GUAA - ECOLI - GREMLIN Contacts

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GUAA - GMP synthase [glutamine-hydrolyzing]

UniProt:	P04079	Sequences: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFITVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10420
Length:	525 (509)
Sequences:	2678 (1072)
Seq/√Len:	47.5

ECOLI - GUAA
BACSU - GUAA
HALSA - GUAAB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
92_M	175_F	4.895	1.00
267_L	426_R	4.807	1.00
53_G	202_C	4.708	1.00
293_R	321_E	4.418	1.00
170_N	173_K	4.297	1.00
421_C	425_R	3.787	1.00
322_E	325_K	3.480	1.00
389_L	395_Y	3.340	1.00
228_D	330_K	3.325	1.00
221_I	225_V	3.212	1.00
389_L	399_Y	3.142	1.00
445_S	480_F	2.828	1.00
291_E	418_K	2.801	1.00
243_T	333_A	2.771	1.00
126_E	189_Q	2.753	1.00
219_A	223_E	2.743	1.00
313_R	317_E	2.734	1.00
445_S	477_T	2.712	1.00
476_E	486_A	2.669	1.00
231_I	329_V	2.646	1.00
247_L	333_A	2.642	1.00
259_F	265_L	2.631	1.00
431_F	472_L	2.626	1.00
477_T	480_F	2.623	1.00
10_I	53_G	2.622	1.00
292_D	296_S	2.608	1.00
515_S	520_A	2.590	1.00
27_V	55_I	2.528	1.00
399_Y	442_D	2.527	1.00
270_A	287_H	2.522	1.00
470_V	507_I	2.514	1.00
99_H	149_A	2.498	1.00
488_L	492_F	2.480	1.00
123_R	200_D	2.461	1.00
401_H	447_A	2.431	1.00
245_M	393_L	2.419	1.00
326_L	329_V	2.388	1.00
170_N	174_R	2.353	1.00
196_R	200_D	2.331	1.00
228_D	331_W	2.240	1.00
422_D	425_R	2.221	1.00
217_A	220_R	2.197	1.00
499_R	503_E	2.179	1.00
8_H	206_A	2.177	1.00
492_F	496_V	2.159	1.00
341_V	377_K	2.155	1.00
418_K	422_D	2.149	1.00
301_E	310_I	2.130	1.00
116_V	159_S	2.126	1.00
8_H	52_S	2.126	1.00
465_K	508_S	2.091	1.00
259_F	270_A	2.080	1.00
297_A	314_V	2.053	1.00
440_L	492_F	2.050	1.00
274_L	285_I	2.036	1.00
268_N	271_E	2.035	1.00
157_V	169_A	2.015	0.99
199_R	206_A	1.976	0.99
214_I	387_I	1.966	0.99
271_E	287_H	1.935	0.99
125_I	137_L	1.919	0.99
265_L	270_A	1.917	0.99
119_S	169_A	1.913	0.99
494_G	498_N	1.913	0.99
101_E	148_T	1.903	0.99
74_Y	77_E	1.896	0.99
485_W	490_Y	1.890	0.99
243_T	247_L	1.861	0.99
10_I	198_V	1.848	0.99
27_V	198_V	1.839	0.99
274_L	287_H	1.833	0.99
232_L	333_A	1.810	0.99
119_S	157_V	1.809	0.99
433_E	437_K	1.798	0.99
231_I	258_V	1.794	0.99
56_L	82_V	1.788	0.99
37_W	41_V	1.777	0.99
10_I	202_C	1.776	0.99
444_V	488_L	1.764	0.99
275_D	279_D	1.763	0.99
431_F	496_V	1.760	0.99
137_L	189_Q	1.752	0.98
261_D	287_H	1.748	0.98
444_V	486_A	1.739	0.98
52_S	204_C	1.733	0.98
53_G	204_C	1.729	0.98
210_P	387_I	1.714	0.98
192_R	195_E	1.710	0.98
268_N	272_Q	1.691	0.98
267_L	429_A	1.670	0.98
450_V	524_W	1.669	0.98
293_R	314_V	1.662	0.98
189_Q	192_R	1.660	0.98
76_F	92_M	1.658	0.98
297_A	313_R	1.657	0.98
295_L	421_C	1.652	0.98
395_Y	442_D	1.651	0.98
389_L	442_D	1.640	0.98
11_L	37_W	1.634	0.98
501_I	515_S	1.630	0.98
317_E	320_D	1.615	0.97
138_D	188_R	1.604	0.97
155_I	171_E	1.601	0.97
432_I	441_Y	1.590	0.97
112_Q	128_A	1.587	0.97
469_V	511_V	1.586	0.97
45_Q	48_D	1.582	0.97
460_M	465_K	1.569	0.97
227_D	254_N	1.562	0.97
93_A	151_P	1.556	0.97
429_A	433_E	1.538	0.97
122_V	167_I	1.534	0.96
168_M	177_G	1.528	0.96
113_V	158_A	1.519	0.96
11_L	46_I	1.501	0.96
89_M	147_V	1.498	0.96
330_K	371_G	1.495	0.96
386_K	389_L	1.492	0.96
230_V	333_A	1.487	0.96
71_A	91_T	1.476	0.96
214_I	218_V	1.476	0.96
224_Q	373_V	1.466	0.95
47_R	78_A	1.461	0.95
293_R	297_A	1.461	0.95
412_V	421_C	1.431	0.95
484_H	516_G	1.415	0.94
93_A	168_M	1.403	0.94
434_E	437_K	1.401	0.94
438_A	495_R	1.400	0.94
452_L	471_S	1.398	0.94
224_Q	371_G	1.389	0.94
434_E	499_R	1.385	0.94
270_A	289_P	1.383	0.94
346_A	352_A	1.378	0.94
460_M	501_I	1.377	0.94
441_Y	447_A	1.377	0.94
440_L	443_K	1.361	0.93
299_A	415_E	1.360	0.93
474_A	486_A	1.357	0.93
117_N	155_I	1.357	0.93
247_L	373_V	1.355	0.93
71_A	76_F	1.354	0.93
487_H	494_G	1.346	0.93
420_Y	468_W	1.341	0.93
153_D	170_N	1.341	0.93
13_L	37_W	1.334	0.92
114_E	159_S	1.332	0.92
232_L	247_L	1.330	0.92
306_A	310_I	1.326	0.92
229_K	328_D	1.309	0.92
475_V	522_I	1.307	0.92
472_L	496_V	1.299	0.91
345_A	352_A	1.297	0.91
9_R	49_F	1.290	0.91
42_T	45_Q	1.280	0.91
220_R	224_Q	1.277	0.91
40_D	350_G	1.276	0.91
396_D	436_R	1.275	0.91
417_K	420_Y	1.269	0.90
270_A	274_L	1.268	0.90
455_R	467_D	1.267	0.90
320_D	368_M	1.266	0.90
427_A	449_T	1.262	0.90
438_A	492_F	1.261	0.90
292_D	418_K	1.256	0.90
418_K	421_C	1.256	0.90
106_R	144_G	1.254	0.90
229_K	254_N	1.249	0.90
256_T	286_V	1.249	0.90
271_E	275_D	1.244	0.90
241_S	393_L	1.230	0.89
432_I	447_A	1.224	0.89
232_L	244_A	1.221	0.89
126_E	137_L	1.221	0.89
367_E	370_M	1.219	0.89
211_A	390_E	1.219	0.89
460_M	508_S	1.217	0.89
195_E	200_D	1.214	0.88
149_A	152_S	1.212	0.88
314_V	317_E	1.197	0.88
150_I	165_F	1.196	0.88
20_T	36_L	1.187	0.87
253_K	282_G	1.181	0.87
485_W	497_S	1.170	0.86
41_V	45_Q	1.170	0.86
401_H	432_I	1.169	0.86
70_R	95_Q	1.163	0.86
43_E	72_P	1.162	0.86
471_S	511_V	1.161	0.86
277_F	285_I	1.157	0.86
467_D	506_G	1.152	0.86
401_H	441_Y	1.146	0.85
435_L	447_A	1.145	0.85
423_L	506_G	1.143	0.85
443_K	476_E	1.142	0.85
436_R	441_Y	1.141	0.85
15_F	56_L	1.140	0.85
346_A	351_K	1.139	0.85
431_F	449_T	1.132	0.85
434_E	495_R	1.127	0.84
234_L	257_C	1.126	0.84
291_E	422_D	1.119	0.84
8_H	205_E	1.115	0.84
31_G	209_T	1.113	0.84
401_H	435_L	1.110	0.83
7_K	207_L	1.108	0.83
423_L	468_W	1.108	0.83
511_V	524_W	1.104	0.83
41_V	46_I	1.103	0.83
165_F	168_M	1.098	0.83
140_W	186_H	1.093	0.82
258_V	288_V	1.092	0.82
487_H	491_D	1.089	0.82
320_D	369_K	1.087	0.82
435_L	438_A	1.084	0.82
261_D	291_E	1.082	0.82
70_R	94_M	1.082	0.82
217_A	221_I	1.079	0.82
10_I	204_C	1.079	0.82
314_V	318_V	1.078	0.82
228_D	254_N	1.078	0.82
125_I	189_Q	1.077	0.82
300_G	415_E	1.071	0.81
302_N	415_E	1.071	0.81
219_A	222_R	1.069	0.81
120_A	169_A	1.066	0.81
423_L	507_I	1.062	0.81
221_I	247_L	1.060	0.80
306_A	313_R	1.058	0.80
437_K	495_R	1.057	0.80
493_L	514_I	1.048	0.80
264_L	409_G	1.048	0.80
99_H	148_T	1.042	0.79
36_L	342_I	1.039	0.79
225_V	254_N	1.036	0.79
272_Q	396_D	1.027	0.78
265_L	273_V	1.026	0.78
286_V	325_K	1.025	0.78
221_I	373_V	1.023	0.78
274_L	278_G	1.021	0.78
113_V	160_T	1.020	0.78
449_T	507_I	1.019	0.78
232_L	257_C	1.018	0.78
434_E	503_E	1.016	0.78
225_V	373_V	1.015	0.78
327_E	330_K	1.013	0.77
210_P	213_I	1.009	0.77
426_R	429_A	1.008	0.77
160_T	163_C	1.006	0.77
444_V	474_A	1.005	0.77
431_F	474_A	1.005	0.77
126_E	188_R	1.002	0.77
158_A	167_I	1.001	0.77
424_L	450_V	0.998	0.76
301_E	306_A	0.991	0.76
7_K	216_D	0.991	0.76
389_L	398_L	0.980	0.75
262_N	295_L	0.978	0.75
155_I	169_A	0.968	0.74
245_M	281_F	0.968	0.74
449_T	470_V	0.966	0.74
53_G	198_V	0.964	0.74
366_K	369_K	0.963	0.74
30_L	194_L	0.955	0.73
42_T	46_I	0.955	0.73
215_D	219_A	0.952	0.73
79_G	82_V	0.952	0.73
146_K	163_C	0.949	0.73
349_T	352_A	0.947	0.72
110_Y	140_W	0.944	0.72
178_V	193_M	0.943	0.72
497_S	515_S	0.940	0.72
288_V	322_E	0.939	0.72
229_K	256_T	0.938	0.72
24_A	36_L	0.937	0.72
43_E	74_Y	0.934	0.71
230_V	251_I	0.933	0.71
8_H	204_C	0.933	0.71
259_F	273_V	0.930	0.71
103_S	146_K	0.930	0.71
89_M	168_M	0.929	0.71
71_A	95_Q	0.928	0.71
31_G	386_K	0.928	0.71
242_V	388_G	0.927	0.71
151_P	168_M	0.925	0.71
345_A	351_K	0.924	0.71
435_L	444_V	0.923	0.70
213_I	387_I	0.922	0.70
120_A	157_V	0.919	0.70
297_A	310_I	0.918	0.70
303_D	306_A	0.916	0.70
368_M	372_L	0.915	0.70
412_V	425_R	0.914	0.70
353_H	463_G	0.913	0.70
73_Q	77_E	0.911	0.69
324_L	369_K	0.910	0.69
295_L	425_R	0.909	0.69
150_I	156_T	0.904	0.69
233_G	316_V	0.902	0.69
44_A	48_D	0.902	0.69
110_Y	138_D	0.898	0.68
178_V	182_P	0.895	0.68
290_A	318_V	0.892	0.68
456_S	469_V	0.892	0.68
125_I	192_R	0.890	0.68
418_K	425_R	0.889	0.68
195_E	206_A	0.887	0.67
433_E	499_R	0.883	0.67
276_M	397_M	0.880	0.67
361_V	364_L	0.876	0.66
180_F	193_M	0.874	0.66
467_D	501_I	0.871	0.66
92_M	96_L	0.870	0.66
434_E	438_A	0.870	0.66
156_T	165_F	0.868	0.66
293_R	318_V	0.868	0.66
291_E	295_L	0.864	0.65
260_V	318_V	0.856	0.65
75_V	82_V	0.856	0.65
114_E	128_A	0.855	0.65
311_I	409_G	0.855	0.65
277_F	282_G	0.854	0.64
174_R	203_Q	0.854	0.64
261_D	274_L	0.853	0.64
11_L	49_F	0.852	0.64
260_V	288_V	0.851	0.64
62_S	145_D	0.849	0.64
278_G	285_I	0.849	0.64
184_V	482_T	0.849	0.64
439_D	444_V	0.847	0.64
320_D	367_E	0.847	0.64
112_Q	161_E	0.841	0.63
40_D	351_K	0.840	0.63
333_A	373_V	0.838	0.63
159_S	163_C	0.837	0.63
420_Y	451_F	0.835	0.63
153_D	174_R	0.834	0.63
146_K	164_P	0.834	0.63
12_I	20_T	0.832	0.62
245_M	283_L	0.832	0.62
258_V	329_V	0.831	0.62
432_I	436_R	0.831	0.62
277_F	283_L	0.829	0.62
238_V	388_G	0.829	0.62
13_L	42_T	0.828	0.62
262_N	314_V	0.827	0.62
469_V	524_W	0.824	0.62
89_M	177_G	0.823	0.62
32_V	199_R	0.822	0.61
112_Q	138_D	0.822	0.61
94_M	99_H	0.820	0.61
440_L	444_V	0.817	0.61
137_L	188_R	0.815	0.61
31_G	206_A	0.814	0.61
187_T	193_M	0.814	0.61
29_E	482_T	0.813	0.61
331_W	371_G	0.812	0.60
46_I	51_P	0.811	0.60
422_D	426_R	0.807	0.60
209_T	212_K	0.806	0.60
346_A	349_T	0.806	0.60
395_Y	399_Y	0.805	0.60
386_K	390_E	0.804	0.60
495_R	498_N	0.803	0.60
321_E	325_K	0.803	0.60
218_V	250_A	0.803	0.60
195_E	199_R	0.800	0.59
91_T	95_Q	0.800	0.59
346_A	350_G	0.797	0.59
44_A	47_R	0.796	0.59
82_V	175_F	0.796	0.59
257_C	277_F	0.792	0.59
216_D	220_R	0.791	0.58
116_V	155_I	0.790	0.58
231_I	330_K	0.790	0.58
213_I	217_A	0.788	0.58
229_K	329_V	0.787	0.58
198_V	204_C	0.786	0.58
295_L	418_K	0.785	0.58
241_S	277_F	0.785	0.58
296_S	299_A	0.783	0.58
467_D	505_N	0.782	0.58
64_T	463_G	0.779	0.57
222_R	254_N	0.778	0.57
120_A	200_D	0.778	0.57
51_P	80_V	0.775	0.57
25_R	29_E	0.773	0.57
121_L	193_M	0.773	0.57
76_F	95_Q	0.771	0.57
494_G	497_S	0.771	0.57
171_E	174_R	0.769	0.56
450_V	511_V	0.769	0.56
30_L	198_V	0.768	0.56
234_L	285_I	0.768	0.56
9_R	51_P	0.767	0.56
43_E	47_R	0.762	0.56
424_L	524_W	0.760	0.55
61_E	353_H	0.758	0.55
170_N	175_F	0.757	0.55
271_E	291_E	0.751	0.55
455_R	468_W	0.748	0.54
60_P	69_P	0.746	0.54
320_D	324_L	0.745	0.54
47_R	50_N	0.744	0.54
323_A	329_V	0.742	0.54
476_E	484_H	0.742	0.54
96_L	175_F	0.741	0.54
339_P	377_K	0.741	0.54
29_E	191_M	0.739	0.53
118_D	127_D	0.738	0.53
362_G	377_K	0.737	0.53
22_L	141_M	0.734	0.53
74_Y	78_A	0.732	0.53
82_V	95_Q	0.728	0.52
153_D	171_E	0.727	0.52
492_F	495_R	0.727	0.52
234_L	277_F	0.726	0.52
21_Q	380_F	0.724	0.52
509_R	513_D	0.723	0.52
453_P	467_D	0.722	0.52
444_V	476_E	0.722	0.52
272_Q	429_A	0.722	0.52
243_T	376_L	0.722	0.52
93_A	177_G	0.720	0.51
217_A	387_I	0.720	0.51
192_R	196_R	0.719	0.51
452_L	469_V	0.719	0.51
232_L	337_I	0.718	0.51
139_V	187_T	0.717	0.51
485_W	494_G	0.717	0.51
469_V	520_A	0.716	0.51
212_K	390_E	0.716	0.51
427_A	470_V	0.714	0.51
431_F	435_L	0.709	0.50
17_S	57_S	0.708	0.50
453_P	469_V	0.706	0.50
124_G	192_R	0.705	0.50
486_A	489_P	0.704	0.50
513_D	525_E	0.703	0.50
497_S	511_V	0.703	0.50
64_T	68_S	0.700	0.49
514_I	524_W	0.699	0.49
113_V	137_L	0.699	0.49
144_G	463_G	0.698	0.49
47_R	74_Y	0.697	0.49
316_V	362_G	0.697	0.49
30_L	191_M	0.696	0.49
460_M	467_D	0.695	0.49
401_H	486_A	0.693	0.49
169_A	174_R	0.692	0.49
497_S	514_I	0.692	0.49
32_V	204_C	0.692	0.49
77_E	173_K	0.690	0.48
70_R	91_T	0.690	0.48
185_T	480_F	0.689	0.48
137_L	187_T	0.689	0.48
110_Y	484_H	0.688	0.48
105_E	162_S	0.688	0.48
231_I	370_M	0.687	0.48
32_V	198_V	0.685	0.48
313_R	366_K	0.685	0.48
474_A	488_L	0.683	0.48
64_T	145_D	0.683	0.48
121_L	201_I	0.683	0.48
12_I	24_A	0.682	0.48
85_V	178_V	0.681	0.48
430_I	433_E	0.680	0.47
185_T	478_I	0.680	0.47
102_A	463_G	0.678	0.47
12_I	36_L	0.678	0.47
497_S	501_I	0.677	0.47
13_L	41_V	0.676	0.47
111_A	140_W	0.675	0.47
120_A	201_I	0.675	0.47
264_L	295_L	0.672	0.47
108_F	144_G	0.671	0.47
30_L	195_E	0.670	0.46
221_I	372_L	0.669	0.46
122_V	196_R	0.669	0.46
362_G	365_P	0.669	0.46
363_G	377_K	0.667	0.46
11_L	41_V	0.665	0.46
427_A	507_I	0.665	0.46
111_A	141_M	0.664	0.46
106_R	463_G	0.663	0.46
140_W	484_H	0.662	0.46
420_Y	453_P	0.661	0.46
413_L	456_S	0.661	0.46
83_F	121_L	0.660	0.45
342_I	351_K	0.657	0.45
212_K	215_D	0.657	0.45
113_V	139_V	0.657	0.45
82_V	92_M	0.655	0.45
229_K	284_N	0.655	0.45
449_T	471_S	0.655	0.45
35_E	49_F	0.653	0.45
83_F	176_Y	0.653	0.45
214_I	249_R	0.650	0.44
37_W	46_I	0.649	0.44
122_V	180_F	0.649	0.44
299_A	418_K	0.648	0.44
357_S	373_V	0.648	0.44
20_T	57_S	0.647	0.44
251_I	255_L	0.647	0.44
56_L	76_F	0.645	0.44
424_L	490_Y	0.644	0.44
230_V	254_N	0.644	0.44
120_A	171_E	0.641	0.44
64_T	70_R	0.639	0.43
69_P	393_L	0.639	0.43
231_I	243_T	0.637	0.43
114_E	161_E	0.636	0.43
268_N	429_A	0.635	0.43
431_F	447_A	0.635	0.43
413_L	454_V	0.633	0.43
424_L	427_A	0.633	0.43
54_I	80_V	0.632	0.43
345_A	349_T	0.631	0.43
460_M	504_V	0.631	0.43
428_D	513_D	0.630	0.43
59_G	69_P	0.628	0.42
245_M	398_L	0.627	0.42
122_V	187_T	0.627	0.42
86_C	90_Q	0.626	0.42
511_V	514_I	0.626	0.42
401_H	424_L	0.625	0.42
253_K	284_N	0.622	0.42
258_V	323_A	0.622	0.42
122_V	157_V	0.621	0.42
230_V	247_L	0.621	0.42
124_G	196_R	0.620	0.42
220_R	223_E	0.619	0.41
413_L	467_D	0.618	0.41
41_V	49_F	0.617	0.41
261_D	270_A	0.614	0.41
302_N	416_V	0.614	0.41
164_P	277_F	0.612	0.41
232_L	277_F	0.612	0.41
83_F	178_V	0.612	0.41
233_G	320_D	0.612	0.41
17_S	20_T	0.611	0.41
501_I	506_G	0.611	0.41
316_V	373_V	0.611	0.41
299_A	416_V	0.610	0.41
485_W	514_I	0.609	0.40
337_I	480_F	0.607	0.40
75_V	78_A	0.605	0.40
108_F	201_I	0.604	0.40
450_V	470_V	0.604	0.40
262_N	515_S	0.604	0.40
477_T	484_H	0.603	0.40
86_C	143_H	0.602	0.40
108_F	463_G	0.600	0.40
43_E	78_A	0.600	0.40
120_A	123_R	0.599	0.40
73_Q	95_Q	0.597	0.39
278_G	283_L	0.597	0.39
63_T	94_M	0.596	0.39
117_N	120_A	0.595	0.39
12_I	34_C	0.595	0.39
37_W	45_Q	0.595	0.39
90_Q	179_Q	0.594	0.39
268_N	426_R	0.594	0.39
427_A	431_F	0.594	0.39
472_L	492_F	0.594	0.39
244_A	257_C	0.594	0.39
248_H	283_L	0.593	0.39
436_R	447_A	0.593	0.39
59_G	63_T	0.593	0.39
316_V	329_V	0.593	0.39
276_M	282_G	0.592	0.39
269_E	400_R	0.592	0.39
279_D	396_D	0.591	0.39
211_A	216_D	0.591	0.39
264_L	298_L	0.591	0.39
331_W	370_M	0.590	0.39
431_F	492_F	0.590	0.39
11_L	51_P	0.589	0.39
64_T	94_M	0.589	0.39
484_H	487_H	0.589	0.39
37_W	42_T	0.589	0.39
10_I	111_A	0.588	0.38
249_R	253_K	0.588	0.38
185_T	477_T	0.587	0.38
86_C	355_I	0.587	0.38
275_D	280_H	0.586	0.38
449_T	472_L	0.585	0.38
124_G	200_D	0.583	0.38
9_R	247_L	0.583	0.38
288_V	293_R	0.583	0.38
238_V	241_S	0.583	0.38
324_L	367_E	0.581	0.38
387_I	498_N	0.581	0.38
316_V	357_S	0.581	0.38
497_S	520_A	0.581	0.38
146_K	162_S	0.580	0.38
13_L	71_A	0.580	0.38
13_L	46_I	0.580	0.38
125_I	187_T	0.579	0.38
469_V	508_S	0.579	0.38
19_Y	463_G	0.578	0.38
401_H	431_F	0.578	0.38
484_H	494_G	0.577	0.37
96_L	173_K	0.577	0.37
100_V	145_D	0.576	0.37
191_M	195_E	0.575	0.37
93_A	150_I	0.575	0.37
345_A	378_E	0.574	0.37
438_A	444_V	0.573	0.37
232_L	255_L	0.571	0.37
185_T	445_S	0.571	0.37
316_V	320_D	0.571	0.37
30_L	199_R	0.571	0.37
18_Q	86_C	0.571	0.37
169_A	176_Y	0.570	0.37
86_C	462_D	0.570	0.37
495_R	499_R	0.569	0.37
351_K	354_V	0.568	0.37
306_A	309_K	0.568	0.37
194_L	198_V	0.568	0.37
412_V	416_V	0.566	0.36
171_E	176_Y	0.566	0.36
257_C	282_G	0.566	0.36
451_F	513_D	0.565	0.36
153_D	173_K	0.565	0.36
234_L	255_L	0.564	0.36
172_E	176_Y	0.562	0.36
409_G	418_K	0.561	0.36
475_V	520_A	0.560	0.36
218_V	245_M	0.559	0.36
57_S	337_I	0.559	0.36
457_V	464_R	0.558	0.36
233_G	333_A	0.558	0.36
447_A	474_A	0.558	0.36
445_S	484_H	0.558	0.36
66_E	227_D	0.558	0.36
108_F	211_A	0.557	0.36
118_D	201_I	0.556	0.35
91_T	108_F	0.556	0.35
27_V	339_P	0.556	0.35
9_R	50_N	0.555	0.35
153_D	169_A	0.554	0.35
122_V	357_S	0.554	0.35
17_S	333_A	0.553	0.35
101_E	146_K	0.553	0.35
424_L	513_D	0.552	0.35
17_S	453_P	0.552	0.35
329_V	373_V	0.552	0.35
12_I	357_S	0.551	0.35
19_Y	184_V	0.550	0.35
228_D	327_E	0.550	0.35
194_L	455_R	0.550	0.35
257_C	281_F	0.550	0.35
63_T	100_V	0.549	0.35
337_I	351_K	0.549	0.35
446_Q	473_R	0.548	0.35
489_P	492_F	0.548	0.35
410_V	421_C	0.548	0.35
54_I	82_V	0.547	0.35
52_S	59_G	0.547	0.35
337_I	484_H	0.547	0.35
180_F	187_T	0.546	0.35
105_E	146_K	0.545	0.34
410_V	476_E	0.545	0.34
320_D	370_M	0.544	0.34
313_R	368_M	0.544	0.34
12_I	64_T	0.544	0.34
86_C	109_G	0.543	0.34
86_C	461_G	0.543	0.34
256_T	284_N	0.542	0.34
437_K	503_E	0.542	0.34
293_R	317_E	0.542	0.34
337_I	445_S	0.541	0.34
224_Q	377_K	0.540	0.34
277_F	284_N	0.540	0.34
362_G	372_L	0.540	0.34
217_A	225_V	0.539	0.34
121_L	178_V	0.539	0.34
410_V	502_N	0.538	0.34
243_T	283_L	0.538	0.34
106_R	515_S	0.537	0.34
207_L	410_V	0.536	0.34
447_A	512_Y	0.534	0.33
233_G	329_V	0.534	0.33
27_V	30_L	0.534	0.33
450_V	454_V	0.534	0.33
490_Y	497_S	0.534	0.33
487_H	490_Y	0.533	0.33
423_L	427_A	0.533	0.33
448_F	474_A	0.532	0.33
498_N	502_N	0.532	0.33
316_V	361_V	0.532	0.33
295_L	301_E	0.531	0.33
517_K	521_T	0.531	0.33
39_W	69_P	0.531	0.33
435_L	439_D	0.529	0.33
103_S	148_T	0.528	0.33
422_D	507_I	0.526	0.33
473_R	481_M	0.526	0.33
41_V	48_D	0.525	0.33
322_E	326_L	0.525	0.33
243_T	373_V	0.525	0.33
417_K	451_F	0.524	0.33
120_A	174_R	0.524	0.33
165_F	397_M	0.524	0.33
191_M	386_K	0.524	0.33
147_V	156_T	0.523	0.33
274_L	283_L	0.523	0.33
211_A	498_N	0.523	0.33
127_D	161_E	0.523	0.33
140_W	516_G	0.522	0.32
220_R	378_E	0.522	0.32
355_I	462_D	0.522	0.32
309_K	363_G	0.521	0.32
318_V	321_E	0.520	0.32
277_F	388_G	0.520	0.32
317_E	367_E	0.518	0.32
214_I	391_L	0.518	0.32
410_V	451_F	0.517	0.32
342_I	349_T	0.517	0.32
90_Q	100_V	0.517	0.32
92_M	154_F	0.516	0.32
272_Q	275_D	0.516	0.32
409_G	421_C	0.515	0.32
413_L	453_P	0.515	0.32
316_V	364_L	0.515	0.32
270_A	291_E	0.512	0.32
409_G	415_E	0.512	0.32
469_V	507_I	0.511	0.31
465_K	504_V	0.511	0.31
345_A	354_V	0.510	0.31
517_K	523_E	0.510	0.31
20_T	480_F	0.509	0.31
495_R	503_E	0.508	0.31
316_V	377_K	0.508	0.31
61_E	277_F	0.507	0.31
36_L	501_I	0.507	0.31
232_L	316_V	0.507	0.31
449_T	512_Y	0.507	0.31
309_K	362_G	0.506	0.31
13_L	20_T	0.506	0.31
431_F	488_L	0.506	0.31
349_T	353_H	0.505	0.31
64_T	100_V	0.504	0.31
488_L	496_V	0.504	0.31
17_S	345_A	0.504	0.31
31_G	262_N	0.504	0.31
513_D	524_W	0.504	0.31
37_W	49_F	0.503	0.31
437_K	499_R	0.503	0.31
45_Q	49_F	0.503	0.31
262_N	276_M	0.502	0.31
456_S	520_A	0.502	0.31
170_N	176_Y	0.502	0.31
316_V	372_L	0.502	0.31
103_S	418_K	0.502	0.31
241_S	247_L	0.501	0.31
17_S	247_L	0.501	0.31
473_R	513_D	0.501	0.31
214_I	390_E	0.501	0.31
319_F	365_P	0.501	0.31
233_G	247_L	0.500	0.31
262_N	318_V	0.500	0.31
150_I	168_M	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tqiA	3	0.8838	100	0.315	Contact Map
1gpmA	3	0.9562	100	0.319	Contact Map
2ywbA	4	0.901	100	0.332	Contact Map
3uowA	2	0.9181	100	0.332	Contact Map
2vxoA	2	0.9657	100	0.342	Contact Map
2dplA	2	0.5467	100	0.61	Contact Map
2vpiA	1	0.3543	100	0.805	Contact Map
2lxnA	1	0.3562	100	0.831	Contact Map
3r75A	2	0.36	100	0.841	Contact Map
1qdlB	2	0.3524	100	0.844	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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