GREMLIN Database
LIVK - Leucine-specific-binding protein
UniProt: P04816 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10540
Length: 369 (345)
Sequences: 16984 (12331)
Seq/√Len: 663.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_D68_V3.7161.00
54_K291_D3.6891.00
27_K68_V3.4711.00
182_Q195_F3.3781.00
72_Y87_K3.1451.00
46_F50_R2.9811.00
95_Y310_L2.9391.00
163_R191_N2.9331.00
185_L190_A2.6921.00
56_I311_A2.6801.00
312_T315_E2.6581.00
25_D65_D2.6441.00
286_D290_A2.6331.00
283_G287_A2.6071.00
116_G136_H2.5791.00
289_K295_P2.5751.00
75_A80_Q2.5721.00
55_D287_A2.5661.00
312_T316_R2.5561.00
54_K58_A2.4471.00
196_D211_R2.4251.00
81_A104_S2.3821.00
335_N340_P2.2851.00
76_C101_C2.2791.00
29_A88_I2.2441.00
25_D66_K2.2091.00
321_E324_A2.1741.00
333_G340_P2.1661.00
184_G187_A2.0031.00
311_A315_E1.9931.00
72_Y84_V1.9841.00
182_Q186_K1.9731.00
168_H197_G1.9731.00
165_A194_F1.9561.00
55_D304_Y1.9311.00
31_V84_V1.9131.00
328_D331_A1.9021.00
162_Q218_D1.8811.00
50_R54_K1.8601.00
96_V112_Y1.8591.00
53_I69_G1.8511.00
157_E188_A1.8361.00
282_Q286_D1.8311.00
31_V74_D1.8241.00
53_I307_V1.8031.00
24_D65_D1.7921.00
333_G342_N1.7921.00
116_G323_L1.7781.00
153_K188_A1.7381.00
307_V311_A1.6811.00
323_L327_K1.6781.00
55_D308_Q1.6631.00
49_A307_V1.6561.00
316_R328_D1.6321.00
46_F71_E1.6211.00
77_D80_Q1.6041.00
326_V330_K1.5901.00
153_K157_E1.5831.00
305_A336_T1.5781.00
161_P219_F1.5671.00
138_M330_K1.5671.00
324_A327_K1.5521.00
47_N50_R1.5491.00
255_S258_N1.5421.00
47_N294_D1.5221.00
47_N292_K1.5221.00
55_D59_K1.5151.00
27_K70_V1.5011.00
327_K331_A1.4881.00
287_A290_A1.4861.00
283_G286_D1.4811.00
235_Q238_S1.4791.00
80_Q84_V1.4781.00
183_D187_A1.4691.00
139_R348_D1.4541.00
138_M326_V1.4371.00
260_A264_A1.4301.00
85_A112_Y1.4251.00
170_K199_T1.4161.00
87_K91_D1.4151.00
72_Y88_I1.4131.00
89_V117_I1.4001.00
149_P184_G1.3981.00
310_L314_L1.3951.00
67_L311_A1.3881.00
179_R183_D1.3881.00
148_G152_A1.3741.00
163_R218_D1.3631.00
72_Y91_D1.3471.00
33_A74_D1.3451.00
30_V49_A1.3361.00
112_Y119_M1.3111.00
118_L322_P1.3111.00
166_I178_A1.3041.00
164_I219_F1.3021.00
279_P283_G1.3001.00
209_I235_Q1.2961.00
288_L292_K1.2931.00
48_G303_T1.2801.00
317_T328_D1.2791.00
165_A217_I1.2751.00
198_I224_G1.2741.00
56_I308_Q1.2731.00
43_D47_N1.2661.00
161_P218_D1.2661.00
47_N288_L1.2651.00
163_R216_N1.2591.00
113_E135_Q1.2571.00
50_R71_E1.2551.00
63_K315_E1.2531.00
136_H326_V1.2491.00
201_G228_E1.2451.00
165_A196_D1.2401.00
168_H178_A1.2251.00
175_E197_G1.2221.00
209_I236_A1.2181.00
286_D289_K1.2121.00
99_H108_A1.2101.00
284_I300_V1.2041.00
164_I185_L1.1991.00
330_K347_G1.1981.00
110_D114_D1.1951.00
236_A241_L1.1931.00
51_Q55_D1.1831.00
52_A311_A1.1821.00
70_V91_D1.1821.00
285_V289_K1.1721.00
165_A212_L1.1671.00
170_K175_E1.1661.00
154_Y268_L1.1631.00
90_N115_E1.1551.00
277_Q282_Q1.1471.00
155_I246_M1.1471.00
74_D104_S1.1431.00
236_A245_F1.1331.00
186_K191_N1.1321.00
211_R215_E1.1261.00
280_A335_N1.1251.00
102_S126_N1.1241.00
80_Q83_A1.1181.00
89_V111_I1.1131.00
35_S73_D1.1121.00
178_A182_Q1.1101.00
105_T124_A1.1061.00
209_I239_V1.1051.00
48_G300_V1.1021.00
128_E131_Q1.0991.00
49_A69_G1.0951.00
247_G251_V1.0951.00
180_S183_D1.0921.00
125_T144_D1.0881.00
10_A13_I1.0871.00
99_H105_T1.0871.00
49_A303_T1.0841.00
34_M71_E1.0811.00
219_F246_M1.0761.00
254_A258_N1.0741.00
309_S329_L1.0691.00
14_A17_I1.0671.00
127_P145_S1.0661.00
52_A304_Y1.0641.00
213_K241_L1.0631.00
178_A195_F1.0611.00
45_E303_T1.0601.00
206_S235_Q1.0591.00
56_I307_V1.0581.00
308_Q311_A1.0501.00
279_P282_Q1.0481.00
210_A239_V1.0481.00
163_R193_V1.0451.00
52_A307_V1.0411.00
86_N90_N1.0391.00
316_R331_A1.0381.00
202_E208_L1.0381.00
185_L192_V1.0321.00
86_N111_I1.0311.00
85_A96_V1.0291.00
319_S324_A1.0281.00
99_H119_M1.0281.00
199_T202_E1.0271.00
235_Q239_V1.0231.00
27_K93_I1.0221.00
31_V108_A1.0211.00
105_T119_M1.0101.00
287_A291_D1.0091.00
82_V86_N1.0041.00
52_A308_Q1.0001.00
184_G188_A0.9981.00
50_R69_G0.9971.00
89_V115_E0.9901.00
309_S343_W0.9851.00
44_M297_G0.9821.00
12_M15_L0.9811.00
29_A93_I0.9791.00
168_H195_F0.9791.00
57_N61_G0.9701.00
85_A108_A0.9691.00
120_I310_L0.9681.00
167_I232_M0.9671.00
151_A221_Y0.9661.00
49_A97_I0.9661.00
165_A215_E0.9651.00
210_A214_K0.9611.00
324_A328_D0.9611.00
177_L223_G0.9601.00
149_P153_K0.9581.00
152_A181_V0.9461.00
121_S124_A0.9441.00
43_D46_F0.9431.00
305_A338_I0.9401.00
30_V69_G0.9391.00
336_T339_G0.9361.00
327_K330_K0.9341.00
94_K322_P0.9331.00
31_V85_A0.9321.00
28_V95_Y0.9321.00
106_Q128_E0.9281.00
84_V87_K0.9251.00
213_K239_V0.9241.00
280_A283_G0.9231.00
30_V71_E0.9231.00
34_M46_F0.9181.00
85_A115_E0.9181.00
130_T139_R0.9121.00
308_Q312_T0.9101.00
51_Q287_A0.9061.00
193_V217_I0.9051.00
50_R291_D0.9021.00
121_S137_I0.9021.00
11_G14_A0.8971.00
262_D265_E0.8971.00
344_D348_D0.8971.00
48_G52_A0.8951.00
183_D186_K0.8951.00
13_I16_A0.8951.00
167_I208_L0.8881.00
53_I57_N0.8881.00
140_T309_S0.8871.00
153_K158_T0.8841.00
51_Q292_K0.8841.00
118_L326_V0.8811.00
209_I241_L0.8781.00
224_G232_M0.8711.00
138_M329_L0.8651.00
55_D58_A0.8641.00
278_D281_N0.8641.00
194_F211_R0.8621.00
56_I67_L0.8601.00
175_E179_R0.8551.00
138_M343_W0.8531.00
316_R332_N0.8471.00
30_V53_I0.8431.00
179_R182_Q0.8421.00
165_A193_V0.8411.00
194_F215_E0.8411.00
52_A56_I0.8401.00
136_H323_L0.8401.00
317_T324_A0.8361.00
27_K91_D0.8341.00
181_V185_L0.8311.00
176_G179_R0.8251.00
62_I311_A0.8241.00
152_A185_L0.8191.00
169_D174_G0.8151.00
140_T306_A0.8131.00
94_K320_D0.8121.00
109_S137_I0.8081.00
288_L294_D0.8051.00
82_V111_I0.8031.00
119_M137_I0.8021.00
51_Q291_D0.8011.00
26_I65_D0.7991.00
313_A329_L0.7991.00
154_Y159_V0.7981.00
178_A197_G0.7961.00
308_Q334_A0.7951.00
164_I190_A0.7941.00
117_I322_P0.7921.00
74_D99_H0.7901.00
222_Y232_M0.7861.00
85_A89_V0.7851.00
122_P303_T0.7831.00
278_D282_Q0.7821.00
153_K184_G0.7821.00
21_A24_D0.7811.00
51_Q288_L0.7781.00
237_R262_D0.7771.00
303_T307_V0.7771.00
135_Q326_V0.7761.00
97_I120_I0.7751.00
281_N285_V0.7751.00
314_L325_L0.7741.00
193_V215_E0.7741.00
301_W337_V0.7721.00
45_E100_L0.7711.00
93_I96_V0.7681.00
213_K216_N0.7671.00
171_Q174_G0.7651.00
95_Y325_L0.7621.00
212_L217_I0.7621.00
99_H112_Y0.7621.00
97_I306_A0.7611.00
233_L245_F0.7591.00
264_A267_M0.7571.00
9_I12_M0.7571.00
290_A293_K0.7551.00
33_A42_G0.7541.00
289_K293_K0.7531.00
312_T332_N0.7521.00
23_A65_D0.7521.00
309_S334_A0.7501.00
342_N350_K0.7501.00
128_E132_R0.7501.00
67_L307_V0.7481.00
51_Q54_K0.7461.00
206_S238_S0.7431.00
170_K197_G0.7411.00
111_I114_D0.7401.00
273_K281_N0.7401.00
57_N66_K0.7391.00
148_G177_L0.7381.00
59_K315_E0.7381.00
28_V307_V0.7371.00
305_A337_V0.7351.00
334_A341_L0.7331.00
20_T23_A0.7311.00
31_V99_H0.7301.00
231_Q235_Q0.7301.00
152_A188_A0.7281.00
74_D81_A0.7271.00
16_A19_H0.7241.00
260_A263_A0.7171.00
84_V88_I0.7171.00
313_A317_T0.7171.00
209_I213_K0.7171.00
255_S259_I0.7161.00
41_W100_L0.7121.00
31_V88_I0.7081.00
198_I228_E0.7061.00
94_K117_I0.7011.00
86_N114_D0.6981.00
149_P187_A0.6961.00
245_F248_P0.6891.00
26_I314_L0.6881.00
120_I329_L0.6881.00
151_A270_T0.6841.00
152_A184_G0.6841.00
95_Y118_L0.6801.00
15_L18_S0.6801.00
232_M236_A0.6781.00
88_I93_I0.6741.00
86_N115_E0.6731.00
205_F235_Q0.6701.00
17_I20_T0.6701.00
196_D208_L0.6661.00
288_L291_D0.6661.00
125_T141_A0.6651.00
234_R238_S0.6631.00
17_I21_A0.6621.00
166_I192_V0.6621.00
70_V93_I0.6581.00
288_L293_K0.6581.00
181_V221_Y0.6541.00
85_A111_I0.6501.00
237_R263_A0.6491.00
141_A302_I0.6471.00
22_M65_D0.6471.00
344_D347_G0.6461.00
211_R214_K0.6441.00
12_M17_I0.6441.00
59_K63_K0.6411.00
101_C104_S0.6411.00
76_C104_S0.6371.00
171_Q200_A0.6361.00
220_V245_F0.6341.00
229_M251_V0.6321.00
204_D207_A0.6261.00
257_S261_G0.6251.00
28_V310_L0.6221.00
182_Q192_V0.6221.00
118_L136_H0.6201.00
144_D176_G0.6191.00
154_Y158_T0.6181.00
130_T348_D0.6181.00
332_N342_N0.6171.00
129_L137_I0.6171.00
55_D283_G0.6161.00
106_Q129_L0.6151.00
213_K243_T0.6141.00
36_G39_A0.6141.00
62_I67_L0.6141.00
282_Q285_V0.6131.00
341_L349_L0.6131.00
204_D235_Q0.6121.00
313_A325_L0.6091.00
111_I115_E0.6081.00
155_I161_P0.6071.00
180_S184_G0.6061.00
326_V329_L0.6051.00
36_G42_G0.6031.00
127_P176_G0.6021.00
209_I232_M0.6011.00
31_V112_Y0.6011.00
312_T334_A0.6001.00
185_L188_A0.5991.00
277_Q281_N0.5981.00
310_L325_L0.5971.00
147_Q249_E0.5961.00
206_S239_V0.5951.00
136_H322_P0.5941.00
23_A66_K0.5941.00
168_H175_E0.5931.00
109_S134_Y0.5921.00
233_L256_L0.5921.00
61_G65_D0.5911.00
83_A86_N0.5891.00
89_V112_Y0.5871.00
120_I140_T0.5871.00
113_E134_Y0.5871.00
26_I94_K0.5851.00
231_Q234_R0.5841.00
212_L215_E0.5841.00
106_Q126_N0.5841.00
323_L326_V0.5841.00
220_V241_L0.5801.00
322_P326_V0.5801.00
237_R242_K0.5761.00
45_E122_P0.5731.00
81_A108_A0.5731.00
33_A76_C0.5731.00
33_A100_L0.5721.00
34_M73_D0.5721.00
152_A190_A0.5721.00
56_I62_I0.5701.00
108_A112_Y0.5701.00
95_Y120_I0.5691.00
144_D147_Q0.5621.00
166_I181_V0.5611.00
79_K83_A0.5611.00
121_S129_L0.5601.00
208_L212_L0.5591.00
60_G64_G0.5591.00
258_N261_G0.5581.00
60_G63_K0.5561.00
26_I320_D0.5561.00
164_I181_V0.5561.00
58_A61_G0.5531.00
135_Q323_L0.5521.00
51_Q304_Y0.5491.00
22_M25_D0.5491.00
207_A210_A0.5481.00
94_K325_L0.5481.00
49_A53_I0.5481.00
118_L325_L0.5471.00
280_A308_Q0.5471.00
29_A72_Y0.5461.00
10_A14_A0.5441.00
315_E318_G0.5441.00
284_I288_L0.5441.00
281_N284_I0.5441.00
159_V268_L0.5431.00
192_V195_F0.5421.00
166_I195_F0.5411.00
98_G119_M0.5391.00
347_G351_G0.5381.00
89_V96_V0.5381.00
51_Q284_I0.5351.00
161_P244_Q0.5351.00
52_A55_D0.5341.00
144_D173_Y0.5341.00
97_I310_L0.5321.00
122_P306_A0.5301.00
220_V236_A0.5301.00
288_L296_S0.5260.99
234_R261_G0.5240.99
172_Q175_E0.5230.99
107_P110_D0.5220.99
301_W305_A0.5220.99
82_V107_P0.5220.99
212_L220_V0.5210.99
27_K30_V0.5210.99
110_D113_E0.5210.99
50_R53_I0.5200.99
154_Y356_V0.5200.99
118_L122_P0.5190.99
325_L328_D0.5190.99
61_G64_G0.5190.99
50_R292_K0.5180.99
233_L237_R0.5170.99
186_K189_N0.5160.99
222_Y229_M0.5160.99
309_S332_N0.5160.99
56_I60_G0.5160.99
256_L264_A0.5160.99
124_A129_L0.5150.99
113_E136_H0.5140.99
172_Q176_G0.5140.99
252_G269_V0.5140.99
171_Q225_Y0.5120.99
305_A308_Q0.5120.99
224_G229_M0.5110.99
339_G349_L0.5110.99
155_I219_F0.5110.99
53_I67_L0.5100.99
256_L260_A0.5090.99
167_I212_L0.5090.99
115_E118_L0.5090.99
105_T129_L0.5080.99
174_G223_G0.5070.99
85_A99_H0.5070.99
94_K118_L0.5070.99
179_R195_F0.5060.99
63_K66_K0.5040.99
157_E160_K0.5040.99
328_D332_N0.5030.99
89_V93_I0.5030.99
220_V243_T0.5010.99
151_A155_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xaqA 2 0.9377 100 0.21 Contact Map
4n0qA 1 0.9295 100 0.232 Contact Map
1usgA 2 0.935 100 0.241 Contact Map
3ipcA 1 0.935 100 0.241 Contact Map
4ms4A 1 0.916 100 0.244 Contact Map
4ms4B 1 0.9268 100 0.245 Contact Map
3sm9A 2 0.9404 100 0.245 Contact Map
4mptA 1 0.9295 100 0.259 Contact Map
2e4uA 2 0.9539 100 0.261 Contact Map
4maaA 1 0.9295 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.