KEFC - ECOLI - GREMLIN Contacts

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KEFC - Glutathione-regulated potassium-efflux system protein KefC

UniProt:	P03819	Sequences: MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAAVFGCGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAIPLVAMIPLLATSSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQVPNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQPRVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAMVENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10521
Length:	620 (529)
Sequences:	3520 (2392)
Seq/√Len:	104.0

ECOLI - KEFC KEFB YBAL
BACSU - YJBQ
HALSA - Q9HNK1
SULSO - Q97UN8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
467_L	484_V	6.755	1.00
378_L	381_L	5.093	1.00
378_L	382_E	4.143	1.00
469_N	481_T	3.856	1.00
404_I	415_G	3.749	1.00
312_W	329_A	3.727	1.00
401_R	465_E	3.462	1.00
186_L	190_G	3.416	1.00
103_L	107_L	3.262	1.00
139_L	144_M	3.223	1.00
300_L	366_L	3.175	1.00
102_G	119_G	3.152	1.00
467_L	491_L	3.042	1.00
183_L	187_K	2.970	1.00
312_W	322_N	2.841	1.00
382_E	385_S	2.802	1.00
485_K	493_I	2.747	1.00
481_T	511_V	2.744	1.00
399_Q	463_K	2.652	1.00
182_A	186_L	2.608	1.00
379_N	382_E	2.585	1.00
484_V	491_L	2.508	1.00
466_V	529_A	2.504	1.00
100_L	310_M	2.489	1.00
485_K	512_E	2.474	1.00
403_I	464_A	2.461	1.00
297_V	301_L	2.421	1.00
482_E	509_A	2.373	1.00
197_L	201_Y	2.344	1.00
98_G	120_M	2.318	1.00
457_E	462_A	2.304	1.00
105_C	115_A	2.296	1.00
260_A	264_D	2.265	1.00
359_S	363_A	2.257	1.00
204_R	256_E	2.248	1.00
469_N	477_N	2.231	1.00
468_I	525_T	2.228	1.00
469_N	480_L	2.222	1.00
343_F	360_L	2.221	1.00
299_L	363_A	2.214	1.00
53_E	56_L	2.198	1.00
461_A	488_F	2.182	1.00
102_G	106_M	2.168	1.00
353_E	356_W	2.146	1.00
377_I	381_L	2.139	1.00
381_L	385_S	2.121	1.00
19_I	40_I	2.086	1.00
527_R	531_E	2.084	1.00
461_A	467_L	2.055	1.00
377_I	382_E	2.019	1.00
520_E	524_K	2.018	1.00
14_G	225_F	1.995	1.00
492_Q	512_E	1.967	1.00
334_Q	371_T	1.961	1.00
17_A	225_F	1.946	1.00
300_L	367_S	1.931	1.00
347_Q	357_A	1.929	1.00
99_G	103_L	1.927	1.00
312_W	316_R	1.922	1.00
120_M	162_L	1.920	1.00
403_I	461_A	1.911	1.00
302_G	306_I	1.902	1.00
345_A	349_A	1.886	1.00
15_S	41_I	1.884	1.00
121_T	343_F	1.877	1.00
303_F	363_A	1.872	1.00
111_R	114_V	1.870	1.00
471_I	480_L	1.859	1.00
405_A	467_L	1.835	1.00
102_G	116_E	1.833	1.00
468_I	529_A	1.810	1.00
345_A	348_M	1.806	1.00
315_A	325_R	1.802	1.00
102_G	112_W	1.801	1.00
296_I	359_S	1.769	1.00
335_G	339_A	1.764	1.00
205_P	209_F	1.760	1.00
41_I	48_L	1.753	1.00
391_E	394_E	1.739	1.00
339_A	364_V	1.738	1.00
473_D	476_T	1.727	1.00
129_I	368_M	1.724	1.00
404_I	414_T	1.724	1.00
105_C	110_L	1.721	1.00
380_R	384_S	1.719	1.00
390_R	393_D	1.717	1.00
148_A	331_L	1.714	1.00
400_P	465_E	1.681	1.00
393_D	396_D	1.668	1.00
212_R	433_D	1.631	1.00
137_R	376_V	1.631	1.00
429_D	435_I	1.627	1.00
117_L	346_A	1.627	1.00
67_L	124_L	1.627	1.00
147_S	320_V	1.622	1.00
151_V	328_F	1.622	1.00
290_L	293_P	1.622	1.00
56_L	279_G	1.609	1.00
438_L	443_M	1.599	1.00
118_I	360_L	1.599	1.00
431_D	434_H	1.598	1.00
410_F	525_T	1.566	1.00
335_G	364_V	1.560	1.00
405_A	480_L	1.558	1.00
198_L	202_V	1.557	1.00
398_E	401_R	1.556	1.00
285_D	358_K	1.548	1.00
294_L	298_I	1.539	1.00
303_F	335_G	1.528	1.00
330_V	374_L	1.519	1.00
492_Q	532_S	1.518	1.00
505_R	508_Q	1.499	1.00
377_I	380_R	1.498	1.00
304_L	370_A	1.496	1.00
429_D	434_H	1.495	1.00
97_C	101_L	1.483	1.00
457_E	487_H	1.483	1.00
316_R	322_N	1.482	1.00
497_A	503_Y	1.473	1.00
104_F	107_L	1.472	1.00
461_A	487_H	1.472	1.00
96_I	100_L	1.465	1.00
166_I	349_A	1.461	1.00
379_N	383_Q	1.458	1.00
178_M	182_A	1.431	1.00
450_A	480_L	1.427	1.00
408_G	411_G	1.420	1.00
29_G	132_Q	1.417	1.00
315_A	320_V	1.414	1.00
36_I	40_I	1.412	1.00
385_S	388_E	1.407	1.00
435_I	445_V	1.402	1.00
98_G	162_L	1.398	1.00
384_S	387_E	1.394	1.00
101_L	105_C	1.392	1.00
256_E	439_R	1.389	1.00
284_I	365_A	1.383	1.00
481_T	493_I	1.380	1.00
162_L	342_V	1.360	0.99
494_I	532_S	1.357	0.99
392_A	395_I	1.355	0.99
289_L	362_L	1.354	0.99
90_G	93_Q	1.348	0.99
91_A	95_V	1.342	0.99
103_L	112_W	1.338	0.99
205_P	208_R	1.335	0.99
404_I	468_I	1.334	0.99
130_A	332_L	1.329	0.99
24_V	27_G	1.326	0.99
499_D	502_H	1.325	0.99
144_M	327_W	1.323	0.99
295_R	359_S	1.320	0.99
511_V	514_P	1.317	0.99
405_A	450_A	1.312	0.99
95_V	99_G	1.311	0.99
232_L	236_E	1.311	0.99
316_R	319_Q	1.306	0.99
295_R	298_I	1.303	0.99
89_C	314_I	1.302	0.99
51_D	54_S	1.297	0.99
308_I	330_V	1.291	0.99
40_I	45_G	1.290	0.99
528_L	531_E	1.288	0.99
378_L	385_S	1.285	0.99
417_L	526_G	1.284	0.99
144_M	324_Q	1.269	0.99
252_L	261_L	1.267	0.99
103_L	106_M	1.266	0.99
99_G	102_G	1.261	0.99
386_T	393_D	1.255	0.99
159_A	342_V	1.250	0.99
461_A	491_L	1.246	0.99
504_I	508_Q	1.244	0.99
494_I	525_T	1.239	0.99
498_R	517_E	1.239	0.99
85_A	150_A	1.238	0.99
264_D	452_R	1.236	0.99
516_R	519_F	1.235	0.99
87_F	91_A	1.230	0.99
379_N	384_S	1.223	0.99
402_V	468_I	1.221	0.99
134_M	145_G	1.215	0.99
478_L	509_A	1.210	0.99
184_S	188_V	1.210	0.99
482_E	486_E	1.210	0.99
124_L	162_L	1.209	0.99
97_C	311_L	1.204	0.99
478_L	505_R	1.195	0.99
407_F	415_G	1.192	0.99
453_M	487_H	1.188	0.99
190_G	194_L	1.176	0.99
376_V	380_R	1.175	0.99
7_I	10_L	1.175	0.99
460_G	463_K	1.174	0.99
524_K	528_L	1.167	0.98
480_L	484_V	1.162	0.98
494_I	529_A	1.159	0.98
12_Y	20_V	1.158	0.98
402_V	418_L	1.154	0.98
484_V	488_F	1.146	0.98
500_V	516_R	1.144	0.98
184_S	187_K	1.143	0.98
94_M	154_F	1.136	0.98
119_G	123_A	1.132	0.98
28_L	35_L	1.130	0.98
438_L	441_F	1.129	0.98
300_L	304_L	1.129	0.98
110_L	115_A	1.128	0.98
409_R	496_R	1.127	0.98
301_L	305_I	1.126	0.98
478_L	482_E	1.125	0.98
125_S	155_Q	1.122	0.98
379_N	385_S	1.122	0.98
139_L	375_L	1.121	0.98
100_L	103_L	1.115	0.98
72_L	250_V	1.104	0.98
401_R	424_K	1.102	0.98
152_L	338_F	1.098	0.98
390_R	395_I	1.089	0.98
391_E	395_I	1.085	0.97
379_N	386_T	1.085	0.97
357_A	361_T	1.084	0.97
97_C	155_Q	1.083	0.97
204_R	255_S	1.076	0.97
472_D	517_E	1.074	0.97
207_L	226_L	1.073	0.97
130_A	152_L	1.072	0.97
130_A	331_L	1.072	0.97
513_K	528_L	1.070	0.97
344_G	348_M	1.069	0.97
110_L	118_I	1.069	0.97
419_L	425_M	1.060	0.97
411_G	429_D	1.058	0.97
89_C	318_L	1.056	0.97
179_G	183_L	1.054	0.97
381_L	384_S	1.054	0.97
94_M	158_A	1.053	0.97
415_G	425_M	1.051	0.97
336_S	340_F	1.042	0.97
474_P	477_N	1.039	0.97
390_R	394_E	1.036	0.97
403_I	467_L	1.033	0.97
393_D	398_E	1.033	0.97
11_I	15_S	1.033	0.97
292_N	355_E	1.024	0.96
180_A	183_L	1.023	0.96
191_A	195_V	1.015	0.96
471_I	477_N	1.015	0.96
303_F	367_S	1.013	0.96
316_R	325_R	1.013	0.96
392_A	396_D	1.012	0.96
229_G	233_L	1.010	0.96
75_D	254_S	1.010	0.96
423_V	535_L	1.006	0.96
378_L	384_S	1.005	0.96
395_I	398_E	1.002	0.96
36_I	53_E	0.998	0.96
117_L	121_T	0.998	0.96
479_Q	482_E	0.991	0.96
80_W	83_R	0.991	0.96
434_H	437_T	0.991	0.96
279_G	283_S	0.990	0.96
104_F	306_I	0.990	0.96
518_T	522_A	0.987	0.96
87_F	93_Q	0.982	0.95
321_P	325_R	0.979	0.95
307_K	332_L	0.977	0.95
496_R	517_E	0.976	0.95
218_V	522_A	0.975	0.95
314_I	318_L	0.974	0.95
10_L	232_L	0.971	0.95
432_P	436_E	0.969	0.95
382_E	387_E	0.967	0.95
350_N	354_P	0.967	0.95
97_C	310_M	0.967	0.95
82_L	85_A	0.967	0.95
427_V	443_M	0.966	0.95
382_E	386_T	0.966	0.95
231_G	241_M	0.964	0.95
478_L	502_H	0.960	0.95
105_C	356_W	0.959	0.95
86_V	93_Q	0.957	0.95
210_V	222_V	0.953	0.95
114_V	353_E	0.952	0.95
201_Y	205_P	0.948	0.95
32_L	369_A	0.943	0.94
488_F	491_L	0.941	0.94
469_N	495_A	0.940	0.94
453_M	483_M	0.939	0.94
360_L	365_A	0.938	0.94
387_E	394_E	0.938	0.94
407_F	427_V	0.937	0.94
124_L	159_A	0.937	0.94
502_H	506_L	0.935	0.94
95_V	98_G	0.935	0.94
106_M	112_W	0.933	0.94
71_G	281_G	0.919	0.94
528_L	532_S	0.916	0.93
181_F	185_A	0.916	0.93
407_F	443_M	0.915	0.93
260_A	263_S	0.915	0.93
350_N	353_E	0.914	0.93
515_E	525_T	0.913	0.93
101_L	306_I	0.913	0.93
284_I	362_L	0.909	0.93
368_M	371_T	0.907	0.93
364_V	367_S	0.906	0.93
81_K	84_A	0.905	0.93
453_M	486_E	0.905	0.93
118_I	122_L	0.904	0.93
385_S	390_R	0.901	0.93
366_L	370_A	0.897	0.93
93_Q	97_C	0.894	0.93
384_S	388_E	0.892	0.93
526_G	533_L	0.892	0.93
10_L	228_F	0.889	0.92
330_V	378_L	0.888	0.92
402_V	466_V	0.887	0.92
77_Q	81_K	0.883	0.92
10_L	225_F	0.883	0.92
389_A	398_E	0.881	0.92
217_E	221_A	0.881	0.92
304_L	333_G	0.879	0.92
115_A	353_E	0.877	0.92
512_E	532_S	0.877	0.92
210_V	219_F	0.872	0.92
41_I	282_M	0.871	0.92
361_T	365_A	0.870	0.92
194_L	197_L	0.867	0.91
73_E	128_A	0.865	0.91
155_Q	337_E	0.865	0.91
305_I	308_I	0.865	0.91
95_V	370_A	0.864	0.91
34_Y	42_G	0.862	0.91
148_A	280_V	0.861	0.91
435_I	447_Y	0.860	0.91
211_A	257_Y	0.859	0.91
511_V	525_T	0.859	0.91
431_D	445_V	0.857	0.91
193_V	197_L	0.851	0.91
319_Q	322_N	0.850	0.91
313_L	317_P	0.850	0.91
126_S	276_F	0.845	0.90
198_L	201_Y	0.845	0.90
155_Q	338_F	0.844	0.90
102_G	105_C	0.844	0.90
83_R	523_L	0.840	0.90
434_H	438_L	0.839	0.90
495_A	509_A	0.838	0.90
303_F	329_A	0.837	0.90
89_C	93_Q	0.837	0.90
474_P	505_R	0.837	0.90
425_M	444_K	0.836	0.90
203_T	226_L	0.836	0.90
515_E	524_K	0.835	0.90
377_I	383_Q	0.834	0.90
155_Q	159_A	0.831	0.90
331_L	375_L	0.827	0.89
91_A	154_F	0.827	0.89
476_T	479_Q	0.825	0.89
517_E	522_A	0.825	0.89
36_I	478_L	0.824	0.89
221_A	270_G	0.822	0.89
45_G	48_L	0.822	0.89
152_L	155_Q	0.821	0.89
117_L	166_I	0.818	0.89
26_L	451_T	0.817	0.89
438_L	445_V	0.816	0.89
509_A	515_E	0.815	0.89
111_R	115_A	0.815	0.89
84_A	290_L	0.812	0.89
93_Q	338_F	0.812	0.89
20_V	274_G	0.811	0.89
526_G	530_L	0.811	0.89
337_E	340_F	0.810	0.88
90_G	94_M	0.810	0.88
100_L	306_I	0.810	0.88
83_R	89_C	0.809	0.88
380_R	386_T	0.808	0.88
428_L	446_F	0.806	0.88
474_P	502_H	0.804	0.88
520_E	525_T	0.804	0.88
74_L	253_A	0.801	0.88
399_Q	465_E	0.800	0.88
292_N	359_S	0.796	0.88
292_N	295_R	0.796	0.88
245_A	325_R	0.793	0.87
230_F	251_L	0.793	0.87
86_V	105_C	0.792	0.87
288_T	292_N	0.791	0.87
128_A	274_G	0.790	0.87
343_F	352_L	0.789	0.87
82_L	86_V	0.788	0.87
503_Y	514_P	0.788	0.87
125_S	332_L	0.787	0.87
125_S	128_A	0.787	0.87
151_V	332_L	0.786	0.87
62_G	244_G	0.786	0.87
402_V	529_A	0.784	0.87
477_N	509_A	0.784	0.87
14_G	229_G	0.781	0.87
161_P	238_G	0.777	0.86
186_L	193_V	0.775	0.86
47_R	59_A	0.775	0.86
182_A	185_A	0.775	0.86
414_T	468_I	0.773	0.86
266_E	270_G	0.772	0.86
325_R	329_A	0.772	0.86
402_V	423_V	0.769	0.86
428_L	448_G	0.768	0.86
513_K	532_S	0.765	0.85
308_I	333_G	0.765	0.85
302_G	305_I	0.763	0.85
183_L	186_L	0.763	0.85
514_P	525_T	0.761	0.85
11_I	41_I	0.760	0.85
114_V	356_W	0.758	0.85
493_I	511_V	0.758	0.85
223_A	278_I	0.757	0.85
411_G	470_A	0.757	0.85
525_T	529_A	0.755	0.85
155_Q	276_F	0.754	0.85
223_A	261_L	0.753	0.85
500_V	503_Y	0.753	0.85
26_L	258_R	0.752	0.84
323_K	327_W	0.752	0.84
346_A	350_N	0.751	0.84
121_T	162_L	0.751	0.84
188_V	192_L	0.750	0.84
94_M	123_A	0.749	0.84
411_G	435_I	0.749	0.84
498_R	516_R	0.749	0.84
105_C	299_L	0.748	0.84
151_V	159_A	0.746	0.84
128_A	152_L	0.744	0.84
369_A	373_I	0.743	0.84
497_A	501_D	0.743	0.84
496_R	518_T	0.742	0.84
219_F	222_V	0.742	0.84
517_E	521_G	0.740	0.84
370_A	374_L	0.739	0.83
85_A	147_S	0.738	0.83
492_Q	513_K	0.736	0.83
378_L	383_Q	0.736	0.83
447_Y	497_A	0.735	0.83
509_A	512_E	0.735	0.83
34_Y	274_G	0.734	0.83
89_C	308_I	0.732	0.83
511_V	516_R	0.731	0.83
128_A	159_A	0.731	0.83
466_V	492_Q	0.730	0.83
380_R	385_S	0.730	0.83
43_P	448_G	0.729	0.83
391_E	396_D	0.728	0.83
387_E	390_R	0.727	0.82
64_V	67_L	0.726	0.82
98_G	102_G	0.726	0.82
195_V	247_L	0.726	0.82
515_E	528_L	0.726	0.82
96_I	109_G	0.724	0.82
195_V	251_L	0.724	0.82
322_N	329_A	0.722	0.82
392_A	397_E	0.722	0.82
127_T	337_E	0.720	0.82
139_L	327_W	0.720	0.82
409_R	498_R	0.720	0.82
132_Q	270_G	0.720	0.82
92_L	318_L	0.719	0.82
14_G	18_L	0.718	0.82
382_E	392_A	0.718	0.82
30_S	329_A	0.717	0.82
134_M	148_A	0.717	0.82
74_L	282_M	0.716	0.81
419_L	443_M	0.716	0.81
231_G	234_L	0.715	0.81
50_T	55_I	0.715	0.81
347_Q	354_P	0.714	0.81
285_D	288_T	0.713	0.81
410_F	470_A	0.711	0.81
104_F	114_V	0.710	0.81
313_L	330_V	0.709	0.81
88_G	318_L	0.709	0.81
405_A	471_I	0.709	0.81
258_R	272_L	0.707	0.81
32_L	228_F	0.706	0.81
222_V	226_L	0.703	0.80
220_S	243_M	0.703	0.80
408_G	470_A	0.702	0.80
222_V	227_V	0.702	0.80
60_E	127_T	0.700	0.80
165_M	289_L	0.700	0.80
17_A	20_V	0.700	0.80
121_T	352_L	0.698	0.80
401_R	464_A	0.697	0.80
409_R	499_D	0.697	0.80
304_L	374_L	0.697	0.80
159_A	163_V	0.696	0.80
203_T	207_L	0.696	0.80
311_L	328_F	0.696	0.80
304_L	528_L	0.696	0.80
70_I	127_T	0.694	0.79
39_C	45_G	0.692	0.79
208_R	256_E	0.689	0.79
524_K	531_E	0.689	0.79
404_I	522_A	0.689	0.79
255_S	261_L	0.689	0.79
293_P	297_V	0.688	0.79
87_F	90_G	0.688	0.79
494_I	513_K	0.687	0.79
219_F	223_A	0.687	0.79
415_G	427_V	0.686	0.79
177_T	181_F	0.684	0.78
125_S	310_M	0.682	0.78
393_D	397_E	0.681	0.78
437_T	440_K	0.681	0.78
437_T	441_F	0.680	0.78
298_I	302_G	0.679	0.78
97_C	100_L	0.677	0.78
311_L	314_I	0.676	0.78
352_L	356_W	0.676	0.78
94_M	97_C	0.674	0.77
65_L	163_V	0.673	0.77
262_E	274_G	0.672	0.77
96_I	314_I	0.672	0.77
409_R	518_T	0.672	0.77
413_I	519_F	0.672	0.77
426_V	461_A	0.672	0.77
207_L	222_V	0.670	0.77
279_G	522_A	0.670	0.77
189_A	193_V	0.669	0.77
364_V	371_T	0.669	0.77
70_I	74_L	0.669	0.77
43_P	282_M	0.669	0.77
86_V	154_F	0.669	0.77
383_Q	387_E	0.668	0.77
202_V	205_P	0.668	0.77
389_A	392_A	0.667	0.77
108_L	436_E	0.666	0.77
37_A	237_V	0.665	0.76
127_T	152_L	0.664	0.76
221_A	271_L	0.663	0.76
492_Q	495_A	0.662	0.76
79_L	296_I	0.661	0.76
461_A	484_V	0.661	0.76
37_A	255_S	0.660	0.76
23_A	36_I	0.660	0.76
200_R	251_L	0.659	0.76
189_A	197_L	0.659	0.76
39_C	44_W	0.658	0.76
293_P	296_I	0.658	0.76
467_L	480_L	0.658	0.76
481_T	495_A	0.656	0.75
160_I	242_A	0.656	0.75
16_A	52_A	0.656	0.75
130_A	195_V	0.654	0.75
394_E	397_E	0.654	0.75
396_D	399_Q	0.653	0.75
241_M	275_L	0.653	0.75
12_Y	278_I	0.653	0.75
356_W	359_S	0.652	0.75
100_L	465_E	0.651	0.75
409_R	472_D	0.651	0.75
210_V	257_Y	0.651	0.75
465_E	492_Q	0.650	0.75
195_V	218_V	0.649	0.75
129_I	427_V	0.649	0.75
10_L	247_L	0.648	0.75
230_F	234_L	0.648	0.75
23_A	33_G	0.648	0.75
66_M	127_T	0.644	0.74
371_T	375_L	0.644	0.74
295_R	299_L	0.644	0.74
297_V	300_L	0.642	0.74
370_A	508_Q	0.641	0.74
276_F	281_G	0.641	0.74
403_I	444_K	0.638	0.73
320_V	324_Q	0.638	0.73
358_K	361_T	0.636	0.73
130_A	334_Q	0.636	0.73
91_A	94_M	0.635	0.73
453_M	488_F	0.635	0.73
522_A	526_G	0.634	0.73
381_L	386_T	0.633	0.73
122_L	360_L	0.632	0.73
243_M	272_L	0.631	0.73
112_W	116_E	0.630	0.73
380_R	383_Q	0.628	0.72
70_I	124_L	0.628	0.72
381_L	388_E	0.628	0.72
415_G	424_K	0.626	0.72
412_Q	441_F	0.626	0.72
74_L	260_A	0.626	0.72
42_G	49_V	0.625	0.72
181_F	184_S	0.624	0.72
105_C	118_I	0.624	0.72
224_L	268_F	0.623	0.72
95_V	107_L	0.623	0.72
414_T	522_A	0.622	0.72
124_L	128_A	0.621	0.71
92_L	96_I	0.621	0.71
20_V	30_S	0.620	0.71
180_A	184_S	0.619	0.71
103_L	475_Q	0.619	0.71
155_Q	310_M	0.619	0.71
415_G	438_L	0.619	0.71
291_E	294_L	0.618	0.71
190_G	467_L	0.618	0.71
171_T	180_A	0.618	0.71
261_L	272_L	0.616	0.71
301_L	370_A	0.616	0.71
379_N	390_R	0.616	0.71
515_E	521_G	0.615	0.71
165_M	175_S	0.615	0.71
287_G	291_E	0.614	0.71
221_A	227_V	0.613	0.70
433_D	437_T	0.611	0.70
368_M	372_P	0.611	0.70
123_A	307_K	0.610	0.70
428_L	459_A	0.610	0.70
7_I	94_M	0.609	0.70
18_L	22_I	0.608	0.70
64_V	241_M	0.608	0.70
495_A	506_L	0.607	0.70
32_L	346_A	0.607	0.70
151_V	311_L	0.604	0.69
133_A	331_L	0.603	0.69
39_C	190_G	0.603	0.69
347_Q	352_L	0.602	0.69
522_A	529_A	0.602	0.69
115_A	329_A	0.601	0.69
524_K	527_R	0.600	0.69
172_S	194_L	0.600	0.69
520_E	523_L	0.599	0.69
101_L	303_F	0.598	0.69
29_G	121_T	0.597	0.68
468_I	494_I	0.596	0.68
93_Q	105_C	0.595	0.68
59_A	279_G	0.595	0.68
224_L	402_V	0.595	0.68
470_A	519_F	0.595	0.68
389_A	393_D	0.595	0.68
86_V	89_C	0.595	0.68
160_I	341_V	0.595	0.68
240_S	246_F	0.594	0.68
426_V	451_T	0.593	0.68
223_A	227_V	0.592	0.68
61_I	196_V	0.591	0.68
94_M	162_L	0.589	0.67
74_L	122_L	0.589	0.67
354_P	358_K	0.588	0.67
74_L	131_M	0.588	0.67
112_W	115_A	0.585	0.67
295_R	509_A	0.585	0.67
336_S	341_V	0.584	0.67
110_L	299_L	0.584	0.67
523_L	534_G	0.584	0.67
177_T	228_F	0.582	0.67
36_I	96_I	0.581	0.66
182_A	187_K	0.580	0.66
19_I	37_A	0.579	0.66
146_R	484_V	0.578	0.66
122_L	409_R	0.578	0.66
152_L	337_E	0.577	0.66
16_A	203_T	0.576	0.66
386_T	390_R	0.572	0.65
235_E	261_L	0.572	0.65
506_L	510_G	0.570	0.65
133_A	318_L	0.570	0.65
132_Q	136_E	0.570	0.65
411_G	450_A	0.569	0.65
421_S	441_F	0.569	0.65
453_M	457_E	0.568	0.65
529_A	532_S	0.568	0.65
208_R	212_R	0.568	0.65
70_I	359_S	0.567	0.65
61_I	228_F	0.567	0.65
7_I	130_A	0.566	0.64
219_F	257_Y	0.566	0.64
389_A	394_E	0.565	0.64
432_P	435_I	0.565	0.64
183_L	189_A	0.564	0.64
84_A	87_F	0.562	0.64
66_M	328_F	0.559	0.63
8_Q	67_L	0.558	0.63
519_F	523_L	0.558	0.63
62_G	276_F	0.557	0.63
153_L	418_L	0.557	0.63
93_Q	152_L	0.556	0.63
387_E	392_A	0.555	0.63
125_S	159_A	0.555	0.63
159_A	166_I	0.555	0.63
35_L	41_I	0.555	0.63
127_T	338_F	0.554	0.63
245_A	535_L	0.554	0.63
122_L	303_F	0.553	0.63
337_E	341_V	0.551	0.62
155_Q	332_L	0.550	0.62
436_E	440_K	0.549	0.62
223_A	253_A	0.549	0.62
92_L	95_V	0.548	0.62
153_L	275_L	0.548	0.62
129_I	273_L	0.547	0.62
446_F	455_L	0.547	0.62
503_Y	515_E	0.546	0.62
221_A	272_L	0.546	0.62
6_L	232_L	0.546	0.62
217_E	228_F	0.544	0.61
296_I	329_A	0.544	0.61
36_I	46_L	0.544	0.61
478_L	481_T	0.544	0.61
315_A	328_F	0.544	0.61
223_A	304_L	0.543	0.61
40_I	43_P	0.542	0.61
227_V	231_G	0.541	0.61
379_N	388_E	0.541	0.61
204_R	219_F	0.541	0.61
130_A	302_G	0.540	0.61
244_G	276_F	0.539	0.61
138_N	430_H	0.539	0.61
13_L	225_F	0.539	0.61
220_S	470_A	0.539	0.61
323_K	381_L	0.539	0.61
163_V	265_I	0.539	0.61
174_A	190_G	0.538	0.61
238_G	244_G	0.538	0.61
206_A	209_F	0.537	0.60
87_F	251_L	0.536	0.60
105_C	108_L	0.536	0.60
82_L	447_Y	0.535	0.60
469_N	511_V	0.535	0.60
65_L	241_M	0.535	0.60
10_L	17_A	0.534	0.60
365_A	371_T	0.533	0.60
120_M	339_A	0.533	0.60
192_L	247_L	0.531	0.60
410_F	496_R	0.530	0.59
133_A	252_L	0.530	0.59
324_Q	328_F	0.530	0.59
96_I	179_G	0.530	0.59
334_Q	342_V	0.529	0.59
155_Q	160_I	0.529	0.59
71_G	269_K	0.529	0.59
99_G	116_E	0.529	0.59
94_M	307_K	0.528	0.59
216_R	264_D	0.528	0.59
19_I	185_A	0.527	0.59
109_G	112_W	0.526	0.59
126_S	156_D	0.525	0.59
179_G	297_V	0.525	0.59
192_L	196_V	0.523	0.58
504_I	507_R	0.523	0.58
183_L	193_V	0.522	0.58
165_M	431_D	0.522	0.58
39_C	369_A	0.521	0.58
122_L	335_G	0.521	0.58
62_G	246_F	0.521	0.58
257_Y	299_L	0.519	0.58
246_F	307_K	0.519	0.58
129_I	375_L	0.519	0.58
74_L	283_S	0.514	0.57
450_A	471_I	0.514	0.57
220_S	223_A	0.514	0.57
144_M	328_F	0.513	0.57
123_A	155_Q	0.513	0.57
436_E	482_E	0.512	0.57
294_L	433_D	0.512	0.57
11_I	297_V	0.512	0.57
134_M	139_L	0.511	0.57
88_G	93_Q	0.511	0.57
526_G	534_G	0.511	0.57
293_P	298_I	0.511	0.57
104_F	299_L	0.511	0.57
284_I	311_L	0.511	0.57
269_K	426_V	0.510	0.57
23_A	157_I	0.509	0.56
136_E	369_A	0.509	0.56
408_G	450_A	0.507	0.56
225_F	472_D	0.507	0.56
70_I	264_D	0.506	0.56
321_P	324_Q	0.505	0.56
96_I	202_V	0.505	0.56
151_V	336_S	0.505	0.56
521_G	524_K	0.505	0.56
495_A	511_V	0.504	0.56
417_L	519_F	0.504	0.56
355_E	358_K	0.503	0.55
331_L	334_Q	0.503	0.55
175_S	178_M	0.503	0.55
127_T	242_A	0.502	0.55
428_L	455_L	0.502	0.55
287_G	290_L	0.502	0.55
434_H	453_M	0.501	0.55
103_L	172_S	0.501	0.55
507_R	532_S	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4bwzA	2	0.6129	100	0.602	Contact Map
4czbA	2	0.6129	100	0.648	Contact Map
4cz8A	2	0.6113	100	0.653	Contact Map
3l9wA	2	0.2935	100	0.764	Contact Map
4gx0A	3	0.5129	100	0.817	Contact Map
1zcdA	1	0.55	100	0.82	Contact Map
1lnqA	6	0.4661	99.9	0.825	Contact Map
2aefA	2	0.3484	99.9	0.839	Contact Map
3nafA	3	0.3435	99.9	0.849	Contact Map
3c85A	2	0.2403	99.9	0.852	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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