GREMLIN Database
DAPB - 4-hydroxy-tetrahydrodipicolinate reductase
UniProt: P04036 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10206
Length: 273 (247)
Sequences: 3871 (2347)
Seq/√Len: 149.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_A173_A3.7731.00
7_R32_Q3.5191.00
28_L252_L3.1871.00
138_K142_K3.1461.00
90_A113_A2.6121.00
30_G252_L2.5801.00
139_L143_A2.3181.00
141_E180_H2.3061.00
77_I251_A2.3051.00
175_G208_F2.2991.00
9_A73_F2.2771.00
221_T234_T2.2561.00
86_L110_G2.2161.00
107_D110_G2.1561.00
24_A248_V2.1511.00
124_V267_V2.1151.00
158_A216_I2.0811.00
20_Q23_Q2.0241.00
65_S68_A2.0081.00
136_M233_I2.0061.00
34_G73_F2.0011.00
8_V31_V1.9911.00
98_G122_A1.9611.00
112_Q115_R1.9541.00
10_I21_L1.9511.00
221_T232_E1.9291.00
13_A36_A1.8681.00
142_K145_K1.8411.00
185_D188_D1.8071.00
25_A33_L1.8021.00
153_I178_I1.7931.00
93_R120_D1.7921.00
202_V205_T1.7581.00
85_T106_F1.7391.00
156_I211_V1.7251.00
230_R238_S1.7191.00
67_D94_Q1.6991.00
81_R164_V1.6791.00
111_K125_F1.6721.00
21_L79_F1.6581.00
124_V254_L1.6491.00
76_F92_C1.5951.00
91_F95_H1.5781.00
19_R23_Q1.5751.00
116_D119_A1.5611.00
16_R162_H1.5601.00
31_V252_L1.5321.00
141_E265_R1.5321.00
73_F97_K1.5191.00
124_V250_S1.5151.00
201_R207_G1.5131.00
140_L174_M1.5121.00
219_E236_K1.4951.00
23_Q27_A1.4921.00
11_A76_F1.4541.00
9_A35_A1.4411.00
232_E236_K1.4361.00
23_Q241_M1.4351.00
132_G235_H1.4161.00
90_A94_Q1.4071.00
213_A225_A1.3961.00
137_L177_A1.3921.00
86_L106_F1.3881.00
25_A31_V1.3851.00
259_S262_F1.3811.00
136_M231_L1.3731.00
86_L113_A1.3711.00
156_I223_M1.3701.00
173_A177_A1.3681.00
14_G38_E1.3681.00
134_N264_M1.3641.00
98_G255_S1.3601.00
96_G120_D1.3531.00
20_Q241_M1.3501.00
137_L174_M1.3451.00
108_E187_K1.3441.00
64_S68_A1.3371.00
10_I25_A1.3291.00
115_R261_L1.3221.00
109_A112_Q1.3181.00
7_R74_D1.3151.00
141_E181_A1.2921.00
173_A176_E1.2921.00
87_N90_A1.2901.00
192_Y195_E1.2851.00
162_H215_D1.2771.00
111_K115_R1.2711.00
151_T226_D1.2691.00
112_Q116_D1.2631.00
81_R84_G1.2511.00
108_E112_Q1.2211.00
11_A88_H1.2191.00
13_A22_I1.2081.00
138_K265_R1.2041.00
162_H200_E1.1971.00
140_L178_I1.1911.00
137_L173_A1.1781.00
10_I22_I1.1651.00
237_A242_T1.1541.00
93_R121_I1.1501.00
134_N137_L1.1481.00
141_E145_K1.1421.00
197_H200_E1.1351.00
138_K141_E1.1321.00
25_A248_V1.1310.99
82_P110_G1.1310.99
17_M79_F1.1040.99
140_L222_A1.1030.99
136_M174_M1.0970.99
99_M123_I1.0930.99
100_V254_L1.0890.99
89_L93_R1.0890.99
67_D95_H1.0870.99
63_Q71_D1.0800.99
147_M151_T1.0780.99
237_A243_F1.0780.99
110_G113_A1.0750.99
28_L31_V1.0720.99
75_V251_A1.0620.99
215_D228_G1.0620.99
215_D238_S1.0580.99
16_R240_R1.0540.99
193_S210_T1.0540.99
156_I209_A1.0490.99
93_R117_A1.0490.99
211_V223_M1.0490.99
86_L89_L1.0410.99
8_V25_A1.0340.99
227_I241_M1.0310.99
76_F97_K1.0300.99
253_W257_K1.0290.99
216_I219_E1.0250.99
113_A117_A1.0190.99
184_K189_C1.0120.99
253_W267_V1.0080.99
17_M244_A0.9940.99
31_V248_V0.9920.99
145_K181_A0.9840.99
140_L233_I0.9800.99
158_A211_V0.9790.99
41_G64_S0.9780.99
141_E177_A0.9750.99
82_P103_T0.9660.98
248_V252_L0.9520.98
6_I31_V0.9520.98
117_A121_I0.9510.98
196_G199_G0.9500.98
164_V200_E0.9500.98
135_V146_V0.9460.98
22_I60_V0.9420.98
253_W256_G0.9380.98
89_L101_I0.9360.98
66_L91_F0.9360.98
27_A241_M0.9360.98
193_S196_G0.9330.98
193_S209_A0.9320.98
122_A262_F0.9300.98
22_I36_A0.9300.98
86_L90_A0.9280.98
24_A244_A0.9270.98
12_G15_G0.9250.98
115_R118_A0.9210.98
22_I33_L0.9170.98
158_A219_E0.9120.98
106_F114_I0.9110.98
139_L233_I0.9090.98
193_S198_T0.9080.98
162_H227_I0.9040.98
155_I175_G0.8990.97
219_E234_T0.8930.97
118_A261_L0.8920.97
113_A116_D0.8870.97
85_T101_I0.8830.97
10_I33_L0.8830.97
122_A259_S0.8810.97
11_A78_D0.8780.97
75_V100_V0.8760.97
213_A226_D0.8720.97
184_K204_G0.8710.97
131_V249_R0.8690.97
216_I225_A0.8660.97
11_A37_L0.8630.97
6_I75_V0.8590.97
85_T89_L0.8580.97
101_I114_I0.8550.97
79_F247_A0.8510.96
7_R72_D0.8510.96
67_D91_F0.8500.96
223_M230_R0.8420.96
144_A224_F0.8420.96
35_A69_V0.8380.96
191_V205_T0.8370.96
118_A123_I0.8300.96
24_A241_M0.8280.96
9_A34_G0.8260.96
135_V139_L0.8210.96
106_F110_G0.8160.96
91_F94_Q0.8070.95
147_M150_Y0.8060.95
9_A37_L0.8000.95
21_L25_A0.8000.95
115_R119_A0.7960.95
213_A216_I0.7940.95
220_H235_H0.7940.95
250_S267_V0.7940.95
94_Q120_D0.7940.95
130_S229_E0.7930.95
155_I208_F0.7770.94
91_F97_K0.7760.94
75_V254_L0.7700.94
83_E110_G0.7700.94
230_R236_K0.7690.94
102_G129_F0.7670.94
90_A117_A0.7650.94
244_A247_A0.7610.94
177_A181_A0.7530.93
13_A62_V0.7480.93
136_M220_H0.7470.93
217_V239_S0.7460.93
92_C99_M0.7440.93
140_L177_A0.7440.93
140_L143_A0.7420.93
124_V129_F0.7420.93
88_H99_M0.7350.92
218_G240_R0.7350.92
133_V137_L0.7300.92
228_G242_T0.7280.92
28_L248_V0.7270.92
89_L114_I0.7250.92
98_G254_L0.7240.92
67_D87_N0.7220.92
158_A234_T0.7190.91
85_T88_H0.7180.91
80_T88_H0.7130.91
20_Q24_A0.7090.91
199_G202_V0.7080.91
114_I117_A0.7020.90
11_A80_T0.7020.90
178_I222_A0.6990.90
80_T102_G0.6980.90
6_I255_S0.6970.90
7_R34_G0.6960.90
148_G182_L0.6960.90
70_K73_F0.6950.90
93_R113_A0.6930.90
200_E227_I0.6890.90
154_E209_A0.6870.90
8_V77_I0.6860.89
63_Q70_K0.6850.89
122_A254_L0.6850.89
149_D203_P0.6850.89
90_A93_R0.6790.89
225_A230_R0.6790.89
96_G121_I0.6770.89
17_M240_R0.6770.89
184_K202_V0.6670.88
24_A245_N0.6670.88
86_L117_A0.6660.88
130_S237_A0.6630.88
175_G179_A0.6590.87
25_A34_G0.6530.87
191_V195_E0.6520.87
132_G220_H0.6520.87
160_H240_R0.6490.87
134_N268_L0.6490.87
30_G248_V0.6450.86
109_A113_A0.6440.86
21_L77_I0.6430.86
24_A27_A0.6410.86
158_A221_T0.6400.86
136_M140_L0.6360.86
40_E64_S0.6350.86
106_F125_F0.6330.85
81_R103_T0.6320.85
29_E252_L0.6320.85
216_I223_M0.6310.85
70_K91_F0.6270.85
36_A60_V0.6230.84
123_I261_L0.6220.84
143_A224_F0.6190.84
7_R73_F0.6180.84
253_W264_M0.6170.84
74_D97_K0.6140.84
127_A137_L0.6140.84
178_I181_A0.6110.83
225_A238_S0.6110.83
158_A223_M0.6100.83
6_I252_L0.6100.83
126_A173_A0.6070.83
11_A106_F0.6070.83
147_M226_D0.6040.83
39_R83_E0.6040.83
10_I13_A0.6040.83
94_Q119_A0.5990.82
17_M21_L0.5980.82
92_C121_I0.5980.82
254_L262_F0.5970.82
172_L175_G0.5940.82
188_D204_G0.5930.81
114_I125_F0.5930.81
223_M234_T0.5930.81
235_H243_F0.5920.81
151_T242_T0.5870.81
258_E262_F0.5860.81
150_Y226_D0.5850.81
182_L204_G0.5820.80
152_D161_R0.5780.80
186_L208_F0.5750.79
122_A125_F0.5740.79
115_R180_H0.5720.79
151_T214_G0.5710.79
11_A84_G0.5710.79
111_K176_E0.5690.79
162_H240_R0.5680.79
117_A120_D0.5670.78
193_S199_G0.5670.78
195_E198_T0.5610.78
186_L190_A0.5610.78
160_H218_G0.5600.78
84_G88_H0.5590.78
154_E225_A0.5550.77
239_S242_T0.5540.77
249_R253_W0.5540.77
23_Q26_L0.5520.77
21_L102_G0.5490.76
148_G183_D0.5470.76
33_L36_A0.5440.76
159_H220_H0.5440.76
215_D230_R0.5410.75
254_L257_K0.5390.75
101_I123_I0.5390.75
39_R42_S0.5390.75
211_V216_I0.5380.75
176_E187_K0.5380.75
209_A225_A0.5370.75
9_A97_K0.5360.75
153_I224_F0.5360.75
174_M178_I0.5350.74
37_L66_L0.5350.74
221_T236_K0.5350.74
9_A69_V0.5330.74
94_Q117_A0.5330.74
161_R214_G0.5330.74
98_G262_F0.5310.74
181_A184_K0.5280.73
38_E42_S0.5280.73
101_I106_F0.5280.73
189_C204_G0.5260.73
21_L39_R0.5260.73
60_V63_Q0.5250.73
174_M220_H0.5240.73
130_S235_H0.5230.73
190_A195_E0.5210.72
175_G206_I0.5190.72
32_Q61_T0.5170.72
263_D267_V0.5150.72
215_D225_A0.5150.72
179_A186_L0.5140.71
25_A28_L0.5140.71
249_R252_L0.5100.71
158_A225_A0.5100.71
136_M222_A0.5090.71
142_K146_V0.5090.71
133_V136_M0.5080.71
8_V251_A0.5080.71
67_D96_G0.5060.70
89_L106_F0.5060.70
150_Y203_P0.5040.70
226_D245_N0.5030.70
249_R267_V0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ywjA 3 0.9744 100 0.146 Contact Map
1vm6A 4 0.8059 100 0.192 Contact Map
1dihA 4 0.9963 100 0.21 Contact Map
1p9lA 4 0.8755 100 0.235 Contact Map
3ijpA 4 0.978 100 0.239 Contact Map
3qy9A 3 0.8828 100 0.411 Contact Map
4f3yA 4 0.978 100 0.445 Contact Map
3wb9A 5 0.9048 100 0.528 Contact Map
1j5pA 2 0.8095 100 0.621 Contact Map
1f06A 2 0.9121 100 0.635 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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