GREMLIN Database
YGEA - Uncharacterized protein YgeA
UniProt: P03813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11157
Length: 230 (224)
Sequences: 2254 (1732)
Seq/√Len: 115.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_E59_K3.7961.00
119_R145_N3.5141.00
153_E184_R3.0361.00
6_L82_C3.0271.00
159_Q163_E3.0081.00
80_V224_A2.8921.00
78_G227_F2.8051.00
130_E154_R2.7831.00
115_A214_F2.6911.00
72_Q98_T2.6581.00
20_R24_E2.5231.00
121_A185_L2.4771.00
106_D137_R2.4401.00
81_L101_F2.4351.00
132_D136_G2.3381.00
118_T191_Q2.3331.00
34_H44_D2.2731.00
107_A219_I2.1411.00
109_G142_F2.0711.00
72_Q99_L2.0661.00
126_R155_A2.0581.00
156_K177_Y2.0291.00
111_A114_G2.0091.00
182_I193_V1.9971.00
4_I78_G1.9391.00
25_G222_E1.9291.00
90_A101_F1.8531.00
84_N134_Y1.8041.00
61_G65_A1.7851.00
160_I174_S1.7811.00
111_A222_E1.6981.00
22_I225_V1.6951.00
112_I214_F1.6771.00
39_L74_A1.6721.00
113_T142_F1.6681.00
112_I120_V1.6451.00
150_E153_E1.6431.00
186_A211_L1.6351.00
110_R142_F1.6311.00
25_G225_V1.6301.00
214_F219_I1.6171.00
72_Q97_C1.6131.00
29_R226_A1.6011.00
156_K159_Q1.5821.00
108_T216_T1.5781.00
33_L166_C1.5751.00
201_G215_D1.5551.00
177_Y180_Q1.5391.00
150_E188_Q1.4921.00
111_A115_A1.4831.00
110_R223_D1.4771.00
147_L190_A1.4621.00
61_G92_A1.4531.00
223_D226_A1.4491.00
117_M192_G1.4491.00
19_Y39_L1.4441.00
17_P201_G1.4221.00
182_I204_V1.4201.00
10_M83_T1.3441.00
158_N162_F1.3361.00
17_P20_R1.3261.00
121_A193_V1.3261.00
175_R208_R1.3141.00
61_G89_V1.3131.00
126_R158_N1.3081.00
50_E54_R1.3071.00
65_A96_R1.3061.00
41_H70_G1.2951.00
68_A97_C1.2931.00
195_F200_I1.2891.00
177_Y181_V1.2790.99
4_I224_A1.2610.99
81_L93_I1.2410.99
4_I228_M1.2290.99
218_A222_E1.2270.99
7_L67_A1.2260.99
192_G214_F1.2220.99
91_D94_E1.2030.99
88_K131_Q1.1940.99
117_M191_Q1.1780.99
132_D135_R1.1760.99
136_G139_T1.1730.99
61_G93_I1.1670.99
15_T40_L1.1610.99
21_L218_A1.1550.99
68_A79_I1.1530.99
223_D227_F1.1480.99
17_P217_A1.1440.99
122_L128_T1.1400.99
37_Q47_E1.1300.99
59_K92_A1.1220.99
107_A110_R1.1190.99
156_K160_I1.1180.99
84_N104_I1.1100.98
59_K62_D1.1020.98
39_L71_L1.1010.98
94_E101_F1.1000.98
135_R139_T1.1000.98
178_C200_I1.0930.98
178_C203_L1.0820.98
21_L25_G1.0790.98
64_L89_V1.0680.98
21_L221_A1.0630.98
69_L72_Q1.0580.98
221_A225_V1.0540.98
111_A219_I1.0540.98
127_Y158_N1.0530.98
79_I99_L1.0430.98
69_L73_R1.0330.98
66_E70_G1.0270.97
103_H106_D1.0270.97
46_H50_E1.0260.97
12_W23_N1.0250.97
3_T37_Q1.0240.97
15_T38_V1.0210.97
179_A209_S1.0180.97
90_A94_E1.0150.97
139_T145_N1.0030.97
22_I221_A0.9980.97
41_H67_A0.9970.97
52_Q88_K0.9920.97
48_I63_I0.9900.97
51_C59_K0.9870.97
153_E181_V0.9850.97
120_V191_Q0.9840.97
18_Y22_I0.9820.97
183_A187_E0.9750.97
83_T86_M0.9680.96
164_E174_S0.9580.96
84_N216_T0.9570.96
85_T125_T0.9560.96
122_L146_C0.9520.96
25_G28_Q0.9500.96
182_I200_I0.9430.96
120_V192_G0.9390.96
49_E162_F0.9380.96
156_K180_Q0.9380.96
11_S166_C0.9380.96
112_I117_M0.9350.96
136_G140_E0.9320.96
107_A223_D0.9310.96
175_R179_A0.9280.95
26_I225_V0.9030.95
147_L188_Q0.9000.95
27_K167_L0.8930.94
138_L146_C0.8930.94
7_L68_A0.8760.94
60_T63_I0.8730.94
179_A183_A0.8610.93
51_C63_I0.8610.93
48_I52_Q0.8600.93
16_I20_R0.8500.93
36_A42_S0.8490.93
124_G129_M0.8400.92
17_P21_L0.8340.92
169_Q173_A0.8340.92
119_R191_Q0.8330.92
78_G228_M0.8260.92
3_T77_E0.8160.91
180_Q184_R0.8120.91
52_Q60_T0.8050.91
90_A103_H0.8010.90
104_I216_T0.8000.90
7_L10_M0.7970.90
135_R148_I0.7950.90
49_E53_R0.7950.90
129_M154_R0.7940.90
138_L194_I0.7940.90
155_A159_Q0.7900.90
71_L79_I0.7850.90
13_E168_G0.7840.90
25_G218_A0.7770.89
109_G138_L0.7750.89
53_R162_F0.7740.89
119_R147_L0.7730.89
53_R60_T0.7710.89
36_A40_L0.7670.88
83_T166_C0.7670.88
150_E184_R0.7670.88
113_T144_I0.7670.88
122_L148_I0.7650.88
92_A95_S0.7630.88
49_E127_Y0.7590.88
58_D92_A0.7580.88
156_K181_V0.7520.87
170_F174_S0.7480.87
118_T145_N0.7470.87
53_R127_Y0.7440.87
68_A93_I0.7440.87
82_C220_H0.7420.87
67_A70_G0.7400.87
70_G73_R0.7390.87
18_Y220_H0.7380.87
160_I177_Y0.7370.86
120_V194_I0.7370.86
21_L201_G0.7300.86
201_G217_A0.7280.86
186_A210_V0.7280.86
60_T86_M0.7270.86
103_H137_R0.7240.85
36_A44_D0.7200.85
102_L223_D0.7200.85
199_E202_L0.7160.85
6_L22_I0.7150.85
51_C54_R0.7090.84
5_G9_G0.7050.84
184_R187_E0.7050.84
110_R114_G0.7040.84
65_A69_L0.6980.83
176_A180_Q0.6970.83
77_E228_M0.6960.83
151_A155_A0.6950.83
201_G218_A0.6940.83
23_N36_A0.6890.83
183_A186_A0.6870.82
48_I60_T0.6820.82
204_V213_V0.6820.82
112_I192_G0.6810.82
42_S67_A0.6800.82
26_I35_S0.6790.82
138_L144_I0.6790.82
43_V67_A0.6740.81
123_L185_L0.6730.81
69_L96_R0.6730.81
102_L227_F0.6700.81
13_E27_K0.6690.81
120_V144_I0.6680.81
65_A89_V0.6640.80
16_I23_N0.6640.80
85_T197_C0.6640.80
129_M148_I0.6620.80
69_L97_C0.6600.80
37_Q41_H0.6530.79
10_M86_M0.6510.79
205_P208_R0.6510.79
18_Y80_V0.6510.79
52_Q162_F0.6470.78
117_M120_V0.6470.78
51_C158_N0.6470.78
175_R203_L0.6430.78
153_E188_Q0.6430.78
176_A179_A0.6430.78
222_E226_A0.6380.77
184_R188_Q0.6360.77
30_L33_L0.6320.77
51_C127_Y0.6310.77
152_D184_R0.6290.76
26_I228_M0.6270.76
22_I37_Q0.6240.76
6_L80_V0.6240.76
160_I181_V0.6170.75
119_R189_G0.6170.75
15_T19_Y0.6150.75
24_E27_K0.6150.75
60_T64_L0.6150.75
157_I181_V0.6130.75
127_Y162_F0.6110.74
108_T214_F0.6090.74
181_V185_L0.6080.74
5_G8_G0.6070.74
102_L224_A0.5980.73
17_P202_L0.5970.73
19_Y37_Q0.5960.73
68_A72_Q0.5960.73
121_A181_V0.5930.72
157_I178_C0.5930.72
36_A43_V0.5920.72
180_Q183_A0.5910.72
65_A68_A0.5910.72
121_A147_L0.5910.72
91_D95_S0.5900.72
209_S213_V0.5880.72
26_I34_H0.5870.71
22_I26_I0.5860.71
47_E125_T0.5850.71
23_N35_S0.5810.71
11_S83_T0.5810.71
152_D155_A0.5780.70
161_I197_C0.5760.70
159_Q177_Y0.5750.70
21_L24_E0.5720.69
51_C60_T0.5720.69
52_Q127_Y0.5720.69
124_G128_T0.5710.69
79_I97_C0.5700.69
5_G71_L0.5700.69
84_N197_C0.5700.69
206_E213_V0.5670.69
98_T187_E0.5660.69
23_N26_I0.5660.69
165_L174_S0.5640.68
35_S42_S0.5640.68
53_R158_N0.5640.68
153_E180_Q0.5630.68
33_L49_E0.5610.68
165_L202_L0.5600.68
97_C101_F0.5560.67
48_I86_M0.5530.67
170_F202_L0.5520.67
7_L70_G0.5460.66
178_C204_V0.5460.66
73_R140_E0.5450.66
78_G224_A0.5420.65
179_A208_R0.5410.65
15_T39_L0.5400.65
109_G113_T0.5390.65
60_T89_V0.5360.65
109_G137_R0.5350.64
153_E156_K0.5340.64
153_E177_Y0.5330.64
96_R101_F0.5320.64
45_F60_T0.5270.63
49_E83_T0.5270.63
47_E127_Y0.5260.63
45_F48_I0.5260.63
34_H134_Y0.5240.63
105_A133_F0.5220.62
216_T219_I0.5200.62
83_T127_Y0.5190.62
156_K163_E0.5160.62
108_T111_A0.5150.61
37_Q228_M0.5150.61
105_A138_L0.5140.61
48_I127_Y0.5110.61
10_M166_C0.5100.61
121_A189_G0.5090.61
97_C100_P0.5090.61
126_R130_E0.5080.60
58_D62_D0.5070.60
132_D139_T0.5060.60
18_Y44_D0.5050.60
4_I38_V0.5050.60
93_I101_F0.5030.60
110_R113_T0.5010.59
144_I192_G0.5010.59
123_L157_I0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jflA 2 0.987 100 0.268 Contact Map
3ojcA 4 0.9913 100 0.291 Contact Map
2zskA 2 0.9783 100 0.3 Contact Map
3s81A 2 0.9783 100 0.312 Contact Map
4ix1A 2 0.8522 100 0.489 Contact Map
2dgdA 4 0.8913 100 0.519 Contact Map
2jfnA 1 0.9 100 0.523 Contact Map
2jfqA 2 0.913 100 0.532 Contact Map
2xedA 1 0.9087 100 0.532 Contact Map
3outA 5 0.9087 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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