GREMLIN Database
UMUC - Protein UmuC
UniProt: P04152 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11056
Length: 422 (366)
Sequences: 8835 (6224)
Seq/√Len: 325.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_E126_T3.8951.00
126_T130_R3.0021.00
182_D192_S2.9441.00
259_D262_S2.8811.00
264_R327_T2.8811.00
28_V67_V2.8471.00
90_E130_R2.7941.00
285_C347_L2.6901.00
18_F76_L2.6281.00
248_I346_M2.4141.00
196_D201_K2.3561.00
7_V135_V2.3361.00
55_W69_C2.3271.00
264_R331_D2.3121.00
128_L161_G2.2921.00
80_M83_R2.2861.00
125_A129_Q2.2131.00
73_N76_L2.2081.00
122_E126_T2.2071.00
24_G43_E2.1931.00
182_D196_D2.1851.00
201_K205_D2.1661.00
91_L126_T2.1141.00
96_E143_K2.0901.00
204_L208_D2.0671.00
198_M217_H2.0631.00
92_S105_C2.0541.00
227_R232_E2.0341.00
226_V230_R2.0231.00
127_V135_V2.0071.00
16_T41_N1.9781.00
260_Y331_D1.9711.00
215_R223_E1.9661.00
177_S204_L1.9531.00
200_I206_L1.9521.00
25_K68_V1.9401.00
124_R161_G1.9401.00
177_S207_A1.9311.00
200_I209_T1.9131.00
7_V84_V1.8711.00
274_A347_L1.8551.00
3_A107_L1.8551.00
18_F73_N1.8461.00
7_V133_L1.8181.00
287_F349_D1.8081.00
211_I223_E1.7941.00
278_L347_L1.7821.00
359_N362_D1.7481.00
57_K61_L1.7461.00
85_M103_A1.7271.00
167_S171_R1.7091.00
224_R228_E1.6811.00
268_C323_I1.6761.00
318_D321_D1.6391.00
289_S348_G1.6291.00
317_Q353_Q1.6231.00
76_L79_D1.6191.00
12_A27_V1.6071.00
124_R163_V1.6051.00
310_V328_R1.6001.00
89_E95_V1.6001.00
291_F344_G1.5971.00
19_R22_L1.5901.00
43_E46_A1.5781.00
98_Y104_F1.5551.00
117_T121_R1.5411.00
271_A322_I1.5401.00
310_V332_A1.5281.00
28_V37_V1.5251.00
17_V80_M1.5241.00
53_D61_L1.5111.00
28_V69_C1.5041.00
145_L166_L1.4851.00
193_K197_A1.4841.00
115_D118_D1.4811.00
287_F348_G1.4721.00
192_S196_D1.4701.00
79_D83_R1.4641.00
202_T205_D1.4561.00
257_I263_M1.4551.00
209_T213_F1.4501.00
211_I227_R1.4451.00
171_R174_K1.4451.00
119_F123_I1.4401.00
249_C274_A1.4371.00
91_L122_E1.4281.00
275_A319_S1.4271.00
198_M218_F1.4261.00
141_Q172_Q1.4241.00
3_A137_V1.4201.00
272_A319_S1.4171.00
173_R177_S1.4141.00
47_L64_R1.4111.00
312_L325_A1.4051.00
326_A345_V1.3981.00
16_T23_W1.3921.00
223_E227_R1.3871.00
5_C135_V1.3831.00
120_G137_V1.3811.00
14_C76_L1.3671.00
15_E77_Y1.3551.00
271_A345_V1.3541.00
88_L105_C1.3471.00
54_P57_K1.3461.00
258_T339_R1.3351.00
121_R125_A1.3311.00
222_L226_V1.3291.00
260_Y264_R1.3231.00
120_G139_I1.3181.00
278_L285_C1.3111.00
28_V49_V1.3091.00
57_K60_D1.3081.00
139_I163_V1.3061.00
87_T130_R1.3031.00
286_R349_D1.3031.00
275_A322_I1.2991.00
14_C80_M1.2991.00
209_T214_I1.2981.00
211_I226_V1.2961.00
293_K299_L1.2871.00
9_A13_S1.2801.00
140_A145_L1.2761.00
22_L27_V1.2721.00
284_Y351_F1.2721.00
255_E262_S1.2691.00
19_R70_F1.2681.00
3_A120_G1.2621.00
104_F185_W1.2611.00
107_L119_F1.2581.00
173_R207_A1.2581.00
250_S344_G1.2541.00
87_T126_T1.2521.00
211_I215_R1.2501.00
12_A16_T1.2451.00
117_T165_D1.2401.00
42_A46_A1.2391.00
86_S89_E1.2391.00
75_E79_D1.2321.00
214_I226_V1.2301.00
16_T43_E1.2281.00
47_L62_F1.2271.00
249_C277_K1.2261.00
279_R378_D1.2081.00
190_R193_K1.2031.00
249_C273_R1.2011.00
289_S309_S1.2001.00
121_R124_R1.1991.00
76_L80_M1.1981.00
357_Q360_L1.1891.00
5_C88_L1.1861.00
312_L316_T1.1821.00
87_T131_T1.1801.00
253_F266_A1.1791.00
293_K342_K1.1751.00
194_K217_H1.1741.00
152_A164_V1.1711.00
321_D325_A1.1701.00
247_I281_E1.1681.00
253_F257_I1.1681.00
323_I327_T1.1661.00
325_A328_R1.1601.00
205_D208_D1.1571.00
310_V325_A1.1561.00
27_V70_F1.1561.00
149_A166_L1.1431.00
287_F309_S1.1401.00
37_V49_V1.1381.00
213_F217_H1.1341.00
15_E73_N1.1341.00
88_L103_A1.1301.00
271_A275_A1.1141.00
4_L150_N1.1131.00
210_D213_F1.1051.00
257_I262_S1.1041.00
17_V76_L1.1011.00
94_R239_E1.0931.00
30_L55_W1.0841.00
85_M97_I1.0841.00
37_V40_R1.0771.00
327_T331_D1.0671.00
49_V67_V1.0671.00
324_N328_R1.0631.00
148_L179_L1.0621.00
33_N59_K1.0531.00
207_A230_R1.0491.00
271_A323_I1.0481.00
250_S291_F1.0481.00
266_A269_S1.0441.00
110_V114_R1.0391.00
17_V132_H1.0361.00
193_K196_D1.0351.00
311_K349_D1.0341.00
15_E19_R1.0331.00
12_A39_A1.0281.00
184_V203_V1.0281.00
263_M330_L1.0281.00
287_F311_K1.0251.00
91_L123_I1.0231.00
5_C105_C1.0211.00
37_V58_Q1.0171.00
153_A164_V1.0161.00
38_I72_S1.0091.00
219_N222_L1.0051.00
114_R122_E1.0031.00
118_D122_E1.0001.00
283_Q352_S0.9981.00
140_A146_A0.9961.00
40_R51_M0.9921.00
279_R317_Q0.9921.00
256_R341_Q0.9921.00
143_K237_L0.9901.00
373_L376_V0.9891.00
271_A326_A0.9811.00
286_R351_F0.9801.00
110_V119_F0.9781.00
316_T321_D0.9741.00
328_R332_A0.9691.00
9_A42_A0.9671.00
16_T27_V0.9671.00
256_R295_S0.9621.00
151_H183_D0.9611.00
18_F80_M0.9601.00
121_R163_V0.9591.00
56_F60_D0.9591.00
290_T329_S0.9561.00
85_M89_E0.9561.00
267_I290_T0.9401.00
286_R311_K0.9391.00
10_F14_C0.9361.00
98_Y185_W0.9351.00
286_R315_P0.9341.00
284_Y317_Q0.9321.00
187_I222_L0.9291.00
74_Y78_A0.9291.00
275_A279_R0.9271.00
294_T338_H0.9191.00
28_V62_F0.9191.00
289_S307_S0.9171.00
53_D57_K0.9161.00
84_V131_T0.9111.00
167_S170_E0.9101.00
289_S346_M0.9061.00
218_F222_L0.9051.00
267_I326_A0.9021.00
83_R86_S0.8991.00
319_S374_M0.8991.00
267_I343_A0.8981.00
256_R339_R0.8961.00
274_A345_V0.8931.00
292_I343_A0.8911.00
88_L123_I0.8891.00
144_T228_E0.8881.00
294_T306_N0.8841.00
194_K197_A0.8821.00
221_V224_R0.8811.00
30_L35_G0.8711.00
213_F216_K0.8651.00
206_L214_I0.8621.00
50_K53_D0.8621.00
53_D58_Q0.8601.00
9_A16_T0.8591.00
128_L132_H0.8581.00
306_N333_I0.8571.00
220_V224_R0.8561.00
372_Q375_T0.8541.00
191_I194_K0.8541.00
319_S323_I0.8501.00
315_P351_F0.8501.00
322_I326_A0.8481.00
11_Y74_Y0.8471.00
180_P196_D0.8471.00
251_R266_A0.8451.00
200_I205_D0.8411.00
110_V113_C0.8391.00
120_G163_V0.8391.00
207_A229_L0.8391.00
284_Y353_Q0.8331.00
353_Q371_E0.8331.00
267_I323_I0.8261.00
87_T91_L0.8261.00
310_V329_S0.8181.00
260_Y330_L0.8181.00
320_R324_N0.8141.00
137_V163_V0.8131.00
288_I325_A0.8121.00
277_K281_E0.8071.00
58_Q62_F0.8061.00
39_A45_K0.8061.00
173_R208_D0.8051.00
214_I218_F0.8041.00
139_I165_D0.8031.00
181_V196_D0.8021.00
227_R234_C0.8021.00
204_L207_A0.8011.00
250_S342_K0.8001.00
267_I330_L0.7991.00
335_Q338_H0.7991.00
308_A333_I0.7981.00
95_V103_A0.7981.00
122_E125_A0.7941.00
261_P264_R0.7871.00
376_V380_L0.7831.00
11_Y72_S0.7801.00
78_A82_N0.7771.00
29_V70_F0.7771.00
2_F106_D0.7741.00
83_R131_T0.7731.00
142_T145_L0.7721.00
320_R370_S0.7721.00
314_T321_D0.7701.00
283_Q350_F0.7681.00
178_A204_L0.7681.00
375_T379_T0.7681.00
194_K218_F0.7661.00
40_R49_V0.7661.00
96_E237_L0.7651.00
114_R119_F0.7641.00
280_S382_A0.7621.00
268_C327_T0.7611.00
212_R216_K0.7600.99
271_A319_S0.7590.99
16_T24_G0.7580.99
94_R106_D0.7540.99
128_L134_T0.7520.99
107_L120_G0.7520.99
308_A332_A0.7510.99
124_R137_V0.7510.99
85_M95_V0.7510.99
181_V200_I0.7500.99
308_A329_S0.7480.99
233_P236_Q0.7460.99
371_E375_T0.7460.99
87_T127_V0.7420.99
92_S95_V0.7420.99
59_K63_R0.7420.99
81_S85_M0.7390.99
180_P183_D0.7390.99
379_T382_A0.7330.99
44_A67_V0.7320.99
172_Q176_M0.7310.99
265_Q269_S0.7310.99
288_I322_I0.7300.99
187_I225_T0.7290.99
206_L226_V0.7250.99
322_I347_L0.7230.99
174_K177_S0.7200.99
80_M131_T0.7200.99
104_F143_K0.7190.99
273_R276_E0.7180.99
7_V10_F0.7170.99
191_I218_F0.7140.99
37_V69_C0.7120.99
150_N153_A0.7070.99
22_L68_V0.7070.99
40_R45_K0.7070.99
87_T90_E0.7060.99
181_V192_S0.7060.99
12_A41_N0.7040.99
62_F67_V0.7040.99
198_M209_T0.7000.99
265_Q268_C0.6990.99
116_L120_G0.6960.99
26_P62_F0.6930.99
55_W62_F0.6920.99
244_K281_E0.6920.99
118_D121_R0.6910.99
292_I340_Y0.6900.99
97_I100_I0.6900.99
125_A128_L0.6900.99
59_K69_C0.6890.99
292_I333_I0.6850.99
372_Q376_V0.6840.99
381_N386_R0.6830.99
260_Y334_W0.6820.99
294_T298_A0.6780.99
38_I51_M0.6770.99
11_Y100_I0.6760.99
166_L175_L0.6740.99
37_V67_V0.6730.99
284_Y350_F0.6710.99
261_P265_Q0.6700.99
94_R236_Q0.6700.99
80_M133_L0.6680.99
126_T129_Q0.6680.99
31_S71_S0.6680.99
8_N136_G0.6670.99
86_S90_E0.6670.99
210_D230_R0.6630.99
272_A276_E0.6630.99
211_I230_R0.6620.99
325_A329_S0.6560.99
91_L119_F0.6560.99
42_A45_K0.6560.99
36_C51_M0.6550.99
198_M213_F0.6550.99
264_R268_C0.6530.98
262_S265_Q0.6480.98
145_L172_Q0.6480.98
25_K43_E0.6480.98
56_F59_K0.6470.98
291_F307_S0.6460.98
330_L334_W0.6460.98
172_Q177_S0.6460.98
248_I344_G0.6440.98
268_C272_A0.6440.98
153_A162_G0.6440.98
274_A288_I0.6440.98
88_L95_V0.6420.98
169_L173_R0.6400.98
321_D324_N0.6400.98
319_S378_D0.6400.98
251_R273_R0.6390.98
270_Y343_A0.6370.98
59_K67_V0.6370.98
318_D370_S0.6350.98
134_T153_A0.6350.98
294_T340_Y0.6350.98
119_F122_E0.6320.98
75_E78_A0.6310.98
37_V62_F0.6310.98
263_M343_A0.6300.98
175_L179_L0.6290.98
181_V195_L0.6290.98
252_S342_K0.6250.98
107_L110_V0.6250.98
263_M340_Y0.6230.98
179_L183_D0.6230.98
24_G41_N0.6220.98
39_A51_M0.6200.98
206_L218_F0.6170.98
141_Q145_L0.6150.98
72_S77_Y0.6140.98
247_I283_Q0.6140.98
218_F225_T0.6110.98
347_L350_F0.6110.98
267_I327_T0.6110.98
257_I266_A0.6100.98
117_T167_S0.6100.98
14_C18_F0.6100.98
247_I277_K0.6080.98
352_S355_V0.6070.98
9_A45_K0.6060.98
28_V44_A0.6060.98
2_F237_L0.6040.97
30_L72_S0.5990.97
94_R109_G0.5980.97
166_L172_Q0.5960.97
78_A100_I0.5940.97
83_R130_R0.5920.97
268_C319_S0.5910.97
58_Q67_V0.5860.97
117_T163_V0.5860.97
3_A139_I0.5860.97
279_R319_S0.5830.97
282_H353_Q0.5810.97
310_V313_L0.5810.97
15_E18_F0.5810.97
116_L139_I0.5790.97
42_A155_K0.5780.97
312_L315_P0.5780.97
211_I222_L0.5780.97
16_T25_K0.5780.97
25_K64_R0.5770.97
276_E280_S0.5750.97
134_T161_G0.5730.97
316_T322_I0.5730.97
206_L229_L0.5720.97
295_S341_Q0.5720.97
203_V229_L0.5710.96
171_R175_L0.5700.96
228_E233_P0.5690.96
148_L185_W0.5680.96
225_T228_E0.5680.96
88_L92_S0.5670.96
28_V55_W0.5630.96
357_Q361_F0.5630.96
195_L200_I0.5610.96
3_A116_L0.5610.96
114_R118_D0.5600.96
30_L69_C0.5590.96
178_A202_T0.5570.96
16_T19_R0.5570.96
50_K61_L0.5550.96
102_E147_K0.5550.96
14_C17_V0.5550.96
376_V379_T0.5540.96
320_R323_I0.5540.96
31_S35_G0.5520.96
189_R193_K0.5510.96
13_S39_A0.5500.96
378_D381_N0.5500.96
20_P23_W0.5490.96
330_L333_I0.5490.96
285_C288_I0.5490.96
262_S266_A0.5490.96
144_T148_L0.5490.96
223_E226_V0.5490.96
152_A175_L0.5450.95
266_A343_A0.5450.95
55_W59_K0.5440.95
120_G123_I0.5420.95
8_N42_A0.5410.95
194_K219_N0.5400.95
82_N86_S0.5380.95
44_A49_V0.5380.95
92_S119_F0.5370.95
27_V41_N0.5370.95
85_M88_L0.5360.95
292_I330_L0.5340.95
17_V83_R0.5330.95
127_V131_T0.5330.95
351_F354_G0.5320.95
144_T225_T0.5310.95
58_Q61_L0.5310.95
74_Y100_I0.5310.95
187_I206_L0.5300.95
295_S338_H0.5290.95
290_T330_L0.5290.95
64_R67_V0.5290.95
174_K178_A0.5280.95
88_L97_I0.5270.95
142_T233_P0.5260.94
275_A326_A0.5240.94
264_R323_I0.5240.94
247_I278_L0.5230.94
326_A329_S0.5220.94
185_W228_E0.5210.94
8_N153_A0.5170.94
227_R230_R0.5170.94
379_T384_E0.5170.94
33_N254_G0.5160.94
173_R230_R0.5160.94
68_V71_S0.5140.94
99_S102_E0.5140.94
5_C137_V0.5130.94
253_F343_A0.5130.94
275_A347_L0.5130.94
7_V14_C0.5100.94
249_C270_Y0.5100.94
318_D374_M0.5090.93
21_D25_K0.5080.93
37_V55_W0.5070.93
178_A203_V0.5050.93
128_L131_T0.5040.93
244_K283_Q0.5020.93
377_M381_N0.5010.93
45_K51_M0.5010.93
215_R222_L0.5000.93
43_E47_L0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f50A 1 0.7844 100 0.175 Contact Map
4dezA 2 0.5427 100 0.181 Contact Map
3gqcA 3 0.8175 100 0.185 Contact Map
4q45F 1 0.7915 100 0.196 Contact Map
4tqrA 1 0.7891 100 0.2 Contact Map
2aq4A 1 0.8081 100 0.211 Contact Map
3pzpA 1 0.7938 100 0.211 Contact Map
1t94A 1 0.7796 100 0.217 Contact Map
3osnA 1 0.7962 100 0.218 Contact Map
4ecqA 1 0.8009 100 0.224 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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