649_A	656_L	0.935	0.97
607_K	613_A	0.931	0.97
204_R	239_E	0.930	0.97
478_K	481_L	0.928	0.96
459_E	525_Y	0.927	0.96
707_A	712_D	0.927	0.96
66_I	71_W	0.926	0.96
110_Y	258_F	0.926	0.96
452_D	527_Q	0.925	0.96
405_Q	408_F	0.925	0.96
38_A	100_P	0.923	0.96
481_L	487_I	0.922	0.96
121_E	319_K	0.922	0.96
274_K	290_D	0.920	0.96
236_W	330_F	0.919	0.96
132_L	137_V	0.917	0.96
682_N	703_Q	0.916	0.96
661_N	664_Y	0.915	0.96
422_V	437_R	0.913	0.96
488_E	496_V	0.912	0.96
263_M	297_H	0.911	0.96
402_K	428_A	0.910	0.96
551_L	567_A	0.910	0.96
454_Y	526_F	0.909	0.96
479_Q	482_H	0.908	0.96
200_T	210_A	0.907	0.96
484_P	489_L	0.907	0.96
162_V	175_Q	0.907	0.96
393_T	537_S	0.906	0.96
315_Q	365_R	0.905	0.96
182_K	266_K	0.902	0.96
695_L	699_L	0.902	0.96
473_P	478_K	0.898	0.96
65_H	93_K	0.898	0.96
177_Q	248_D	0.896	0.96
475_Q	478_K	0.895	0.96
333_D	397_E	0.894	0.96
736_D	773_S	0.893	0.96
102_A	116_L	0.889	0.96
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85_N	88_E	0.885	0.95
221_D	224_P	0.885	0.95
204_R	235_K	0.884	0.95
263_M	298_E	0.883	0.95
263_M	381_Y	0.883	0.95
553_F	556_R	0.882	0.95
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20_I	42_A	0.881	0.95
466_S	515_A	0.881	0.95
264_E	320_E	0.880	0.95
482_H	513_T	0.879	0.95
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452_D	545_K	0.878	0.95
451_K	462_T	0.877	0.95
110_Y	257_F	0.877	0.95
491_D	528_P	0.876	0.95
540_V	544_Y	0.875	0.95
262_A	381_Y	0.872	0.95
634_P	639_E	0.872	0.95
426_E	437_R	0.869	0.95
608_I	612_L	0.868	0.95
80_A	83_I	0.867	0.95
318_L	407_Y	0.867	0.95
216_D	273_S	0.866	0.95
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298_E	320_E	0.859	0.95
545_K	548_D	0.858	0.95
156_L	214_Y	0.857	0.95
159_G	179_P	0.855	0.94
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58_D	105_A	0.854	0.94
630_D	637_I	0.852	0.94
533_L	540_V	0.851	0.94
468_R	567_A	0.850	0.94
138_L	309_T	0.849	0.94
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494_G	497_I	0.848	0.94
463_L	485_F	0.847	0.94
345_V	389_R	0.847	0.94
649_A	691_G	0.841	0.94
28_D	37_T	0.840	0.94
748_K	752_L	0.838	0.94
329_E	397_E	0.838	0.94
308_V	424_A	0.837	0.94
784_S	788_A	0.837	0.94
403_G	428_A	0.835	0.94
23_I	42_A	0.835	0.94
435_H	513_T	0.834	0.94
481_L	485_F	0.834	0.94
37_T	97_E	0.832	0.94
697_D	731_L	0.832	0.94
167_L	170_G	0.831	0.94
120_C	125_F	0.830	0.94
655_E	658_A	0.830	0.94
737_D	740_H	0.830	0.94
480_P	488_E	0.829	0.94
258_F	272_N	0.828	0.93
699_L	703_Q	0.827	0.93
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261_G	381_Y	0.823	0.93
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331_S	340_N	0.820	0.93
217_R	220_L	0.819	0.93
698_V	730_A	0.818	0.93
192_G	253_V	0.817	0.93
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656_L	687_F	0.814	0.93
737_D	741_Q	0.813	0.93
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316_L	362_H	0.812	0.93
695_L	698_V	0.810	0.93
64_V	83_I	0.809	0.93
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434_S	437_R	0.807	0.93
304_T	404_M	0.805	0.93
66_I	92_L	0.805	0.93
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50_A	85_N	0.800	0.92
632_I	639_E	0.799	0.92
241_F	400_F	0.799	0.92
622_V	626_A	0.799	0.92
634_P	640_V	0.797	0.92
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214_Y	251_M	0.795	0.92
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394_L	511_N	0.789	0.92
668_Y	696_A	0.788	0.92
293_R	324_V	0.787	0.92
289_L	331_S	0.785	0.92
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19_Q	43_V	0.785	0.92
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287_D	748_K	0.783	0.91
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480_P	487_I	0.777	0.91
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621_S	624_E	0.772	0.91
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265_N	298_E	0.769	0.91
663_N	684_C	0.769	0.91
157_S	176_W	0.769	0.91
107_E	124_G	0.767	0.91
589_L	643_A	0.767	0.91
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419_D	437_R	0.765	0.90
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452_D	530_P	0.763	0.90
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364_I	418_C	0.760	0.90
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613_A	652_L	0.759	0.90
98_I	101_A	0.757	0.90
325_F	329_E	0.757	0.90
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531_A	553_F	0.755	0.90
240_R	329_E	0.755	0.90
483_I	486_A	0.752	0.90
658_A	661_N	0.752	0.90
426_E	433_L	0.750	0.90
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225_W	288_Y	0.744	0.89
241_F	329_E	0.744	0.89
660_Y	703_Q	0.743	0.89
260_M	272_N	0.743	0.89
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757_P	760_N	0.740	0.89
452_D	544_Y	0.740	0.89
582_R	586_G	0.740	0.89
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376_Y	381_Y	0.738	0.89
454_Y	458_T	0.737	0.89
565_W	573_A	0.736	0.89
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213_L	252_I	0.735	0.89
743_G	752_L	0.735	0.89
310_C	319_K	0.734	0.89
164_Q	174_V	0.734	0.89
447_I	468_R	0.733	0.89
143_T	159_G	0.732	0.88
450_V	485_F	0.730	0.88
593_V	597_D	0.729	0.88
38_A	98_I	0.728	0.88
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119_Q	373_N	0.727	0.88
292_E	331_S	0.726	0.88
44_R	88_E	0.725	0.88
317_S	364_I	0.725	0.88
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261_G	301_H	0.724	0.88
653_A	656_L	0.724	0.88
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554_L	586_G	0.722	0.88
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109_L	189_L	0.721	0.88
575_Y	580_V	0.721	0.88
307_R	412_D	0.721	0.88
613_A	621_S	0.720	0.88
81_L	86_L	0.720	0.88
278_A	291_I	0.719	0.88
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150_I	153_P	0.717	0.87
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664_Y	681_R	0.717	0.87
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226_A	291_I	0.715	0.87
90_F	99_S	0.714	0.87
262_A	271_F	0.714	0.87
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185_Y	407_Y	0.711	0.87
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395_L	403_G	0.711	0.87
83_I	86_L	0.710	0.87
218_G	256_D	0.708	0.87
321_G	380_V	0.708	0.87
154_F	194_F	0.708	0.87
250_Y	269_N	0.708	0.87
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558_A	563_S	0.707	0.87
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730_A	734_E	0.706	0.87
724_Q	728_R	0.704	0.86
607_K	610_P	0.704	0.86
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643_A	647_T	0.702	0.86
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487_I	532_L	0.697	0.86
155_L	176_W	0.697	0.86
106_L	110_Y	0.697	0.86
185_Y	298_E	0.697	0.86
82_V	86_L	0.696	0.86
607_K	612_L	0.696	0.86
685_L	694_H	0.696	0.86
79_G	82_V	0.695	0.86
736_D	771_H	0.695	0.86
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629_F	660_Y	0.691	0.85
632_I	640_V	0.691	0.85
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607_K	628_L	0.688	0.85
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280_T	288_Y	0.687	0.85
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118_T	188_A	0.686	0.85
176_W	179_P	0.682	0.85
411_H	416_A	0.682	0.85
292_E	335_G	0.682	0.85
469_T	472_T	0.681	0.85
157_S	189_L	0.680	0.85
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666_S	669_R	0.676	0.84
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785_L	789_F	0.672	0.84
397_E	401_Q	0.671	0.84
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493_E	497_I	0.670	0.84
234_M	245_Y	0.669	0.84
299_Y	306_N	0.669	0.84
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736_D	767_G	0.669	0.84
91_T	100_P	0.668	0.83
462_T	516_E	0.668	0.83
613_A	620_P	0.668	0.83
551_L	554_L	0.668	0.83
680_L	684_C	0.668	0.83
126_R	141_F	0.667	0.83
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478_K	482_H	0.664	0.83
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622_V	641_R	0.663	0.83
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112_S	272_N	0.661	0.83
388_I	391_I	0.661	0.83
478_K	487_I	0.660	0.83
490_Y	528_P	0.660	0.83
227_M	231_K	0.659	0.83
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767_G	772_R	0.657	0.82
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322_L	388_I	0.656	0.82
631_I	636_A	0.656	0.82
631_I	637_I	0.655	0.82
144_K	165_G	0.655	0.82
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15_A	20_I	0.655	0.82
263_M	322_L	0.655	0.82
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643_A	646_R	0.650	0.82
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352_Q	539_P	0.649	0.82
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396_G	399_N	0.649	0.82
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335_G	338_A	0.647	0.82
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545_K	549_Q	0.646	0.81
558_A	567_A	0.646	0.81
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365_R	418_C	0.644	0.81
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749_W	753_Q	0.638	0.81
368_M	375_F	0.637	0.80
262_A	265_N	0.635	0.80
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784_S	789_F	0.634	0.80
482_H	486_A	0.634	0.80
255_V	270_I	0.634	0.80
475_Q	485_F	0.634	0.80
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612_L	620_P	0.632	0.80
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287_D	290_D	0.629	0.80
185_Y	381_Y	0.628	0.80
609_D	620_P	0.628	0.80
600_R	652_L	0.628	0.80
377_T	380_V	0.627	0.79
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607_K	611_A	0.626	0.79
609_D	613_A	0.626	0.79
438_R	442_Q	0.625	0.79
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682_N	715_A	0.622	0.79
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783_R	790_A	0.619	0.79
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646_R	650_T	0.619	0.79
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596_A	647_T	0.618	0.78
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657_L	699_L	0.616	0.78
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642_E	645_T	0.616	0.78
312_D	315_Q	0.615	0.78
185_Y	263_M	0.615	0.78
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220_L	223_A	0.614	0.78
745_V	752_L	0.614	0.78
29_L	191_A	0.614	0.78
87_P	92_L	0.613	0.78
530_P	533_L	0.611	0.78
212_E	249_I	0.609	0.77
730_A	733_Q	0.608	0.77
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147_A	172_H	0.607	0.77
75_K	84_S	0.606	0.77
649_A	687_F	0.606	0.77
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224_P	280_T	0.606	0.77
533_L	538_A	0.606	0.77
421_F	425_M	0.605	0.77
649_A	652_L	0.605	0.77
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769_L	772_R	0.603	0.77
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278_A	283_A	0.602	0.77
150_I	154_F	0.602	0.77
776_M	782_I	0.602	0.77
286_K	290_D	0.599	0.76
704_F	713_A	0.599	0.76
362_H	379_T	0.598	0.76
638_A	641_R	0.598	0.76
689_A	696_A	0.597	0.76
262_A	306_N	0.596	0.76
649_A	690_F	0.596	0.76
724_Q	758_A	0.595	0.76
455_N	460_Q	0.595	0.76
591_L	595_V	0.595	0.76
243_L	307_R	0.594	0.76
746_M	773_S	0.594	0.76
261_G	294_V	0.593	0.76
123_E	369_V	0.593	0.76
161_R	175_Q	0.592	0.75
129_T	143_T	0.592	0.75
616_I	620_P	0.591	0.75
96_N	99_S	0.591	0.75
357_A	445_T	0.590	0.75
541_K	544_Y	0.590	0.75
52_L	132_L	0.589	0.75
93_K	96_N	0.589	0.75
689_A	692_E	0.589	0.75
727_C	730_A	0.589	0.75
647_T	650_T	0.589	0.75
487_I	490_Y	0.589	0.75
375_F	380_V	0.589	0.75
586_G	592_P	0.588	0.75
696_A	700_V	0.588	0.75
339_V	342_I	0.588	0.75
222_R	279_R	0.588	0.75
419_D	423_Q	0.588	0.75
750_F	753_Q	0.588	0.75
13_Y	16_P	0.587	0.75
619_L	622_V	0.587	0.75
48_S	85_N	0.586	0.75
370_I	373_N	0.586	0.75
261_G	297_H	0.586	0.75
533_L	544_Y	0.586	0.75
186_L	264_E	0.586	0.75
670_V	675_I	0.585	0.75
264_E	309_T	0.585	0.75
531_A	536_F	0.584	0.74
44_R	66_I	0.584	0.74
89_R	98_I	0.584	0.74
401_Q	404_M	0.584	0.74
774_F	778_N	0.583	0.74
489_L	492_N	0.581	0.74
276_V	295_I	0.581	0.74
106_L	258_F	0.581	0.74
454_Y	460_Q	0.577	0.74
27_F	118_T	0.577	0.74
394_L	433_L	0.577	0.74
322_L	326_R	0.575	0.73
264_E	306_N	0.575	0.73
339_V	588_P	0.575	0.73
661_N	699_L	0.574	0.73
454_Y	523_N	0.574	0.73
782_I	786_I	0.574	0.73
700_V	703_Q	0.573	0.73
258_F	265_N	0.572	0.73
482_H	485_F	0.572	0.73
96_N	101_A	0.572	0.73
531_A	534_C	0.571	0.73
786_I	789_F	0.571	0.73
705_H	734_E	0.570	0.73
491_D	498_P	0.570	0.73
488_E	492_N	0.570	0.73
181_P	414_S	0.570	0.73
551_L	557_H	0.569	0.73
154_F	195_D	0.569	0.73
699_L	702_K	0.569	0.73
252_I	269_N	0.568	0.72
264_E	322_L	0.567	0.72
23_I	40_S	0.567	0.72
48_S	89_R	0.566	0.72
362_H	380_V	0.566	0.72
594_H	597_D	0.565	0.72
225_W	232_N	0.565	0.72
479_Q	489_L	0.564	0.72
74_W	83_I	0.564	0.72
617_L	653_A	0.563	0.72
58_D	127_H	0.563	0.72
701_S	730_A	0.561	0.72
165_G	172_H	0.561	0.72
478_K	483_I	0.560	0.71
418_C	441_S	0.560	0.71
744_L	752_L	0.559	0.71
701_S	720_A	0.559	0.71
751_I	755_T	0.559	0.71
332_S	337_R	0.558	0.71
620_P	625_M	0.558	0.71
322_L	400_F	0.558	0.71
216_D	256_D	0.558	0.71
728_R	753_Q	0.557	0.71
310_C	315_Q	0.556	0.71
550_Q	553_F	0.556	0.71
273_S	291_I	0.556	0.71
362_H	366_P	0.556	0.71
765_V	772_R	0.556	0.71
561_D	564_R	0.555	0.71
159_G	180_F	0.555	0.71
628_L	641_R	0.555	0.71
491_D	497_I	0.554	0.71
391_I	425_M	0.554	0.71
37_T	95_I	0.553	0.70
477_E	481_L	0.553	0.70
243_L	308_V	0.553	0.70
779_P	789_F	0.552	0.70
215_V	218_G	0.552	0.70
745_V	749_W	0.551	0.70
74_W	79_G	0.551	0.70
328_Q	340_N	0.551	0.70
213_L	223_A	0.551	0.70
764_T	771_H	0.550	0.70
552_T	556_R	0.550	0.70
665_Q	669_R	0.550	0.70
483_I	512_V	0.549	0.70
195_D	216_D	0.548	0.70
82_V	85_N	0.548	0.70
533_L	539_P	0.548	0.70
316_L	319_K	0.548	0.70
349_R	536_F	0.547	0.70
56_G	61_L	0.545	0.69
422_V	436_F	0.545	0.69
580_V	615_E	0.545	0.69
606_E	610_P	0.545	0.69
400_F	404_M	0.544	0.69
435_H	438_R	0.543	0.69
90_F	93_K	0.543	0.69
697_D	727_C	0.542	0.69
579_N	589_L	0.542	0.69
461_Y	465_I	0.542	0.69
257_F	260_M	0.541	0.69
492_N	495_K	0.541	0.69
262_A	270_I	0.539	0.69
122_A	260_M	0.539	0.69
661_N	665_Q	0.539	0.69
742_N	752_L	0.539	0.69
462_T	520_V	0.538	0.68
398_E	402_K	0.538	0.68
261_G	319_K	0.538	0.68
69_E	87_P	0.537	0.68
300_F	319_K	0.537	0.68
54_L	94_I	0.537	0.68
478_K	484_P	0.537	0.68
722_A	757_P	0.537	0.68
322_L	381_Y	0.537	0.68
93_K	100_P	0.536	0.68
241_F	404_M	0.536	0.68
747_D	781_R	0.535	0.68
758_A	761_V	0.534	0.68
94_I	99_S	0.534	0.68
203_T	206_G	0.533	0.68
599_F	612_L	0.533	0.68
107_E	127_H	0.533	0.68
591_L	644_L	0.533	0.68
668_Y	699_L	0.532	0.68
298_E	306_N	0.532	0.68
634_P	641_R	0.531	0.67
270_I	295_I	0.531	0.67
447_I	564_R	0.531	0.67
476_A	481_L	0.531	0.67
89_R	92_L	0.530	0.67
233_S	330_F	0.530	0.67
600_R	604_L	0.530	0.67
327_D	348_M	0.530	0.67
638_A	642_E	0.530	0.67
485_F	510_L	0.529	0.67
93_K	98_I	0.529	0.67
123_E	372_M	0.529	0.67
240_R	296_G	0.528	0.67
785_L	788_A	0.528	0.67
784_S	790_A	0.528	0.67
418_C	440_Y	0.527	0.67
31_A	34_T	0.527	0.67
605_D	613_A	0.526	0.67
180_F	247_L	0.526	0.67
188_A	265_N	0.526	0.67
613_A	624_E	0.526	0.67
17_D	46_G	0.526	0.67
479_Q	485_F	0.525	0.67
30_D	99_S	0.525	0.67
411_H	427_D	0.525	0.67
141_F	182_K	0.524	0.66
27_F	40_S	0.523	0.66
491_D	496_V	0.522	0.66
182_K	247_L	0.522	0.66
621_S	653_A	0.521	0.66
288_Y	291_I	0.521	0.66
416_A	420_D	0.521	0.66
641_R	644_L	0.521	0.66
139_A	183_P	0.521	0.66
558_A	561_D	0.520	0.66
573_A	625_M	0.520	0.66
660_Y	663_N	0.520	0.66
324_V	331_S	0.519	0.66
77_E	83_I	0.519	0.66
199_D	228_T	0.519	0.66
592_P	595_V	0.519	0.66
728_R	756_S	0.519	0.66
486_A	509_V	0.518	0.66
788_A	791_G	0.518	0.66
345_V	350_G	0.518	0.66
56_G	81_L	0.518	0.66
689_A	719_A	0.518	0.66
656_L	660_Y	0.517	0.65
319_K	415_A	0.517	0.65
449_T	468_R	0.517	0.65
531_A	558_A	0.517	0.65
186_L	416_A	0.516	0.65
653_A	657_L	0.516	0.65
697_D	701_S	0.515	0.65
117_C	190_V	0.515	0.65
113_G	257_F	0.514	0.65
571_L	575_Y	0.514	0.65
664_Y	688_L	0.514	0.65
707_A	713_A	0.513	0.65
488_E	558_A	0.513	0.65
329_E	332_S	0.512	0.65
190_V	255_V	0.512	0.65
612_L	615_E	0.512	0.65
572_L	595_V	0.511	0.64
81_L	88_E	0.511	0.64
283_A	291_I	0.510	0.64
252_I	295_I	0.510	0.64
264_E	376_Y	0.509	0.64
24_D	39_V	0.509	0.64
480_P	486_A	0.509	0.64
91_T	94_I	0.509	0.64
109_L	118_T	0.509	0.64
564_R	567_A	0.508	0.64
471_A	475_Q	0.508	0.64
460_Q	463_L	0.508	0.64
602_V	613_A	0.508	0.64
630_D	635_I	0.507	0.64
112_S	255_V	0.507	0.64
309_T	415_A	0.506	0.64
612_L	619_L	0.506	0.64
657_L	687_F	0.505	0.64
30_D	34_T	0.504	0.63
642_E	646_R	0.504	0.63
752_L	755_T	0.504	0.63
654_D	662_A	0.501	0.63
451_K	706_E	0.501	0.63
573_A	624_E	0.500	0.63
48_S	88_E	0.500	0.63
263_M	376_Y	0.500	0.63
666_S	674_D	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yd0A	1	0.9322	100	0.19	Contact Map
4jbsA	1	0.9402	100	0.194	Contact Map
4kx7A	1	0.9368	100	0.198	Contact Map
4fkeA	1	0.9391	100	0.198	Contact Map
4pj6A	2	0.9299	100	0.208	Contact Map
4wz9A	2	0.9356	100	0.211	Contact Map
1z5hA	3	0.8736	100	0.264	Contact Map
4x2uA	1	0.9805	100	0.339	Contact Map
4qhpA	1	0.9874	100	0.347	Contact Map
3b34A	1	0.9885	100	0.347	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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