GREMLIN Database
INSG - Transposase InsG for insertion sequence element IS4
UniProt: P03835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40007
Length: 442 (379)
Sequences: 759 (609)
Seq/√Len: 31.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_H291_S6.1161.00
90_S94_Q5.4011.00
292_M298_F4.5121.00
95_A98_R4.2421.00
167_V212_Y3.7791.00
333_S338_L3.7781.00
91_A94_Q3.7771.00
134_G189_E3.6301.00
109_T179_A3.5481.00
201_G204_T3.4751.00
145_N336_P3.4421.00
332_R342_E3.4421.00
254_K273_T3.2391.00
58_I61_M3.2321.00
96_R341_Q3.1691.00
179_A199_Q3.0341.00
288_L303_M2.9371.00
207_L306_L2.8161.00
131_A172_L2.7611.00
228_R291_S2.7071.00
108_F347_L2.6571.00
188_S191_E2.6251.00
71_Q74_N2.4730.99
130_L204_T2.4570.99
228_R274_A2.4430.99
88_A91_A2.4400.99
208_M230_W2.4280.99
168_C317_Y2.4050.99
101_S340_E2.3690.99
315_L318_R2.3260.99
318_R322_Q2.3190.99
203_N227_H2.2610.99
128_T204_T2.1780.99
252_L273_T2.1050.98
124_W129_L2.1000.98
205_L229_H2.0790.98
228_R231_M2.0760.98
277_L290_T2.0610.98
313_I317_Y1.9690.97
222_S291_S1.9500.97
200_T206_T1.9450.97
318_R323_T1.8840.96
108_F196_L1.8760.96
127_L227_H1.8680.96
125_C302_E1.8320.96
136_F165_K1.7940.95
252_L295_A1.7820.95
135_V321_K1.7410.94
210_K231_M1.7330.94
105_R109_T1.7260.94
95_A126_G1.7040.94
47_R99_L1.6890.93
130_L178_T1.6820.93
137_W166_M1.6590.93
385_L403_L1.6590.93
253_V276_L1.6350.92
148_A340_E1.6280.92
354_R357_M1.6130.92
51_L103_A1.6000.91
131_A341_Q1.5890.91
127_L291_S1.5880.91
314_E321_K1.5800.91
319_E354_R1.5770.91
133_D209_D1.5760.91
54_M95_A1.5720.90
105_R302_E1.5680.90
278_T285_V1.5660.90
168_C177_L1.5580.90
43_T51_L1.5400.89
189_E193_A1.5370.89
133_D314_E1.5270.89
105_R340_E1.4950.88
162_P342_E1.4700.87
275_R311_W1.4680.87
190_N233_P1.4590.87
209_D314_E1.4420.86
169_Q206_T1.4410.86
124_W306_L1.4370.86
210_K233_P1.4310.86
101_S337_E1.4180.85
111_T351_N1.4140.85
71_Q75_R1.4050.85
229_H233_P1.4030.85
231_M314_E1.4000.84
40_G197_I1.3950.84
165_K188_S1.3900.84
138_R163_Q1.3850.84
140_P339_V1.3810.84
47_R292_M1.3800.83
250_D253_V1.3790.83
417_E420_F1.3750.83
89_P150_P1.3730.83
163_Q185_M1.3710.83
96_R342_E1.3600.83
124_W348_L1.3450.82
49_L92_V1.3440.82
96_R99_L1.3340.81
221_W226_E1.3320.81
25_D29_P1.3320.81
51_L99_L1.3310.81
173_T309_H1.3280.81
59_V345_G1.3130.80
211_G233_P1.3100.80
130_L169_Q1.3040.80
341_Q345_G1.3010.80
130_L206_T1.2840.79
246_L347_L1.2800.79
140_P342_E1.2780.78
99_L104_V1.2720.78
410_V413_P1.2710.78
133_D290_T1.2680.78
333_S342_E1.2670.78
307_Y314_E1.2650.78
189_E314_E1.2600.77
322_Q352_L1.2550.77
49_L57_C1.2520.77
303_M350_Y1.2440.76
193_A206_T1.2250.75
211_G232_I1.2220.75
361_A372_L1.2210.75
241_E254_K1.2160.75
114_L117_N1.2140.75
47_R354_R1.2130.75
189_E307_Y1.1980.74
105_R372_L1.1970.74
189_E351_N1.1960.74
229_H306_L1.1880.73
196_L350_Y1.1840.73
222_S228_R1.1840.73
133_D311_W1.1780.72
90_S93_I1.1750.72
357_M377_S1.1580.71
87_V343_L1.1570.71
179_A358_I1.1480.70
218_L230_W1.1420.70
386_M403_L1.1360.70
50_P53_M1.1280.69
54_M99_L1.1270.69
189_E327_S1.1240.69
145_N162_P1.1240.69
149_F340_E1.1220.69
167_V183_G1.1210.69
142_T145_N1.1170.68
209_D321_K1.1140.68
209_D311_W1.0890.66
229_H277_L1.0890.66
137_W343_L1.0870.66
407_G413_P1.0850.66
180_A347_L1.0840.66
108_F350_Y1.0800.66
215_L272_V1.0790.66
133_D231_M1.0780.66
402_D406_M1.0740.65
59_V306_L1.0700.65
55_V107_V1.0680.65
105_R267_G1.0520.64
207_L222_S1.0460.63
26_Y31_L1.0450.63
134_G210_K1.0420.63
183_G187_N1.0410.63
108_F279_V1.0330.62
290_T311_W1.0290.62
99_L341_Q1.0280.62
127_L205_L1.0180.61
225_G228_R1.0160.61
27_L55_V1.0150.61
339_V383_R1.0150.61
311_W314_E1.0150.61
177_L351_N1.0120.61
164_V347_L1.0080.60
189_E209_D1.0080.60
38_E106_R1.0040.60
319_E323_T0.9970.59
229_H303_M0.9910.59
39_S103_A0.9910.59
69_L72_I0.9860.58
227_H231_M0.9720.57
57_C128_T0.9690.57
208_M288_L0.9630.57
133_D310_R0.9620.57
297_R301_G0.9620.57
124_W127_L0.9600.56
27_L34_R0.9570.56
128_T210_K0.9570.56
319_E350_Y0.9550.56
371_Q412_L0.9540.56
99_L351_N0.9500.56
236_K421_P0.9500.56
84_R106_R0.9470.55
128_T171_E0.9450.55
280_T283_G0.9430.55
167_V189_E0.9420.55
295_A298_F0.9290.54
247_G313_I0.9280.54
142_T377_S0.9280.54
209_D307_Y0.9280.54
171_E174_S0.9250.54
214_S333_S0.9200.53
205_L292_M0.9160.53
307_Y310_R0.9120.53
402_D405_S0.9080.52
375_S382_M0.9020.52
92_V326_R0.9000.52
193_A317_Y0.8990.52
192_L215_L0.8980.51
166_M192_L0.8980.51
32_I35_C0.8980.51
49_L91_A0.8980.51
31_L35_C0.8980.51
135_V139_T0.8970.51
223_L273_T0.8960.51
209_D310_R0.8940.51
214_S351_N0.8940.51
183_G192_L0.8920.51
95_A99_L0.8910.51
124_W298_F0.8880.51
188_S211_G0.8880.51
72_I76_L0.8820.50
192_L332_R0.8810.50
184_T366_G0.8810.50
411_K418_R0.8790.50
96_R124_W0.8780.50
165_K189_E0.8770.50
112_A161_Y0.8770.50
374_F378_C0.8730.49
310_R314_E0.8720.49
318_R321_K0.8700.49
50_P54_M0.8650.49
377_S388_L0.8640.49
33_S37_A0.8630.49
57_C92_V0.8620.49
47_R348_L0.8610.48
284_K381_V0.8600.48
162_P332_R0.8600.48
96_R103_A0.8590.48
220_A224_A0.8500.48
25_D31_L0.8500.48
27_L111_T0.8450.47
89_P149_F0.8440.47
240_Y253_V0.8420.47
115_W248_K0.8380.47
278_T287_H0.8360.46
404_A410_V0.8330.46
372_L377_S0.8320.46
134_G165_K0.8310.46
200_T291_S0.8290.46
412_L420_F0.8250.46
185_M256_K0.8230.45
150_P163_Q0.8220.45
100_G175_H0.8220.45
73_V128_T0.8210.45
233_P277_L0.8210.45
108_F342_E0.8200.45
240_Y276_L0.8200.45
413_P418_R0.8170.45
43_T47_R0.8150.45
179_A205_L0.8140.45
184_T383_R0.8140.45
145_N163_Q0.8120.44
405_S408_Q0.8100.44
197_I339_V0.8080.44
304_G403_L0.8080.44
178_T339_V0.8060.44
125_C225_G0.8040.44
316_G324_M0.8030.44
250_D275_R0.7990.43
111_T145_N0.7950.43
141_D162_P0.7940.43
108_F341_Q0.7940.43
318_R324_M0.7920.43
376_E410_V0.7910.43
230_W289_L0.7910.43
198_E220_A0.7890.43
45_R292_M0.7870.42
126_G129_L0.7870.42
51_L57_C0.7850.42
164_V182_F0.7810.42
45_R211_G0.7800.42
21_T26_Y0.7800.42
107_V289_L0.7790.42
162_P192_L0.7780.42
136_F233_P0.7770.42
302_E354_R0.7770.42
177_L316_G0.7730.41
264_K271_E0.7730.41
53_M56_W0.7730.41
189_E211_G0.7680.41
130_L200_T0.7650.41
326_R346_V0.7650.41
22_S25_D0.7640.41
80_L205_L0.7630.41
101_S343_L0.7630.41
336_P340_E0.7630.41
34_R38_E0.7620.41
102_E147_A0.7610.40
377_S383_R0.7590.40
104_V202_D0.7580.40
237_G243_I0.7570.40
171_E210_K0.7570.40
408_Q411_K0.7550.40
165_K185_M0.7490.40
150_P210_K0.7490.40
190_N297_R0.7470.39
123_H352_L0.7460.39
305_D308_S0.7460.39
279_V304_G0.7460.39
145_N150_P0.7450.39
132_I193_A0.7450.39
246_L251_H0.7440.39
161_Y185_M0.7400.39
198_E289_L0.7330.38
197_I217_L0.7330.38
44_L51_L0.7320.38
54_M205_L0.7290.38
254_K282_K0.7290.38
33_S52_E0.7290.38
125_C343_L0.7290.38
55_V60_G0.7280.38
213_Y345_G0.7270.38
115_W355_Y0.7270.38
127_L297_R0.7260.38
88_A232_I0.7250.38
253_V296_M0.7200.37
149_F182_F0.7180.37
368_W414_T0.7180.37
45_R377_S0.7180.37
357_M372_L0.7160.37
243_I246_L0.7160.37
404_A408_Q0.7160.37
186_K202_D0.7150.37
116_H308_S0.7140.37
225_G299_P0.7130.37
73_V89_P0.7130.37
289_L303_M0.7120.37
227_H294_D0.7120.37
58_I333_S0.7100.37
113_Q222_S0.7090.36
182_F301_G0.7080.36
368_W371_Q0.7080.36
186_K294_D0.7070.36
128_T201_G0.7060.36
61_M333_S0.7050.36
47_R306_L0.7050.36
303_M317_Y0.7040.36
76_L335_K0.7030.36
256_K266_P0.7030.36
58_I345_G0.7030.36
133_D321_K0.7020.36
179_A198_E0.7010.36
275_R310_R0.6980.36
131_A189_E0.6980.36
48_R53_M0.6960.35
189_E334_K0.6960.35
127_L298_F0.6920.35
233_P340_E0.6920.35
225_G231_M0.6900.35
59_V349_A0.6900.35
185_M353_V0.6880.35
255_L408_Q0.6850.35
45_R345_G0.6850.35
210_K314_E0.6840.35
109_T205_L0.6820.34
134_G209_D0.6820.34
189_E210_K0.6790.34
170_M316_G0.6790.34
145_N332_R0.6790.34
324_M353_V0.6780.34
115_W356_Q0.6760.34
169_Q200_T0.6750.34
23_L26_Y0.6750.34
107_V406_M0.6730.34
93_I334_K0.6730.34
23_L52_E0.6720.34
23_L28_D0.6710.34
169_Q178_T0.6700.34
145_N342_E0.6660.33
167_V196_L0.6660.33
106_R137_W0.6630.33
281_R304_G0.6630.33
166_M343_L0.6620.33
242_E253_V0.6620.33
59_V375_S0.6610.33
95_A162_P0.6590.33
99_L210_K0.6590.33
205_L299_P0.6540.32
208_M211_G0.6530.32
87_V245_K0.6520.32
269_G297_R0.6500.32
167_V342_E0.6500.32
189_E230_W0.6490.32
245_K248_K0.6480.32
231_M311_W0.6480.32
299_P302_E0.6480.32
402_D417_E0.6470.32
104_V287_H0.6440.32
113_Q277_L0.6430.32
87_V313_I0.6430.32
131_A163_Q0.6400.31
169_Q309_H0.6400.31
167_V373_S0.6390.31
96_R134_G0.6390.31
77_D81_P0.6380.31
405_S411_K0.6380.31
135_V320_I0.6370.31
378_C390_G0.6360.31
194_E220_A0.6360.31
67_E75_R0.6350.31
177_L214_S0.6340.31
189_E333_S0.6340.31
416_R420_F0.6340.31
49_L61_M0.6330.31
120_P301_G0.6320.31
209_D275_R0.6310.31
248_K253_V0.6310.31
342_E374_F0.6290.31
142_T336_P0.6280.31
323_T375_S0.6260.30
142_T334_K0.6250.30
90_S211_G0.6220.30
149_F172_L0.6220.30
74_N78_I0.6200.30
25_D28_D0.6180.30
115_W176_L0.6180.30
383_R388_L0.6170.30
88_A137_W0.6170.30
170_M344_W0.6170.30
238_A243_I0.6160.30
291_S297_R0.6160.30
169_Q299_P0.6160.30
302_E313_I0.6160.30
96_R351_N0.6150.30
390_G393_P0.6130.30
301_G305_D0.6130.30
50_P369_P0.6120.30
200_T224_A0.6120.30
214_S345_G0.6110.29
212_Y326_R0.6100.29
143_P163_Q0.6100.29
96_R230_W0.6090.29
45_R50_P0.6070.29
61_M255_L0.6060.29
94_Q415_R0.6060.29
370_N373_S0.6050.29
55_V186_K0.6010.29
31_L106_R0.6010.29
72_I342_E0.6000.29
286_C304_G0.6000.29
207_L258_S0.6000.29
36_L55_V0.6000.29
321_K344_W0.5980.29
354_R374_F0.5980.29
331_L371_Q0.5980.29
150_P185_M0.5970.29
307_Y313_I0.5950.28
44_L297_R0.5950.28
165_K177_L0.5950.28
95_A338_L0.5930.28
139_T164_V0.5930.28
30_E117_N0.5900.28
68_P79_M0.5900.28
228_R279_V0.5890.28
276_L319_E0.5880.28
317_Y383_R0.5870.28
277_L414_T0.5860.28
68_P71_Q0.5860.28
47_R91_A0.5860.28
267_G270_N0.5850.28
418_R421_P0.5820.28
337_E392_S0.5820.28
212_Y325_Q0.5810.27
406_M409_L0.5800.27
119_T212_Y0.5800.27
152_Q212_Y0.5800.27
181_A282_K0.5790.27
403_L408_Q0.5790.27
149_F336_P0.5770.27
31_L114_L0.5770.27
295_A339_V0.5750.27
108_F166_M0.5750.27
110_K113_Q0.5750.27
107_V348_L0.5740.27
319_E374_F0.5740.27
46_K356_Q0.5730.27
49_L53_M0.5720.27
205_L297_R0.5720.27
102_E123_H0.5720.27
414_T418_R0.5710.27
165_K374_F0.5710.27
87_V91_A0.5690.27
189_E341_Q0.5660.27
105_R193_A0.5640.26
20_L352_L0.5610.26
409_L419_A0.5590.26
375_S379_G0.5580.26
134_G230_W0.5540.26
188_S199_Q0.5510.26
48_R86_F0.5500.26
348_L421_P0.5500.26
353_V369_P0.5490.25
153_T158_P0.5490.25
150_P194_E0.5490.25
200_T226_E0.5490.25
294_D299_P0.5480.25
49_L56_W0.5470.25
190_N194_E0.5460.25
253_V274_A0.5460.25
34_R110_K0.5460.25
42_V51_L0.5450.25
127_L341_Q0.5450.25
111_T177_L0.5450.25
96_R185_M0.5440.25
90_S321_K0.5430.25
164_V220_A0.5430.25
371_Q375_S0.5420.25
264_K272_V0.5420.25
190_N211_G0.5420.25
255_L266_P0.5420.25
20_L27_L0.5420.25
131_A180_A0.5410.25
90_S138_R0.5410.25
214_S324_M0.5380.25
28_D107_V0.5370.25
275_R307_Y0.5360.25
103_A189_E0.5360.25
167_V318_R0.5350.25
189_E214_S0.5350.25
228_R322_Q0.5330.24
94_Q360_M0.5320.24
132_I403_L0.5320.24
153_T355_Y0.5310.24
334_K339_V0.5270.24
191_E285_V0.5260.24
182_F343_L0.5250.24
256_K271_E0.5250.24
133_D275_R0.5220.24
201_G291_S0.5220.24
165_K332_R0.5220.24
403_L410_V0.5210.24
182_F340_E0.5200.24
223_L270_N0.5200.24
152_Q163_Q0.5170.24
35_C57_C0.5160.23
91_A205_L0.5160.23
209_D290_T0.5160.23
61_M92_V0.5160.23
49_L333_S0.5150.23
186_K343_L0.5140.23
150_P153_T0.5120.23
394_G416_R0.5120.23
299_P343_L0.5120.23
238_A241_E0.5110.23
103_A341_Q0.5110.23
140_P162_P0.5110.23
410_V421_P0.5100.23
164_V343_L0.5100.23
160_L331_L0.5090.23
166_M182_F0.5090.23
309_H312_E0.5080.23
168_C350_Y0.5070.23
291_S367_Y0.5060.23
187_N273_T0.5060.23
258_S268_L0.5050.23
160_L219_N0.5050.23
140_P326_R0.5040.23
194_E197_I0.5030.23
365_K411_K0.5030.23
189_E275_R0.5010.23
21_T28_D0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.7851 99.9 0.727 Contact Map
2za4B 1 0.1946 5.7 0.976 Contact Map
4o4oA 2 0.3959 4.3 0.977 Contact Map
4nscA 5 0.3439 4 0.978 Contact Map
2jp7A 1 0.129 3.8 0.978 Contact Map
2cx6A 1 0.1923 3.8 0.978 Contact Map
3oq9A 3 0.1946 3.3 0.978 Contact Map
2p61A 1 0.2443 3.1 0.979 Contact Map
4mq3A 1 0.2805 2.7 0.979 Contact Map
4ociA 2 0.2941 2.6 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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