GREMLIN Database
MALM - Maltose operon periplasmic protein
UniProt: P03841 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10559
Length: 306 (286)
Sequences: 201 (140)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_V301_S4.2730.98
287_E295_R3.8070.97
50_T69_Q3.6300.96
140_D180_A3.2510.92
264_N297_T2.8710.86
73_V78_G2.6880.82
260_E264_N2.5910.79
291_S303_K2.5620.79
267_I294_A2.4710.76
96_L205_L2.4270.75
172_T199_H2.2370.68
277_D303_K2.2100.67
139_A142_L2.1580.65
190_P282_L2.1490.65
164_T199_H2.1400.65
42_P73_V2.1100.63
259_T285_E2.1000.63
291_S297_T2.0610.62
255_M284_D2.0400.61
260_E291_S2.0180.60
98_S186_G2.0100.59
17_L22_G2.0040.59
64_L107_F1.9800.58
266_A283_L1.9800.58
265_T293_S1.9630.58
264_N293_S1.9540.57
298_F302_V1.9240.56
283_L298_F1.9130.56
45_A275_D1.9030.55
271_V299_I1.8910.55
259_T262_Y1.8680.54
76_I79_P1.8310.52
111_V159_V1.8230.52
190_P194_D1.7910.50
142_L187_N1.7880.50
37_D228_P1.7860.50
255_M291_S1.7750.50
296_S299_I1.7420.48
287_E303_K1.7120.47
74_P107_F1.7110.47
81_A302_V1.7070.47
73_V76_I1.7070.47
42_P76_I1.6950.46
46_L295_R1.6880.46
113_I148_L1.6860.46
98_S190_P1.6750.46
17_L79_P1.6300.44
90_G209_V1.6290.44
105_S207_L1.6200.43
271_V298_F1.5980.42
165_E213_S1.5840.42
54_V302_V1.5760.42
88_N155_Q1.5550.41
267_I271_V1.5230.39
76_I80_V1.5110.39
136_V271_V1.4980.38
286_A294_A1.4960.38
264_N268_K1.4880.38
121_S156_K1.4860.38
293_S296_S1.4830.38
264_N291_S1.4750.38
48_Q105_S1.4740.38
146_M255_M1.4710.37
62_T83_Y1.4670.37
274_G291_S1.4370.36
121_S150_P1.4350.36
64_L290_G1.4210.35
169_Q200_T1.4210.35
255_M275_D1.4110.35
17_L20_A1.4110.35
115_D119_T1.4050.35
43_S76_I1.3900.34
221_P224_G1.3890.34
262_Y266_A1.3830.34
182_A190_P1.3740.34
113_I150_P1.3740.34
54_V57_S1.3560.33
250_K275_D1.3510.33
14_A224_G1.3500.33
262_Y285_E1.3410.32
107_F221_P1.3400.32
271_V283_L1.3400.32
52_T85_V1.3300.32
49_L141_R1.3270.32
182_A194_D1.3180.32
295_R303_K1.3150.32
80_V164_T1.3110.31
282_L285_E1.3050.31
50_T275_D1.3020.31
73_V79_P1.2970.31
46_L287_E1.2950.31
285_E289_L1.2850.30
174_L180_A1.2850.30
167_D295_R1.2780.30
276_V284_D1.2770.30
277_D299_I1.2720.30
136_V197_A1.2700.30
124_F141_R1.2690.30
131_Y140_D1.2570.29
250_K302_V1.2450.29
160_L164_T1.2410.29
180_A192_I1.2410.29
169_Q199_H1.2380.29
184_G190_P1.2310.29
122_A150_P1.2310.29
101_N161_V1.2280.28
134_P184_G1.2210.28
100_V197_A1.2200.28
80_V263_F1.1980.27
184_G189_I1.1960.27
43_S69_Q1.1930.27
46_L148_L1.1900.27
203_G279_A1.1880.27
12_L20_A1.1740.27
71_L78_G1.1740.27
209_V284_D1.1540.26
43_S73_V1.1440.26
22_G97_T1.1400.26
131_Y274_G1.1300.25
263_F295_R1.1150.25
58_K69_Q1.1130.25
179_K192_I1.1040.24
178_A192_I1.0980.24
133_E140_D1.0910.24
267_I286_A1.0900.24
78_G123_F1.0880.24
293_S303_K1.0870.24
179_K195_P1.0860.24
140_D175_L1.0840.24
20_A24_S1.0820.24
70_Q77_S1.0780.24
271_V291_S1.0760.24
288_R296_S1.0660.23
277_D287_E1.0650.23
31_V35_T1.0630.23
73_V77_S1.0600.23
108_A161_V1.0550.23
84_S166_K1.0540.23
48_Q65_A1.0520.23
52_T172_T1.0480.23
60_Q64_L1.0470.23
296_S300_S1.0240.22
129_F162_F1.0190.22
78_G107_F1.0130.22
271_V294_A1.0120.22
96_L195_P1.0070.22
286_A290_G1.0070.22
54_V133_E1.0030.21
178_A187_N1.0030.21
148_L159_V0.9970.21
120_P148_L0.9960.21
42_P69_Q0.9940.21
283_L289_L0.9880.21
122_A156_K0.9860.21
213_S216_S0.9860.21
168_L289_L0.9850.21
139_A161_V0.9840.21
160_L269_N0.9840.21
166_K229_A0.9790.21
263_F269_N0.9770.21
140_D179_K0.9730.21
200_T265_T0.9730.21
255_M266_A0.9700.21
90_G276_V0.9620.20
281_K284_D0.9610.20
38_A231_V0.9580.20
288_R303_K0.9540.20
262_Y289_L0.9530.20
164_T172_T0.9530.20
84_S141_R0.9420.20
148_L201_T0.9390.20
106_V284_D0.9350.20
113_I149_T0.9340.20
176_D190_P0.9300.19
283_L287_E0.9280.19
300_S304_G0.9260.19
73_V82_A0.9260.19
53_P303_K0.9250.19
129_F178_A0.9230.19
190_P289_L0.9230.19
231_V274_G0.9220.19
83_Y214_S0.9220.19
189_I192_I0.9140.19
67_G261_S0.9110.19
75_G79_P0.9110.19
24_S88_N0.9110.19
190_P195_P0.9080.19
131_Y134_P0.9050.19
113_I263_F0.9040.19
183_K274_G0.9040.19
292_T300_S0.9040.19
300_S303_K0.9030.19
126_S214_S0.9010.19
65_A161_V0.8990.19
255_M259_T0.8990.19
269_N300_S0.8950.19
71_L76_I0.8940.19
95_T111_V0.8940.19
110_N288_R0.8930.19
140_D174_L0.8930.19
287_E290_G0.8860.18
40_A236_T0.8840.18
177_P278_K0.8790.18
56_Q171_T0.8710.18
173_Q194_D0.8700.18
48_Q171_T0.8690.18
105_S201_T0.8680.18
115_D262_Y0.8640.18
292_T303_K0.8640.18
268_K303_K0.8590.18
262_Y282_L0.8540.18
15_G20_A0.8540.18
127_S284_D0.8520.18
114_L118_M0.8520.18
54_V69_Q0.8510.17
113_I122_A0.8490.17
84_S227_A0.8490.17
94_L171_T0.8460.17
171_T226_S0.8440.17
141_R209_V0.8410.17
210_K232_T0.8400.17
15_G18_A0.8380.17
57_S89_I0.8360.17
80_V160_L0.8310.17
12_L161_V0.8230.17
129_F302_V0.8220.17
150_P156_K0.8190.17
178_A182_A0.8150.17
171_T304_G0.8140.17
63_Q229_A0.8120.17
65_A133_E0.8120.17
228_P237_A0.8110.17
179_K188_S0.8110.17
84_S288_R0.8080.16
260_E303_K0.8040.16
182_A195_P0.8000.16
153_G207_L0.7970.16
160_L260_E0.7970.16
46_L164_T0.7960.16
112_L120_P0.7960.16
46_L49_L0.7950.16
264_N295_R0.7950.16
229_A272_A0.7930.16
59_T85_V0.7900.16
124_F272_A0.7900.16
83_Y133_E0.7890.16
114_L120_P0.7880.16
112_L141_R0.7870.16
164_T264_N0.7870.16
86_P260_E0.7860.16
265_T272_A0.7800.16
14_A229_A0.7800.16
78_G110_N0.7740.16
135_G280_L0.7720.16
89_I162_F0.7710.16
294_A299_I0.7690.16
164_T180_A0.7670.16
27_D63_Q0.7660.16
19_S28_V0.7660.16
67_G161_V0.7640.15
156_K218_L0.7630.15
191_D271_V0.7620.15
18_A94_L0.7560.15
235_N250_K0.7500.15
51_W114_L0.7480.15
57_S65_A0.7480.15
107_F163_T0.7420.15
260_E293_S0.7400.15
298_F303_K0.7370.15
25_L28_V0.7370.15
48_Q170_Q0.7340.15
21_P275_D0.7330.15
285_E298_F0.7280.15
162_F272_A0.7260.15
42_P79_P0.7220.15
280_L303_K0.7210.15
187_N266_A0.7180.15
82_A114_L0.7180.15
14_A269_N0.7160.14
162_F298_F0.7120.14
116_Q155_Q0.7120.14
268_K297_T0.7110.14
80_V88_N0.7080.14
21_P268_K0.7030.14
178_A194_D0.6980.14
146_M284_D0.6970.14
131_Y142_L0.6960.14
131_Y175_L0.6940.14
277_D295_R0.6920.14
47_Q274_G0.6910.14
92_L150_P0.6890.14
129_F282_L0.6850.14
270_A278_K0.6850.14
152_L256_L0.6840.14
75_G88_N0.6810.14
107_F138_S0.6750.14
180_A197_A0.6720.14
174_L197_A0.6720.14
57_S88_N0.6700.14
237_A246_P0.6650.13
96_L190_P0.6640.13
291_S294_A0.6630.13
85_V279_A0.6630.13
237_A275_D0.6600.13
16_L207_L0.6580.13
184_G187_N0.6570.13
112_L115_D0.6540.13
266_A296_S0.6500.13
22_G62_T0.6490.13
194_D285_E0.6480.13
94_L125_P0.6480.13
49_L80_V0.6460.13
102_K169_Q0.6450.13
257_N261_S0.6450.13
71_L79_P0.6440.13
278_K282_L0.6430.13
65_A253_E0.6420.13
127_S257_N0.6370.13
15_G22_G0.6340.13
53_P119_T0.6330.13
256_L303_K0.6300.13
86_P172_T0.6260.13
45_A273_K0.6260.13
48_Q59_T0.6250.13
57_S73_V0.6250.13
265_T299_I0.6220.13
290_G303_K0.6220.13
96_L288_R0.6210.13
247_A252_S0.6200.13
132_Q206_K0.6200.13
181_Y198_R0.6200.13
45_A152_L0.6190.13
160_L200_T0.6180.13
178_A208_K0.6150.13
131_Y172_T0.6120.12
256_L288_R0.6090.12
218_L222_L0.6090.12
144_G180_A0.6090.12
181_Y187_N0.6080.12
67_G179_K0.6070.12
64_L142_L0.6070.12
51_W82_A0.6040.12
100_V136_V0.6020.12
176_D184_G0.6010.12
199_H209_V0.5970.12
166_K227_A0.5970.12
280_L284_D0.5960.12
41_I295_R0.5960.12
150_P184_G0.5950.12
194_D282_L0.5930.12
164_T169_Q0.5930.12
131_Y294_A0.5910.12
11_C24_S0.5890.12
35_T218_L0.5880.12
22_G36_S0.5860.12
163_T178_A0.5860.12
196_V248_P0.5850.12
94_L113_I0.5840.12
271_V297_T0.5840.12
21_P41_I0.5820.12
68_G81_A0.5810.12
263_F287_E0.5790.12
278_K294_A0.5780.12
167_D262_Y0.5770.12
143_E274_G0.5750.12
209_V272_A0.5700.12
95_T274_G0.5650.12
110_N167_D0.5640.12
100_V176_D0.5640.12
71_L118_M0.5630.12
134_P140_D0.5600.12
68_G99_E0.5580.12
91_E107_F0.5550.11
52_T106_V0.5540.11
90_G278_K0.5510.11
256_L275_D0.5510.11
276_V296_S0.5500.11
164_T167_D0.5500.11
294_A297_T0.5490.11
83_Y224_G0.5470.11
138_S214_S0.5460.11
46_L126_S0.5460.11
147_R161_V0.5410.11
179_K189_I0.5410.11
182_A192_I0.5410.11
86_P288_R0.5400.11
14_A24_S0.5400.11
23_I166_K0.5360.11
71_L283_L0.5360.11
207_L211_T0.5350.11
216_S221_P0.5350.11
255_M269_N0.5350.11
129_F286_A0.5350.11
207_L257_N0.5330.11
98_S182_A0.5330.11
39_P111_V0.5330.11
172_T184_G0.5300.11
73_V283_L0.5300.11
73_V118_M0.5270.11
173_Q196_V0.5260.11
268_K301_S0.5250.11
64_L146_M0.5250.11
182_A186_G0.5240.11
142_L193_P0.5230.11
37_D227_A0.5230.11
277_D292_T0.5230.11
67_G111_V0.5190.11
18_A54_V0.5180.11
160_L199_H0.5180.11
58_K106_V0.5170.11
257_N296_S0.5170.11
46_L263_F0.5170.11
68_G79_P0.5160.11
14_A97_T0.5160.11
283_L291_S0.5130.11
92_L276_V0.5130.11
129_F195_P0.5120.11
140_D197_A0.5090.11
265_T268_K0.5080.11
190_P262_Y0.5070.11
106_V288_R0.5060.11
160_L214_S0.5050.11
109_P159_V0.5040.11
271_V303_K0.5040.11
277_D291_S0.5040.11
41_I93_T0.5020.11
219_V223_F0.5020.11
63_Q230_P0.5010.11
70_Q225_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uzyA 1 0.1797 45.5 0.963 Contact Map
4fybB 1 0.3889 42.3 0.963 Contact Map
4hnyA 1 0.0686 31.3 0.966 Contact Map
4g26A 1 0.1601 27.8 0.967 Contact Map
4ymxA 1 0.6373 25.5 0.967 Contact Map
1xb2B 1 0.1961 24.2 0.968 Contact Map
2kckA 1 0.1699 22.3 0.968 Contact Map
4la9A 1 0.6699 20.3 0.969 Contact Map
4ja7A 1 0.1699 20.1 0.969 Contact Map
4nn3A 1 0.817 19.4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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