3MG2 - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

3MG2 - DNA-3-methyladenine glycosylase 2

UniProt:	P04395	Sequences: MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTAIPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGAARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11222
Length:	282 (265)
Sequences:	2708 (2038)
Seq/√Len:	125.2

ECOLI - 3MG2
BACSU - YFJP 3MGA
HALSA - Q9HQ94 Q9HQ62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_T	160_R	3.996	1.00
79_S	85_Q	3.771	1.00
144_E	160_R	3.641	1.00
133_K	137_R	3.445	1.00
201_D	204_Q	3.171	1.00
258_E	261_K	3.124	1.00
206_M	221_N	3.023	1.00
239_Y	243_Q	2.932	1.00
117_G	223_F	2.674	1.00
210_Q	220_A	2.440	1.00
249_T	252_Q	2.424	1.00
208_T	211_T	2.389	1.00
177_K	180_E	2.381	1.00
127_S	130_M	2.356	1.00
180_E	184_H	2.351	1.00
114_F	158_P	2.332	1.00
36_A	49_T	2.322	1.00
165_D	168_A	2.286	1.00
117_G	185_L	2.229	1.00
138_V	161_L	2.227	1.00
210_Q	217_R	2.224	1.00
232_D	264_R	2.142	1.00
121_I	185_L	2.138	1.00
87_N	90_I	2.114	1.00
183_I	187_N	2.113	1.00
206_M	210_Q	2.081	1.00
80_R	85_Q	1.969	1.00
202_V	230_A	1.956	1.00
114_F	186_A	1.948	1.00
34_Y	49_T	1.831	1.00
122_L	135_T	1.817	1.00
27_V	139_A	1.811	1.00
118_V	155_F	1.806	1.00
92_N	260_W	1.788	1.00
40_A	144_E	1.767	1.00
193_T	196_M	1.740	1.00
118_V	182_L	1.734	1.00
122_L	134_L	1.721	1.00
83_D	86_C	1.709	1.00
187_N	191_E	1.694	1.00
75_L	79_S	1.680	1.00
188_A	212_F	1.666	1.00
136_A	140_Q	1.646	1.00
49_T	62_N	1.638	1.00
125_L	130_M	1.623	1.00
61_I	78_M	1.621	1.00
206_M	220_A	1.616	1.00
205_A	224_A	1.567	1.00
10_Y	15_M	1.544	1.00
53_D	60_H	1.528	1.00
37_R	115_E	1.527	1.00
142_Y	168_A	1.523	1.00
109_G	229_Q	1.520	1.00
233_V	265_S	1.517	1.00
11_D	14_W	1.500	1.00
225_L	265_S	1.499	1.00
245_F	253_I	1.481	1.00
180_E	213_P	1.470	1.00
141_L	168_A	1.442	1.00
140_Q	153_I	1.429	1.00
184_H	212_F	1.423	1.00
120_A	222_Y	1.420	1.00
59_L	82_F	1.420	1.00
142_Y	164_A	1.412	1.00
166_P	183_I	1.409	1.00
31_A	34_Y	1.401	1.00
189_A	196_M	1.394	1.00
148_D	151_E	1.391	1.00
241_I	268_L	1.390	1.00
29_T	36_A	1.389	1.00
204_Q	207_K	1.380	1.00
114_F	118_V	1.379	1.00
134_L	137_R	1.364	1.00
134_L	174_M	1.357	1.00
16_L	30_V	1.356	1.00
137_R	173_G	1.354	1.00
130_M	133_K	1.338	1.00
236_P	254_R	1.335	1.00
206_M	224_A	1.335	1.00
260_W	267_A	1.317	1.00
37_R	41_V	1.314	1.00
184_H	188_A	1.310	1.00
114_F	189_A	1.307	1.00
255_R	258_E	1.277	1.00
184_H	187_N	1.273	1.00
50_A	61_I	1.266	1.00
127_S	239_Y	1.246	1.00
224_A	230_A	1.244	1.00
240_L	244_R	1.241	1.00
159_Q	190_L	1.221	0.99
42_G	73_E	1.215	0.99
44_Y	70_V	1.215	0.99
166_P	179_A	1.204	0.99
124_Q	218_W	1.202	0.99
158_P	186_A	1.182	0.99
110_C	116_Q	1.179	0.99
200_G	204_Q	1.177	0.99
97_R	101_A	1.176	0.99
200_G	205_A	1.176	0.99
123_G	126_V	1.173	0.99
205_A	228_W	1.161	0.99
253_I	257_A	1.160	0.99
63_L	74_C	1.155	0.99
235_L	268_L	1.153	0.99
126_V	218_W	1.150	0.99
234_F	257_A	1.137	0.99
13_S	33_S	1.137	0.99
175_P	178_R	1.135	0.99
117_G	215_I	1.135	0.99
145_R	151_E	1.129	0.99
235_L	241_I	1.129	0.99
131_A	218_W	1.126	0.99
12_W	52_P	1.112	0.99
204_Q	208_T	1.107	0.99
80_R	229_Q	1.106	0.99
122_L	174_M	1.100	0.99
126_V	131_A	1.087	0.99
181_A	184_H	1.080	0.99
230_A	233_V	1.077	0.99
142_Y	161_L	1.074	0.99
176_L	179_A	1.074	0.99
39_L	111_V	1.069	0.99
162_A	190_L	1.065	0.98
143_G	154_C	1.061	0.98
178_R	216_G	1.061	0.98
195_P	198_I	1.058	0.98
177_K	181_A	1.041	0.98
36_A	39_L	1.040	0.98
224_A	228_W	1.035	0.98
36_A	41_V	1.032	0.98
115_E	155_F	1.025	0.98
38_S	154_C	1.024	0.98
202_V	232_D	1.020	0.98
162_A	187_N	1.018	0.98
158_P	189_A	1.018	0.98
121_I	181_A	1.017	0.98
96_G	100_A	1.011	0.98
73_E	76_A	1.003	0.98
22_R	120_A	1.002	0.98
257_A	260_W	1.000	0.98
119_R	135_T	0.997	0.98
83_D	266_Y	0.994	0.98
261_K	264_R	0.992	0.98
123_G	272_W	0.987	0.98
139_A	153_I	0.987	0.98
126_V	130_M	0.986	0.97
170_K	176_L	0.985	0.97
86_C	91_V	0.985	0.97
130_M	173_G	0.983	0.97
34_Y	51_I	0.977	0.97
17_G	21_A	0.975	0.97
129_A	132_A	0.954	0.97
188_A	192_G	0.944	0.97
265_S	268_L	0.943	0.97
205_A	230_A	0.935	0.97
80_R	109_G	0.933	0.96
125_L	218_W	0.929	0.96
123_G	222_Y	0.929	0.96
164_A	168_A	0.929	0.96
98_L	270_H	0.927	0.96
117_G	212_F	0.925	0.96
188_A	193_T	0.920	0.96
116_Q	227_G	0.918	0.96
179_A	183_I	0.916	0.96
40_A	45_R	0.916	0.96
169_L	182_L	0.915	0.96
102_R	273_Y	0.913	0.96
86_C	266_Y	0.903	0.96
45_R	144_E	0.900	0.96
160_R	163_A	0.900	0.96
46_G	52_P	0.896	0.96
235_L	265_S	0.895	0.96
51_I	60_H	0.892	0.95
222_Y	226_R	0.888	0.95
241_I	271_I	0.885	0.95
202_V	205_A	0.882	0.95
91_V	266_Y	0.873	0.95
217_R	267_A	0.870	0.95
92_N	95_L	0.867	0.95
126_V	219_T	0.864	0.95
134_L	173_G	0.859	0.94
92_N	99_G	0.857	0.94
137_R	140_Q	0.854	0.94
202_V	224_A	0.854	0.94
202_V	233_V	0.854	0.94
17_G	20_A	0.852	0.94
130_M	134_L	0.850	0.94
164_A	171_A	0.845	0.94
128_V	222_Y	0.844	0.94
218_W	238_D	0.840	0.94
162_A	183_I	0.838	0.94
221_N	235_L	0.832	0.93
185_L	212_F	0.830	0.93
203_E	207_K	0.828	0.93
251_A	255_R	0.814	0.93
28_E	37_R	0.813	0.93
71_A	75_L	0.809	0.92
118_V	185_L	0.809	0.92
48_V	61_I	0.808	0.92
243_Q	246_P	0.805	0.92
47_V	53_D	0.803	0.92
184_H	213_P	0.803	0.92
196_M	208_T	0.799	0.92
20_A	32_D	0.796	0.92
49_T	52_P	0.792	0.92
50_A	59_L	0.792	0.92
249_T	253_I	0.791	0.92
78_M	82_F	0.789	0.92
145_R	153_I	0.788	0.91
16_L	20_A	0.788	0.91
22_R	222_Y	0.787	0.91
200_G	208_T	0.785	0.91
168_A	171_A	0.782	0.91
124_Q	219_T	0.781	0.91
235_L	242_K	0.779	0.91
22_R	35_Y	0.776	0.91
232_D	261_K	0.772	0.91
126_V	178_R	0.771	0.91
253_I	256_Y	0.771	0.91
95_L	98_L	0.769	0.90
50_A	54_I	0.765	0.90
194_L	212_F	0.759	0.90
138_V	141_L	0.759	0.90
240_L	270_H	0.758	0.90
254_R	257_A	0.757	0.90
100_A	103_P	0.757	0.90
202_V	206_M	0.756	0.90
116_Q	119_R	0.748	0.89
225_L	235_L	0.746	0.89
59_L	64_S	0.746	0.89
83_D	231_K	0.745	0.89
219_T	272_W	0.745	0.89
167_Q	171_A	0.742	0.89
222_Y	235_L	0.741	0.89
38_S	41_V	0.741	0.89
163_A	183_I	0.741	0.89
162_A	186_A	0.735	0.88
14_W	17_G	0.731	0.88
236_P	268_L	0.730	0.88
81_L	111_V	0.727	0.88
42_G	136_A	0.724	0.88
121_I	134_L	0.724	0.88
218_W	222_Y	0.723	0.88
41_V	44_Y	0.721	0.87
120_A	219_T	0.720	0.87
134_L	172_L	0.720	0.87
37_R	40_A	0.717	0.87
232_D	262_P	0.708	0.86
131_A	219_T	0.706	0.86
176_L	180_E	0.699	0.86
126_V	174_M	0.698	0.86
125_L	244_R	0.698	0.86
52_P	55_A	0.695	0.85
98_L	274_T	0.693	0.85
72_A	76_A	0.688	0.85
96_G	103_P	0.684	0.85
210_Q	221_N	0.674	0.84
125_L	239_Y	0.674	0.84
147_D	151_E	0.674	0.84
231_K	263_W	0.673	0.84
242_K	246_P	0.672	0.83
222_Y	272_W	0.670	0.83
28_E	35_Y	0.670	0.83
93_G	99_G	0.669	0.83
192_G	195_P	0.667	0.83
65_A	70_V	0.667	0.83
113_A	263_W	0.665	0.83
252_Q	255_R	0.663	0.83
138_V	172_L	0.662	0.83
116_Q	120_A	0.660	0.82
130_M	177_K	0.660	0.82
143_G	160_R	0.660	0.82
218_W	272_W	0.656	0.82
124_Q	216_G	0.655	0.82
59_L	62_N	0.654	0.82
165_D	170_K	0.654	0.82
220_A	224_A	0.652	0.82
193_T	211_T	0.650	0.81
130_M	178_R	0.649	0.81
137_R	172_L	0.647	0.81
35_Y	46_G	0.643	0.81
39_L	155_F	0.643	0.81
187_N	190_L	0.642	0.81
218_W	240_L	0.636	0.80
15_M	18_F	0.635	0.80
190_L	212_F	0.634	0.80
88_P	263_W	0.634	0.80
244_R	274_T	0.631	0.79
225_L	268_L	0.631	0.79
145_R	158_P	0.628	0.79
217_R	221_N	0.626	0.79
123_G	131_A	0.623	0.79
47_V	64_S	0.619	0.78
54_I	57_H	0.619	0.78
135_T	155_F	0.618	0.78
123_G	218_W	0.617	0.78
224_A	227_G	0.617	0.78
125_L	175_P	0.617	0.78
125_L	240_L	0.617	0.78
181_A	219_T	0.616	0.78
159_Q	193_T	0.613	0.78
124_Q	181_A	0.611	0.77
68_E	165_D	0.608	0.77
149_F	152_Y	0.606	0.77
125_L	176_L	0.606	0.77
192_G	196_M	0.605	0.77
234_F	237_D	0.605	0.77
74_C	260_W	0.604	0.76
185_L	223_F	0.603	0.76
223_F	227_G	0.602	0.76
221_N	236_P	0.598	0.76
174_M	182_L	0.597	0.76
105_L	273_Y	0.596	0.76
18_F	222_Y	0.596	0.76
127_S	174_M	0.594	0.75
202_V	221_N	0.594	0.75
21_A	25_S	0.592	0.75
125_L	272_W	0.587	0.74
218_W	239_Y	0.586	0.74
236_P	250_P	0.586	0.74
23_A	132_A	0.585	0.74
127_S	172_L	0.584	0.74
250_P	253_I	0.583	0.74
18_F	30_V	0.583	0.74
58_T	187_N	0.582	0.74
125_L	217_R	0.580	0.74
74_C	82_F	0.580	0.74
71_A	79_S	0.576	0.73
99_G	103_P	0.573	0.73
83_D	88_P	0.573	0.73
116_Q	229_Q	0.573	0.73
123_G	128_V	0.569	0.72
184_H	189_A	0.569	0.72
97_R	100_A	0.568	0.72
54_I	58_T	0.564	0.72
161_L	165_D	0.561	0.71
126_V	239_Y	0.557	0.71
126_V	272_W	0.557	0.71
125_L	177_K	0.554	0.70
19_L	27_V	0.554	0.70
241_I	248_M	0.553	0.70
103_P	262_P	0.550	0.70
37_R	109_G	0.549	0.69
81_L	241_I	0.548	0.69
100_A	270_H	0.548	0.69
55_A	58_T	0.547	0.69
35_Y	81_L	0.546	0.69
77_K	80_R	0.546	0.69
198_I	208_T	0.544	0.69
18_F	269_L	0.543	0.69
127_S	134_L	0.541	0.68
107_L	269_L	0.540	0.68
117_G	121_I	0.539	0.68
20_A	25_S	0.538	0.68
48_V	51_I	0.536	0.68
55_A	59_L	0.534	0.67
174_M	179_A	0.534	0.67
166_P	180_E	0.532	0.67
188_A	191_E	0.531	0.67
207_K	211_T	0.528	0.67
84_L	106_R	0.527	0.66
191_E	208_T	0.527	0.66
41_V	46_G	0.526	0.66
40_A	43_E	0.526	0.66
256_Y	259_R	0.524	0.66
11_D	215_I	0.524	0.66
116_Q	226_R	0.524	0.66
113_A	227_G	0.523	0.66
216_G	238_D	0.523	0.66
67_L	70_V	0.523	0.66
115_E	226_R	0.522	0.66
267_A	271_I	0.520	0.65
23_A	30_V	0.520	0.65
96_G	101_A	0.518	0.65
106_R	123_G	0.517	0.65
126_V	181_A	0.517	0.65
161_L	186_A	0.516	0.65
14_W	21_A	0.513	0.64
18_F	22_R	0.513	0.64
14_W	18_F	0.513	0.64
137_R	141_L	0.511	0.64
15_M	21_A	0.510	0.64
269_L	273_Y	0.510	0.64
33_S	36_A	0.508	0.64
115_E	120_A	0.508	0.64
10_Y	30_V	0.507	0.63
44_Y	50_A	0.506	0.63
174_M	178_R	0.506	0.63
128_V	216_G	0.506	0.63
224_A	233_V	0.505	0.63
46_G	74_C	0.504	0.63
250_P	258_E	0.504	0.63
29_T	151_E	0.503	0.63
249_T	257_A	0.502	0.63
90_I	263_W	0.501	0.63
58_T	62_N	0.501	0.63
88_P	228_W	0.500	0.62
197_T	211_T	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mpgA	1	1	100	0.165	Contact Map
2jhnA	1	0.9645	100	0.234	Contact Map
4ejyA	1	0.9326	100	0.284	Contact Map
3i0wA	1	0.9326	100	0.312	Contact Map
2xhiA	1	0.9433	100	0.327	Contact Map
4b21A	2	0.6667	100	0.406	Contact Map
2yg9A	1	0.6844	100	0.442	Contact Map
2h56A	1	0.7057	100	0.459	Contact Map
3s6iA	1	0.6844	100	0.466	Contact Map
3fhgA	2	0.6525	100	0.588	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.