GREMLIN Database
FIMA1 - Type-1 fimbrial protein, A chain
UniProt: P04128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10308
Length: 182 (164)
Sequences: 3379 (2659)
Seq/√Len: 207.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_T167_T3.1591.00
124_V158_A3.0951.00
108_V123_G3.0481.00
125_Q159_R2.7911.00
45_A83_D2.7121.00
127_L159_R2.7101.00
125_Q161_F2.7031.00
92_A179_V2.6851.00
67_Q70_A2.6761.00
78_N153_T2.6701.00
109_L136_L2.4741.00
47_D82_N2.4691.00
111_L171_A2.4661.00
160_Y171_A2.3561.00
121_N166_A2.3131.00
124_V173_A2.1791.00
128_D132_A2.0961.00
80_Q153_T2.0841.00
109_L175_A2.0431.00
66_A70_A2.0211.00
118_S170_A1.9861.00
131_G157_Q1.8941.00
78_N155_P1.8911.00
125_Q133_A1.8141.00
27_T30_G1.7861.00
74_A159_R1.7461.00
76_G157_Q1.7041.00
108_V161_F1.6721.00
47_D80_Q1.6601.00
98_G109_L1.6091.00
60_V72_S1.6061.00
71_T125_Q1.5831.00
97_L137_D1.5741.00
47_D50_S1.5681.00
97_L178_K1.5201.00
38_E59_Q1.4301.00
107_N135_T1.4141.00
58_G75_V1.4021.00
57_L160_Y1.3891.00
65_L162_A1.3781.00
58_G73_S1.3471.00
53_Q79_I1.3471.00
50_S80_Q1.3441.00
71_T159_R1.3261.00
93_A180_Q1.3221.00
108_V125_Q1.3211.00
76_G155_P1.3181.00
147_L152_N1.3161.00
58_G171_A1.2821.00
77_F126_I1.2811.00
13_A16_L1.2631.00
162_A165_A1.2501.00
103_A123_G1.2461.00
92_A152_N1.2291.00
45_A82_N1.2151.00
14_L17_S1.2131.00
23_A27_T1.2081.00
65_L166_A1.1951.00
50_S53_Q1.1941.00
94_V154_I1.1761.00
100_A107_N1.1531.00
68_E165_A1.1441.00
57_L171_A1.1431.00
91_K146_T1.1431.00
71_T161_F1.1331.00
66_A162_A1.1251.00
18_S21_A1.1121.00
162_A166_A1.1101.00
71_T127_L1.1011.00
31_G35_F1.0991.00
67_Q162_A1.0871.00
20_A24_A1.0851.00
41_N62_T1.0711.00
61_R64_S1.0651.00
17_S20_A1.0601.00
102_D106_T1.0271.00
126_I175_A1.0201.00
102_D105_H1.0161.00
55_V77_F1.0151.00
93_A182_Q0.9931.00
74_A157_Q0.9931.00
12_S15_S0.9911.00
129_R155_P0.9751.00
34_H174_D0.9711.00
17_S21_A0.9661.00
31_G177_F0.9631.00
19_T23_A0.9631.00
65_L70_A0.9500.99
96_F126_I0.9450.99
112_Q174_D0.9400.99
96_F156_F0.9390.99
79_I177_F0.9370.99
57_L124_V0.9340.99
95_A180_Q0.9310.99
15_S18_S0.9280.99
103_A106_T0.9240.99
65_L122_V0.9240.99
64_S72_S0.9240.99
21_A25_A0.9220.99
60_V65_L0.9090.99
91_K144_E0.9000.99
53_Q177_F0.8910.99
70_A162_A0.8840.99
122_V160_Y0.8830.99
102_D163_T0.8770.99
119_A122_V0.8740.99
142_S145_T0.8600.99
21_A26_T0.8570.99
127_L157_Q0.8550.99
124_V171_A0.8530.99
65_L163_T0.8450.99
109_L173_A0.8420.99
21_A24_A0.8400.99
13_A20_A0.8390.99
60_V171_A0.8380.99
20_A23_A0.8330.99
36_K54_T0.8240.99
36_K56_Q0.8240.99
16_L21_A0.8220.98
18_S22_L0.8190.98
18_S23_A0.8150.98
81_L152_N0.8130.98
26_T29_N0.8060.98
22_L26_T0.8050.98
135_T140_T0.8040.98
25_A29_N0.7980.98
48_A51_V0.7960.98
56_Q160_Y0.7890.98
41_N85_D0.7840.98
16_L19_T0.7820.98
136_L173_A0.7820.98
60_V160_Y0.7670.98
127_L133_A0.7670.98
136_L156_F0.7670.98
85_D127_L0.7540.97
117_G170_A0.7510.97
126_I136_L0.7480.97
19_T22_L0.7470.97
23_A26_T0.7400.97
100_A136_L0.7390.97
143_S146_T0.7370.97
12_S19_T0.7350.97
112_Q172_N0.7280.97
13_A17_S0.7240.97
43_A160_Y0.7200.97
62_T168_P0.7200.97
96_F177_F0.7130.96
16_L20_A0.7130.96
26_T30_G0.7120.96
123_G163_T0.7050.96
19_T24_A0.7040.96
12_S21_A0.6940.96
68_E121_N0.6890.96
48_A53_Q0.6890.96
39_V166_A0.6810.95
93_A142_S0.6800.95
140_T146_T0.6790.95
111_L172_N0.6780.95
112_Q118_S0.6770.95
86_T149_N0.6760.95
111_L117_G0.6760.95
57_L158_A0.6750.95
122_V166_A0.6720.95
24_A27_T0.6680.95
57_L125_Q0.6650.95
134_L156_F0.6650.95
39_V60_V0.6650.95
22_L25_A0.6600.94
58_G172_N0.6590.94
31_G37_G0.6500.94
102_D107_N0.6470.94
56_Q75_V0.6460.94
31_G38_E0.6460.94
93_A144_E0.6450.94
68_E164_G0.6410.93
16_L22_L0.6400.93
142_S147_L0.6380.93
32_T52_D0.6350.93
144_E182_Q0.6340.93
54_T176_T0.6320.93
21_A27_T0.6320.93
13_A18_S0.6310.93
12_S16_L0.6280.93
34_H54_T0.6280.93
16_L26_T0.6250.93
80_Q151_T0.6240.93
18_S24_A0.6210.92
55_V158_A0.6200.92
95_A141_F0.6180.92
62_T166_A0.6160.92
23_A30_G0.6140.92
41_N90_S0.6080.92
121_N163_T0.6040.91
72_S160_Y0.6020.91
99_T110_A0.6000.91
74_A127_L0.5990.91
15_S19_T0.5940.91
106_T109_L0.5910.90
85_D88_V0.5910.90
57_L75_V0.5880.90
14_L18_S0.5870.90
64_S73_S0.5850.90
140_T143_S0.5820.90
71_T74_A0.5770.89
111_L118_S0.5690.89
43_A85_D0.5660.88
24_A28_V0.5640.88
107_N133_A0.5620.88
111_L173_A0.5570.88
121_N164_G0.5560.88
111_L166_A0.5550.87
95_A137_D0.5530.87
119_A173_A0.5490.87
57_L159_R0.5470.87
40_V85_D0.5460.87
22_L27_T0.5420.86
105_H161_F0.5410.86
97_L176_T0.5390.86
20_A25_A0.5380.86
174_D179_V0.5370.86
93_A141_F0.5350.85
56_Q93_A0.5340.85
86_T90_S0.5340.85
72_S159_R0.5340.85
127_L161_F0.5310.85
17_S22_L0.5300.85
102_D123_G0.5300.85
23_A28_V0.5290.85
18_S26_T0.5270.85
13_A22_L0.5260.85
82_N151_T0.5250.84
70_A165_A0.5210.84
96_F179_V0.5190.84
39_V111_L0.5170.84
78_N100_A0.5160.83
95_A98_G0.5160.83
95_A179_V0.5150.83
16_L23_A0.5140.83
96_F134_L0.5110.83
57_L77_F0.5110.83
102_D108_V0.5040.82
81_L147_L0.5040.82
34_H52_D0.5030.82
98_G174_D0.5030.82
77_F158_A0.5010.82
133_A136_L0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jtyA 1 0.8736 100 0.223 Contact Map
2jmrA 1 0.8352 100 0.249 Contact Map
2xg5B 1 0.7637 100 0.263 Contact Map
2uy6B 2 0.7912 100 0.277 Contact Map
1pdkB 1 0.7692 100 0.283 Contact Map
3bwuF 1 0.6868 100 0.344 Contact Map
4dwhB 1 0.7527 100 0.347 Contact Map
2w07B 1 0.6429 99.9 0.365 Contact Map
5afoA 1 0.9505 99.9 0.377 Contact Map
3bfqG 1 0.7088 99.9 0.378 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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