GREMLIN Database
LACI - Lactose operon repressor
UniProt: P03023 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10525
Length: 360 (325)
Sequences: 32536 (24216)
Seq/√Len: 1343.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_H240_T3.4461.00
164_E203_K3.4241.00
12_Y44_E3.2351.00
263_R266_A3.1761.00
170_G271_V2.7371.00
275_D290_K2.6201.00
179_H269_S2.5791.00
198_L202_H2.5311.00
157_N307_L2.5191.00
121_G304_L2.4621.00
168_R207_R2.3771.00
32_A36_E2.2781.00
40_A44_E2.2551.00
36_E40_A2.2211.00
226_F259_E2.2061.00
86_R89_Q2.1201.00
86_R302_D2.1181.00
175_V208_N2.0731.00
230_M260_S2.0611.00
299_T302_D2.0371.00
23_V38_V1.9961.00
257_I268_I1.9941.00
167_T171_V1.9921.00
168_R203_K1.9871.00
225_G252_G1.9811.00
87_A301_V1.9691.00
82_A297_G1.9651.00
35_R39_E1.9531.00
168_R204_Y1.9511.00
172_E176_A1.9421.00
165_D169_L1.9371.00
177_L329_T1.9221.00
172_E204_Y1.9091.00
24_V42_M1.9091.00
234_N260_S1.9051.00
230_M256_A1.8991.00
166_G273_Y1.8651.00
164_E199_A1.8481.00
167_T243_L1.8341.00
7_Y17_Y1.8311.00
290_K322_S1.8161.00
171_V201_W1.7621.00
306_Q311_Q1.7501.00
172_E208_N1.7391.00
85_S294_R1.7301.00
13_A41_A1.7071.00
86_R298_Q1.6951.00
168_R172_E1.6781.00
174_L241_A1.6611.00
263_R267_D1.6581.00
299_T317_Q1.6551.00
12_Y41_A1.6531.00
226_F256_A1.6511.00
229_T253_A1.6461.00
82_A294_R1.6371.00
262_L267_D1.6341.00
169_L321_V1.6321.00
292_D295_L1.6291.00
184_L245_A1.6251.00
65_G119_V1.6191.00
285_P327_K1.6111.00
23_V42_M1.5611.00
244_V253_A1.5541.00
275_D326_R1.5461.00
258_T283_I1.5451.00
39_E43_A1.5251.00
183_A239_P1.5161.00
162_S165_D1.5021.00
9_V41_A1.4991.00
211_Q214_A1.4841.00
199_A203_K1.4791.00
256_A260_S1.4791.00
148_L300_S1.4781.00
181_Q211_Q1.4561.00
39_E42_M1.4551.00
86_R90_L1.4481.00
175_V204_Y1.4351.00
295_L299_T1.4211.00
271_V287_T1.4181.00
256_A259_E1.4151.00
166_G321_V1.4101.00
173_H177_L1.3991.00
229_T242_M1.3951.00
86_R301_V1.3881.00
90_L305_L1.3861.00
212_P215_E1.3791.00
173_H325_K1.3781.00
64_I87_A1.3761.00
165_D168_R1.3741.00
230_M259_E1.3671.00
167_T200_G1.3651.00
196_L199_A1.3631.00
171_V200_G1.3581.00
257_I262_L1.3481.00
181_Q238_V1.3471.00
173_H329_T1.3401.00
295_L298_Q1.3331.00
171_V175_V1.3281.00
179_H241_A1.3251.00
9_V13_A1.3191.00
171_V204_Y1.3121.00
173_H176_A1.3051.00
32_A35_R1.2981.00
183_A232_M1.2951.00
62_L92_A1.2941.00
202_H206_T1.2911.00
7_Y11_E1.2881.00
172_E207_R1.2881.00
62_L120_S1.2871.00
8_D11_E1.2771.00
31_S34_T1.2641.00
200_G204_Y1.2591.00
229_T257_I1.2591.00
22_R27_A1.2551.00
12_Y45_L1.2541.00
216_R231_Q1.2521.00
302_D306_Q1.2501.00
204_Y207_R1.2461.00
181_Q240_T1.2341.00
226_F255_R1.2311.00
219_D224_S1.2221.00
66_V83_I1.2191.00
87_A94_V1.2171.00
37_K41_A1.2071.00
254_M270_V1.2071.00
83_I123_I1.2021.00
41_A44_E1.2011.00
41_A45_L1.2011.00
230_M234_N1.1981.00
226_F230_M1.1871.00
136_V140_C1.1861.00
9_V45_L1.1751.00
185_L253_A1.1731.00
65_G114_L1.1691.00
164_E196_L1.1601.00
180_Q240_T1.1561.00
97_S110_A1.1531.00
247_D288_T1.1521.00
6_L17_Y1.1521.00
182_I205_L1.1431.00
4_V45_L1.1401.00
123_I300_S1.1401.00
97_S114_L1.1371.00
169_L172_E1.1361.00
252_G256_A1.1331.00
305_L309_Q1.1291.00
164_E168_R1.1291.00
201_W205_L1.1231.00
83_I301_V1.1201.00
34_T37_K1.1171.00
231_Q235_E1.1101.00
242_M253_A1.1031.00
303_R317_Q1.1001.00
66_V94_V1.0991.00
6_L20_V1.0981.00
223_M227_Q1.0981.00
88_D106_A1.0941.00
294_R298_Q1.0851.00
176_A208_N1.0811.00
23_V30_V1.0811.00
177_L325_K1.0801.00
269_S329_T1.0791.00
50_N56_L1.0791.00
203_K207_R1.0781.00
112_H137_E1.0741.00
40_A43_A1.0711.00
247_D272_G1.0631.00
236_G239_P1.0621.00
90_L302_D1.0601.00
36_E39_E1.0571.00
225_G229_T1.0561.00
170_G243_L1.0481.00
50_N53_A1.0451.00
181_Q237_I1.0431.00
175_V210_I1.0421.00
205_L210_I1.0401.00
297_G301_V1.0381.00
184_L198_L1.0351.00
26_Q35_R1.0301.00
204_Y208_N1.0271.00
90_L309_Q1.0231.00
164_E200_G1.0211.00
254_M264_V1.0191.00
84_K88_D1.0161.00
299_T303_R1.0121.00
52_V55_Q1.0051.00
42_M45_L0.9991.00
108_K112_H0.9911.00
292_D319_L0.9911.00
228_Q231_Q0.9831.00
299_T319_L0.9791.00
227_Q231_Q0.9761.00
66_V80_V0.9741.00
244_V250_A0.9691.00
182_I241_A0.9681.00
199_A202_H0.9671.00
304_L308_S0.9671.00
170_G289_I0.9581.00
221_S224_S0.9561.00
13_A20_V0.9561.00
201_W243_L0.9561.00
106_A109_A0.9531.00
63_L95_V0.9521.00
53_A56_L0.9511.00
298_Q302_D0.9491.00
161_F292_D0.9481.00
244_V249_M0.9451.00
165_D320_P0.9421.00
254_M282_Y0.9371.00
158_S316_N0.9351.00
229_T233_L0.9341.00
92_A305_L0.9331.00
290_K324_V0.9301.00
85_S298_Q0.9241.00
49_P54_Q0.9231.00
195_R199_A0.9191.00
180_Q210_I0.9111.00
89_Q298_Q0.9091.00
162_S318_L0.8981.00
177_L269_S0.8941.00
26_Q39_E0.8901.00
171_V205_L0.8881.00
175_V180_Q0.8831.00
322_S325_K0.8811.00
272_G288_T0.8811.00
275_D279_S0.8741.00
83_I297_G0.8711.00
187_G220_W0.8701.00
63_L93_S0.8681.00
123_I304_L0.8671.00
192_V196_L0.8671.00
274_D291_Q0.8661.00
218_G249_M0.8621.00
61_S120_S0.8601.00
262_L268_I0.8591.00
173_H287_T0.8571.00
247_D275_D0.8551.00
157_N315_G0.8541.00
159_I303_R0.8491.00
81_A85_S0.8461.00
23_V39_E0.8451.00
224_S227_Q0.8451.00
247_D250_A0.8411.00
161_F291_Q0.8391.00
157_N303_R0.8371.00
183_A242_M0.8331.00
165_D321_V0.8321.00
216_R228_Q0.8301.00
325_K329_T0.8291.00
222_A255_R0.8291.00
161_F321_V0.8271.00
160_I318_L0.8241.00
242_M268_I0.8231.00
275_D324_V0.8191.00
64_I123_I0.8181.00
233_L256_A0.8171.00
162_S320_P0.8141.00
292_D322_S0.8111.00
15_V38_V0.8101.00
121_G308_S0.8091.00
257_I270_V0.8081.00
173_H323_L0.8051.00
33_K36_E0.8031.00
163_H197_R0.7971.00
190_S195_R0.7971.00
301_V305_L0.7951.00
238_V262_L0.7911.00
303_R306_Q0.7911.00
19_T22_R0.7871.00
269_S330_L0.7861.00
184_L243_L0.7851.00
51_R54_Q0.7831.00
189_L217_E0.7811.00
60_Q120_S0.7791.00
112_H116_A0.7781.00
227_Q230_M0.7751.00
33_K37_K0.7741.00
79_I148_L0.7671.00
78_Q294_R0.7641.00
251_L282_Y0.7631.00
181_Q214_A0.7611.00
75_A293_F0.7611.00
82_A298_Q0.7591.00
65_G122_L0.7581.00
203_K206_T0.7581.00
174_L271_V0.7571.00
64_I301_V0.7551.00
69_S76_P0.7541.00
240_T269_S0.7531.00
22_R29_H0.7531.00
243_L271_V0.7531.00
233_L260_S0.7521.00
196_L200_G0.7521.00
160_I316_N0.7511.00
169_L289_I0.7501.00
83_I94_V0.7501.00
22_R28_S0.7461.00
18_Q22_R0.7461.00
224_S228_Q0.7461.00
287_T329_T0.7451.00
235_E238_V0.7441.00
48_I116_A0.7441.00
229_T256_A0.7411.00
186_A198_L0.7411.00
185_L244_V0.7291.00
109_A112_H0.7221.00
287_T323_L0.7201.00
84_K98_M0.7161.00
175_V205_L0.7151.00
229_T232_M0.7131.00
235_E239_P0.7131.00
138_A145_A0.7081.00
63_L117_Q0.7041.00
60_Q309_Q0.7031.00
229_T252_G0.7031.00
306_Q310_G0.7001.00
5_T8_D0.6991.00
82_A86_R0.6991.00
115_L141_T0.6991.00
137_E140_C0.6981.00
218_G224_S0.6971.00
84_K94_V0.6951.00
255_R285_P0.6921.00
36_E43_A0.6911.00
85_S89_Q0.6911.00
151_S316_N0.6891.00
257_I264_V0.6851.00
225_G228_Q0.6841.00
147_F156_I0.6791.00
182_I201_W0.6791.00
121_G146_L0.6791.00
23_V35_R0.6781.00
257_I260_S0.6741.00
255_R258_T0.6681.00
80_V96_V0.6671.00
279_S282_Y0.6671.00
182_I240_T0.6651.00
258_T285_P0.6651.00
168_R200_G0.6601.00
100_E106_A0.6601.00
214_A235_E0.6591.00
177_L330_L0.6591.00
132_D136_V0.6571.00
4_V46_N0.6561.00
231_Q234_N0.6561.00
105_E109_A0.6491.00
106_A110_A0.6491.00
48_I112_H0.6461.00
139_A145_A0.6451.00
250_A272_G0.6441.00
20_V23_V0.6431.00
7_Y57_A0.6411.00
255_R283_I0.6391.00
95_V119_V0.6371.00
149_D163_H0.6371.00
306_Q315_G0.6331.00
285_P326_R0.6331.00
294_R297_G0.6331.00
81_A84_K0.6321.00
29_H34_T0.6321.00
78_Q293_F0.6301.00
194_A220_W0.6301.00
81_A294_R0.6291.00
37_K40_A0.6281.00
163_H196_L0.6261.00
246_N274_D0.6261.00
20_V42_M0.6261.00
123_I148_L0.6251.00
310_G313_V0.6241.00
251_L276_T0.6241.00
102_S106_A0.6221.00
9_V20_V0.6211.00
198_L215_E0.6201.00
184_L201_W0.6171.00
251_L278_D0.6161.00
4_V41_A0.6131.00
43_A46_N0.6131.00
73_L248_Q0.6121.00
115_L143_V0.6111.00
87_A305_L0.6101.00
296_L319_L0.6091.00
111_V122_L0.6091.00
121_G300_S0.6081.00
168_R171_V0.6081.00
146_L159_I0.6081.00
187_G194_A0.6071.00
145_A156_I0.6071.00
220_W245_A0.6061.00
139_A156_I0.6051.00
79_I293_F0.6041.00
82_A293_F0.6031.00
22_R30_V0.6021.00
15_V34_T0.6011.00
239_P262_L0.6011.00
174_L243_L0.6001.00
255_R259_E0.5971.00
169_L173_H0.5951.00
273_Y291_Q0.5941.00
202_H212_P0.5921.00
92_A308_S0.5921.00
216_R235_E0.5921.00
139_A155_P0.5891.00
75_A79_I0.5881.00
222_A252_G0.5851.00
64_I308_S0.5851.00
92_A120_S0.5841.00
170_G241_A0.5831.00
243_L273_Y0.5821.00
73_L76_P0.5801.00
48_I52_V0.5791.00
181_Q239_P0.5791.00
271_V329_T0.5791.00
81_A100_E0.5741.00
136_V139_A0.5721.00
149_D193_S0.5681.00
244_V272_G0.5681.00
54_Q58_G0.5661.00
67_A110_A0.5651.00
64_I92_A0.5641.00
287_T325_K0.5631.00
80_V84_K0.5631.00
146_L304_L0.5591.00
13_A23_V0.5561.00
177_L240_T0.5551.00
64_I121_G0.5551.00
289_I321_V0.5551.00
216_R232_M0.5551.00
20_V38_V0.5541.00
246_N249_M0.5541.00
259_E283_I0.5511.00
254_M258_T0.5491.00
99_V107_C0.5471.00
108_K134_I0.5471.00
222_A278_D0.5471.00
279_S288_T0.5461.00
303_R307_L0.5461.00
253_A257_I0.5451.00
133_A136_V0.5441.00
284_P328_T0.5431.00
226_F252_G0.5401.00
15_V20_V0.5391.00
255_R280_S0.5381.00
258_T263_R0.5381.00
146_L300_S0.5371.00
146_L307_L0.5371.00
30_V35_R0.5351.00
159_I299_T0.5341.00
151_S158_S0.5321.00
280_S285_P0.5311.00
55_Q58_G0.5311.00
102_S105_E0.5311.00
279_S286_L0.5301.00
112_H115_L0.5291.00
220_W249_M0.5291.00
233_L257_I0.5281.00
253_A270_V0.5281.00
146_L303_R0.5271.00
114_L119_V0.5271.00
173_H271_V0.5231.00
18_Q27_A0.5221.00
74_H248_Q0.5221.00
119_V122_L0.5211.00
70_S81_A0.5211.00
276_T288_T0.5201.00
247_D276_T0.5191.00
161_F273_Y0.5191.00
95_V117_Q0.5181.00
164_E167_T0.5171.00
194_A245_A0.5161.00
104_V108_K0.5151.00
239_P242_M0.5151.00
13_A38_V0.5141.00
26_Q29_H0.5141.00
4_V12_Y0.5141.00
124_I147_F0.5131.00
226_F229_T0.5131.00
161_F166_G0.5131.00
171_V243_L0.5111.00
224_S249_M0.5111.00
28_S35_R0.5101.00
159_I319_L0.5091.00
134_I137_E0.5061.00
19_T38_V0.5031.00
86_R305_L0.5031.00
168_R208_N0.5031.00
262_L265_G0.5021.00
163_H193_S0.5011.00
110_A113_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jyeA 2 0.75 100 0.13 Contact Map
3dbiA 2 0.7611 100 0.136 Contact Map
4o5aA 2 0.7444 100 0.147 Contact Map
2hsgA 1 0.8972 100 0.152 Contact Map
3e3mA 2 0.7361 100 0.155 Contact Map
3h5oA 2 0.7417 100 0.155 Contact Map
3kjxA 2 0.9139 100 0.158 Contact Map
1qpzA 2 0.925 100 0.161 Contact Map
3ctpA 2 0.7333 100 0.162 Contact Map
3bilA 2 0.7083 100 0.162 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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