GREMLIN Database
DNAA - Chromosomal replication initiator protein DnaA
UniProt: P03004 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10235
Length: 467 (439)
Sequences: 2986 (1854)
Seq/√Len: 88.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
411_M437_V4.0311.00
188_G191_A3.5871.00
185_V265_I3.4901.00
153_A290_L3.2341.00
307_M319_G3.2021.00
189_I231_A3.1991.00
376_I380_Q3.1171.00
448_R458_F3.0051.00
227_R253_T2.8571.00
193_K196_A2.8551.00
321_V359_V2.8371.00
387_Y457_D2.8251.00
426_G431_G2.7151.00
416_E462_I2.6621.00
448_R455_K2.6561.00
48_L52_R2.6061.00
455_K459_S2.5631.00
441_C445_E2.5441.00
258_L288_W2.5271.00
218_A221_E2.5251.00
435_T438_L2.4331.00
376_I414_A2.4111.00
157_V168_L2.4081.00
410_A429_F2.3651.00
50_W54_K2.3631.00
380_Q395_L2.3581.00
23_S27_R2.3551.00
145_K148_Q2.3431.00
209_D226_Y2.3101.00
426_G430_G2.2501.00
199_V229_V2.2481.00
273_K287_G2.2361.00
62_L66_F2.1901.00
29_L40_L2.1891.00
209_D225_Y2.1471.00
12_R65_S2.1331.00
151_R155_R2.1311.00
16_E58_N2.1281.00
250_F266_L2.1271.00
426_G432_R2.1201.00
204_E227_R2.1101.00
143_E151_R2.1091.00
444_I454_I2.0941.00
387_Y409_M2.0791.00
380_Q429_F2.0741.00
309_K337_E2.0591.00
448_R454_I2.0531.00
19_A23_S2.0511.00
284_S332_N2.0471.00
324_F367_L2.0461.00
207_V246_S2.0331.00
390_K393_D2.0141.00
210_M245_R1.9741.00
299_L303_V1.9711.00
384_A391_V1.9591.00
416_E445_E1.9591.00
38_L63_L1.9581.00
447_L451_S1.9521.00
306_L340_L1.9501.00
188_G192_R1.9221.00
32_E39_A1.9171.00
376_I428_A1.9131.00
210_M222_F1.8891.00
341_N348_N1.8561.00
386_Y457_D1.8531.00
214_L219_I1.8081.00
204_E239_F1.8041.00
447_L454_I1.8011.00
357_D360_R1.7971.00
153_A168_L1.7831.00
33_L38_L1.7601.00
446_Q450_E1.7521.00
310_A322_A1.7421.00
380_Q391_V1.7171.00
37_T75_R1.7081.00
233_L267_T1.7011.00
429_F440_A1.7011.00
303_V323_F1.7001.00
381_K385_E1.6971.00
233_L265_I1.6921.00
56_L76_F1.6811.00
223_K249_E1.6781.00
303_V322_A1.6761.00
408_Q439_H1.6741.00
408_Q411_M1.6631.00
67_C71_A1.6631.00
29_L42_A1.6551.00
204_E253_T1.6531.00
51_V76_F1.6431.00
237_I266_L1.6301.00
411_M440_A1.6271.00
422_L441_C1.6221.00
158_A188_G1.5991.00
318_P321_V1.5961.00
227_R249_E1.5781.00
132_V186_G1.5751.00
376_I420_H1.5731.00
31_A41_Y1.5611.00
201_M226_Y1.5461.00
36_N69_A1.5401.00
413_L462_I1.5251.00
377_D428_A1.5231.00
462_I466_S1.5151.00
443_K447_L1.5151.00
356_I360_R1.5121.00
142_V308_K1.5091.00
325_I343_V1.5091.00
41_Y79_G1.5071.00
174_T284_S1.5011.00
255_N259_E1.4991.00
332_N335_E1.4991.00
321_V356_I1.4981.00
249_E253_T1.4951.00
150_A181_L1.4821.00
300_E304_A1.4700.99
391_V395_L1.4640.99
412_A458_F1.4590.99
251_F281_R1.4590.99
60_N70_D1.4580.99
386_Y460_N1.4530.99
424_E427_D1.4480.99
306_L336_L1.4440.99
60_N73_Q1.4390.99
307_M322_A1.4280.99
9_C63_L1.4280.99
14_Q19_A1.4230.99
443_K446_Q1.4210.99
11_A14_Q1.4120.99
290_L345_A1.4110.99
58_N62_L1.4100.99
149_L345_A1.4070.99
22_F26_I1.4040.99
393_D398_R1.3720.99
385_E464_T1.3690.99
138_F184_A1.3660.99
189_I196_A1.3640.99
324_F356_I1.3450.99
14_Q27_R1.3420.99
227_R252_H1.3400.99
64_T70_D1.3320.99
13_L26_I1.3120.99
10_L26_I1.3030.99
14_Q22_F1.2890.99
275_I278_V1.2870.99
282_L286_F1.2780.99
306_L322_A1.2770.99
317_L322_A1.2670.98
26_I51_V1.2650.98
190_M198_V1.2600.98
154_A185_V1.2530.98
210_M214_L1.2510.98
152_A304_A1.2490.98
354_I358_F1.2400.98
199_V225_Y1.2370.98
414_A429_F1.2300.98
405_R447_L1.2280.98
234_I237_I1.2220.98
167_P263_Q1.2130.98
42_A76_F1.2050.98
161_P263_Q1.2050.98
445_E449_E1.2010.98
44_N47_V1.2000.98
347_A358_F1.1990.98
437_V440_A1.1970.98
37_T73_Q1.1940.98
342_R365_D1.1920.98
10_L22_F1.1870.98
8_Q66_F1.1680.97
252_H255_N1.1670.97
454_I457_D1.1630.97
224_R228_S1.1570.97
461_L465_L1.1400.97
302_R329_L1.1370.97
157_V263_Q1.1360.97
203_S240_F1.1280.97
460_N464_T1.1270.97
319_G323_F1.1200.97
313_N341_N1.1160.97
49_D53_D1.1030.96
423_P435_T1.1000.96
438_L442_R1.0950.96
48_L76_F1.0940.96
30_Q41_Y1.0890.96
381_K391_V1.0860.96
155_R188_G1.0860.96
50_W55_Y1.0840.96
173_G176_L1.0790.96
352_R355_T1.0790.96
254_F264_I1.0770.96
207_V211_V1.0770.96
420_H424_E1.0680.96
12_R16_E1.0670.95
248_E252_H1.0650.95
459_S462_I1.0630.95
176_L301_T1.0620.95
309_K340_L1.0580.95
182_L233_L1.0520.95
26_I29_L1.0490.95
343_V359_V1.0480.95
7_Q11_A1.0480.95
452_H455_K1.0470.95
204_E208_Q1.0450.95
329_L339_A1.0410.95
280_D283_K1.0400.95
415_K442_R1.0350.95
56_L60_N1.0330.95
380_Q394_L1.0330.95
278_V282_L1.0290.95
269_D281_R1.0270.94
397_K432_R1.0210.94
172_G294_I1.0140.94
30_Q79_G1.0100.94
382_T465_L1.0100.94
162_G263_Q1.0080.94
12_R66_F1.0060.94
12_R15_D1.0030.94
33_L71_A1.0030.94
187_N291_T1.0020.94
449_E455_K1.0010.94
49_D52_R0.9970.94
132_V187_N0.9960.94
45_R49_D0.9940.93
234_I250_F0.9920.93
239_F252_H0.9880.93
244_E277_G0.9870.93
299_L323_F0.9870.93
256_A260_G0.9830.93
158_A189_I0.9820.93
21_E55_Y0.9690.93
386_Y464_T0.9670.92
210_M219_I0.9670.92
201_M331_S0.9660.92
213_A219_I0.9660.92
387_Y406_P0.9630.92
240_F275_I0.9610.92
358_F362_A0.9580.92
270_R280_D0.9490.92
377_D380_Q0.9450.92
251_F254_F0.9450.92
394_L410_A0.9410.91
379_I418_T0.9390.91
132_V182_L0.9380.91
234_I266_L0.9350.91
13_L58_N0.9320.91
166_N254_F0.9310.91
42_A78_V0.9240.91
408_Q436_T0.9220.91
189_I192_R0.9210.91
389_I394_L0.9180.90
264_I278_V0.9180.90
20_T24_M0.9130.90
342_R346_N0.9130.90
22_F55_Y0.9120.90
43_P47_V0.9080.90
378_N465_L0.9070.90
287_G291_T0.9000.89
169_F291_T0.8970.89
382_T464_T0.8960.89
257_L262_Q0.8940.89
56_L74_L0.8940.89
46_F50_W0.8900.89
16_E61_G0.8890.89
118_D122_A0.8870.89
347_A354_I0.8830.89
5_L63_L0.8800.88
256_A259_E0.8780.88
135_K261_N0.8780.88
28_P47_V0.8760.88
414_A418_T0.8740.88
415_K422_L0.8720.88
217_N245_R0.8680.88
63_L74_L0.8620.87
34_S37_T0.8590.87
380_Q428_A0.8540.87
254_F263_Q0.8540.87
146_S301_T0.8510.87
201_M209_D0.8490.87
374_V465_L0.8480.87
83_V90_A0.8480.87
238_Q269_D0.8460.86
214_L223_K0.8440.86
10_L27_R0.8400.86
343_V354_I0.8390.86
230_D262_Q0.8370.86
5_L67_C0.8370.86
39_A75_R0.8350.86
409_M458_F0.8350.86
227_R239_F0.8350.86
384_A389_I0.8340.86
204_E249_E0.8340.86
380_Q410_A0.8280.85
241_A275_I0.8270.85
454_I458_F0.8270.85
415_K438_L0.8250.85
453_D459_S0.8220.85
422_L437_V0.8190.85
212_K216_N0.8190.85
179_T269_D0.8130.84
339_A363_L0.8120.84
166_N263_Q0.8110.84
85_Q119_N0.8090.84
188_G357_D0.8090.84
323_F327_K0.8080.84
118_D121_P0.8070.84
22_F27_R0.8030.83
38_L48_L0.8020.83
39_A77_E0.8000.83
247_Q309_K0.8000.83
137_T140_N0.7990.83
25_W50_W0.7970.83
410_A414_A0.7930.83
221_E224_R0.7930.83
52_R56_L0.7930.83
359_V419_N0.7920.83
422_L438_L0.7910.82
383_V387_Y0.7900.82
239_F243_K0.7870.82
9_C29_L0.7870.82
251_F255_N0.7870.82
156_Q304_A0.7850.82
227_R257_L0.7840.82
40_L76_F0.7820.82
352_R361_E0.7800.82
144_G298_E0.7800.82
414_A417_L0.7780.81
238_Q266_L0.7780.81
361_E364_R0.7780.81
202_H205_R0.7750.81
335_E363_L0.7750.81
208_Q227_R0.7750.81
404_A439_H0.7740.81
321_V354_I0.7730.81
438_L441_C0.7720.81
352_R358_F0.7710.81
271_Y275_I0.7690.81
5_L9_C0.7690.81
457_D461_L0.7680.81
308_K311_D0.7680.81
157_V166_N0.7670.80
418_T421_S0.7640.80
169_F286_F0.7630.80
21_E24_M0.7620.80
418_T423_P0.7590.80
12_R62_L0.7590.80
41_Y77_E0.7570.80
391_V394_L0.7560.80
146_S298_E0.7560.80
182_L265_I0.7550.79
207_V243_K0.7520.79
144_G176_L0.7510.79
42_A51_V0.7480.79
346_N358_F0.7460.79
409_M413_L0.7450.79
239_F248_E0.7450.79
264_I362_A0.7430.78
415_K441_C0.7420.78
324_F404_A0.7410.78
167_P254_F0.7400.78
343_V362_A0.7400.78
132_V183_H0.7380.78
283_K287_G0.7370.78
379_I413_L0.7370.78
447_L450_E0.7360.78
399_R439_H0.7340.78
42_A47_V0.7330.77
267_T277_G0.7330.77
176_L333_V0.7320.77
5_L8_Q0.7310.77
133_N183_H0.7300.77
55_Y58_N0.7290.77
417_L461_L0.7290.77
308_K312_E0.7270.77
254_F258_L0.7270.77
212_K215_Q0.7260.77
203_S403_V0.7230.76
409_M450_E0.7200.76
251_F269_D0.7190.76
220_E224_R0.7180.76
206_F253_T0.7170.76
417_L462_I0.7170.76
139_D188_G0.7170.76
398_R403_V0.7140.76
405_R432_R0.7130.75
10_L14_Q0.7120.75
143_E148_Q0.7120.75
16_E62_L0.7110.75
29_L51_V0.7110.75
207_V210_M0.7110.75
13_L62_L0.7100.75
401_R405_R0.7100.75
17_L26_I0.7090.75
463_R466_S0.7090.75
418_T422_L0.7080.75
359_V362_A0.7030.74
25_W28_P0.7000.74
223_K253_T0.7000.74
411_M429_F0.6990.74
149_L290_L0.6980.74
296_P365_D0.6940.73
44_N78_V0.6920.73
237_I286_F0.6900.73
149_L291_T0.6890.73
90_A120_V0.6880.73
22_F76_F0.6840.72
186_G198_V0.6830.72
36_N73_Q0.6830.72
203_S238_Q0.6810.72
176_L326_A0.6800.72
33_L67_C0.6800.72
182_L235_D0.6800.72
87_P121_P0.6790.72
25_W408_Q0.6770.72
141_F181_L0.6760.72
209_D363_L0.6750.71
308_K385_E0.6740.71
126_P197_K0.6730.71
4_S7_Q0.6720.71
234_I291_T0.6720.71
372_K406_P0.6700.71
159_D188_G0.6680.71
79_G82_P0.6680.71
145_K292_V0.6670.70
432_R453_D0.6660.70
13_L17_L0.6650.70
182_L398_R0.6650.70
40_L436_T0.6650.70
247_Q278_V0.6640.70
61_G65_S0.6610.70
86_T90_A0.6610.70
162_G421_S0.6610.70
301_T304_A0.6610.70
8_Q12_R0.6600.70
160_N163_G0.6590.70
427_D431_G0.6570.69
174_T205_R0.6570.69
413_L417_L0.6570.69
208_Q253_T0.6550.69
460_N463_R0.6550.69
456_E460_N0.6540.69
8_Q11_A0.6530.69
345_A349_F0.6490.68
117_W122_A0.6480.68
401_R408_Q0.6470.68
324_F328_R0.6460.68
157_V293_A0.6440.68
245_R248_E0.6440.68
302_R306_L0.6440.68
439_H443_K0.6410.67
289_G434_H0.6400.67
235_D269_D0.6400.67
60_N64_T0.6380.67
208_Q223_K0.6370.67
43_P78_V0.6370.67
240_F292_V0.6340.67
210_M217_N0.6330.67
157_V167_P0.6330.67
271_Y291_T0.6330.67
38_L71_A0.6320.66
378_N381_K0.6320.66
155_R159_D0.6320.66
219_I432_R0.6320.66
340_L363_L0.6310.66
176_L300_E0.6310.66
276_N341_N0.6310.66
167_P255_N0.6300.66
457_D460_N0.6280.66
417_L423_P0.6270.66
405_R457_D0.6260.66
393_D402_S0.6250.66
253_T301_T0.6230.65
394_L404_A0.6230.65
423_P429_F0.6230.65
14_Q55_Y0.6230.65
91_V118_D0.6200.65
159_D192_R0.6190.65
252_H345_A0.6190.65
225_Y237_I0.6170.65
63_L67_C0.6160.64
393_D409_M0.6160.64
57_N353_A0.6160.64
258_L266_L0.6150.64
87_P93_S0.6140.64
318_P353_A0.6120.64
120_V123_P0.6110.64
278_V283_K0.6110.64
253_T257_L0.6100.64
176_L332_N0.6100.64
247_Q279_E0.6100.64
229_V310_A0.6090.64
382_T461_L0.6080.63
82_P86_T0.6080.63
261_N266_L0.6070.63
84_T90_A0.6040.63
88_Q93_S0.6040.63
238_Q338_G0.6020.63
296_P332_N0.6020.63
52_R60_N0.6020.63
302_R330_R0.6020.63
409_M444_I0.6010.63
206_F227_R0.5990.62
405_R409_M0.5990.62
137_T187_N0.5980.62
399_R433_D0.5980.62
435_T439_H0.5980.62
405_R444_I0.5970.62
146_S294_I0.5970.62
311_D317_L0.5950.62
156_Q295_E0.5930.61
31_A79_G0.5920.61
238_Q250_F0.5910.61
27_R154_A0.5910.61
380_Q414_A0.5900.61
153_A331_S0.5900.61
219_I253_T0.5900.61
156_Q293_A0.5900.61
14_Q29_L0.5890.61
188_G308_K0.5880.61
375_T378_N0.5880.61
382_T385_E0.5860.61
204_E252_H0.5860.61
396_S438_L0.5860.61
214_L228_S0.5860.61
170_L292_V0.5850.60
136_H201_M0.5840.60
174_T342_R0.5840.60
247_Q293_A0.5840.60
290_L342_R0.5810.60
253_T256_A0.5800.60
235_D338_G0.5800.60
245_R422_L0.5800.60
38_L67_C0.5800.60
413_L461_L0.5780.60
237_I267_T0.5780.60
183_H186_G0.5780.60
325_I363_L0.5770.59
83_V195_N0.5760.59
31_A77_E0.5750.59
165_Y287_G0.5750.59
58_N61_G0.5750.59
298_E301_T0.5740.59
458_F462_I0.5740.59
277_G283_K0.5730.59
314_D391_V0.5710.59
401_R448_R0.5700.58
229_V465_L0.5690.58
151_R187_N0.5680.58
203_S234_I0.5670.58
241_A270_R0.5670.58
226_Y254_F0.5660.58
146_S321_V0.5660.58
214_L253_T0.5650.58
88_Q357_D0.5640.58
345_A418_T0.5630.58
83_V89_A0.5630.58
54_K432_R0.5630.58
255_N285_R0.5610.57
159_D325_I0.5610.57
406_P409_M0.5590.57
83_V91_V0.5590.57
84_T120_V0.5580.57
50_W403_V0.5570.57
279_E283_K0.5570.57
381_K424_E0.5560.57
400_S404_A0.5560.57
92_T117_W0.5550.56
74_L118_D0.5540.56
210_M223_K0.5540.56
378_N382_T0.5540.56
422_L435_T0.5540.56
140_N313_N0.5540.56
87_P91_V0.5530.56
40_L191_A0.5520.56
246_S375_T0.5510.56
389_I404_A0.5510.56
258_L341_N0.5500.56
267_T270_R0.5490.56
268_S286_F0.5490.56
420_H428_A0.5480.56
18_P21_E0.5480.56
427_D453_D0.5480.56
220_E398_R0.5470.55
148_Q155_R0.5470.55
251_F286_F0.5460.55
145_K248_E0.5440.55
270_R277_G0.5430.55
149_L292_V0.5420.55
17_L25_W0.5420.55
25_W247_Q0.5410.55
411_M439_H0.5410.55
154_A157_V0.5400.54
301_T349_F0.5390.54
377_D381_K0.5380.54
453_D457_D0.5370.54
127_T197_K0.5370.54
26_I272_P0.5370.54
62_L202_H0.5370.54
33_L397_K0.5360.54
262_Q271_Y0.5360.54
25_W436_T0.5360.54
432_R439_H0.5360.54
305_I333_V0.5360.54
261_N343_V0.5350.54
211_V239_F0.5340.54
186_G340_L0.5330.53
389_I464_T0.5310.53
231_A395_L0.5310.53
190_M194_P0.5300.53
129_R190_M0.5290.53
145_K323_F0.5290.53
223_K261_N0.5280.53
238_Q281_R0.5270.53
201_M373_L0.5270.53
455_K462_I0.5260.53
81_K85_Q0.5250.52
223_K227_R0.5250.52
266_L286_F0.5250.52
41_Y76_F0.5240.52
233_L245_R0.5240.52
427_D432_R0.5230.52
277_G333_V0.5220.52
14_Q59_I0.5210.52
320_E356_I0.5210.52
87_P92_T0.5200.52
19_A465_L0.5200.52
386_Y461_L0.5200.52
204_E248_E0.5200.52
168_L290_L0.5180.51
279_E359_V0.5180.51
37_T185_V0.5170.51
200_Y267_T0.5160.51
4_S53_D0.5150.51
380_Q420_H0.5150.51
433_D443_K0.5130.51
451_S454_I0.5130.51
169_F272_P0.5130.51
87_P123_P0.5130.51
400_S406_P0.5120.51
382_T386_Y0.5120.51
421_S437_V0.5110.50
415_K423_P0.5110.50
189_I195_N0.5110.50
369_L375_T0.5100.50
88_Q91_V0.5090.50
275_I415_K0.5060.50
52_R307_M0.5060.50
174_T183_H0.5060.50
32_E445_E0.5060.50
40_L56_L0.5050.50
270_R282_L0.5050.50
186_G267_T0.5040.50
165_Y252_H0.5040.50
235_D263_Q0.5040.50
204_E243_K0.5030.49
167_P235_D0.5030.49
408_Q443_K0.5020.49
208_Q275_I0.5020.49
207_V223_K0.5010.49
65_S124_A0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z4sA 1 0.5118 100 0.401 Contact Map
1l8qA 1 0.6788 100 0.583 Contact Map
3nbxX 1 0.6724 100 0.661 Contact Map
3bosA 2 0.4925 100 0.763 Contact Map
4w5wA 1 0.5054 100 0.782 Contact Map
1j1vA 1 0.2013 100 0.784 Contact Map
3pvvA 1 0.1991 100 0.79 Contact Map
2qgzA 1 0.3683 100 0.793 Contact Map
2r44A 1 0.5675 100 0.817 Contact Map
3u61B 3 0.6574 100 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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