GREMLIN Database
SYE - Glutamate--tRNA ligase
UniProt: P04805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10407
Length: 471 (412)
Sequences: 6599 (3693)
Seq/√Len: 181.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_Q92_E5.0041.00
153_D159_P4.6711.00
87_D91_E4.6191.00
51_P55_E4.1411.00
99_Y138_C3.2041.00
100_C125_C3.1771.00
316_P348_G3.1621.00
55_E59_D2.9341.00
215_K221_V2.8421.00
214_L224_Y2.7241.00
121_Y125_C2.7051.00
111_E115_K2.7011.00
190_W219_A2.5711.00
101_S104_R2.4521.00
129_H132_H2.4351.00
402_T405_N2.4231.00
127_H131_H2.4151.00
150_V164_N2.3911.00
317_E341_A2.3391.00
85_V191_D2.3071.00
62_N67_E2.2901.00
80_D84_A2.2821.00
107_A111_E2.2751.00
280_E284_K2.2541.00
86_I140_V2.2311.00
54_I74_Y2.2081.00
151_V161_E2.2041.00
87_D130_E2.1941.00
157_R201_E2.1871.00
151_V159_P2.1811.00
255_Y304_L2.1801.00
81_R191_D2.1721.00
394_K416_E2.1711.00
94_T216_A2.1361.00
110_E113_M2.1221.00
74_Y77_K2.0981.00
62_N68_W2.0601.00
29_F33_H2.0571.00
149_S161_E2.0111.00
383_V386_Q2.0091.00
100_C108_L2.0081.00
211_I221_V2.0051.00
160_I204_I1.9971.00
407_H411_Q1.9951.00
308_H312_N1.9891.00
390_V417_L1.9761.00
134_D137_P1.9701.00
4_K194_I1.9631.00
81_R85_V1.9201.00
155_Q223_V1.8951.00
314_L318_Y1.8881.00
149_S163_S1.8881.00
82_Y188_D1.8421.00
108_L122_D1.8211.00
38_V194_I1.8181.00
148_G215_K1.8151.00
7_F19_G1.8071.00
84_A88_Q1.7871.00
4_K36_E1.7731.00
39_L58_M1.7701.00
15_L19_G1.7681.00
315_P318_Y1.7451.00
278_T281_E1.7441.00
235_G297_A1.7381.00
97_K138_C1.7271.00
80_D170_L1.7251.00
393_D396_A1.7221.00
153_D223_V1.6971.00
79_F178_S1.6891.00
90_L97_K1.6831.00
196_H223_V1.6771.00
392_R396_A1.6491.00
123_G126_R1.6441.00
59_D248_M1.6201.00
390_V394_K1.6141.00
256_L286_F1.5911.00
182_N210_Q1.5901.00
112_Q117_E1.5861.00
81_R84_A1.5761.00
104_R108_L1.5621.00
142_F216_A1.5571.00
408_H412_A1.5501.00
106_E110_E1.5491.00
85_V217_L1.5211.00
50_T53_A1.5191.00
135_D162_F1.5151.00
20_A64_L1.5121.00
36_E69_D1.5061.00
198_I225_A1.5061.00
413_T417_L1.5051.00
98_C125_C1.5041.00
59_D62_N1.4981.00
89_M94_T1.4951.00
4_K38_V1.4911.00
142_F212_N1.4901.00
390_V393_D1.4751.00
401_W406_V1.4671.00
144_N212_N1.4671.00
232_G242_H1.4631.00
258_E318_Y1.4611.00
225_A288_L1.4591.00
276_I306_L1.4471.00
88_Q91_E1.4461.00
309_H313_A1.4321.00
301_D304_L1.4291.00
128_S132_H1.4251.00
362_R366_E1.4081.00
63_W251_R1.3981.00
190_W220_P1.3971.00
4_K193_E1.3941.00
86_I90_L1.3921.00
5_T26_S1.3891.00
83_N87_D1.3841.00
372_D375_A1.3821.00
265_V282_M1.3801.00
262_N266_R1.3761.00
318_Y322_H1.3721.00
352_K356_E1.3691.00
58_M72_P1.3621.00
309_H312_N1.3591.00
68_W71_G1.3571.00
70_E73_Y1.3541.00
58_M62_N1.3421.00
394_K412_A1.3401.00
286_F290_A1.3361.00
97_K140_V1.3271.00
102_K106_E1.3161.00
376_A380_L1.3141.00
38_V71_G1.3131.00
249_Q252_D1.3011.00
412_A415_D1.2961.00
147_E165_Q1.2931.00
274_Q281_E1.2851.00
85_V187_V1.2801.00
412_A416_E1.2771.00
104_R122_D1.2761.00
388_L391_V1.2601.00
333_D336_N1.2601.00
90_L140_V1.2571.00
24_L66_L1.2541.00
22_T200_G1.2541.00
95_A140_V1.2521.00
398_I406_V1.2451.00
104_R124_R1.2451.00
104_R107_A1.2441.00
92_E218_K1.2381.00
186_V213_I1.2381.00
114_A119_P1.2341.00
317_E331_N1.2321.00
348_G351_C1.2261.00
55_E58_M1.2251.00
321_T337_G1.2201.00
125_C128_S1.2181.00
155_Q288_L1.2081.00
400_D405_N1.2031.00
52_E55_E1.2001.00
88_Q218_K1.1981.00
324_Q337_G1.1901.00
36_E70_E1.1881.00
29_F196_H1.1801.00
211_I215_K1.1761.00
375_A378_K1.1631.00
343_L364_F1.1621.00
90_L95_A1.1581.00
152_F204_I1.1581.00
249_Q253_D1.1571.00
38_V73_Y1.1541.00
27_W31_R1.1511.00
85_V219_A1.1511.00
182_N206_N1.1511.00
100_C121_Y1.1461.00
107_A110_E1.1381.00
51_P54_I1.1361.00
37_F66_L1.1191.00
203_H206_N1.1171.00
99_Y137_P1.1151.00
75_Q184_C1.1121.00
318_Y321_T1.1091.00
261_L279_R1.1071.00
315_P331_N1.1051.00
134_D162_F1.1041.00
203_H210_Q1.1011.00
148_G164_N1.1001.00
126_R143_A1.0991.00
95_A172_I1.0991.00
80_D83_N1.0991.00
99_Y136_E1.0971.00
128_S133_A1.0971.00
393_D397_A1.0961.00
324_Q328_E1.0921.00
128_S131_H1.0891.00
104_R125_C1.0881.00
123_G143_A1.0831.00
281_E285_Y1.0741.00
85_V88_Q1.0701.00
320_A341_A1.0671.00
110_E114_A1.0651.00
157_R213_I1.0641.00
4_K70_E1.0641.00
31_R69_D1.0611.00
58_M68_W1.0491.00
27_W37_F1.0471.00
142_F213_I1.0411.00
91_E94_T1.0401.00
324_Q327_I1.0391.00
29_F198_I1.0331.00
3_I29_F1.0311.00
86_I95_A1.0271.00
281_E284_K1.0241.00
112_Q116_G1.0231.00
112_Q115_K1.0210.99
122_D125_C1.0180.99
111_E114_A1.0170.99
22_T26_S1.0130.99
84_A91_E1.0120.99
394_K397_A1.0090.99
75_Q188_D1.0040.99
411_Q415_D1.0020.99
279_R283_I1.0010.99
345_K348_G0.9950.99
347_L357_M0.9930.99
82_Y184_C0.9930.99
90_L129_H0.9900.99
78_R82_Y0.9820.99
98_C105_L0.9810.99
46_L76_T0.9810.99
92_E216_A0.9800.99
354_L392_R0.9790.99
405_N408_H0.9780.99
14_Y52_E0.9770.99
182_N203_H0.9730.99
252_D329_Q0.9680.99
258_E286_F0.9670.99
404_E408_H0.9620.99
46_L178_S0.9580.99
14_Y56_A0.9550.99
339_Q343_L0.9550.99
42_E185_V0.9550.99
304_L353_T0.9490.99
411_Q414_A0.9480.99
113_M116_G0.9480.99
59_D251_R0.9470.99
311_I350_R0.9470.99
7_F15_L0.9390.99
127_H133_A0.9370.99
76_T178_S0.9350.99
304_L352_K0.9330.99
299_N386_Q0.9330.99
346_L364_F0.9320.99
5_T29_F0.9270.99
87_D90_L0.9260.99
310_Y313_A0.9190.99
386_Q389_E0.9160.99
84_A87_D0.9120.99
38_V70_E0.9000.99
255_Y260_L0.8940.99
32_N287_T0.8880.99
299_N334_T0.8840.99
356_E359_Q0.8820.99
4_K71_G0.8800.98
113_M119_P0.8800.98
343_L361_C0.8770.98
342_D345_K0.8730.98
314_L322_H0.8700.98
256_L259_A0.8700.98
79_F83_N0.8690.98
330_E358_A0.8680.98
100_C124_R0.8680.98
233_D301_D0.8670.98
78_R81_R0.8620.98
81_R88_Q0.8580.98
151_V206_N0.8580.98
31_R67_E0.8530.98
3_I196_H0.8530.98
320_A324_Q0.8500.98
162_F208_P0.8480.98
316_P345_K0.8470.98
347_L361_C0.8430.98
389_E393_D0.8430.98
404_E407_H0.8420.98
91_E130_E0.8420.98
322_H325_W0.8290.98
162_F172_I0.8280.98
280_E283_I0.8270.98
335_R338_P0.8260.98
174_R184_C0.8260.98
14_Y245_V0.8250.98
121_Y124_R0.8250.98
214_L217_L0.8200.98
68_W72_P0.8170.98
83_N130_E0.8110.97
22_T198_I0.8100.97
390_V416_E0.8080.97
19_G202_D0.8080.97
60_G248_M0.8080.97
108_L124_R0.8060.97
152_F211_I0.8050.97
288_L323_L0.8050.97
258_E322_H0.8040.97
403_A407_H0.8010.97
142_F172_I0.7980.97
370_E373_A0.7930.97
100_C105_L0.7890.97
391_V396_A0.7890.97
356_E360_S0.7840.97
111_E117_E0.7840.97
157_R202_D0.7820.97
288_L291_V0.7800.97
22_T25_Y0.7760.97
187_V217_L0.7750.97
112_Q119_P0.7740.97
213_I217_L0.7730.97
244_A253_D0.7680.96
26_S29_F0.7680.96
88_Q94_T0.7680.96
207_T224_Y0.7670.96
300_T304_L0.7640.96
374_D378_K0.7630.96
387_P413_T0.7620.96
258_E290_A0.7610.96
277_F282_M0.7600.96
401_W405_N0.7590.96
337_G341_A0.7580.96
105_L121_Y0.7580.96
163_S166_E0.7570.96
61_M66_L0.7570.96
266_R282_M0.7550.96
306_L310_Y0.7540.96
319_V323_L0.7500.96
32_N283_I0.7500.96
339_Q342_D0.7490.96
287_T290_A0.7490.96
296_S355_K0.7490.96
323_L357_M0.7490.96
334_T337_G0.7470.96
261_L282_M0.7470.96
99_Y120_R0.7460.96
353_T356_E0.7460.96
277_F281_E0.7450.96
103_E106_E0.7430.96
56_A248_M0.7420.96
394_K409_A0.7400.96
336_N339_Q0.7400.96
250_Y260_L0.7390.96
256_L307_N0.7390.96
391_V394_K0.7370.96
235_G367_D0.7360.95
267_L296_S0.7360.95
150_V212_N0.7360.95
387_P417_L0.7340.95
7_F57_I0.7320.95
262_N282_M0.7320.95
406_V409_A0.7310.95
255_Y303_L0.7300.95
276_I310_Y0.7250.95
328_E333_D0.7250.95
206_N210_Q0.7220.95
155_Q196_H0.7200.95
77_K166_E0.7200.95
30_A35_G0.7200.95
27_W67_E0.7180.95
120_R123_G0.7170.95
198_I288_L0.7170.95
61_M229_M0.7160.95
46_L49_S0.7120.95
127_H143_A0.7100.95
391_V410_I0.7050.94
232_G236_K0.7020.94
38_V69_D0.7010.94
143_A146_Q0.7010.94
100_C104_R0.7010.94
311_I314_L0.7010.94
170_L209_R0.7000.94
82_Y187_V0.6990.94
371_F375_A0.6980.94
142_F170_L0.6980.94
174_R178_S0.6950.94
382_P385_R0.6940.94
186_V214_L0.6940.94
234_D242_H0.6930.94
21_R230_I0.6930.94
47_E50_T0.6910.94
46_L176_D0.6900.94
178_S202_D0.6890.94
214_L219_A0.6880.94
201_E229_M0.6880.94
86_I183_F0.6880.94
394_K413_T0.6880.94
3_I33_H0.6870.93
83_N177_G0.6860.93
375_A379_H0.6830.93
187_V219_A0.6810.93
272_G290_A0.6770.93
407_H415_D0.6740.93
73_Y192_M0.6730.93
155_Q225_A0.6720.93
328_E331_N0.6710.93
334_T338_P0.6710.93
409_A413_T0.6700.93
103_E107_A0.6700.93
99_Y121_Y0.6680.93
205_N208_P0.6640.92
157_R204_I0.6640.92
152_F208_P0.6640.92
197_V207_T0.6640.92
214_L222_P0.6630.92
190_W193_E0.6620.92
164_N167_L0.6590.92
106_E113_M0.6590.92
385_R389_E0.6570.92
317_E329_Q0.6560.92
61_M200_G0.6530.92
409_A412_A0.6530.92
144_N167_L0.6510.92
187_V191_D0.6500.91
398_I405_N0.6490.91
22_T238_L0.6490.91
388_L392_R0.6470.91
250_Y259_A0.6460.91
111_E116_G0.6440.91
54_I165_Q0.6410.91
215_K218_K0.6410.91
131_H138_C0.6400.91
398_I409_A0.6400.91
258_E314_L0.6390.91
49_S53_A0.6390.91
319_V344_V0.6380.91
406_V410_I0.6350.91
255_Y279_R0.6340.90
320_A344_V0.6320.90
97_K136_E0.6310.90
150_V211_I0.6300.90
212_N215_K0.6290.90
317_E321_T0.6270.90
220_P223_V0.6270.90
405_N409_A0.6250.90
174_R210_Q0.6180.89
294_S320_A0.6180.89
330_E359_Q0.6160.89
85_V183_F0.6150.89
391_V395_L0.6150.89
322_H354_L0.6150.89
305_W309_H0.6130.89
190_W217_L0.6130.89
244_A249_Q0.6120.89
387_P390_V0.6120.89
104_R136_E0.6110.89
377_K381_R0.6100.89
381_R384_A0.6100.89
333_D337_G0.6090.89
17_V298_F0.6080.89
184_C190_W0.6080.89
325_W328_E0.6070.88
338_P342_D0.6070.88
410_I413_T0.6060.88
112_Q120_R0.6060.88
321_T324_Q0.6050.88
232_G243_G0.6040.88
274_Q285_Y0.6040.88
85_V186_V0.6040.88
232_G244_A0.6010.88
41_I54_I0.5990.88
186_V206_N0.5970.88
408_H411_Q0.5970.88
316_P320_A0.5950.87
24_L261_L0.5930.87
311_I354_L0.5920.87
112_Q150_V0.5920.87
78_R188_D0.5910.87
253_D300_T0.5910.87
266_R278_T0.5900.87
396_A400_D0.5890.87
162_F169_D0.5890.87
242_H245_V0.5890.87
236_K242_H0.5890.87
402_T406_V0.5880.87
341_A345_K0.5880.87
386_Q390_V0.5880.87
184_C188_D0.5870.87
88_Q219_A0.5870.87
75_Q82_Y0.5860.87
381_R385_R0.5850.87
15_L22_T0.5850.87
366_E369_A0.5850.87
152_F207_T0.5840.87
264_L267_L0.5830.86
398_I401_W0.5830.86
15_L20_A0.5830.86
407_H410_I0.5830.86
168_D209_R0.5820.86
108_L112_Q0.5800.86
355_K392_R0.5790.86
382_P386_Q0.5790.86
391_V413_T0.5790.86
119_P122_D0.5790.86
28_L265_V0.5770.86
49_S52_E0.5760.86
152_F162_F0.5760.86
314_L319_V0.5760.86
206_N213_I0.5760.86
156_I225_A0.5760.86
84_A191_D0.5750.86
76_T79_F0.5740.86
49_S203_H0.5730.85
105_L109_R0.5720.85
24_L28_L0.5720.85
174_R203_H0.5720.85
123_G146_Q0.5710.85
214_L221_V0.5710.85
248_M252_D0.5700.85
371_F374_D0.5700.85
370_E374_D0.5680.85
394_K398_I0.5680.85
73_Y77_K0.5660.85
190_W214_L0.5660.85
351_C360_S0.5660.85
6_R9_P0.5660.85
5_T37_F0.5630.84
356_E387_P0.5600.84
114_A146_Q0.5600.84
366_E371_F0.5600.84
197_V224_Y0.5580.84
97_K137_P0.5570.84
23_A66_L0.5570.84
338_P341_A0.5560.84
368_F371_F0.5540.84
121_Y126_R0.5540.84
202_D210_Q0.5520.83
6_R11_P0.5510.83
54_I58_M0.5510.83
321_T328_E0.5500.83
390_V413_T0.5480.83
274_Q277_F0.5480.83
162_F166_E0.5470.83
407_H414_A0.5470.83
255_Y259_A0.5460.83
156_I291_V0.5440.82
360_S363_Y0.5440.82
266_R271_H0.5440.82
119_P123_G0.5420.82
127_H130_E0.5420.82
262_N281_E0.5420.82
99_Y135_D0.5420.82
206_N209_R0.5410.82
63_W257_P0.5400.82
207_T211_I0.5390.82
7_F21_R0.5390.82
361_C365_Y0.5390.82
133_A137_P0.5390.82
105_L139_V0.5390.82
87_D97_K0.5380.82
170_L213_I0.5380.82
9_P13_G0.5370.82
15_L56_A0.5360.82
57_I60_G0.5350.81
182_N209_R0.5350.81
253_D355_K0.5350.81
225_A291_V0.5340.81
69_D73_Y0.5340.81
32_N284_K0.5320.81
312_N349_E0.5320.81
94_T215_K0.5320.81
307_N354_L0.5310.81
262_N286_F0.5310.81
258_E279_R0.5310.81
410_I414_A0.5300.81
119_P126_R0.5300.81
47_E51_P0.5300.81
46_L79_F0.5290.81
321_T327_I0.5280.81
233_D300_T0.5270.80
91_E123_G0.5260.80
19_G227_V0.5260.80
174_R202_D0.5260.80
99_Y134_D0.5250.80
326_H330_E0.5240.80
73_Y82_Y0.5240.80
191_D219_A0.5240.80
395_L398_I0.5240.80
164_N212_N0.5230.80
278_T310_Y0.5230.80
19_G22_T0.5230.80
155_Q289_N0.5210.80
374_D379_H0.5210.80
209_R232_G0.5200.80
28_L282_M0.5200.80
79_F82_Y0.5190.79
400_D408_H0.5190.79
5_T198_I0.5180.79
128_S136_E0.5160.79
49_S210_Q0.5150.79
373_A377_K0.5150.79
410_I417_L0.5150.79
345_K349_E0.5150.79
322_H326_H0.5150.79
339_Q364_F0.5140.79
347_L360_S0.5140.79
38_V72_P0.5130.79
66_L261_L0.5130.79
319_V322_H0.5120.79
33_H287_T0.5120.79
377_K380_L0.5120.79
157_R183_F0.5110.78
149_S164_N0.5100.78
109_R119_P0.5100.78
151_V205_N0.5090.78
365_Y379_H0.5090.78
157_R209_R0.5080.78
372_D379_H0.5070.78
151_V208_P0.5060.78
266_R292_S0.5040.77
17_V260_L0.5040.77
187_V213_I0.5030.77
4_K73_Y0.5030.77
120_R124_R0.5010.77
188_D206_N0.5000.77
51_P74_Y0.5000.77
207_T226_H0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ja2A 1 0.9745 100 0.233 Contact Map
2cfoA 1 0.9979 100 0.237 Contact Map
4griA 1 0.983 100 0.241 Contact Map
1j09A 1 0.9618 100 0.25 Contact Map
4g6zA 1 0.7877 100 0.257 Contact Map
3al0C 1 0.9512 100 0.259 Contact Map
3afhA 1 0.9512 100 0.262 Contact Map
2o5rA 1 0.9575 100 0.285 Contact Map
2hz7A 1 0.879 100 0.466 Contact Map
4h3sA 1 0.9406 100 0.477 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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