GREMLIN Database
OTC1 - Ornithine carbamoyltransferase chain I
UniProt: P04391 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10069
Length: 334 (296)
Sequences: 7168 (3655)
Seq/√Len: 212.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_S304_E4.1151.00
158_T183_D3.8371.00
41_A44_T3.3811.00
158_T185_R3.2971.00
271_F301_V3.1251.00
160_V226_A3.1001.00
220_A263_L2.9921.00
31_K147_E2.8301.00
145_M228_F2.7931.00
26_L329_V2.7331.00
98_G122_S2.7181.00
227_D266_N2.6261.00
99_R315_D2.6091.00
148_H312_I2.5941.00
218_D221_K2.5651.00
270_K312_I2.5581.00
28_A146_Q2.4851.00
91_K116_T2.3031.00
49_A101_Y2.3031.00
11_K133_F2.2951.00
25_Q146_Q2.2611.00
67_A72_A2.1911.00
272_L312_I2.1851.00
28_A143_L2.1181.00
48_I67_A2.1121.00
103_G328_M2.1051.00
21_N146_Q2.1031.00
196_A200_T2.0761.00
138_L176_A2.0251.00
190_Q217_E1.9951.00
187_V222_G1.9411.00
193_W217_E1.9401.00
149_L268_E1.9391.00
223_V229_I1.9041.00
142_L176_A1.9001.00
278_F299_M1.8791.00
69_D325_K1.8431.00
148_H315_D1.8361.00
261_M269_V1.8281.00
177_A184_L1.8161.00
99_R318_E1.8021.00
17_P21_N1.7981.00
258_S262_Q1.7931.00
68_Y73_R1.7611.00
105_Q128_G1.7521.00
183_D214_T1.7301.00
16_T19_E1.7091.00
216_T221_K1.6711.00
22_S330_A1.6681.00
110_G113_I1.6381.00
61_C97_L1.6351.00
185_R216_T1.6261.00
30_L329_V1.5921.00
136_T327_V1.5921.00
259_K262_Q1.5791.00
264_T269_V1.5671.00
48_I103_G1.5661.00
149_L157_M1.5421.00
23_L330_A1.5181.00
192_C250_L1.5061.00
190_Q193_W1.5001.00
26_L330_A1.4851.00
17_P179_L1.4821.00
78_G81_G1.4781.00
173_M230_Y1.4741.00
53_E113_I1.4641.00
183_D212_N1.4631.00
220_A260_M1.4621.00
133_F175_E1.4581.00
160_V187_V1.4551.00
7_K19_E1.4531.00
269_V310_A1.4521.00
9_F139_L1.4471.00
17_P155_N1.4171.00
246_E250_L1.4151.00
228_F270_K1.4051.00
27_A143_L1.3881.00
42_K329_V1.3801.00
225_G266_N1.3661.00
230_Y316_Q1.3561.00
95_R307_E1.3421.00
136_T324_I1.3411.00
24_L146_Q1.3271.00
162_A223_V1.3211.00
219_V260_M1.3181.00
115_E119_E1.3071.00
188_A193_W1.2981.00
229_I256_V1.2971.00
160_V185_R1.2841.00
94_A117_L1.2841.00
257_N302_T1.2831.00
24_L143_L1.2811.00
29_K33_D1.2651.00
224_E263_L1.2631.00
60_R64_E1.2601.00
26_L29_K1.2521.00
95_R314_F1.2481.00
57_T93_T1.2461.00
9_F327_V1.2391.00
13_L175_E1.2361.00
261_M271_F1.2321.00
298_G303_D1.2321.00
12_L176_A1.2261.00
255_Q302_T1.2261.00
231_T256_V1.2241.00
48_I105_Q1.2231.00
143_L323_T1.2181.00
153_A157_M1.2161.00
322_H325_K1.2131.00
277_A306_F1.2051.00
216_T222_G1.1921.00
21_N180_T1.1881.00
91_K120_Y1.1831.00
57_T87_K1.1801.00
157_M228_F1.1681.00
185_R214_T1.1571.00
34_K69_D1.1501.00
68_Y74_V1.1481.00
297_G307_E1.1451.00
177_A182_L1.1411.00
57_T83_Q1.1381.00
8_H118_A1.1271.00
139_L327_V1.1201.00
104_I123_V1.1181.00
245_A249_A1.1181.00
223_V260_M1.1131.00
66_A328_M1.1021.00
261_M310_A1.0961.00
149_L227_D1.0941.00
21_N25_Q1.0841.00
256_V271_F1.0831.00
199_V215_L1.0821.00
104_I117_L1.0791.00
11_K14_D1.0691.00
28_A147_E1.0681.00
67_A74_V1.0651.00
308_S311_S1.0561.00
149_L270_K1.0521.00
31_K319_N1.0501.00
96_V317_A1.0451.00
9_F15_F1.0451.00
318_E322_H1.0441.00
174_L186_L1.0411.00
112_E116_T1.0241.00
55_D85_G1.0241.00
187_V216_T1.0231.00
103_G332_L1.0171.00
24_L28_A1.0161.00
159_L177_A0.9981.00
95_R120_Y0.9901.00
138_L173_M0.9901.00
138_L169_M0.9881.00
20_L180_T0.9771.00
142_L180_T0.9671.00
250_L253_E0.9651.00
69_D321_M0.9601.00
24_L323_T0.9581.00
159_L173_M0.9561.00
64_E76_Y0.9531.00
306_F313_V0.9491.00
61_C77_L0.9400.99
103_G126_W0.9360.99
48_I72_A0.9360.99
126_W327_V0.9360.99
31_K143_L0.9360.99
165_A188_A0.9340.99
32_A36_S0.9310.99
98_G123_V0.9310.99
147_E319_N0.9300.99
20_L179_L0.9300.99
221_K224_E0.9280.99
11_K175_E0.9210.99
114_V130_T0.9210.99
111_Q115_E0.9210.99
83_Q93_T0.9140.99
171_N198_L0.9130.99
41_A71_G0.9030.99
153_A156_E0.9010.99
91_K95_R0.9010.99
194_P215_L0.9000.99
149_L312_I0.8990.99
108_G130_T0.8970.99
217_E254_Y0.8960.99
91_K307_E0.8930.99
297_G306_F0.8890.99
47_N73_R0.8890.99
8_H98_G0.8860.99
246_E249_A0.8860.99
145_M157_M0.8820.99
106_Y117_L0.8740.99
187_V226_A0.8730.99
154_F180_T0.8730.99
12_L138_L0.8720.99
133_F172_S0.8720.99
245_A248_I0.8710.99
259_K263_L0.8680.99
64_E68_Y0.8650.99
25_Q29_K0.8610.99
47_N69_D0.8590.99
67_A328_M0.8580.99
185_R226_A0.8580.99
143_L147_E0.8570.99
315_D318_E0.8570.99
83_Q86_H0.8540.99
8_H121_A0.8510.99
132_E195_E0.8480.99
64_E74_V0.8420.99
258_S308_S0.8390.99
158_T225_G0.8390.99
220_A224_E0.8380.99
139_L323_T0.8360.99
33_D40_E0.8350.99
33_D36_S0.8310.99
63_F136_T0.8270.99
165_A170_G0.8230.99
297_G303_D0.8200.99
303_D307_E0.8170.99
29_K32_A0.8160.99
53_E84_I0.8140.99
46_K102_D0.8130.98
261_M305_V0.8120.98
162_A229_I0.8120.98
185_R225_G0.8120.98
187_V219_V0.8080.98
83_Q87_K0.8080.98
28_A32_A0.8070.98
305_V308_S0.8060.98
214_T221_K0.8040.98
91_K303_D0.8030.98
6_H331_T0.7960.98
174_L184_L0.7950.98
145_M154_F0.7920.98
145_M149_L0.7900.98
261_M264_T0.7890.98
106_Y113_I0.7840.98
47_N65_V0.7730.98
144_T312_I0.7730.98
22_S26_L0.7670.98
162_A260_M0.7670.98
20_L176_A0.7640.98
10_L118_A0.7590.98
116_T120_Y0.7560.98
23_L323_T0.7560.98
95_R98_G0.7520.97
12_L20_L0.7500.97
49_A104_I0.7490.97
222_G226_A0.7480.97
115_E118_A0.7480.97
220_A259_K0.7470.97
248_I299_M0.7440.97
62_S324_I0.7420.97
108_G113_I0.7420.97
15_F23_L0.7410.97
149_L228_F0.7380.97
257_N260_M0.7350.97
303_D306_F0.7340.97
43_L103_G0.7330.97
27_A326_A0.7330.97
144_T319_N0.7320.97
326_A330_A0.7290.97
312_I315_D0.7260.97
174_L194_P0.7250.97
256_V301_V0.7240.97
33_D39_E0.7230.97
170_G186_L0.7220.97
62_S100_M0.7200.97
27_A323_T0.7130.97
94_A121_A0.7130.97
87_K93_T0.7120.97
158_T226_A0.7110.96
199_V213_I0.7060.96
7_K330_A0.7060.96
101_Y123_V0.7060.96
150_P154_F0.7060.96
173_M177_A0.7050.96
110_G131_N0.7010.96
145_M177_A0.7000.96
261_M301_V0.6990.96
26_L30_L0.6990.96
150_P156_E0.6980.96
116_T119_E0.6960.96
162_A219_V0.6940.96
145_M270_K0.6920.96
66_A324_I0.6910.96
229_I269_V0.6890.96
23_L326_A0.6840.96
223_V263_L0.6800.95
258_S302_T0.6800.95
50_L67_A0.6790.95
112_E115_E0.6760.95
235_V243_K0.6750.95
18_A21_N0.6740.95
9_F331_T0.6730.95
50_L74_V0.6700.95
82_S87_K0.6700.95
90_I113_I0.6690.95
260_M263_L0.6680.95
252_R255_Q0.6670.95
148_H270_K0.6650.95
57_T86_H0.6650.95
43_L72_A0.6650.95
41_A45_G0.6620.95
193_W215_L0.6610.95
6_H330_A0.6600.95
159_L230_Y0.6570.95
50_L76_Y0.6560.95
298_G304_E0.6530.94
17_P209_N0.6520.94
193_W196_A0.6500.94
271_F305_V0.6480.94
12_L15_F0.6470.94
48_I328_M0.6470.94
219_V223_V0.6460.94
138_L316_Q0.6440.94
142_L146_Q0.6430.94
308_S313_V0.6410.94
233_V237_M0.6400.94
20_L139_L0.6390.94
98_G121_A0.6350.94
249_A252_R0.6340.93
243_K248_I0.6330.93
82_S86_H0.6310.93
30_L39_E0.6310.93
229_I261_M0.6300.93
230_Y233_V0.6300.93
262_Q310_A0.6300.93
277_A301_V0.6280.93
145_M159_L0.6270.93
47_N68_Y0.6260.93
57_T82_S0.6240.93
63_F324_I0.6240.93
30_L33_D0.6190.93
65_V75_T0.6170.93
62_S136_T0.6170.93
103_G331_T0.6150.92
162_A231_T0.6130.92
89_S307_E0.6120.92
23_L327_V0.6050.92
230_Y272_L0.6030.92
55_D83_Q0.6010.92
160_V222_G0.6000.91
126_W331_T0.5970.91
194_P199_V0.5960.91
69_D102_D0.5960.91
129_L168_N0.5950.91
233_V278_F0.5950.91
93_T97_L0.5940.91
18_A22_S0.5940.91
251_L302_T0.5920.91
55_D81_G0.5890.91
176_A180_T0.5890.91
175_E198_L0.5880.91
328_M332_L0.5870.91
126_W328_M0.5870.91
54_K238_G0.5870.91
12_L133_F0.5840.90
160_V216_T0.5840.90
142_L154_F0.5840.90
55_D87_K0.5840.90
241_K246_E0.5830.90
112_E130_T0.5830.90
258_S310_A0.5810.90
188_A194_P0.5810.90
306_F311_S0.5810.90
138_L142_L0.5800.90
30_L42_K0.5790.90
146_Q153_A0.5760.90
178_A184_L0.5760.90
24_L27_A0.5740.90
10_L115_E0.5700.89
147_E315_D0.5690.89
112_E132_E0.5680.89
104_I121_A0.5670.89
65_V321_M0.5670.89
160_V229_I0.5660.89
34_K39_E0.5650.89
239_E242_E0.5640.89
228_F272_L0.5630.89
197_A200_T0.5610.89
94_A104_I0.5590.88
43_L328_M0.5570.88
63_F105_Q0.5570.88
14_D179_L0.5560.88
133_F198_L0.5560.88
9_F20_L0.5560.88
169_M230_Y0.5520.88
65_V69_D0.5500.88
157_M227_D0.5490.87
150_P270_K0.5480.87
31_K322_H0.5450.87
63_F128_G0.5440.87
188_A217_E0.5420.87
306_F314_F0.5420.87
166_R192_C0.5410.87
62_S96_V0.5410.87
39_E42_K0.5410.87
54_K237_M0.5410.87
25_Q28_A0.5400.87
242_E247_R0.5400.87
96_V99_R0.5400.87
8_H122_S0.5400.87
247_R251_L0.5390.87
19_E22_S0.5380.86
178_A211_G0.5370.86
178_A209_N0.5350.86
105_Q126_W0.5340.86
53_E108_G0.5340.86
191_A250_L0.5340.86
55_D82_S0.5330.86
169_M173_M0.5320.86
308_S312_I0.5320.86
22_S25_Q0.5320.86
149_L153_A0.5310.86
54_K109_Y0.5290.86
186_L213_I0.5270.85
36_S40_E0.5260.85
256_V261_M0.5240.85
19_E330_A0.5240.85
40_E45_G0.5230.85
271_F311_S0.5220.85
129_L237_M0.5210.85
243_K278_F0.5200.85
223_V264_T0.5190.84
13_L133_F0.5190.84
109_Y113_I0.5180.84
187_V223_V0.5170.84
60_R76_Y0.5170.84
94_A125_V0.5160.84
77_L82_S0.5160.84
50_L105_Q0.5130.84
216_T219_V0.5130.84
191_A249_A0.5100.83
88_E92_D0.5090.83
90_I106_Y0.5080.83
176_A182_L0.5070.83
154_F182_L0.5070.83
96_V314_F0.5060.83
55_D76_Y0.5050.83
11_K115_E0.5040.83
178_A213_I0.5040.83
146_Q149_L0.5030.83
275_L314_F0.5020.82
228_F312_I0.5010.82
39_E44_T0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h31A 3 0.991 100 0.053 Contact Map
1duvG 3 0.994 100 0.054 Contact Map
2w37A 5 0.985 100 0.058 Contact Map
1pvvA 6 0.9311 100 0.063 Contact Map
1dxhA 6 0.988 100 0.065 Contact Map
4nf2A 3 0.9162 100 0.067 Contact Map
2i6uA 3 0.9162 100 0.069 Contact Map
3gd5A 4 0.8533 100 0.069 Contact Map
4amuA 6 0.988 100 0.07 Contact Map
1vlvA 6 0.9012 100 0.075 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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