GREMLIN Database
ATKC - Potassium-transporting ATPase C chain
UniProt: P03961 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10515
Length: 190 (182)
Sequences: 1765 (1245)
Seq/√Len: 92.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_Q39_N4.0931.00
97_L101_R3.6451.00
65_F181_L3.3711.00
120_L136_A3.2591.00
141_I159_I3.1711.00
138_A156_T3.0941.00
5_R9_S3.0611.00
64_Y186_D2.9311.00
42_L49_V2.8191.00
72_T76_P2.6611.00
53_A180_E2.6231.00
142_P152_V2.5661.00
131_N164_Q2.5321.00
56_G67_G2.2991.00
141_I152_V2.2061.00
148_R186_D2.1261.00
96_K100_A2.1181.00
138_A160_A2.0821.00
11_F15_L2.0051.00
82_S128_L1.9951.00
65_F144_V1.9551.00
66_H108_A1.9081.00
51_G179_V1.9071.00
134_P163_S1.8881.00
102_V121_V1.8721.00
150_L155_L1.8531.00
138_A163_S1.8051.00
72_T78_N1.7871.00
158_L181_L1.7651.00
141_I155_L1.7351.00
152_V156_T1.6961.00
29_L33_W1.6691.00
132_I137_A1.6631.00
93_E96_K1.6441.00
120_L139_W1.6081.00
166_P173_Q1.5931.00
151_S154_Q1.5921.00
36_W53_A1.5891.00
157_Q161_K1.5871.00
131_N175_V1.5771.00
154_Q157_Q1.5431.00
44_R49_V1.5341.00
65_F158_L1.4471.00
162_Y184_A1.4460.99
44_R47_D1.4220.99
62_N108_A1.4080.99
34_F37_Q1.4060.99
164_Q180_E1.4050.99
119_E132_I1.3770.99
109_N112_A1.3770.99
162_Y180_E1.3290.99
66_H109_N1.3020.99
109_N139_W1.3000.99
119_E133_T1.3000.99
141_I156_T1.2940.99
96_K99_A1.2720.99
166_P174_P1.2610.99
144_V181_L1.2600.99
148_R185_L1.2540.99
92_P96_K1.2540.99
61_G64_Y1.2460.98
99_A103_A1.2450.98
167_L175_V1.2410.98
156_T160_A1.2240.98
164_Q175_V1.2180.98
138_A142_P1.2120.98
144_V147_A1.1940.98
167_L171_I1.1800.98
95_D99_A1.1730.98
72_T83_G1.1590.98
97_L123_A1.1250.97
65_F159_I1.1020.97
105_L139_W1.0970.97
85_S123_A1.0850.96
102_V106_R1.0820.96
71_A123_A1.0710.96
16_L21_V1.0630.96
101_R123_A1.0590.96
21_V25_L1.0540.96
56_G76_P1.0400.95
105_L136_A1.0240.95
132_I178_I1.0240.95
153_E156_T1.0190.95
14_L18_T1.0180.95
59_F179_V1.0150.95
10_T14_L1.0120.95
106_R111_D1.0100.95
87_L94_L1.0050.94
138_A141_I0.9990.94
137_A144_V0.9780.94
112_A139_W0.9620.93
150_L188_L0.9620.93
105_L110_P0.9510.93
19_G27_T0.9420.92
82_S126_S0.9300.92
135_Q138_A0.9290.92
117_P139_W0.9210.91
93_E97_L0.9110.91
103_A107_A0.9080.91
148_R155_L0.9020.91
11_F18_T0.9020.91
150_L154_Q0.8940.90
110_P139_W0.8920.90
58_N67_G0.8920.90
156_T159_I0.8890.90
28_V32_W0.8860.90
59_F148_R0.8840.90
134_P159_I0.8830.90
64_Y148_R0.8790.89
66_H143_R0.8770.89
104_A108_A0.8770.89
9_S12_I0.8740.89
23_P82_S0.8730.89
105_L108_A0.8640.89
45_E48_T0.8620.88
16_L20_G0.8610.88
6_P10_T0.8550.88
154_Q161_K0.8520.88
30_G35_P0.8480.88
106_R109_N0.8470.88
15_L18_T0.8440.87
142_P146_K0.8430.87
109_N143_R0.8380.87
15_L19_G0.8260.86
43_I183_L0.8250.86
69_P123_A0.8220.86
111_D139_W0.8200.86
169_K175_V0.8160.86
101_R104_A0.8150.86
161_K184_A0.8130.85
41_S52_S0.7950.84
136_A139_W0.7940.84
24_L28_V0.7940.84
6_P9_S0.7860.83
89_V95_D0.7850.83
116_V121_V0.7840.83
27_T30_G0.7820.83
44_R48_T0.7770.83
105_L111_D0.7640.82
146_K149_N0.7640.82
158_L188_L0.7610.81
45_E183_L0.7600.81
55_I82_S0.7590.81
160_A163_S0.7560.81
168_V171_I0.7530.81
27_T34_F0.7500.80
58_N76_P0.7490.80
115_S139_W0.7490.80
179_V183_L0.7490.80
94_L97_L0.7440.80
88_A97_L0.7310.79
105_L109_N0.7300.79
59_F64_Y0.7270.78
153_E157_Q0.7220.78
26_T89_V0.7190.78
144_V185_L0.7160.77
79_P82_S0.7150.77
67_G136_A0.6920.75
20_G26_T0.6910.75
106_R139_W0.6890.75
11_F14_L0.6890.75
61_G66_H0.6840.74
101_R105_L0.6810.74
20_G23_P0.6810.74
142_P155_L0.6770.73
10_T183_L0.6750.73
67_G120_L0.6720.73
160_A165_Q0.6710.73
137_A178_I0.6690.72
5_R10_T0.6690.72
87_L123_A0.6660.72
78_N81_A0.6650.72
55_I91_N0.6640.72
9_S13_F0.6610.71
45_E50_R0.6600.71
148_R184_A0.6600.71
166_P172_G0.6560.71
27_T31_Q0.6530.71
105_L116_V0.6510.70
100_A103_A0.6510.70
169_K172_G0.6440.70
134_P138_A0.6410.69
72_T127_G0.6410.69
134_P166_P0.6400.69
168_V175_V0.6310.68
40_G52_S0.6310.68
81_A84_G0.6310.68
79_P88_A0.6270.67
111_D146_K0.6260.67
22_Y120_L0.6250.67
72_T80_Q0.6250.67
159_I163_S0.6240.67
100_A104_A0.6230.67
43_I179_V0.6210.67
77_Y80_Q0.6170.66
109_N117_P0.6160.66
67_G147_A0.6120.66
23_P126_S0.6110.65
109_N114_A0.6100.65
105_L112_A0.6100.65
48_T99_A0.6080.65
105_L120_L0.6050.65
91_N95_D0.6030.64
72_T81_A0.6010.64
87_L93_E0.6000.64
58_N66_H0.6000.64
145_A148_R0.6000.64
55_I128_L0.5990.64
62_N147_A0.5990.64
19_G23_P0.5960.64
84_G127_G0.5930.63
12_I29_L0.5930.63
76_P79_P0.5880.63
134_P175_V0.5850.62
163_S172_G0.5820.62
67_G179_V0.5780.61
17_I23_P0.5750.61
23_P40_G0.5750.61
29_L32_W0.5740.61
70_S91_N0.5730.61
56_G179_V0.5720.60
56_G77_Y0.5700.60
180_E183_L0.5680.60
84_G123_A0.5680.60
98_I121_V0.5680.60
118_V135_Q0.5660.60
120_L132_I0.5660.60
38_A41_S0.5650.59
18_T84_G0.5610.59
109_N142_P0.5600.59
30_G58_N0.5580.59
14_L17_I0.5570.58
109_N113_S0.5530.58
102_V113_S0.5530.58
24_L95_D0.5530.58
63_G146_K0.5520.58
18_T23_P0.5480.57
116_V119_E0.5470.57
70_S82_S0.5470.57
56_G72_T0.5400.56
145_A155_L0.5390.56
18_T21_V0.5370.56
76_P81_A0.5340.55
114_A153_E0.5320.55
24_L27_T0.5320.55
183_L187_K0.5320.55
64_Y185_L0.5300.55
10_T17_I0.5270.54
14_L23_P0.5250.54
106_R110_P0.5230.54
25_L28_V0.5210.53
52_S55_I0.5210.53
59_F67_G0.5190.53
4_L8_L0.5190.53
71_A92_P0.5170.53
71_A127_G0.5150.53
87_L97_L0.5130.52
30_G37_Q0.5130.52
158_L184_A0.5110.52
107_A188_L0.5110.52
41_S54_L0.5100.52
29_L90_S0.5100.52
152_V155_L0.5090.52
84_G128_L0.5080.52
65_F70_S0.5080.52
159_I181_L0.5070.52
66_H139_W0.5070.52
123_A127_G0.5070.52
9_S181_L0.5060.51
12_I151_S0.5060.51
59_F147_A0.5050.51
71_A84_G0.5040.51
59_F89_V0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xrvA 1 0.7105 70 0.946 Contact Map
4utoA 1 0.7474 61.5 0.949 Contact Map
4lhfA 1 0.2895 43.3 0.954 Contact Map
4mt1A 3 0.9421 29.6 0.958 Contact Map
1toaA 1 0.7368 29.5 0.958 Contact Map
1xrsA 2 0.3211 27.6 0.959 Contact Map
4dx5A 3 0.9526 18.3 0.962 Contact Map
4h63V 1 0.5316 15.3 0.964 Contact Map
3oioA 1 0.3632 15 0.964 Contact Map
3pzpA 1 0.2789 14 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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