GREMLIN Database
GALR - HTH-type transcriptional regulator GalR
UniProt: P03024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10364
Length: 343 (325)
Sequences: 36411 (26549)
Seq/√Len: 1472.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_R200_D3.4551.00
176_H239_T3.2591.00
10_L42_S3.2181.00
262_D265_G3.1271.00
167_A270_I2.6331.00
118_A303_A2.5651.00
274_D289_R2.5571.00
195_L199_Y2.5481.00
154_R306_L2.4911.00
176_H268_S2.4761.00
165_W204_E2.3491.00
225_E258_D2.2771.00
30_E34_L2.2511.00
84_V87_H2.2411.00
38_S42_S2.2211.00
84_V301_E2.2141.00
34_L38_S2.2091.00
298_Q301_E2.1041.00
165_W200_D2.0721.00
229_T259_N2.0681.00
172_I205_S2.0571.00
165_W201_A1.9861.00
174_Q329_V1.9721.00
85_A300_A1.9681.00
162_Y166_L1.9651.00
169_R201_A1.9521.00
80_A296_A1.9491.00
169_R173_Q1.9481.00
163_G272_F1.9171.00
21_V36_V1.9151.00
164_A168_T1.9151.00
256_L267_I1.9091.00
305_A310_R1.9091.00
33_R37_H1.9041.00
161_R196_Q1.9041.00
229_T255_V1.9021.00
233_G259_N1.8891.00
224_G251_G1.8761.00
22_I40_M1.8521.00
171_L240_A1.8121.00
83_Q293_V1.7951.00
5_K15_V1.7931.00
164_A242_A1.7731.00
84_V297_T1.7671.00
289_R322_T1.7651.00
165_W169_R1.7111.00
169_R205_S1.7091.00
225_E255_V1.6751.00
261_I266_E1.6711.00
11_A39_A1.6611.00
168_T198_Y1.6601.00
291_P294_T1.6431.00
63_G116_C1.6351.00
166_L321_P1.6201.00
228_M252_A1.6201.00
178_R210_N1.6161.00
298_Q317_N1.5931.00
10_L39_A1.5911.00
80_A293_V1.5901.00
284_R327_H1.5791.00
180_G238_F1.5771.00
262_D266_E1.5731.00
181_Y244_Y1.5681.00
243_C252_A1.5541.00
196_Q200_D1.5261.00
178_R237_N1.5221.00
84_V88_T1.5171.00
37_H41_E1.5161.00
144_I299_A1.5131.00
257_N282_R1.5121.00
159_D162_Y1.5011.00
255_V259_N1.4921.00
162_Y165_W1.4891.00
21_V40_M1.4761.00
172_I201_A1.4661.00
274_D326_R1.4571.00
7_V39_A1.4491.00
88_T304_L1.4451.00
215_T230_E1.4381.00
294_T298_Q1.4351.00
37_H40_M1.4241.00
270_I286_T1.4241.00
228_M241_V1.4221.00
193_D196_Q1.4101.00
170_H173_Q1.4031.00
255_V258_D1.3981.00
84_V300_A1.3931.00
168_T172_I1.3821.00
294_T297_T1.3801.00
199_Y203_A1.3791.00
163_G321_P1.3641.00
60_E117_A1.3611.00
170_H174_Q1.3591.00
229_T258_D1.3571.00
170_H325_R1.3521.00
168_T197_G1.3491.00
256_L261_I1.3381.00
170_H329_V1.3121.00
225_E254_G1.3081.00
180_G231_L1.3081.00
218_E223_G1.3041.00
164_A197_G1.3031.00
210_N213_L1.3021.00
178_R239_T1.2831.00
301_E305_A1.2801.00
62_V85_A1.2731.00
60_E90_N1.2711.00
168_T201_A1.2671.00
176_H240_A1.2661.00
225_E229_T1.2641.00
304_L308_D1.2631.00
63_G111_L1.2561.00
197_G201_A1.2531.00
132_A136_K1.2531.00
7_V11_A1.2511.00
5_K9_R1.2481.00
29_S32_S1.2481.00
10_L43_L1.2471.00
30_E33_R1.2471.00
201_A204_E1.2461.00
235_G238_F1.2361.00
6_D9_R1.2351.00
228_M256_L1.2351.00
20_R25_S1.2231.00
120_V299_A1.2091.00
64_L81_V1.2051.00
109_E133_S1.2041.00
95_G111_L1.2021.00
85_A92_L1.2001.00
229_T233_G1.2001.00
169_R204_E1.1951.00
39_A43_L1.1931.00
161_R165_W1.1831.00
35_A39_A1.1821.00
253_M269_L1.1741.00
166_L169_R1.1741.00
230_E234_R1.1691.00
81_V300_A1.1651.00
7_V43_L1.1641.00
161_R193_D1.1631.00
81_V120_V1.1551.00
182_L252_A1.1551.00
95_G107_A1.1521.00
39_A42_S1.1471.00
222_S226_Q1.1341.00
198_Y202_L1.1331.00
4_I15_V1.1251.00
251_G255_V1.1201.00
293_V297_T1.1191.00
268_S329_V1.1111.00
32_S35_A1.1061.00
4_I18_V1.1041.00
241_V252_A1.1011.00
64_L92_L1.1011.00
177_T239_T1.1001.00
246_D287_T1.0881.00
88_T301_E1.0851.00
167_A242_A1.0821.00
179_I202_L1.0781.00
161_R197_G1.0771.00
172_I207_I1.0711.00
173_Q205_S1.0691.00
302_L317_N1.0651.00
82_E86_Y1.0641.00
61_T91_F1.0611.00
48_N54_L1.0601.00
38_S41_E1.0551.00
200_D204_E1.0541.00
181_Y195_L1.0501.00
21_V28_A1.0461.00
226_Q230_E1.0441.00
246_D271_G1.0391.00
174_Q325_R1.0341.00
298_Q302_L1.0291.00
34_L37_H1.0261.00
178_R236_R1.0251.00
220_D223_G1.0241.00
61_T93_L1.0231.00
198_Y242_A1.0221.00
296_A300_A1.0221.00
88_T308_D1.0121.00
201_A205_S1.0101.00
24_N33_R1.0091.00
48_N51_A1.0091.00
224_G228_M1.0041.00
105_R109_E1.0001.00
50_N53_A0.9891.00
243_C249_A0.9891.00
227_A230_E0.9881.00
215_T227_A0.9851.00
86_Y103_K0.9761.00
103_K106_Q0.9721.00
202_L207_I0.9721.00
243_C248_M0.9671.00
223_G226_Q0.9621.00
40_M43_L0.9621.00
196_Q199_Y0.9591.00
186_H216_F0.9561.00
297_T301_E0.9531.00
167_A288_V0.9491.00
90_N304_L0.9481.00
298_Q319_F0.9451.00
174_Q268_S0.9431.00
303_A307_A0.9421.00
253_M281_V0.9401.00
253_M263_V0.9381.00
228_M232_L0.9351.00
83_Q297_T0.9271.00
289_R324_V0.9251.00
11_A18_V0.9251.00
162_Y320_S0.9211.00
179_I240_A0.9191.00
87_H297_T0.9181.00
192_E196_Q0.9161.00
51_A54_L0.9141.00
109_E113_R0.9041.00
158_L291_P0.9041.00
291_P319_F0.9041.00
187_S192_E0.9021.00
170_H286_T0.9011.00
184_S219_P0.9011.00
120_V303_A0.9001.00
168_T202_L0.8971.00
221_E254_G0.8931.00
64_L78_V0.8901.00
159_D318_V0.8901.00
81_V296_A0.8851.00
189_S193_D0.8771.00
322_T325_R0.8751.00
62_V120_V0.8751.00
172_I177_T0.8731.00
271_G287_T0.8671.00
199_Y209_A0.8651.00
47_P52_R0.8651.00
79_K83_Q0.8641.00
154_R302_L0.8621.00
232_L255_V0.8571.00
246_D274_D0.8571.00
156_I302_L0.8561.00
291_P322_T0.8521.00
256_L269_L0.8461.00
155_C316_T0.8411.00
180_G241_V0.8401.00
24_N37_H0.8381.00
162_Y321_P0.8351.00
261_I267_I0.8341.00
226_Q229_T0.8281.00
325_R329_V0.8261.00
200_D203_A0.8221.00
73_F292_I0.8221.00
118_A307_A0.8201.00
217_G248_M0.8181.00
250_A281_V0.8181.00
59_T117_A0.8151.00
274_D324_V0.8111.00
158_L321_P0.8091.00
31_A34_L0.8081.00
21_V37_H0.8081.00
76_A293_V0.8081.00
241_V267_I0.8061.00
159_D320_S0.8061.00
178_R213_L0.8051.00
112_I137_Q0.8031.00
158_L290_Y0.8021.00
202_L209_A0.8011.00
170_H323_L0.8001.00
223_G227_A0.7991.00
81_V92_L0.7931.00
133_S136_K0.7931.00
78_V82_E0.7921.00
237_N261_I0.7851.00
160_D194_R0.7851.00
80_A297_T0.7811.00
209_A212_R0.7781.00
157_A318_V0.7781.00
273_D290_Y0.7771.00
83_Q87_H0.7721.00
300_A304_L0.7721.00
302_L305_A0.7671.00
195_L214_V0.7671.00
17_T20_R0.7661.00
177_T207_I0.7651.00
257_N284_R0.7651.00
77_M144_I0.7641.00
228_M231_L0.7611.00
100_N103_K0.7601.00
171_L270_I0.7591.00
182_L243_C0.7581.00
67_G74_F0.7581.00
13_V36_V0.7571.00
49_A52_R0.7571.00
181_Y242_A0.7561.00
246_D249_A0.7511.00
61_T114_H0.7511.00
46_H113_R0.7491.00
183_C195_L0.7461.00
193_D197_G0.7451.00
103_K107_A0.7441.00
286_T329_V0.7441.00
213_L234_R0.7421.00
31_A35_A0.7401.00
106_Q109_E0.7351.00
228_M255_V0.7351.00
215_T231_L0.7321.00
239_T268_S0.7301.00
63_G119_L0.7291.00
58_T117_A0.7281.00
78_V94_I0.7271.00
80_A84_V0.7261.00
20_R26_P0.7231.00
232_L259_N0.7221.00
274_D278_S0.7221.00
79_K82_E0.7191.00
166_L288_V0.7191.00
134_L141_M0.7191.00
62_V300_A0.7171.00
16_A20_R0.7151.00
286_T323_L0.7141.00
20_R27_K0.7131.00
147_I316_T0.7051.00
118_A142_V0.7051.00
154_R314_E0.7011.00
254_G257_N0.6991.00
305_A309_N0.6991.00
249_A271_G0.6971.00
165_W197_G0.6941.00
157_A316_T0.6921.00
120_V144_I0.6871.00
93_L116_C0.6861.00
58_T308_D0.6861.00
242_A270_I0.6861.00
143_L153_N0.6851.00
234_R238_F0.6821.00
34_L41_E0.6801.00
234_R237_N0.6791.00
230_E233_G0.6771.00
217_G223_G0.6761.00
224_G227_A0.6761.00
143_L148_L0.6761.00
135_M152_E0.6741.00
98_Y103_K0.6731.00
82_E96_N0.6721.00
172_I202_L0.6711.00
132_A135_M0.6711.00
256_L263_V0.6691.00
82_E92_L0.6691.00
65_V107_A0.6661.00
102_Q106_Q0.6591.00
112_I139_P0.6561.00
228_M251_G0.6551.00
215_T234_R0.6551.00
254_G284_R0.6551.00
179_I239_T0.6491.00
27_K32_S0.6491.00
178_R208_A0.6471.00
5_K55_A0.6471.00
254_G258_D0.6381.00
21_V33_R0.6371.00
46_H109_E0.6351.00
191_A219_P0.6341.00
41_E44_S0.6331.00
171_L242_A0.6291.00
145_N160_D0.6251.00
245_N273_D0.6231.00
184_S191_A0.6221.00
179_I198_Y0.6201.00
18_V21_V0.6171.00
35_A38_S0.6161.00
142_V156_I0.6161.00
108_I119_L0.6131.00
160_D193_D0.6131.00
145_N190_D0.6131.00
181_Y198_Y0.6131.00
71_D247_S0.6111.00
118_A299_A0.6081.00
135_M141_M0.6071.00
219_P244_Y0.6071.00
79_K293_V0.6051.00
256_L259_N0.6041.00
180_G213_L0.6021.00
80_A292_I0.6021.00
278_S287_T0.6011.00
142_V303_A0.6011.00
250_A275_V0.6011.00
198_Y209_A0.5991.00
270_I329_V0.5931.00
7_V18_V0.5921.00
90_N117_A0.5921.00
284_R326_R0.5921.00
93_L114_H0.5911.00
77_M292_I0.5911.00
62_V90_N0.5911.00
97_G104_E0.5901.00
165_W168_T0.5901.00
293_V296_A0.5881.00
129_A132_A0.5881.00
20_R28_A0.5871.00
62_V118_A0.5871.00
242_A272_F0.5871.00
62_V307_A0.5861.00
245_N248_M0.5851.00
142_V306_L0.5841.00
167_A240_A0.5821.00
90_N307_A0.5821.00
178_R238_F0.5821.00
166_L170_H0.5811.00
130_D133_S0.5811.00
18_V40_M0.5801.00
278_S285_L0.5761.00
76_A292_I0.5761.00
243_C271_G0.5751.00
141_M153_N0.5751.00
309_N312_L0.5741.00
295_M319_F0.5731.00
286_T325_R0.5721.00
85_A304_L0.5711.00
13_V32_S0.5701.00
222_S225_E0.5691.00
73_F77_M0.5691.00
105_R130_D0.5681.00
18_V36_V0.5671.00
135_M153_N0.5651.00
253_M257_N0.5631.00
257_N283_P0.5621.00
250_A277_V0.5601.00
257_N262_D0.5541.00
199_Y211_D0.5541.00
272_F290_Y0.5521.00
221_E251_G0.5521.00
111_L116_C0.5511.00
232_L256_L0.5481.00
142_V302_L0.5471.00
212_R234_R0.5461.00
46_H50_N0.5461.00
25_S28_A0.5451.00
195_L216_F0.5431.00
283_P328_S0.5431.00
254_G282_R0.5431.00
274_D279_R0.5421.00
119_L139_P0.5401.00
306_L309_N0.5401.00
142_V299_A0.5391.00
170_H270_I0.5381.00
225_E251_G0.5381.00
302_L306_L0.5371.00
221_E277_V0.5371.00
116_C119_L0.5361.00
227_A231_L0.5361.00
191_A244_Y0.5351.00
209_A214_V0.5341.00
238_F261_I0.5341.00
219_P248_M0.5331.00
52_R56_Q0.5321.00
207_I211_D0.5311.00
13_V18_V0.5281.00
281_V284_R0.5261.00
79_K98_Y0.5261.00
156_I298_Q0.5251.00
71_D74_F0.5241.00
183_C216_F0.5231.00
158_L163_G0.5221.00
199_Y214_V0.5211.00
11_A21_V0.5211.00
143_L155_C0.5201.00
174_Q239_T0.5191.00
28_A33_R0.5181.00
72_P247_S0.5181.00
110_Q113_R0.5181.00
279_R284_R0.5151.00
288_V321_P0.5151.00
258_D282_R0.5151.00
101_E105_R0.5141.00
217_G224_G0.5121.00
59_T91_F0.5101.00
183_C214_V0.5101.00
95_G110_Q0.5071.00
254_G279_R0.5071.00
223_G248_M0.5071.00
74_F122_H0.5061.00
84_V304_L0.5051.00
16_A25_S0.5041.00
246_D275_V0.5041.00
109_E112_I0.5031.00
11_A36_V0.5021.00
26_P33_R0.5021.00
252_A256_L0.5021.00
81_V85_A0.5011.00
263_V266_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8047 100 0.082 Contact Map
2hsgA 1 0.9534 100 0.083 Contact Map
1qpzA 2 0.9825 100 0.089 Contact Map
2o20A 2 0.8017 100 0.09 Contact Map
3e3mA 2 0.7813 100 0.096 Contact Map
3bilA 2 0.7464 100 0.097 Contact Map
4o5aA 2 0.7843 100 0.098 Contact Map
3kjxA 2 0.965 100 0.101 Contact Map
3h5oA 2 0.7872 100 0.102 Contact Map
3ctpA 2 0.7726 100 0.104 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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