GREMLIN Database
3MG2 - DNA-3-methyladenine glycosylase 2
UniProt: P04395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11222
Length: 282 (265)
Sequences: 2708 (2038)
Seq/√Len: 125.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_T160_R3.9961.00
79_S85_Q3.7711.00
144_E160_R3.6411.00
133_K137_R3.4451.00
201_D204_Q3.1711.00
258_E261_K3.1241.00
206_M221_N3.0231.00
239_Y243_Q2.9321.00
117_G223_F2.6741.00
210_Q220_A2.4401.00
249_T252_Q2.4241.00
208_T211_T2.3891.00
177_K180_E2.3811.00
127_S130_M2.3561.00
180_E184_H2.3511.00
114_F158_P2.3321.00
36_A49_T2.3221.00
165_D168_A2.2861.00
117_G185_L2.2291.00
138_V161_L2.2271.00
210_Q217_R2.2241.00
232_D264_R2.1421.00
121_I185_L2.1381.00
87_N90_I2.1141.00
183_I187_N2.1131.00
206_M210_Q2.0811.00
80_R85_Q1.9691.00
202_V230_A1.9561.00
114_F186_A1.9481.00
34_Y49_T1.8311.00
122_L135_T1.8171.00
27_V139_A1.8111.00
118_V155_F1.8061.00
92_N260_W1.7881.00
40_A144_E1.7671.00
193_T196_M1.7401.00
118_V182_L1.7341.00
122_L134_L1.7211.00
83_D86_C1.7091.00
187_N191_E1.6941.00
75_L79_S1.6801.00
188_A212_F1.6661.00
136_A140_Q1.6461.00
49_T62_N1.6381.00
125_L130_M1.6231.00
61_I78_M1.6211.00
206_M220_A1.6161.00
205_A224_A1.5671.00
10_Y15_M1.5441.00
53_D60_H1.5281.00
37_R115_E1.5271.00
142_Y168_A1.5231.00
109_G229_Q1.5201.00
233_V265_S1.5171.00
11_D14_W1.5001.00
225_L265_S1.4991.00
245_F253_I1.4811.00
180_E213_P1.4701.00
141_L168_A1.4421.00
140_Q153_I1.4291.00
184_H212_F1.4231.00
120_A222_Y1.4201.00
59_L82_F1.4201.00
142_Y164_A1.4121.00
166_P183_I1.4091.00
31_A34_Y1.4011.00
189_A196_M1.3941.00
148_D151_E1.3911.00
241_I268_L1.3901.00
29_T36_A1.3891.00
204_Q207_K1.3801.00
114_F118_V1.3791.00
134_L137_R1.3641.00
134_L174_M1.3571.00
16_L30_V1.3561.00
137_R173_G1.3541.00
130_M133_K1.3381.00
236_P254_R1.3351.00
206_M224_A1.3351.00
260_W267_A1.3171.00
37_R41_V1.3141.00
184_H188_A1.3101.00
114_F189_A1.3071.00
255_R258_E1.2771.00
184_H187_N1.2731.00
50_A61_I1.2661.00
127_S239_Y1.2461.00
224_A230_A1.2441.00
240_L244_R1.2411.00
159_Q190_L1.2210.99
42_G73_E1.2150.99
44_Y70_V1.2150.99
166_P179_A1.2040.99
124_Q218_W1.2020.99
158_P186_A1.1820.99
110_C116_Q1.1790.99
200_G204_Q1.1770.99
97_R101_A1.1760.99
200_G205_A1.1760.99
123_G126_V1.1730.99
205_A228_W1.1610.99
253_I257_A1.1600.99
63_L74_C1.1550.99
235_L268_L1.1530.99
126_V218_W1.1500.99
234_F257_A1.1370.99
13_S33_S1.1370.99
175_P178_R1.1350.99
117_G215_I1.1350.99
145_R151_E1.1290.99
235_L241_I1.1290.99
131_A218_W1.1260.99
12_W52_P1.1120.99
204_Q208_T1.1070.99
80_R229_Q1.1060.99
122_L174_M1.1000.99
126_V131_A1.0870.99
181_A184_H1.0800.99
230_A233_V1.0770.99
142_Y161_L1.0740.99
176_L179_A1.0740.99
39_L111_V1.0690.99
162_A190_L1.0650.98
143_G154_C1.0610.98
178_R216_G1.0610.98
195_P198_I1.0580.98
177_K181_A1.0410.98
36_A39_L1.0400.98
224_A228_W1.0350.98
36_A41_V1.0320.98
115_E155_F1.0250.98
38_S154_C1.0240.98
202_V232_D1.0200.98
162_A187_N1.0180.98
158_P189_A1.0180.98
121_I181_A1.0170.98
96_G100_A1.0110.98
73_E76_A1.0030.98
22_R120_A1.0020.98
257_A260_W1.0000.98
119_R135_T0.9970.98
83_D266_Y0.9940.98
261_K264_R0.9920.98
123_G272_W0.9870.98
139_A153_I0.9870.98
126_V130_M0.9860.97
170_K176_L0.9850.97
86_C91_V0.9850.97
130_M173_G0.9830.97
34_Y51_I0.9770.97
17_G21_A0.9750.97
129_A132_A0.9540.97
188_A192_G0.9440.97
265_S268_L0.9430.97
205_A230_A0.9350.97
80_R109_G0.9330.96
125_L218_W0.9290.96
123_G222_Y0.9290.96
164_A168_A0.9290.96
98_L270_H0.9270.96
117_G212_F0.9250.96
188_A193_T0.9200.96
116_Q227_G0.9180.96
179_A183_I0.9160.96
40_A45_R0.9160.96
169_L182_L0.9150.96
102_R273_Y0.9130.96
86_C266_Y0.9030.96
45_R144_E0.9000.96
160_R163_A0.9000.96
46_G52_P0.8960.96
235_L265_S0.8950.96
51_I60_H0.8920.95
222_Y226_R0.8880.95
241_I271_I0.8850.95
202_V205_A0.8820.95
91_V266_Y0.8730.95
217_R267_A0.8700.95
92_N95_L0.8670.95
126_V219_T0.8640.95
134_L173_G0.8590.94
92_N99_G0.8570.94
137_R140_Q0.8540.94
202_V224_A0.8540.94
202_V233_V0.8540.94
17_G20_A0.8520.94
130_M134_L0.8500.94
164_A171_A0.8450.94
128_V222_Y0.8440.94
218_W238_D0.8400.94
162_A183_I0.8380.94
221_N235_L0.8320.93
185_L212_F0.8300.93
203_E207_K0.8280.93
251_A255_R0.8140.93
28_E37_R0.8130.93
71_A75_L0.8090.92
118_V185_L0.8090.92
48_V61_I0.8080.92
243_Q246_P0.8050.92
47_V53_D0.8030.92
184_H213_P0.8030.92
196_M208_T0.7990.92
20_A32_D0.7960.92
49_T52_P0.7920.92
50_A59_L0.7920.92
249_T253_I0.7910.92
78_M82_F0.7890.92
145_R153_I0.7880.91
16_L20_A0.7880.91
22_R222_Y0.7870.91
200_G208_T0.7850.91
168_A171_A0.7820.91
124_Q219_T0.7810.91
235_L242_K0.7790.91
22_R35_Y0.7760.91
232_D261_K0.7720.91
126_V178_R0.7710.91
253_I256_Y0.7710.91
95_L98_L0.7690.90
50_A54_I0.7650.90
194_L212_F0.7590.90
138_V141_L0.7590.90
240_L270_H0.7580.90
254_R257_A0.7570.90
100_A103_P0.7570.90
202_V206_M0.7560.90
116_Q119_R0.7480.89
225_L235_L0.7460.89
59_L64_S0.7460.89
83_D231_K0.7450.89
219_T272_W0.7450.89
167_Q171_A0.7420.89
222_Y235_L0.7410.89
38_S41_V0.7410.89
163_A183_I0.7410.89
162_A186_A0.7350.88
14_W17_G0.7310.88
236_P268_L0.7300.88
81_L111_V0.7270.88
42_G136_A0.7240.88
121_I134_L0.7240.88
218_W222_Y0.7230.88
41_V44_Y0.7210.87
120_A219_T0.7200.87
134_L172_L0.7200.87
37_R40_A0.7170.87
232_D262_P0.7080.86
131_A219_T0.7060.86
176_L180_E0.6990.86
126_V174_M0.6980.86
125_L244_R0.6980.86
52_P55_A0.6950.85
98_L274_T0.6930.85
72_A76_A0.6880.85
96_G103_P0.6840.85
210_Q221_N0.6740.84
125_L239_Y0.6740.84
147_D151_E0.6740.84
231_K263_W0.6730.84
242_K246_P0.6720.83
222_Y272_W0.6700.83
28_E35_Y0.6700.83
93_G99_G0.6690.83
192_G195_P0.6670.83
65_A70_V0.6670.83
113_A263_W0.6650.83
252_Q255_R0.6630.83
138_V172_L0.6620.83
116_Q120_A0.6600.82
130_M177_K0.6600.82
143_G160_R0.6600.82
218_W272_W0.6560.82
124_Q216_G0.6550.82
59_L62_N0.6540.82
165_D170_K0.6540.82
220_A224_A0.6520.82
193_T211_T0.6500.81
130_M178_R0.6490.81
137_R172_L0.6470.81
35_Y46_G0.6430.81
39_L155_F0.6430.81
187_N190_L0.6420.81
218_W240_L0.6360.80
15_M18_F0.6350.80
190_L212_F0.6340.80
88_P263_W0.6340.80
244_R274_T0.6310.79
225_L268_L0.6310.79
145_R158_P0.6280.79
217_R221_N0.6260.79
123_G131_A0.6230.79
47_V64_S0.6190.78
54_I57_H0.6190.78
135_T155_F0.6180.78
123_G218_W0.6170.78
224_A227_G0.6170.78
125_L175_P0.6170.78
125_L240_L0.6170.78
181_A219_T0.6160.78
159_Q193_T0.6130.78
124_Q181_A0.6110.77
68_E165_D0.6080.77
149_F152_Y0.6060.77
125_L176_L0.6060.77
192_G196_M0.6050.77
234_F237_D0.6050.77
74_C260_W0.6040.76
185_L223_F0.6030.76
223_F227_G0.6020.76
221_N236_P0.5980.76
174_M182_L0.5970.76
105_L273_Y0.5960.76
18_F222_Y0.5960.76
127_S174_M0.5940.75
202_V221_N0.5940.75
21_A25_S0.5920.75
125_L272_W0.5870.74
218_W239_Y0.5860.74
236_P250_P0.5860.74
23_A132_A0.5850.74
127_S172_L0.5840.74
250_P253_I0.5830.74
18_F30_V0.5830.74
58_T187_N0.5820.74
125_L217_R0.5800.74
74_C82_F0.5800.74
71_A79_S0.5760.73
99_G103_P0.5730.73
83_D88_P0.5730.73
116_Q229_Q0.5730.73
123_G128_V0.5690.72
184_H189_A0.5690.72
97_R100_A0.5680.72
54_I58_T0.5640.72
161_L165_D0.5610.71
126_V239_Y0.5570.71
126_V272_W0.5570.71
125_L177_K0.5540.70
19_L27_V0.5540.70
241_I248_M0.5530.70
103_P262_P0.5500.70
37_R109_G0.5490.69
81_L241_I0.5480.69
100_A270_H0.5480.69
55_A58_T0.5470.69
35_Y81_L0.5460.69
77_K80_R0.5460.69
198_I208_T0.5440.69
18_F269_L0.5430.69
127_S134_L0.5410.68
107_L269_L0.5400.68
117_G121_I0.5390.68
20_A25_S0.5380.68
48_V51_I0.5360.68
55_A59_L0.5340.67
174_M179_A0.5340.67
166_P180_E0.5320.67
188_A191_E0.5310.67
207_K211_T0.5280.67
84_L106_R0.5270.66
191_E208_T0.5270.66
41_V46_G0.5260.66
40_A43_E0.5260.66
256_Y259_R0.5240.66
11_D215_I0.5240.66
116_Q226_R0.5240.66
113_A227_G0.5230.66
216_G238_D0.5230.66
67_L70_V0.5230.66
115_E226_R0.5220.66
267_A271_I0.5200.65
23_A30_V0.5200.65
96_G101_A0.5180.65
106_R123_G0.5170.65
126_V181_A0.5170.65
161_L186_A0.5160.65
14_W21_A0.5130.64
18_F22_R0.5130.64
14_W18_F0.5130.64
137_R141_L0.5110.64
15_M21_A0.5100.64
269_L273_Y0.5100.64
33_S36_A0.5080.64
115_E120_A0.5080.64
10_Y30_V0.5070.63
44_Y50_A0.5060.63
174_M178_R0.5060.63
128_V216_G0.5060.63
224_A233_V0.5050.63
46_G74_C0.5040.63
250_P258_E0.5040.63
29_T151_E0.5030.63
249_T257_A0.5020.63
90_I263_W0.5010.63
58_T62_N0.5010.63
88_P228_W0.5000.62
197_T211_T0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mpgA 1 1 100 0.165 Contact Map
2jhnA 1 0.9645 100 0.234 Contact Map
4ejyA 1 0.9326 100 0.284 Contact Map
3i0wA 1 0.9326 100 0.312 Contact Map
2xhiA 1 0.9433 100 0.327 Contact Map
4b21A 2 0.6667 100 0.406 Contact Map
2yg9A 1 0.6844 100 0.442 Contact Map
2h56A 1 0.7057 100 0.459 Contact Map
3s6iA 1 0.6844 100 0.466 Contact Map
3fhgA 2 0.6525 100 0.588 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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