GREMLIN Database
MIOC - Protein MioC
UniProt: P03817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11199
Length: 147 (137)
Sequences: 3882 (2514)
Seq/√Len: 214.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_E116_Q3.9801.00
89_G102_I3.8961.00
103_D122_K3.3491.00
11_T64_D2.9981.00
84_R115_K2.7311.00
110_K116_Q2.6991.00
100_G104_K2.4951.00
108_E111_N2.4261.00
88_I123_I2.2771.00
108_E112_S2.2681.00
85_F106_E2.2441.00
26_L143_V2.1121.00
85_F110_K2.0281.00
62_I101_A1.9871.00
39_P47_S1.9581.00
4_I26_L1.9291.00
87_A102_I1.8611.00
9_G66_L1.8091.00
52_V105_L1.8081.00
23_A35_T1.7461.00
49_I84_R1.7211.00
118_G141_S1.6691.00
6_L23_A1.6431.00
16_E20_E1.6361.00
51_L142_W1.5541.00
85_F114_A1.5241.00
15_A53_I1.5231.00
85_F116_Q1.5071.00
106_E110_K1.4811.00
9_G54_S1.4801.00
10_S65_N1.4601.00
52_V109_L1.4561.00
54_S105_L1.4231.00
18_V135_A1.4061.00
58_G61_D1.3771.00
106_E120_T1.3731.00
103_D120_T1.3661.00
70_Y105_L1.3511.00
23_A27_E1.3081.00
99_C122_K1.3061.00
88_I135_A1.3051.00
15_A90_I1.2811.00
50_W83_V1.2591.00
86_G118_G1.2551.00
70_Y104_K1.2541.00
69_F105_L1.2471.00
55_S63_P1.2251.00
18_V90_I1.2241.00
109_L114_A1.2171.00
7_I39_P1.2071.00
7_I50_W1.2011.00
74_Q108_E1.1941.00
88_I121_L1.1901.00
107_A111_N1.1851.00
89_G99_C1.1751.00
22_L53_I1.1631.00
23_A33_T1.1561.00
51_L86_G1.1531.00
123_I135_A1.1501.00
7_I36_L1.1421.00
116_Q119_E1.1281.00
22_L139_L1.1161.00
86_G142_W1.0921.00
25_K139_L1.0841.00
56_T99_C1.0841.00
54_S101_A1.0801.00
36_L39_P1.0791.00
62_I66_L1.0761.00
62_I70_Y1.0591.00
54_S63_P1.0481.00
118_G142_W1.0211.00
40_L43_D1.0091.00
9_G65_N0.9971.00
26_L33_T0.9881.00
70_Y108_E0.9791.00
70_Y101_A0.9441.00
20_E35_T0.9360.99
140_G144_N0.9330.99
137_E140_G0.9160.99
100_G103_D0.9140.99
8_S16_E0.8870.99
99_C102_I0.8830.99
54_S66_L0.8810.99
37_H65_N0.8720.99
107_A110_K0.8720.99
14_G131_P0.8670.99
72_A76_Q0.8530.99
93_R126_L0.8520.99
82_A115_K0.8510.99
80_L114_A0.8420.99
137_E141_S0.8380.99
10_S15_A0.8380.99
119_E141_S0.8350.99
5_T47_S0.8340.99
25_K140_G0.8310.99
36_L69_F0.8240.99
39_P72_A0.8230.99
17_Y21_H0.8210.99
56_T102_I0.8170.99
12_L59_A0.8100.99
22_L51_L0.8080.98
47_S50_W0.7990.98
78_P112_S0.7940.98
87_A106_E0.7920.98
70_Y74_Q0.7810.98
21_H136_E0.7780.98
25_K29_A0.7760.98
116_Q120_T0.7760.98
24_E27_E0.7690.98
74_Q104_K0.7650.98
4_I49_I0.7650.98
59_A97_T0.7610.98
16_E65_N0.7580.98
78_P81_S0.7570.98
64_D67_S0.7570.98
5_T48_G0.7560.98
6_L19_A0.7540.98
57_H125_I0.7490.98
7_I52_V0.7490.98
126_L131_P0.7480.97
134_P137_E0.7480.97
83_V109_L0.7350.97
123_I131_P0.7340.97
118_G121_L0.7300.97
102_I120_T0.7280.97
90_I125_I0.7210.97
135_A139_L0.7190.97
41_L72_A0.7020.96
86_G117_T0.6980.96
102_I122_K0.6930.96
121_L134_P0.6890.96
18_V53_I0.6850.96
6_L51_L0.6780.96
30_G33_T0.6770.96
54_S102_I0.6560.95
60_G63_P0.6540.95
141_S144_N0.6510.94
98_F120_T0.6430.94
9_G101_A0.6410.94
59_A96_D0.6400.94
25_K143_V0.6400.94
74_Q107_A0.6400.94
11_T15_A0.6350.94
5_T34_E0.6320.94
36_L66_L0.6310.94
73_L112_S0.6290.93
46_A82_A0.6270.93
4_I51_L0.6140.93
71_E75_E0.6130.93
10_S17_Y0.6130.93
77_K112_S0.6030.92
80_L83_V0.6000.92
25_K136_E0.5990.92
133_D136_E0.5920.91
18_V63_P0.5860.91
6_L26_L0.5850.91
17_Y20_E0.5850.91
53_I88_I0.5840.91
131_P135_A0.5830.91
15_A132_E0.5830.91
8_S53_I0.5820.90
5_T39_P0.5810.90
37_H68_P0.5750.90
133_D137_E0.5710.90
95_Y99_C0.5680.89
92_S126_L0.5670.89
14_G17_Y0.5670.89
26_L31_F0.5670.89
52_V63_P0.5640.89
31_F49_I0.5630.89
77_K81_S0.5570.88
24_E28_E0.5570.88
15_A55_S0.5570.88
62_I104_K0.5560.88
62_I105_L0.5550.88
73_L109_L0.5530.88
12_L125_I0.5470.88
24_E29_A0.5460.87
4_I31_F0.5450.87
91_G95_Y0.5450.87
12_L57_H0.5430.87
85_F109_L0.5400.87
73_L108_E0.5400.87
48_G124_N0.5380.87
5_T50_W0.5380.87
136_E140_G0.5370.87
29_A143_V0.5350.86
94_E126_L0.5340.86
95_Y102_I0.5330.86
66_L69_F0.5330.86
59_A67_S0.5320.86
30_G35_T0.5290.86
14_G55_S0.5260.86
58_G90_I0.5250.85
84_R117_T0.5230.85
11_T57_H0.5230.85
57_H100_G0.5190.85
51_L117_T0.5130.84
90_I102_I0.5120.84
9_G63_P0.5100.84
42_E77_K0.5090.84
103_D107_A0.5080.84
31_F143_V0.5080.84
79_D112_S0.5070.83
61_D132_E0.5070.83
61_D95_Y0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tllA 2 0.9728 100 0.181 Contact Map
2bpoA 1 0.9932 100 0.231 Contact Map
3qe2A 1 0.9864 100 0.233 Contact Map
3hr4A 2 0.9796 100 0.304 Contact Map
1bvyF 1 0.9796 100 0.378 Contact Map
2m6rA 1 1 100 0.398 Contact Map
4h2dA 1 0.9932 100 0.402 Contact Map
2hnaA 1 1 100 0.402 Contact Map
1ykgA 1 0.9524 100 0.409 Contact Map
4oxxA 1 0.9864 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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