GREMLIN Database
FRSA - Esterase FrsA
UniProt: P04335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11091
Length: 414 (321)
Sequences: 1179 (882)
Seq/√Len: 49.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_A409_I4.0201.00
263_D266_R3.8641.00
223_I410_E3.7961.00
169_R187_M3.6911.00
283_A293_V3.3881.00
172_E180_P3.2541.00
188_P224_A3.2221.00
288_P355_P3.0711.00
254_K289_R2.9661.00
221_R410_E2.8771.00
174_T180_P2.8071.00
279_A293_V2.7841.00
196_T224_A2.7741.00
255_A259_V2.7481.00
169_R259_V2.6531.00
294_A409_I2.6191.00
323_S326_G2.5751.00
378_T384_G2.5661.00
198_L290_L2.5351.00
185_L226_L2.5331.00
349_L352_R2.3521.00
255_A258_N2.3511.00
171_M183_G2.3351.00
280_V295_C2.3161.00
196_T226_L2.3141.00
188_P194_F2.2621.00
117_D407_D2.1721.00
265_T291_K2.1571.00
207_Q210_Y2.1531.00
318_L323_S2.1071.00
292_A357_P2.0921.00
197_V409_I2.0781.00
173_F183_G2.0471.00
85_L104_Q2.0441.00
257_P264_H2.0291.00
315_E319_D1.9320.99
285_L349_L1.9120.99
106_M132_Y1.9050.99
311_Q315_E1.8700.99
292_A409_I1.8540.99
268_A292_A1.8350.99
186_H227_T1.8350.99
338_E341_R1.8280.99
194_F224_A1.8180.99
196_T262_V1.8140.99
366_D394_V1.8060.99
316_M321_L1.7840.99
193_P196_T1.7370.99
223_I409_I1.7150.98
109_Q156_A1.7010.98
198_L226_L1.6950.98
171_M226_L1.6540.98
316_M323_S1.6290.98
116_D121_S1.6040.98
231_P248_L1.6040.98
338_E342_Y1.5890.97
363_W369_S1.5650.97
112_A121_S1.5630.97
253_L267_V1.5620.97
392_N395_Y1.5610.97
250_Q254_K1.5570.97
201_G205_A1.5570.97
175_V251_H1.5360.97
196_T256_L1.5320.97
196_T267_V1.5310.97
132_Y135_A1.5080.97
375_R379_S1.5040.96
246_S281_R1.5030.96
279_A283_A1.4880.96
230_M233_V1.4820.96
193_P258_N1.4740.96
311_Q314_P1.4650.96
235_F238_K1.4560.96
185_L259_V1.4420.95
319_D323_S1.4340.95
301_H373_D1.4330.95
173_F252_V1.4190.95
385_K411_K1.4130.95
293_V356_T1.4060.95
389_I400_K1.4020.95
122_G164_L1.4010.95
378_T386_L1.3800.94
273_R394_V1.3670.94
371_E375_R1.3560.94
275_G366_D1.3490.94
401_G405_I1.3490.94
238_K242_T1.3460.93
387_L404_E1.3380.93
173_F228_I1.3200.93
350_L377_I1.3160.93
360_S386_L1.3120.93
195_P266_R1.3060.92
294_A359_L1.3040.92
146_A154_N1.3010.92
293_V358_M1.2860.92
193_P291_K1.2790.92
185_L255_A1.2730.91
149_A152_L1.2730.91
284_Y354_C1.2730.91
145_L156_A1.2650.91
89_V96_N1.2460.90
310_Q313_V1.2380.90
148_Q151_A1.2250.90
314_P323_S1.2240.90
301_H304_L1.2230.90
230_M245_S1.2200.90
371_E388_E1.2190.89
304_L376_L1.2180.89
201_G229_D1.2110.89
185_L262_V1.2060.89
117_D130_T1.2060.89
189_K194_F1.1940.88
160_A164_L1.1910.88
100_E103_T1.1790.88
234_G267_V1.1780.88
145_L148_Q1.1620.87
171_M255_A1.1590.87
301_H343_S1.1510.87
390_P394_V1.1500.87
280_V377_I1.1480.86
253_L286_E1.1410.86
107_V258_N1.1390.86
185_L224_A1.1390.86
239_W243_Q1.1330.86
284_Y377_I1.1230.85
286_E289_R1.1200.85
109_Q152_L1.1130.85
95_G99_Y1.1100.85
271_G276_A1.1080.84
226_L256_L1.1070.84
224_A261_W1.1060.84
290_L356_T1.1020.84
344_L349_L1.0960.84
156_A160_A1.0810.83
320_V323_S1.0780.83
185_L261_W1.0710.82
87_D95_G1.0680.82
110_Q113_C1.0650.82
244_D247_L1.0650.82
250_Q286_E1.0640.82
214_Y268_A1.0620.82
333_E337_V1.0600.82
320_V324_R1.0570.81
320_V326_G1.0530.81
88_T100_E1.0500.81
316_M319_D1.0470.81
301_H376_L1.0450.81
273_R276_A1.0450.81
195_P263_D1.0450.81
311_Q318_L1.0420.81
204_D231_P1.0400.80
375_R388_E1.0390.80
233_V253_L1.0380.80
150_Q154_N1.0370.80
246_S277_N1.0320.80
254_K408_W1.0270.80
316_M320_V1.0210.79
381_S384_G1.0190.79
218_F406_T1.0130.79
97_W112_A1.0110.79
249_H282_L1.0080.78
360_S374_S1.0060.78
207_Q227_T1.0050.78
297_G368_F1.0010.78
148_Q156_A0.9960.77
380_S383_D0.9920.77
201_G230_M0.9890.77
121_S128_A0.9850.77
148_Q152_L0.9820.76
362_Y372_E0.9800.76
390_P395_Y0.9760.76
183_G226_L0.9730.76
273_R363_W0.9720.76
267_V291_K0.9700.76
176_P251_H0.9680.75
400_K404_E0.9680.75
246_S282_L0.9660.75
367_P393_P0.9650.75
297_G344_L0.9640.75
298_P369_S0.9620.75
316_M325_L0.9590.75
228_I252_V0.9480.74
395_Y405_I0.9460.74
270_F294_A0.9360.73
391_F395_Y0.9270.72
157_Y186_H0.9240.72
153_S156_A0.9240.72
272_F296_L0.9230.72
319_D326_G0.9190.72
134_I137_Y0.9180.71
280_V358_M0.9170.71
239_W242_T0.9140.71
90_I93_R0.9120.71
312_Q315_E0.9110.71
389_I408_W0.9080.71
281_R284_Y0.9070.71
139_H145_L0.9070.71
331_S334_A0.9000.70
363_W394_V0.8820.68
304_L350_L0.8820.68
277_N284_Y0.8800.68
317_Y321_L0.8800.68
191_D387_L0.8800.68
314_P320_V0.8790.68
202_G230_M0.8790.68
335_L339_L0.8770.68
147_E151_A0.8750.68
159_E162_Q0.8730.68
270_F296_L0.8720.67
315_E318_L0.8690.67
297_G366_D0.8640.67
354_C357_P0.8560.66
318_L326_G0.8550.66
150_Q229_D0.8510.66
237_S240_K0.8510.66
331_S335_L0.8490.65
385_K388_E0.8480.65
321_L325_L0.8460.65
144_D148_Q0.8450.65
216_R268_A0.8430.65
314_P321_L0.8430.65
159_E197_V0.8410.65
229_D236_S0.8410.65
127_H131_L0.8400.65
185_L188_P0.8400.65
203_L274_F0.8380.64
263_D292_A0.8330.64
198_L253_L0.8320.64
117_D120_L0.8310.64
201_G204_D0.8290.64
283_A356_T0.8270.63
286_E290_L0.8240.63
294_A405_I0.8230.63
277_N281_R0.8180.62
319_D324_R0.8170.62
204_D230_M0.8170.62
95_G103_T0.8160.62
145_L149_A0.8120.62
110_Q258_N0.8090.62
318_L325_L0.8060.61
366_D369_S0.8030.61
201_G248_L0.8020.61
250_Q288_P0.7980.61
186_H219_A0.7980.61
407_D410_E0.7960.60
115_E118_P0.7960.60
245_S248_L0.7930.60
90_I96_N0.7930.60
273_R366_D0.7920.60
158_E170_Q0.7900.60
88_T95_G0.7880.60
133_N209_D0.7880.60
317_Y320_V0.7860.59
381_S408_W0.7810.59
202_G276_A0.7760.58
175_V234_G0.7750.58
203_L206_M0.7740.58
102_A109_Q0.7730.58
403_Q407_D0.7720.58
109_Q132_Y0.7710.58
272_F395_Y0.7700.58
133_N138_P0.7690.58
169_R172_E0.7680.58
362_Y371_E0.7660.57
318_L321_L0.7640.57
335_L338_E0.7620.57
291_K339_L0.7620.57
330_A334_A0.7610.57
205_A241_L0.7600.57
153_S160_A0.7600.57
282_L286_E0.7570.57
203_L368_F0.7530.56
271_G275_G0.7520.56
197_V359_L0.7500.56
97_W101_W0.7490.56
203_L248_L0.7470.56
399_D403_Q0.7430.55
318_L322_A0.7420.55
200_C363_W0.7380.55
152_L155_R0.7340.54
136_A139_H0.7260.53
157_Y161_A0.7250.53
112_A128_A0.7230.53
168_M186_H0.7200.53
142_G161_A0.7180.53
247_L251_H0.7120.52
274_F363_W0.7110.52
201_G233_V0.7100.52
297_G363_W0.7080.52
169_R409_I0.7070.51
385_K408_W0.7060.51
324_R327_M0.7030.51
272_F297_G0.7010.51
106_M109_Q0.6990.51
202_G273_R0.6990.51
95_G98_I0.6980.51
106_M152_L0.6950.50
105_A132_Y0.6940.50
271_G366_D0.6930.50
178_G354_C0.6900.50
256_L334_A0.6890.50
80_R83_D0.6880.50
274_F369_S0.6850.49
379_S384_G0.6850.49
363_W368_F0.6810.49
102_A106_M0.6800.49
149_A156_A0.6800.49
224_A262_V0.6790.49
202_G275_G0.6780.49
142_G146_A0.6760.48
258_N265_T0.6720.48
154_N159_E0.6700.48
298_P372_E0.6690.48
152_L156_A0.6660.47
175_V181_I0.6640.47
362_Y366_D0.6640.47
364_K371_E0.6640.47
215_E227_T0.6600.47
102_A149_A0.6590.47
217_Y402_L0.6560.46
168_M184_F0.6560.46
125_W159_E0.6540.46
80_R267_V0.6500.46
236_S344_L0.6500.46
269_A282_L0.6480.45
175_V179_A0.6470.45
107_V111_K0.6470.45
146_A153_S0.6450.45
268_A294_A0.6440.45
310_Q367_P0.6410.45
321_L324_R0.6400.45
279_A358_M0.6400.45
171_M198_L0.6380.44
253_L370_P0.6380.44
169_R394_V0.6370.44
80_R93_R0.6370.44
299_V332_D0.6360.44
246_S289_R0.6350.44
95_G145_L0.6350.44
105_A128_A0.6340.44
96_N99_Y0.6310.44
155_R343_S0.6300.44
154_N157_Y0.6290.44
171_M174_T0.6260.43
161_A164_L0.6250.43
272_F295_C0.6210.43
143_D148_Q0.6190.43
176_P179_A0.6180.42
232_S363_W0.6170.42
291_K357_P0.6160.42
288_P356_T0.6160.42
310_Q314_P0.6140.42
315_E326_G0.6140.42
125_W174_T0.6140.42
259_V265_T0.6130.42
155_R164_L0.6120.42
94_G108_W0.6110.42
248_L252_V0.6110.42
254_K258_N0.6090.42
112_A137_Y0.6080.41
255_A267_V0.6040.41
81_T85_L0.6040.41
317_Y323_S0.5990.41
280_V293_V0.5980.41
141_K145_L0.5970.40
154_N160_A0.5970.40
203_L278_V0.5970.40
169_R261_W0.5960.40
281_R286_E0.5950.40
310_Q316_M0.5930.40
237_S248_L0.5920.40
212_S218_F0.5900.40
205_A406_T0.5890.40
144_D151_A0.5880.40
233_V245_S0.5860.39
304_L373_D0.5860.39
297_G369_S0.5850.39
113_C162_Q0.5850.39
299_V373_D0.5840.39
110_Q114_A0.5840.39
197_V366_D0.5830.39
281_R285_L0.5820.39
230_M248_L0.5810.39
130_T133_N0.5800.39
94_G137_Y0.5800.39
115_E119_Q0.5800.39
182_T205_A0.5790.39
148_Q154_N0.5790.39
274_F279_A0.5790.39
172_E183_G0.5780.39
88_T243_Q0.5780.39
86_Y91_G0.5780.39
186_H215_E0.5770.38
275_G363_W0.5770.38
330_A338_E0.5750.38
151_A156_A0.5750.38
140_L146_A0.5740.38
98_I124_H0.5740.38
113_C125_W0.5730.38
118_P159_E0.5690.38
284_Y349_L0.5680.38
189_K265_T0.5680.38
269_A290_L0.5670.38
204_D248_L0.5660.37
156_A159_E0.5660.37
89_V97_W0.5630.37
357_P381_S0.5630.37
229_D401_G0.5620.37
370_P376_L0.5610.37
296_L401_G0.5590.37
262_V299_V0.5580.37
288_P293_V0.5560.36
134_I252_V0.5560.36
189_K220_P0.5560.36
117_D410_E0.5540.36
93_R133_N0.5540.36
94_G113_C0.5510.36
100_E135_A0.5510.36
203_L335_L0.5500.36
346_V351_G0.5490.36
301_H342_Y0.5460.36
92_Y137_Y0.5440.35
108_W124_H0.5440.35
216_R220_P0.5440.35
201_G323_S0.5430.35
229_D368_F0.5430.35
262_V268_A0.5430.35
183_G269_A0.5390.35
384_G387_L0.5390.35
253_L257_P0.5380.35
202_G277_N0.5370.35
204_D281_R0.5370.35
151_A155_R0.5370.35
179_A251_H0.5360.35
166_G210_Y0.5360.35
85_L93_R0.5340.34
120_L144_D0.5300.34
135_A281_R0.5300.34
112_A122_G0.5290.34
321_L326_G0.5290.34
281_R408_W0.5280.34
101_W105_A0.5280.34
128_A135_A0.5280.34
274_F300_V0.5280.34
109_Q151_A0.5270.34
134_I138_P0.5260.34
191_D265_T0.5260.34
245_S278_V0.5240.33
157_Y160_A0.5230.33
136_A140_L0.5230.33
356_T410_E0.5210.33
193_P263_D0.5200.33
205_A230_M0.5180.33
298_P367_P0.5170.33
310_Q315_E0.5170.33
146_A150_Q0.5160.33
240_K243_Q0.5160.33
107_V191_D0.5160.33
187_M224_A0.5160.33
257_P289_R0.5140.33
334_A338_E0.5140.33
223_I387_L0.5130.33
84_D374_S0.5120.32
196_T294_A0.5110.32
202_G232_S0.5110.32
86_Y90_I0.5100.32
195_P224_A0.5090.32
214_Y219_A0.5090.32
204_D229_D0.5080.32
101_W231_P0.5070.32
97_W110_Q0.5070.32
87_D96_N0.5070.32
223_I404_E0.5060.32
189_K224_A0.5060.32
253_L357_P0.5050.32
203_L297_G0.5040.32
211_Y215_E0.5040.32
118_P181_I0.5030.32
279_A361_G0.5020.32
194_F261_W0.5010.31
92_Y98_I0.5010.31
132_Y138_P0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i4cA 1 0.9638 100 0.319 Contact Map
3fnbA 2 0.8357 100 0.526 Contact Map
2jbwA 2 0.8116 100 0.549 Contact Map
2z3zA 2 0.9251 100 0.549 Contact Map
1xfdA 2 0.9517 100 0.563 Contact Map
4q1vA 2 0.9275 100 0.567 Contact Map
4wjlA 2 0.9541 100 0.571 Contact Map
4a5sA 2 0.9541 100 0.585 Contact Map
2ecfA 2 0.9493 100 0.588 Contact Map
4bp8A 1 0.9734 100 0.592 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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