GREMLIN Database
TYRB - Aromatic-amino-acid aminotransferase
UniProt: P04693 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11040
Length: 397 (394)
Sequences: 2295 (1376)
Seq/√Len: 69.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_P166_T4.3441.00
111_G210_F4.3041.00
361_R365_E3.9111.00
79_I245_F3.6401.00
51_E307_S3.6021.00
78_A300_N3.4741.00
172_A206_E3.4301.00
168_K204_A3.3211.00
190_L198_V3.2371.00
164_L201_I3.2001.00
305_K309_L3.0921.00
329_V387_Q2.9501.00
29_V389_V2.8561.00
160_F194_Q2.8481.00
159_R162_D2.7981.00
25_R367_G2.7911.00
39_E383_T2.7441.00
123_G144_E2.6961.00
211_L232_I2.6461.00
327_V331_S2.6401.00
112_A138_F2.5921.00
249_F295_V2.5851.00
196_D231_A2.5781.00
381_L389_V2.5521.00
167_L176_V2.4451.00
333_E391_K2.4291.00
54_A58_A2.4191.00
360_D364_E2.3931.00
47_Q307_S2.3721.00
123_G146_S2.3641.00
192_N227_Y2.3381.00
128_D147_T2.3381.00
164_L197_A2.3151.00
203_K235_A2.2751.00
160_F164_L2.2471.00
360_D372_A2.1781.00
158_V188_A2.1501.00
51_E55_R2.1021.00
149_P165_A2.0981.00
109_K113_D2.0941.00
200_E235_A2.0781.00
55_R297_A2.0581.00
197_A200_E2.0571.00
81_P86_A2.0521.00
361_R366_F2.0391.00
55_R301_D2.0361.00
361_R396_V2.0001.00
329_V332_T1.9321.00
96_V260_S1.9111.00
233_A239_A1.8801.00
196_D227_Y1.8681.00
313_E317_T1.8631.00
49_V294_V1.8621.00
227_Y231_A1.8541.00
327_V343_L1.8541.00
267_E271_R1.8321.00
158_V190_L1.8261.00
125_W174_S1.8131.00
200_E204_A1.8041.00
354_L393_F1.7831.00
126_V130_T1.7801.00
29_V388_R1.7761.00
89_P93_Q1.7631.00
220_A346_R1.7401.00
226_A230_R1.7271.00
231_A235_A1.7151.00
389_V393_F1.6670.99
193_D196_D1.6610.99
51_E54_A1.6500.99
84_F241_V1.6460.99
202_L207_L1.6440.99
210_F242_S1.6360.99
115_L175_I1.6280.99
296_A300_N1.6200.99
172_A205_R1.6140.99
101_T107_A1.6060.99
199_I237_L1.6010.99
324_Q328_K1.5980.99
161_N197_A1.5960.99
109_K283_N1.5890.99
365_E395_A1.5760.99
110_V280_V1.5750.99
306_A310_A1.5680.99
80_A98_T1.5670.99
321_A383_T1.5620.99
135_V147_T1.5610.99
366_F395_A1.5480.99
149_P159_R1.5260.99
208_I240_L1.5170.99
27_D388_R1.5160.99
329_V333_E1.5040.99
77_H81_P1.4980.99
356_A372_A1.4970.99
38_N42_I1.4890.99
46_L315_M1.4800.99
19_R363_R1.4780.99
340_D344_N1.4770.99
23_D369_Y1.4620.99
126_V135_V1.4530.99
325_E386_V1.4490.99
70_E277_K1.4400.98
78_A81_P1.4350.98
7_A271_R1.4340.98
222_M309_L1.4330.98
382_N385_N1.4280.98
99_I280_V1.4280.98
67_L72_L1.4210.98
391_K395_A1.4140.98
103_G246_S1.4080.98
53_E290_F1.4010.98
335_P394_A1.4010.98
64_S290_F1.3980.98
84_F260_S1.3950.98
130_T135_V1.3830.98
328_K332_T1.3670.98
47_Q314_E1.3550.98
366_F388_R1.3500.98
135_V139_A1.3470.98
192_N224_E1.3270.97
83_L213_I1.3170.97
360_D363_R1.3070.97
111_G242_S1.3000.97
94_Q266_A1.2990.97
74_C296_A1.2670.97
164_L168_K1.2580.96
263_C269_A1.2550.96
43_I65_L1.2530.96
221_G224_E1.2500.96
125_W146_S1.2490.96
265_D268_A1.2490.96
176_V207_L1.2450.96
352_T374_G1.2380.96
192_N231_A1.2370.96
180_P213_I1.2370.96
72_L296_A1.2350.96
124_V177_L1.2330.96
359_V370_L1.2250.96
161_N165_A1.2160.96
112_A124_V1.2140.96
266_A270_G1.2100.95
231_A234_S1.2080.95
17_M30_N1.2030.95
73_N77_H1.1960.95
112_A141_A1.1880.95
98_T258_G1.1880.95
253_G289_N1.1750.95
356_A360_D1.1640.94
196_D234_S1.1600.94
165_A169_T1.1590.94
83_L241_V1.1540.94
331_S343_L1.1500.94
44_P311_E1.1500.94
98_T260_S1.1490.94
27_D367_G1.1470.94
199_I235_A1.1450.94
194_Q197_A1.1400.94
78_A296_A1.1340.94
127_S148_Y1.1330.94
240_L259_L1.1290.93
76_R98_T1.1220.93
18_E22_E1.1190.93
280_V284_Y1.1160.93
199_I231_A1.1100.93
362_L370_L1.1080.93
90_V96_V1.1040.93
128_D159_R1.0990.93
17_M33_I1.0970.92
325_E329_V1.0930.92
59_Q297_A1.0870.92
125_W170_L1.0870.92
325_E383_T1.0800.92
74_C78_A1.0700.92
13_I30_N1.0640.91
171_P174_S1.0590.91
152_D159_R1.0500.91
111_G259_L1.0450.91
90_V95_R1.0440.90
23_D367_G1.0380.90
44_P314_E1.0240.90
18_E277_K1.0190.89
311_E314_E0.9980.88
113_D140_G0.9970.88
327_V340_D0.9950.88
267_E270_G0.9930.88
165_A168_K0.9920.88
368_V389_V0.9900.88
96_V262_M0.9900.88
361_R395_A0.9880.88
328_K331_S0.9880.88
315_M318_R0.9880.88
355_S358_Q0.9870.88
115_L124_V0.9840.88
201_I205_R0.9820.88
101_T259_L0.9810.88
47_Q51_E0.9790.87
329_V390_A0.9730.87
17_M21_K0.9700.87
84_F96_V0.9680.87
51_E303_A0.9660.87
261_V272_V0.9630.87
240_L261_V0.9630.87
326_L390_A0.9610.86
281_R285_S0.9600.86
216_Q226_A0.9590.86
202_L237_L0.9570.86
54_A57_N0.9550.86
83_L229_I0.9540.86
238_P268_A0.9540.86
295_V299_L0.9520.86
101_T279_T0.9470.86
199_I232_I0.9460.86
200_E203_K0.9390.85
289_N293_Q0.9380.85
113_D283_N0.9360.85
173_R206_E0.9320.85
113_D141_A0.9310.85
101_T108_L0.9300.85
182_C219_G0.9200.84
168_K205_R0.9160.84
47_Q311_E0.9120.83
386_V390_A0.9090.83
387_Q391_K0.9070.83
155_T188_A0.9030.83
64_S254_E0.9030.83
67_L286_S0.9020.83
388_R392_A0.9000.83
172_A207_L0.8960.82
80_A84_F0.8950.82
222_M305_K0.8910.82
149_P162_D0.8890.82
8_Y275_Q0.8880.82
89_P234_S0.8880.82
37_Y43_I0.8870.82
79_I243_N0.8830.81
219_G346_R0.8820.81
62_G293_Q0.8790.81
67_L289_N0.8780.81
17_M32_S0.8770.81
115_L143_F0.8750.81
27_D391_K0.8750.81
198_V201_I0.8750.81
56_L294_V0.8720.81
53_E64_S0.8700.80
35_L43_I0.8690.80
49_V298_V0.8690.80
356_A359_V0.8660.80
216_Q243_N0.8650.80
167_L201_I0.8600.80
261_V276_L0.8600.80
108_L138_F0.8590.80
198_V202_L0.8590.80
202_L232_I0.8570.79
52_A55_R0.8550.79
162_D166_T0.8550.79
74_C300_N0.8540.79
13_I371_I0.8540.79
270_G273_L0.8500.79
110_V279_T0.8490.79
152_D161_N0.8450.78
168_K197_A0.8440.78
70_E76_R0.8390.78
151_Y188_A0.8380.78
294_V297_A0.8360.78
321_A325_E0.8340.78
212_D215_Y0.8340.78
136_A282_R0.8340.78
307_S310_A0.8340.78
160_F197_A0.8290.77
243_N258_G0.8290.77
104_G285_S0.8280.77
196_D235_A0.8280.77
368_V392_A0.8280.77
97_A269_A0.8270.77
359_V363_R0.8250.77
143_F177_L0.8230.77
48_A312_V0.8230.77
56_L297_A0.8200.76
37_Y65_L0.8180.76
174_S207_L0.8150.76
5_V275_Q0.8150.76
45_Q50_A0.8140.76
160_F201_I0.8130.76
223_E226_A0.8090.75
74_C77_H0.8040.75
223_E230_R0.8020.75
135_V145_V0.7990.74
249_F299_L0.7970.74
306_A309_L0.7970.74
79_I258_G0.7960.74
131_W349_F0.7950.74
15_T19_R0.7920.74
81_P305_K0.7890.74
215_Y255_R0.7830.73
331_S340_D0.7830.73
215_Y247_K0.7820.73
166_T169_T0.7820.73
176_V202_L0.7750.72
5_V114_F0.7740.72
121_E175_I0.7710.72
212_D247_K0.7700.72
16_L363_R0.7680.71
388_R391_K0.7660.71
184_N247_K0.7650.71
192_N196_D0.7590.71
326_L386_V0.7590.71
101_T110_V0.7570.70
40_D384_A0.7560.70
107_A242_S0.7520.70
34_G255_R0.7510.70
351_Y373_S0.7510.70
80_A260_S0.7470.69
81_P300_N0.7470.69
191_T194_Q0.7440.69
178_L202_L0.7410.69
325_E328_K0.7400.69
255_R281_R0.7400.69
243_N339_F0.7390.69
139_A144_E0.7390.69
263_C272_V0.7360.68
34_G215_Y0.7350.68
138_F145_V0.7290.68
124_V175_I0.7290.68
247_K375_R0.7280.67
357_A360_D0.7260.67
7_A274_G0.7220.67
104_G107_A0.7200.67
126_V145_V0.7160.66
167_L202_L0.7160.66
90_V233_A0.7150.66
138_F143_F0.7120.66
151_Y156_N0.7120.66
302_E306_A0.7100.65
345_Q351_Y0.7070.65
70_E273_L0.7040.65
48_A307_S0.6990.64
75_Y249_F0.6980.64
5_V118_Y0.6970.64
84_F262_M0.6960.64
247_K255_R0.6960.64
82_L222_M0.6930.64
111_G240_L0.6920.63
109_K141_A0.6890.63
298_V304_L0.6840.63
109_K140_G0.6840.63
150_W163_L0.6830.62
328_K343_L0.6830.62
97_A263_C0.6830.62
385_N388_R0.6820.62
378_V381_L0.6790.62
172_A204_A0.6780.62
117_R140_G0.6780.62
35_L65_L0.6770.62
319_I322_M0.6730.61
317_T321_A0.6730.61
12_P15_T0.6700.61
184_N255_R0.6690.61
298_V329_V0.6660.61
288_P291_G0.6650.60
182_C346_R0.6650.60
150_W189_D0.6640.60
9_A274_G0.6630.60
14_L286_S0.6620.60
215_Y281_R0.6620.60
225_D230_R0.6610.60
338_N344_N0.6600.60
52_A297_A0.6560.59
167_L174_S0.6550.59
140_G282_R0.6540.59
114_F276_L0.6540.59
119_F175_I0.6530.59
7_A270_G0.6520.59
313_E320_L0.6500.59
115_L208_I0.6490.59
87_D92_K0.6490.59
338_N341_Y0.6480.58
268_A271_R0.6470.58
184_N215_Y0.6470.58
321_A324_Q0.6460.58
105_S137_I0.6410.58
64_S311_E0.6410.58
87_D234_S0.6400.57
121_E173_R0.6400.57
139_A278_A0.6370.57
168_K201_I0.6360.57
110_V283_N0.6340.57
302_E305_K0.6330.57
303_A307_S0.6320.57
310_A314_E0.6320.57
161_N164_L0.6300.56
341_Y353_G0.6300.56
131_W247_K0.6280.56
284_Y311_E0.6270.56
29_V385_N0.6260.56
201_I204_A0.6240.56
114_F118_Y0.6240.56
222_M312_V0.6230.55
362_L365_E0.6230.55
8_Y105_S0.6230.55
170_L176_V0.6230.55
90_V93_Q0.6220.55
124_V143_F0.6210.55
253_G377_C0.6200.55
366_F396_V0.6190.55
223_E309_L0.6190.55
65_L339_F0.6190.55
2_F119_F0.6180.55
37_Y250_S0.6180.55
180_P228_A0.6150.55
309_L313_E0.6150.55
46_L218_F0.6140.54
239_A262_M0.6120.54
68_P236_G0.6100.54
88_H96_V0.6090.54
320_L324_Q0.6080.54
52_A304_L0.6080.54
255_R285_S0.6080.54
334_M394_A0.6070.54
214_A247_K0.6060.53
160_F198_V0.6060.53
319_I348_M0.6050.53
79_I98_T0.6030.53
133_N281_R0.6030.53
312_V316_R0.6030.53
97_A260_S0.6020.53
123_G174_S0.6020.53
155_T332_T0.6020.53
340_D343_L0.6010.53
227_Y352_T0.6000.53
75_Y79_I0.5980.52
119_F122_S0.5980.52
35_L377_C0.5960.52
3_Q6_D0.5930.52
363_R370_L0.5920.52
120_P175_I0.5920.52
243_N260_S0.5910.52
30_N68_P0.5900.52
180_P248_I0.5900.52
331_S338_N0.5900.52
203_K237_L0.5900.52
97_A276_L0.5890.51
127_S241_V0.5890.51
88_H91_L0.5880.51
43_I250_S0.5870.51
167_L198_V0.5870.51
354_L358_Q0.5860.51
34_G131_W0.5860.51
34_G212_D0.5850.51
55_R59_Q0.5850.51
48_A52_A0.5850.51
191_T266_A0.5840.51
146_S166_T0.5830.51
157_G188_A0.5830.51
168_K203_K0.5820.51
34_G214_A0.5820.51
6_D328_K0.5810.50
326_L370_L0.5810.50
13_I17_M0.5800.50
61_H289_N0.5800.50
245_F260_S0.5780.50
132_E135_V0.5770.50
56_L301_D0.5750.50
303_A306_A0.5740.50
15_T180_P0.5740.50
131_W212_D0.5730.49
368_V388_R0.5730.49
279_T283_N0.5720.49
103_G243_N0.5710.49
69_M280_V0.5700.49
170_L207_L0.5690.49
43_I64_S0.5680.49
158_V163_L0.5680.49
151_Y218_F0.5670.49
171_P207_L0.5670.49
176_V209_P0.5660.49
15_T105_S0.5660.49
131_W375_R0.5650.48
132_E282_R0.5630.48
112_A126_V0.5600.48
156_N337_R0.5600.48
131_W215_Y0.5600.48
131_W214_A0.5580.48
8_Y274_G0.5580.48
17_M20_F0.5580.48
224_E246_S0.5570.48
196_D200_E0.5570.48
182_C316_R0.5550.47
131_W255_R0.5540.47
97_A270_G0.5520.47
196_D199_I0.5510.47
163_L190_L0.5510.47
37_Y243_N0.5510.47
325_E387_Q0.5510.47
313_E316_R0.5500.47
324_Q343_L0.5500.47
75_Y258_G0.5480.46
112_A137_I0.5460.46
161_N194_Q0.5460.46
215_Y349_F0.5460.46
83_L90_V0.5460.46
199_I228_A0.5450.46
97_A273_L0.5450.46
197_A201_I0.5440.46
228_A231_A0.5440.46
217_G225_D0.5440.46
293_Q296_A0.5440.46
179_H246_S0.5430.46
25_R388_R0.5420.46
213_I243_N0.5410.46
184_N212_D0.5410.46
366_F392_A0.5410.46
200_E302_E0.5410.46
214_A349_F0.5410.46
105_S210_F0.5400.45
110_V143_F0.5400.45
26_S367_G0.5400.45
20_F32_S0.5390.45
32_S371_I0.5390.45
199_I202_L0.5380.45
111_G115_L0.5380.45
116_K122_S0.5370.45
103_G377_C0.5360.45
75_Y198_V0.5360.45
43_I46_L0.5360.45
152_D303_A0.5350.45
108_L284_Y0.5350.45
184_N214_A0.5340.45
83_L243_N0.5330.45
333_E394_A0.5330.45
115_L240_L0.5330.45
110_V272_V0.5320.45
266_A314_E0.5310.44
34_G247_K0.5310.44
113_D279_T0.5290.44
236_G239_A0.5290.44
224_E316_R0.5290.44
121_E144_E0.5280.44
29_V381_L0.5280.44
7_A10_G0.5260.44
163_L198_V0.5260.44
84_F98_T0.5260.44
39_E384_A0.5260.44
199_I203_K0.5250.44
359_V371_I0.5250.44
124_V298_V0.5240.44
212_D375_R0.5240.44
210_F240_L0.5230.43
160_F190_L0.5220.43
11_D15_T0.5210.43
6_D118_Y0.5210.43
34_G281_R0.5200.43
43_I63_A0.5190.43
131_W184_N0.5190.43
53_E57_N0.5190.43
124_V138_F0.5180.43
232_I236_G0.5180.43
46_L312_V0.5170.43
225_D308_W0.5170.43
167_L207_L0.5170.43
43_I182_C0.5160.43
182_C220_A0.5150.43
212_D255_R0.5140.42
249_F304_L0.5130.42
18_E21_K0.5120.42
378_V396_V0.5110.42
176_V201_I0.5110.42
152_D155_T0.5110.42
159_R165_A0.5110.42
79_I260_S0.5090.42
381_L385_N0.5080.42
86_A234_S0.5080.42
132_E136_A0.5080.42
25_R33_I0.5070.42
179_H216_Q0.5070.42
70_E73_N0.5060.41
75_Y245_F0.5060.41
91_L351_Y0.5060.41
310_A313_E0.5060.41
10_G105_S0.5060.41
209_P238_P0.5050.41
34_G184_N0.5050.41
127_S151_Y0.5040.41
99_I210_F0.5030.41
214_A375_R0.5030.41
316_R339_F0.5030.41
114_F275_Q0.5020.41
213_I216_Q0.5010.41
21_K63_A0.5010.41
370_L374_G0.5010.41
211_L248_I0.5000.41
16_L29_V0.5000.41
136_A278_A0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mebA 2 1 100 0.563 Contact Map
1yaaA 2 1 100 0.565 Contact Map
3k7yA 2 0.9924 100 0.594 Contact Map
1ajsA 2 1 100 0.595 Contact Map
4w5kA 2 0.9496 100 0.595 Contact Map
4wd2A 2 0.9899 100 0.599 Contact Map
4rkcA 2 0.9975 100 0.604 Contact Map
2q7wA 2 0.9471 100 0.605 Contact Map
2ay1A 2 0.9899 100 0.609 Contact Map
3fslA 2 0.9975 100 0.61 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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