GREMLIN Database
UVRD - DNA helicase II
UniProt: P03018 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11064
Length: 720 (620)
Sequences: 10727 (7871)
Seq/√Len: 316.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_S215_T4.9621.00
559_L602_G4.2741.00
372_M554_V3.9261.00
15_R19_A3.8901.00
336_R339_T3.8641.00
201_L231_A3.7661.00
333_V573_V3.6231.00
568_P608_Q3.4811.00
575_M612_L3.4381.00
336_R571_F3.3741.00
16_E275_E3.3111.00
11_N283_Y3.2901.00
341_Q347_L3.2821.00
10_L18_V3.2391.00
568_P607_M3.2061.00
569_Q609_K3.1751.00
349_E568_P3.0671.00
577_E631_R2.8781.00
176_A179_E2.8391.00
348_A552_D2.7951.00
346_A552_D2.7161.00
572_I602_G2.6931.00
287_S291_S2.6781.00
195_R198_E2.6721.00
230_Y270_D2.6251.00
557_M567_F2.6111.00
338_K370_A2.6001.00
467_A487_D2.5831.00
355_R595_E2.5821.00
198_E202_N2.5761.00
13_K16_E2.4871.00
86_W214_F2.4121.00
20_A25_L2.4121.00
180_A183_R2.3901.00
337_I350_C2.3471.00
354_Y556_L2.2971.00
571_F611_T2.2751.00
347_L373_P2.2701.00
403_D406_A2.2591.00
336_R611_T2.2501.00
234_R270_D2.2441.00
94_A196_A2.1991.00
569_Q611_T2.1971.00
53_S56_S2.1711.00
334_V370_A2.1471.00
483_R487_D2.0801.00
126_L180_A2.0541.00
345_G569_Q2.0421.00
129_A176_A2.0411.00
387_E508_N2.0381.00
193_L228_I2.0281.00
180_A184_A2.0171.00
481_T516_T2.0171.00
69_E73_R2.0161.00
176_A180_A2.0111.00
396_R536_S1.9961.00
335_N370_A1.9881.00
41_H77_L1.9621.00
37_R41_H1.9601.00
489_G492_T1.9321.00
603_V610_L1.9231.00
407_F411_V1.9231.00
262_E266_R1.9231.00
566_E607_M1.9151.00
201_L235_L1.9151.00
331_R366_A1.9051.00
179_E183_R1.8981.00
354_Y360_S1.8981.00
207_L211_R1.8881.00
204_P207_L1.8861.00
340_W569_Q1.8501.00
88_G93_L1.8491.00
341_Q350_C1.8491.00
25_L277_I1.8471.00
329_E613_T1.8461.00
227_N260_Q1.8441.00
147_N190_A1.8401.00
43_I59_A1.8181.00
101_H209_H1.8161.00
331_R370_A1.8141.00
114_L186_L1.8101.00
363_L573_V1.8071.00
471_E483_R1.7821.00
282_N285_S1.7781.00
129_A180_A1.7771.00
332_F613_T1.7731.00
537_H540_L1.7521.00
346_A349_E1.7361.00
366_A369_Q1.7311.00
340_W350_C1.7191.00
181_C191_E1.7061.00
323_A332_F1.7061.00
340_W571_F1.6971.00
46_L216_N1.6951.00
187_V195_R1.6901.00
104_D206_I1.6881.00
108_P185_G1.6861.00
408_E427_R1.6681.00
366_A370_A1.6611.00
312_G608_Q1.6521.00
27_V244_M1.6381.00
72_H76_Q1.6301.00
559_L580_F1.6291.00
320_L614_Y1.6241.00
155_R158_H1.6221.00
442_R466_D1.6211.00
97_L196_A1.6141.00
200_W207_L1.6121.00
322_C614_Y1.6101.00
231_A234_R1.6091.00
91_H192_L1.6001.00
491_R506_I1.5761.00
197_H231_A1.5681.00
476_P479_V1.5671.00
339_T343_N1.5661.00
19_A45_W1.5651.00
160_Q175_Q1.5541.00
45_W49_V1.5481.00
126_L130_M1.5461.00
208_Q211_R1.5421.00
102_H187_V1.5411.00
250_D303_R1.5371.00
492_T495_E1.5321.00
490_L494_Y1.5271.00
58_M217_I1.5181.00
13_K281_Q1.5171.00
345_G608_Q1.5081.00
44_A77_L1.5071.00
292_A318_I1.4951.00
575_M599_A1.4911.00
101_H210_Y1.4911.00
208_Q212_E1.4891.00
219_V233_I1.4881.00
266_R270_D1.4851.00
352_I367_L1.4841.00
266_R269_N1.4791.00
491_R510_E1.4731.00
281_Q309_W1.4691.00
333_V571_F1.4651.00
25_L244_M1.4631.00
341_Q346_A1.4621.00
178_Q181_C1.4531.00
296_L603_V1.4421.00
217_I237_A1.4411.00
222_F230_Y1.4381.00
596_R635_E1.4371.00
241_G273_G1.4351.00
340_W611_T1.4341.00
200_W235_L1.4331.00
572_I612_L1.4321.00
23_S275_E1.4311.00
424_D428_Q1.4251.00
367_L556_L1.4251.00
40_V74_I1.4201.00
387_E505_R1.4191.00
397_L410_V1.4181.00
47_M78_M1.4101.00
175_Q179_E1.4091.00
527_D530_P1.4091.00
316_E609_K1.4081.00
351_A567_F1.4071.00
419_G422_T1.3961.00
482_D513_V1.3891.00
333_V363_L1.3881.00
359_Q574_G1.3851.00
338_K342_D1.3821.00
178_Q182_D1.3791.00
336_R340_W1.3781.00
531_L534_F1.3691.00
478_H520_S1.3691.00
187_V192_L1.3691.00
319_S609_K1.3661.00
43_I74_I1.3641.00
177_Y188_D1.3611.00
197_H232_W1.3611.00
122_L180_A1.3551.00
12_D15_R1.3501.00
360_S556_L1.3471.00
340_W609_K1.3451.00
267_F274_A1.3411.00
199_L206_I1.3361.00
125_R180_A1.3351.00
268_L276_T1.3351.00
471_E475_M1.3311.00
475_M479_V1.3291.00
123_L173_V1.3281.00
519_F530_P1.3271.00
295_A637_P1.3261.00
97_L200_W1.3251.00
107_L195_R1.3211.00
93_L97_L1.3171.00
287_S313_A1.3121.00
319_S336_R1.3081.00
204_P208_Q1.3061.00
58_M214_F1.3051.00
354_Y573_V1.3031.00
340_W345_G1.3021.00
299_N635_E1.3021.00
337_I554_V1.2991.00
97_L210_Y1.2991.00
355_R598_L1.2961.00
337_I571_F1.2851.00
421_R425_V1.2771.00
126_L176_A1.2771.00
439_Q443_E1.2731.00
12_D16_E1.2721.00
468_L487_D1.2651.00
105_A199_L1.2651.00
281_Q311_D1.2621.00
323_A613_T1.2601.00
393_S409_R1.2591.00
289_I293_A1.2531.00
130_M176_A1.2501.00
391_A509_L1.2471.00
31_A294_N1.2471.00
459_Q463_E1.2471.00
347_L350_C1.2461.00
203_K206_I1.2461.00
334_V366_A1.2441.00
252_S255_G1.2391.00
375_R553_A1.2391.00
451_A454_A1.2381.00
42_R244_M1.2361.00
352_I363_L1.2331.00
197_H235_L1.2321.00
207_L235_L1.2321.00
86_W96_R1.2301.00
534_F537_H1.2291.00
292_A603_V1.2241.00
339_T342_D1.2171.00
345_G350_C1.2161.00
391_A481_T1.2141.00
599_A603_V1.2121.00
94_A232_W1.2101.00
13_K280_E1.2101.00
390_D409_R1.2081.00
74_I87_V1.2031.00
491_R495_E1.2021.00
82_Q85_M1.1901.00
227_N231_A1.1901.00
453_R457_A1.1851.00
569_Q608_Q1.1831.00
216_N242_K1.1811.00
46_L52_C1.1801.00
629_P633_I1.1801.00
119_Q177_Y1.1761.00
28_L249_D1.1741.00
367_L374_Y1.1721.00
528_L531_L1.1621.00
95_H99_R1.1571.00
23_S242_K1.1471.00
88_G92_G1.1471.00
395_L481_T1.1461.00
350_C569_Q1.1431.00
96_R100_A1.1421.00
338_K347_L1.1411.00
126_L173_V1.1381.00
98_L196_A1.1371.00
329_E574_G1.1351.00
16_E19_A1.1341.00
394_Y484_V1.1321.00
197_H201_L1.1321.00
102_H105_A1.1301.00
407_F441_C1.1271.00
45_W50_E1.1261.00
39_L218_L1.1251.00
211_R239_D1.1201.00
26_L245_I1.1151.00
337_I347_L1.1151.00
394_Y410_V1.1141.00
345_G568_P1.1111.00
497_E502_G1.1101.00
252_S259_A1.1071.00
400_N403_D1.1041.00
157_H175_Q1.1031.00
452_G455_A1.0981.00
588_E591_R1.0971.00
429_T433_R1.0931.00
557_M562_A1.0921.00
534_F540_L1.0891.00
254_Y257_R1.0881.00
123_L143_M1.0871.00
153_G228_I1.0861.00
158_H161_S1.0851.00
169_T172_K1.0821.00
68_A72_H1.0811.00
347_L372_M1.0671.00
20_A275_E1.0671.00
462_M466_D1.0651.00
464_L468_L1.0651.00
402_N436_T1.0641.00
322_C616_E1.0591.00
104_D203_K1.0581.00
210_Y214_F1.0561.00
571_F613_T1.0541.00
401_R469_A1.0511.00
107_L187_V1.0481.00
196_A232_W1.0431.00
340_W343_N1.0421.00
91_H193_L1.0401.00
21_P46_L1.0391.00
475_M483_R1.0381.00
396_R406_A1.0361.00
43_I57_I1.0361.00
293_A604_T1.0361.00
172_K175_Q1.0331.00
361_R365_E1.0311.00
20_A23_S1.0271.00
356_S359_Q1.0261.00
26_L276_T1.0251.00
375_R555_Q1.0191.00
332_F336_R1.0151.00
104_D205_H1.0121.00
324_F616_E1.0111.00
350_C571_F1.0061.00
288_N291_S1.0061.00
412_N416_R1.0051.00
330_A334_V1.0051.00
478_H517_R1.0031.00
100_A213_R1.0021.00
166_V170_W1.0011.00
397_L407_F0.9981.00
21_P50_E0.9961.00
125_R129_A0.9961.00
55_Y84_G0.9921.00
516_T531_L0.9911.00
297_I300_N0.9901.00
512_L516_T0.9881.00
148_S152_E0.9871.00
435_L443_E0.9831.00
331_R335_N0.9811.00
482_D486_K0.9711.00
154_L159_I0.9671.00
151_D190_A0.9641.00
338_K341_Q0.9641.00
461_F465_I0.9621.00
402_N439_Q0.9621.00
182_D195_R0.9571.00
582_S585_S0.9501.00
398_I484_V0.9501.00
221_E563_K0.9491.00
112_Q118_D0.9491.00
93_L210_Y0.9491.00
149_Q159_I0.9481.00
65_K69_E0.9461.00
123_L127_I0.9461.00
255_G590_G0.9451.00
398_I480_Q0.9441.00
150_K191_E0.9431.00
286_T608_Q0.9431.00
325_N328_D0.9421.00
365_E369_Q0.9421.00
442_R462_M0.9401.00
464_L467_A0.9361.00
91_H190_A0.9351.00
97_L199_L0.9341.00
435_L440_A0.9321.00
603_V612_L0.9301.00
225_T263_N0.9271.00
410_V461_F0.9251.00
42_R242_K0.9231.00
222_F225_T0.9221.00
573_V613_T0.9181.00
127_I132_L0.9171.00
119_Q143_M0.9131.00
196_A200_W0.9091.00
531_L537_H0.9081.00
357_N360_S0.9071.00
222_F245_I0.9071.00
364_E374_Y0.9051.00
172_K176_A0.9041.00
391_A512_L0.9041.00
321_Y332_F0.8991.00
134_E137_W0.8991.00
10_L37_R0.8991.00
116_S119_Q0.8961.00
60_V233_I0.8941.00
123_L146_I0.8931.00
60_V93_L0.8921.00
288_N318_I0.8921.00
333_V613_T0.8911.00
529_M533_A0.8881.00
334_V338_K0.8871.00
438_W442_R0.8871.00
420_D424_D0.8851.00
101_H104_D0.8821.00
330_A363_L0.8821.00
463_E467_A0.8821.00
426_V437_L0.8811.00
454_A457_A0.8811.00
389_K393_S0.8811.00
52_C56_S0.8801.00
324_F328_D0.8771.00
532_Q537_H0.8761.00
261_V264_I0.8741.00
536_S540_L0.8731.00
377_Y561_S0.8731.00
233_I243_V0.8731.00
396_R403_D0.8701.00
264_I267_F0.8691.00
61_T66_A0.8661.00
388_I512_L0.8661.00
47_M85_M0.8641.00
460_R463_E0.8631.00
548_D551_Q0.8591.00
467_A483_R0.8591.00
91_H98_L0.8581.00
21_P216_N0.8551.00
391_A485_I0.8531.00
193_L197_H0.8531.00
576_E615_A0.8521.00
348_A553_A0.8521.00
316_E319_S0.8511.00
455_A459_Q0.8491.00
103_M109_Q0.8491.00
21_P45_W0.8471.00
364_E368_L0.8461.00
334_V367_L0.8451.00
555_Q567_F0.8431.00
290_L308_L0.8411.00
290_L293_A0.8411.00
466_D469_A0.8411.00
335_N339_T0.8401.00
559_L572_I0.8391.00
154_L158_H0.8371.00
163_G171_Q0.8361.00
68_A71_R0.8361.00
148_S151_D0.8351.00
193_L232_W0.8341.00
422_T425_V0.8341.00
296_L599_A0.8301.00
288_N314_D0.8281.00
263_N267_F0.8281.00
17_A27_V0.8271.00
480_Q484_V0.8261.00
492_T496_Q0.8261.00
363_L556_L0.8261.00
336_R609_K0.8221.00
535_L539_A0.8221.00
575_M580_F0.8191.00
398_I468_L0.8181.00
268_L304_L0.8181.00
160_Q171_Q0.8171.00
511_E514_T0.8151.00
467_A471_E0.8141.00
149_Q170_W0.8121.00
250_D297_I0.8101.00
331_R369_Q0.8101.00
390_D490_L0.8091.00
42_R216_N0.8031.00
381_R384_E0.8031.00
433_R443_E0.8011.00
31_A600_Y0.8001.00
24_N241_G0.7991.00
468_L480_Q0.7981.00
364_E556_L0.7981.00
443_E446_Q0.7941.00
249_D306_K0.7941.00
509_L513_V0.7931.00
145_Y149_Q0.7931.00
581_P595_E0.7921.00
453_R456_S0.7911.00
422_T457_A0.7891.00
429_T440_A0.7871.00
13_K309_W0.7861.00
486_K491_R0.7841.00
22_R216_N0.7841.00
95_H192_L0.7831.00
70_M73_R0.7821.00
194_L228_I0.7821.00
157_H161_S0.7821.00
75_G83_G0.7801.00
330_A362_V0.7801.00
30_G33_S0.7801.00
116_S143_M0.7801.00
174_Y178_Q0.7801.00
218_L244_M0.7791.00
478_H482_D0.7781.00
495_E506_I0.7771.00
399_A532_Q0.7771.00
197_H228_I0.7761.00
334_V372_M0.7761.00
31_A250_D0.7751.00
374_Y556_L0.7751.00
587_D591_R0.7741.00
295_A298_E0.7741.00
337_I367_L0.7741.00
133_D176_A0.7721.00
306_K310_T0.7721.00
537_H542_A0.7700.99
120_L140_R0.7690.99
362_V366_A0.7680.99
287_S314_D0.7680.99
436_T439_Q0.7650.99
347_L554_V0.7650.99
506_I510_E0.7650.99
234_R271_F0.7650.99
231_A235_L0.7640.99
395_L399_A0.7640.99
475_M480_Q0.7630.99
146_I174_Y0.7610.99
326_E362_V0.7600.99
291_S295_A0.7600.99
572_I599_A0.7590.99
156_P174_Y0.7580.99
255_G587_D0.7580.99
100_A209_H0.7580.99
153_G194_L0.7570.99
267_F271_F0.7560.99
286_T289_I0.7540.99
91_H226_N0.7540.99
24_N242_K0.7530.99
418_I422_T0.7510.99
429_T443_E0.7490.99
293_A603_V0.7460.99
382_F388_I0.7460.99
212_E239_D0.7450.99
456_S460_R0.7450.99
252_S256_W0.7440.99
142_A170_W0.7430.99
562_A567_F0.7420.99
300_N596_R0.7410.99
130_M172_K0.7410.99
481_T513_V0.7400.99
60_V64_N0.7400.99
217_I236_L0.7390.99
601_V605_R0.7380.99
98_L199_L0.7370.99
168_Q172_K0.7370.99
483_R486_K0.7360.99
154_L162_Y0.7340.99
532_Q536_S0.7310.99
45_W48_S0.7300.99
86_W213_R0.7290.99
443_E447_E0.7270.99
592_L631_R0.7270.99
428_Q432_D0.7250.99
224_D563_K0.7250.99
519_F526_E0.7240.99
27_V277_I0.7230.99
347_L552_D0.7210.99
264_I268_L0.7210.99
147_N151_D0.7180.99
531_L540_L0.7180.99
390_D393_S0.7170.99
17_A244_M0.7160.99
44_A48_S0.7160.99
531_L535_L0.7160.99
477_L480_Q0.7140.99
392_L396_R0.7130.99
237_A243_V0.7120.99
455_A462_M0.7120.99
532_Q540_L0.7110.99
328_D331_R0.7100.99
534_F538_A0.7090.99
332_F611_T0.7090.99
221_E224_D0.7090.99
385_R388_I0.7080.99
460_R464_L0.7060.99
262_E590_G0.7060.99
144_W148_S0.7060.99
178_Q195_R0.7050.99
215_T240_T0.7030.99
179_E182_D0.7030.99
59_A70_M0.7030.99
114_L181_C0.7020.99
234_R238_G0.7020.99
247_G251_Q0.7000.99
37_R40_V0.7000.99
518_Q522_N0.6990.99
536_S542_A0.6980.99
478_H513_V0.6980.99
572_I575_M0.6980.99
345_G349_E0.6970.99
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422_T458_L0.6760.99
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390_D414_P0.6740.99
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535_L542_A0.6730.99
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191_E195_R0.6710.99
27_V38_V0.6690.99
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225_T229_Q0.6370.98
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517_R521_Y0.5820.97
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362_V365_E0.5580.96
27_V218_L0.5580.96
472_T480_Q0.5580.96
62_F257_R0.5580.96
336_R613_T0.5580.96
159_I171_Q0.5560.96
94_A219_V0.5560.96
265_Q269_N0.5560.96
67_A88_G0.5550.96
60_V90_F0.5540.95
126_L129_A0.5540.95
425_V428_Q0.5540.95
90_F233_I0.5530.95
58_M236_L0.5520.95
19_A49_V0.5520.95
194_L197_H0.5510.95
397_L465_I0.5510.95
513_V516_T0.5500.95
265_Q268_L0.5500.95
221_E601_V0.5490.95
537_H541_E0.5490.95
507_E510_E0.5480.95
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251_Q560_H0.5460.95
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196_A199_L0.5360.95
528_L534_F0.5360.95
530_P533_A0.5350.95
171_Q175_Q0.5340.94
108_P402_N0.5340.94
564_G601_V0.5340.94
244_M256_W0.5330.94
36_T73_R0.5330.94
10_L41_H0.5320.94
142_A145_Y0.5320.94
578_G583_Q0.5320.94
63_T70_M0.5320.94
526_E530_P0.5320.94
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286_T315_G0.5310.94
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300_N635_E0.5310.94
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463_E466_D0.5290.94
429_T432_D0.5280.94
62_F229_Q0.5280.94
70_M87_V0.5280.94
320_L633_I0.5280.94
46_L218_L0.5280.94
511_E515_A0.5270.94
37_R283_Y0.5270.94
422_T454_A0.5270.94
295_A636_L0.5260.94
39_L70_M0.5260.94
387_E509_L0.5260.94
189_F193_L0.5250.94
451_A457_A0.5250.94
94_A193_L0.5240.94
221_E284_R0.5240.94
454_A464_L0.5230.94
20_A242_K0.5230.94
114_L122_L0.5220.94
56_S212_E0.5220.94
560_H563_K0.5220.94
285_S293_A0.5220.94
153_G231_A0.5220.94
26_L268_L0.5210.94
359_Q579_M0.5210.94
101_H206_I0.5200.94
152_E260_Q0.5200.94
63_T69_E0.5190.94
112_Q186_L0.5180.94
115_D118_D0.5170.94
631_R635_E0.5170.94
341_Q554_V0.5160.93
40_V44_A0.5160.93
122_L126_L0.5160.93
471_E487_D0.5150.93
587_D590_G0.5150.93
155_R161_S0.5140.93
211_R240_T0.5140.93
221_E248_D0.5140.93
377_Y555_Q0.5130.93
111_F192_L0.5130.93
493_M496_Q0.5130.93
74_I85_M0.5130.93
564_G605_R0.5130.93
567_F570_V0.5120.93
29_A224_D0.5120.93
114_L119_Q0.5120.93
615_A618_R0.5120.93
247_G264_I0.5110.93
353_L557_M0.5110.93
42_R45_W0.5100.93
20_A46_L0.5100.93
28_L276_T0.5090.93
394_Y414_P0.5090.93
454_A468_L0.5090.93
383_F387_E0.5090.93
535_L538_A0.5090.93
64_N95_H0.5080.93
122_L184_A0.5080.93
248_D563_K0.5070.93
164_N168_Q0.5060.93
48_S51_N0.5050.93
48_S81_S0.5050.93
181_C188_D0.5050.93
416_R464_L0.5050.93
461_F469_A0.5050.93
205_H209_H0.5040.93
61_T69_E0.5040.93
47_M57_I0.5030.93
580_F599_A0.5020.92
328_D332_F0.5020.92
330_A333_V0.5020.92
526_E529_M0.5020.92
330_A574_G0.5010.92
91_H188_D0.5010.92
364_E378_G0.5000.92
298_E307_K0.5000.92
141_Q145_Y0.5000.92
504_T507_E0.5000.92
11_N290_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c2tA 1 0.8903 100 0.096 Contact Map
1pjrA 1 0.8611 100 0.097 Contact Map
3lfuA 1 0.8792 100 0.225 Contact Map
1uaaA 2 0.875 100 0.231 Contact Map
4c2uA 1 0.8972 100 0.242 Contact Map
3u4qA 1 0.9264 100 0.242 Contact Map
1w36B 1 0.9361 100 0.312 Contact Map
3u4qB 1 0.9028 100 0.391 Contact Map
4pj3A 1 0.6958 100 0.576 Contact Map
2xzlA 1 0.5667 100 0.65 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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