GREMLIN Database
LAMB - Maltoporin
UniProt: P02943 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10528
Length: 446 (395)
Sequences: 590 (383)
Seq/√Len: 19.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_N108_E7.5951.00
392_A436_W4.0361.00
139_M382_I3.9081.00
34_S65_T3.7631.00
47_C63_C3.5731.00
347_T372_L3.4541.00
207_N246_Q3.3831.00
345_M374_Q3.2531.00
70_K88_N3.2130.99
375_Q387_A3.1970.99
145_W215_G3.1920.99
82_S114_K3.1560.99
155_E167_A2.8350.99
341_W347_T2.7430.98
166_L199_V2.6890.98
385_R443_E2.6170.98
166_L197_F2.5600.97
57_Y334_G2.5380.97
207_N244_H2.5160.97
347_T374_Q2.4730.97
257_V297_I2.3230.95
32_A442_M2.3160.95
58_R141_D2.2790.95
162_G201_L2.2520.94
214_L242_A2.2510.94
341_W374_Q2.2320.94
210_G244_H2.2000.94
27_D72_G2.1800.93
346_S375_Q2.1650.93
125_I376_W2.1540.93
140_I314_V2.1440.93
58_R62_E2.1400.93
207_N210_G2.1340.93
86_D110_N2.1310.93
15_A19_M2.1160.92
351_I370_I2.0750.92
164_L199_V2.0640.91
345_M375_Q2.0460.91
66_Y136_D2.0200.90
72_G84_Y1.9310.88
10_L14_V1.9230.88
68_E88_N1.9160.88
161_F201_L1.8980.87
7_K12_V1.8950.87
330_W356_V1.8830.87
62_E141_D1.8750.87
348_V375_Q1.8670.86
349_M370_I1.8570.86
258_Q296_R1.8410.86
204_M214_L1.8340.85
216_V240_F1.8280.85
245_T254_K1.7880.84
385_R445_W1.7750.83
138_H385_R1.7610.83
309_W349_M1.7450.82
7_K11_A1.7240.82
376_W388_I1.7100.81
70_K108_E1.6850.80
33_R141_D1.6840.80
210_G246_Q1.6810.80
346_S387_A1.6620.79
159_V164_L1.6490.79
14_V24_M1.6280.78
6_R11_A1.6280.78
90_A107_R1.6180.77
74_E77_K1.6160.77
84_Y112_Q1.5970.76
259_Y295_L1.5970.76
56_K354_D1.5970.76
108_E131_F1.5960.76
56_K334_G1.5950.76
330_W354_D1.5760.75
115_N122_G1.5660.75
68_E131_F1.5650.75
155_E198_D1.5610.75
16_A19_M1.5580.74
386_P445_W1.5550.74
141_D389_R1.5250.73
152_A440_A1.5250.73
8_L21_A1.5200.73
252_F302_A1.4940.71
58_R369_K1.4840.71
313_Y374_Q1.4640.70
310_D340_K1.4630.70
386_P443_E1.4600.69
17_G21_A1.4590.69
10_L13_A1.4480.69
148_S198_D1.4380.68
262_D374_Q1.4360.68
35_G58_R1.4320.68
33_R58_R1.4210.67
33_R62_E1.4200.67
388_I440_A1.4190.67
21_A24_M1.4130.67
371_T393_T1.4090.67
206_I210_G1.4060.66
133_Q156_N1.3840.65
304_S310_D1.3680.64
108_E130_R1.3620.64
319_D329_K1.3550.63
90_A136_D1.3450.63
90_A105_A1.3430.63
241_T258_Q1.3420.63
165_S202_A1.3350.62
10_L19_M1.3340.62
161_F205_E1.3340.62
301_G313_Y1.3330.62
138_H445_W1.3280.62
19_M24_M1.3280.62
8_L11_A1.3260.62
310_D347_T1.3260.62
88_N131_F1.3060.61
41_S327_G1.3040.60
158_D161_F1.2990.60
269_K272_S1.2980.60
32_A85_F1.2960.60
383_W443_E1.2870.59
342_T390_V1.2820.59
18_V21_A1.2780.59
7_K10_L1.2760.59
30_G446_W1.2640.58
172_S387_A1.2630.58
49_Q53_A1.2570.57
90_A143_Y1.2540.57
75_V85_F1.2520.57
62_E369_K1.2470.57
315_G333_V1.2420.57
56_K395_A1.2420.57
77_K80_D1.2350.56
111_V388_I1.2300.56
72_G86_D1.2270.56
253_N299_D1.2210.55
7_K21_A1.2170.55
35_G141_D1.2150.55
122_G158_D1.2130.55
57_Y367_Q1.2120.55
69_L87_T1.2110.55
164_L201_L1.2100.55
34_S98_D1.1890.53
62_E389_R1.1890.53
55_S140_I1.1890.53
389_R441_Q1.1890.53
200_R337_P1.1860.53
141_D369_K1.1740.52
367_Q395_A1.1740.52
334_G395_A1.1740.52
14_V18_V1.1740.52
215_G241_T1.1610.51
303_I309_W1.1580.51
152_A167_A1.1550.51
133_Q165_S1.1530.51
405_Y429_G1.1510.51
18_V24_M1.1420.50
336_R389_R1.1370.50
256_V298_L1.1370.50
33_R389_R1.1290.49
253_N339_Y1.1290.49
343_P379_G1.1270.49
66_Y138_H1.1190.49
79_G344_I1.1180.49
18_V25_A1.1140.48
93_V106_F1.1110.48
341_W379_G1.1040.48
57_Y312_M1.1020.48
203_Q211_T1.0990.48
319_D327_G1.0940.47
17_G24_M1.0930.47
12_V15_A1.0920.47
74_E82_S1.0900.47
57_Y395_A1.0890.47
138_H383_W1.0870.47
138_H443_E1.0850.47
132_Y155_E1.0850.47
98_D129_K1.0840.47
58_R389_R1.0770.46
144_Y298_L1.0750.46
431_G436_W1.0740.46
341_W345_M1.0710.46
70_K86_D1.0700.46
10_L21_A1.0670.45
353_Y366_N1.0650.45
28_F270_G1.0630.45
302_A312_M1.0620.45
57_Y354_D1.0540.45
92_S99_W1.0490.44
214_L324_N1.0470.44
303_I311_M1.0380.44
137_V314_V1.0360.44
355_N364_K1.0320.43
15_A22_Q1.0280.43
26_V72_G1.0270.43
206_I244_H1.0260.43
172_S346_S1.0210.43
297_I353_Y1.0200.43
50_T53_A1.0190.42
135_H145_W1.0170.42
216_V238_W1.0160.42
16_A24_M1.0150.42
255_F299_D1.0140.42
136_D143_Y1.0130.42
84_Y110_N1.0090.42
302_A382_I1.0060.42
268_G294_M0.9990.41
363_D440_A0.9960.41
57_Y397_W0.9940.41
124_T390_V0.9860.40
55_S316_M0.9860.40
133_Q200_R0.9840.40
271_L275_S0.9760.40
78_E321_N0.9730.40
140_I316_M0.9710.40
144_Y241_T0.9690.39
6_R14_V0.9690.39
68_E134_R0.9640.39
28_F71_L0.9620.39
8_L15_A0.9620.39
258_Q441_Q0.9600.39
37_G45_Q0.9550.39
11_A15_A0.9500.38
7_K14_V0.9470.38
17_G342_T0.9460.38
10_L399_E0.9360.37
154_L157_I0.9340.37
338_M348_V0.9340.37
209_G246_Q0.9300.37
98_D102_T0.9240.37
125_I154_L0.9180.36
147_I217_D0.9160.36
77_K291_N0.9160.36
112_Q155_E0.9160.36
53_A56_K0.9140.36
9_P14_V0.9140.36
160_G371_T0.9130.36
354_D367_Q0.9110.36
57_Y330_W0.9100.36
16_A351_I0.9090.36
395_A435_E0.9060.36
255_F297_I0.9060.36
381_S384_S0.9030.35
168_A197_F0.9020.35
350_E369_K0.9020.35
99_W383_W0.9020.35
67_A91_Y0.8990.35
36_I71_L0.8970.35
9_P13_A0.8960.35
356_V393_T0.8950.35
346_S377_Q0.8950.35
341_W349_M0.8880.35
212_L244_H0.8860.34
139_M298_L0.8840.34
312_M334_G0.8830.34
231_D372_L0.8830.34
67_A113_G0.8830.34
68_E132_Y0.8800.34
145_W148_S0.8790.34
243_E254_K0.8700.34
24_M297_I0.8680.33
396_K433_S0.8670.33
131_F134_R0.8670.33
36_I168_A0.8660.33
61_N391_F0.8630.33
177_S190_N0.8590.33
392_A398_D0.8550.33
132_Y167_A0.8540.33
296_R441_Q0.8520.33
78_E438_F0.8510.32
12_V19_M0.8500.32
390_V440_A0.8480.32
12_V23_A0.8440.32
199_V362_G0.8400.32
313_Y347_T0.8350.32
340_K381_S0.8320.31
9_P20_S0.8300.31
142_F296_R0.8280.31
14_V17_G0.8270.31
392_A438_F0.8260.31
57_Y301_G0.8260.31
7_K18_V0.8240.31
158_D163_K0.8230.31
18_V22_Q0.8150.31
262_D347_T0.8150.31
29_H331_W0.8120.30
98_D107_R0.8110.30
49_Q57_Y0.8110.30
52_G334_G0.8080.30
157_I388_I0.8050.30
60_G371_T0.8040.30
214_L226_N0.8020.30
215_G239_L0.8020.30
91_Y104_P0.7970.30
214_L236_D0.7960.29
86_D112_Q0.7950.29
40_G291_N0.7930.29
29_H70_K0.7920.29
37_G170_R0.7890.29
8_L12_V0.7860.29
65_T150_P0.7860.29
132_Y198_D0.7840.29
163_K316_M0.7790.29
295_L317_Y0.7770.29
214_L240_F0.7770.29
367_Q397_W0.7770.29
334_G367_Q0.7770.29
262_D341_W0.7750.28
388_I442_M0.7740.28
297_I363_D0.7740.28
353_Y396_K0.7710.28
16_A22_Q0.7710.28
31_Y62_E0.7710.28
297_I327_G0.7670.28
203_Q206_I0.7650.28
146_D275_S0.7650.28
71_L94_A0.7650.28
108_E213_E0.7640.28
304_S340_K0.7630.28
304_S307_D0.7630.28
117_I120_L0.7580.28
38_W235_K0.7580.28
59_L62_E0.7570.27
136_D445_W0.7560.27
18_V343_P0.7560.27
14_V309_W0.7550.27
144_Y243_E0.7530.27
8_L23_A0.7520.27
164_L204_M0.7520.27
87_T106_F0.7510.27
6_R18_V0.7500.27
71_L241_T0.7490.27
398_D401_W0.7480.27
318_Q330_W0.7430.27
56_K367_Q0.7420.27
138_H441_Q0.7410.27
301_G341_W0.7400.27
336_R441_Q0.7400.27
31_Y35_G0.7320.26
144_Y258_Q0.7290.26
354_D391_F0.7280.26
167_A198_D0.7280.26
88_N110_N0.7270.26
156_N202_A0.7260.26
20_S321_N0.7260.26
157_I166_L0.7240.26
82_S110_N0.7240.26
56_K393_T0.7230.26
24_M370_I0.7210.26
66_Y385_R0.7200.26
136_D383_W0.7190.26
21_A25_A0.7170.25
296_R318_Q0.7160.25
209_G342_T0.7160.25
16_A109_A0.7140.25
13_A17_G0.7130.25
10_L321_N0.7130.25
155_E163_K0.7130.25
204_M212_L0.7120.25
141_D350_E0.7090.25
333_V379_G0.7090.25
250_K433_S0.7090.25
18_V23_A0.7080.25
114_K253_N0.7070.25
17_G305_M0.7070.25
58_R350_E0.7060.25
84_Y124_T0.7040.25
197_F434_D0.7040.25
141_D336_R0.7040.25
9_P24_M0.7030.25
20_S372_L0.7030.25
45_Q195_D0.7030.25
59_L141_D0.6990.25
60_G336_R0.6990.25
118_E250_K0.6970.25
133_Q202_A0.6960.24
50_T334_G0.6950.24
315_G331_W0.6930.24
334_G397_W0.6920.24
10_L23_A0.6910.24
153_G336_R0.6910.24
90_A99_W0.6880.24
12_V125_I0.6870.24
50_T57_Y0.6870.24
320_I328_T0.6850.24
71_L106_F0.6840.24
9_P15_A0.6820.24
123_S156_N0.6810.24
297_I383_W0.6790.24
78_E110_N0.6790.24
316_M381_S0.6780.24
168_A195_D0.6770.24
257_V295_L0.6750.24
242_A440_A0.6740.23
262_D345_M0.6740.23
14_V19_M0.6730.23
327_G357_E0.6720.23
262_D294_M0.6700.23
167_A213_E0.6700.23
48_F56_K0.6690.23
51_T405_Y0.6620.23
125_I388_I0.6610.23
309_W401_W0.6610.23
35_G62_E0.6560.23
141_D153_G0.6550.23
296_R373_A0.6520.22
89_V97_N0.6500.22
58_R371_T0.6500.22
16_A247_S0.6500.22
85_F111_V0.6470.22
28_F335_I0.6470.22
256_V378_A0.6450.22
310_D384_S0.6440.22
29_H247_S0.6430.22
439_G443_E0.6430.22
85_F109_A0.6430.22
58_R336_R0.6410.22
187_D190_N0.6400.22
260_A396_K0.6380.22
57_Y356_V0.6370.22
149_G337_P0.6370.22
79_G233_A0.6360.22
173_E377_Q0.6300.22
218_Y301_G0.6280.21
32_A48_F0.6270.21
143_Y383_W0.6270.21
39_T322_W0.6270.21
172_S195_D0.6270.21
377_Q387_A0.6260.21
311_M335_I0.6250.21
135_H243_E0.6250.21
155_E446_W0.6230.21
172_S338_M0.6200.21
139_M349_M0.6200.21
313_Y341_W0.6190.21
37_G391_F0.6190.21
12_V78_E0.6180.21
350_E389_R0.6160.21
58_R153_G0.6160.21
28_F72_G0.6140.21
62_E68_E0.6130.21
42_G66_Y0.6130.21
15_A112_Q0.6120.21
197_F293_H0.6120.21
102_T438_F0.6110.21
61_N393_T0.6110.21
115_N123_S0.6110.21
128_G439_G0.6090.21
297_I440_A0.6080.21
9_P21_A0.6060.21
369_K446_W0.6060.21
122_G144_Y0.6020.20
112_Q124_T0.6000.20
134_R445_W0.6000.20
301_G392_A0.5990.20
215_G258_Q0.5970.20
195_D295_L0.5960.20
155_E213_E0.5960.20
96_Q103_D0.5960.20
143_Y146_D0.5950.20
106_F159_V0.5940.20
129_K149_G0.5940.20
57_Y393_T0.5930.20
219_G313_Y0.5920.20
237_G260_A0.5920.20
111_V195_D0.5910.20
95_Q100_E0.5910.20
22_Q206_I0.5900.20
140_I328_T0.5900.20
110_N343_P0.5900.20
386_P439_G0.5900.20
153_G389_R0.5890.20
69_L108_E0.5880.20
352_G371_T0.5870.20
136_D139_M0.5870.20
8_L13_A0.5850.20
300_H312_M0.5850.20
107_R131_F0.5840.20
135_H217_D0.5840.20
40_G177_S0.5820.20
163_K254_K0.5810.19
36_I234_S0.5810.19
25_A36_I0.5800.19
78_E357_E0.5790.19
54_Q356_V0.5790.19
34_S308_N0.5770.19
300_H314_V0.5770.19
134_R198_D0.5760.19
104_P110_N0.5750.19
247_S252_F0.5740.19
127_A216_V0.5740.19
125_I216_V0.5730.19
172_S201_L0.5730.19
39_T43_G0.5710.19
90_A138_H0.5710.19
23_A104_P0.5700.19
48_F367_Q0.5670.19
369_K389_R0.5660.19
47_C53_A0.5660.19
244_H253_N0.5650.19
10_L16_A0.5650.19
35_G59_L0.5640.19
66_Y132_Y0.5630.19
187_D192_T0.5630.19
29_H112_Q0.5620.19
155_E165_S0.5610.19
139_M350_E0.5590.19
198_D317_Y0.5590.19
140_I312_M0.5580.19
356_V365_N0.5580.19
400_K435_E0.5570.19
86_D212_L0.5560.19
64_E292_G0.5550.18
99_W105_A0.5550.18
116_L125_I0.5550.18
152_A393_T0.5540.18
38_W199_V0.5540.18
6_R22_Q0.5530.18
204_M371_T0.5530.18
34_S260_A0.5520.18
187_D295_L0.5490.18
128_G153_G0.5480.18
84_Y135_H0.5470.18
389_R439_G0.5470.18
354_D446_W0.5470.18
195_D220_R0.5470.18
364_K400_K0.5460.18
89_V106_F0.5450.18
82_S124_T0.5440.18
11_A163_K0.5440.18
90_A252_F0.5440.18
136_D385_R0.5430.18
57_Y320_I0.5430.18
49_Q54_Q0.5420.18
197_F315_G0.5420.18
48_F354_D0.5410.18
14_V306_G0.5410.18
290_N293_H0.5390.18
200_R239_L0.5390.18
39_T437_T0.5380.18
128_G151_G0.5370.18
287_N399_E0.5370.18
138_H237_G0.5370.18
38_W438_F0.5350.18
134_R149_G0.5350.18
148_S215_G0.5350.18
27_D42_G0.5340.18
22_Q321_N0.5330.18
216_V290_N0.5320.18
140_I205_E0.5310.18
241_T351_I0.5300.18
323_D327_G0.5290.17
262_D292_G0.5270.17
11_A211_T0.5270.17
11_A160_G0.5240.17
136_D152_A0.5220.17
10_L18_V0.5210.17
216_V236_D0.5210.17
95_Q446_W0.5200.17
305_M311_M0.5190.17
143_Y312_M0.5190.17
257_V308_N0.5190.17
33_R441_Q0.5180.17
387_A441_Q0.5180.17
159_V232_G0.5160.17
157_I390_V0.5150.17
237_G373_A0.5150.17
339_Y349_M0.5150.17
439_G445_W0.5140.17
37_G165_S0.5140.17
152_A243_E0.5130.17
8_L158_D0.5130.17
112_Q375_Q0.5120.17
391_F441_Q0.5120.17
75_V378_A0.5120.17
52_G56_K0.5120.17
42_G61_N0.5110.17
129_K170_R0.5090.17
27_D84_Y0.5090.17
317_Y377_Q0.5090.17
53_A140_I0.5090.17
157_I242_A0.5080.17
15_A21_A0.5080.17
101_A216_V0.5070.17
141_D371_T0.5070.17
145_W217_D0.5070.17
244_H304_S0.5070.17
341_W372_L0.5070.17
259_Y319_D0.5040.17
224_R248_V0.5040.17
312_M340_K0.5020.17
107_R254_K0.5010.16
107_R138_H0.5010.16
299_D368_Y0.5010.16
53_A354_D0.5010.16
371_T389_R0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1af6A 3 0.9439 100 0.177 Contact Map
1a0sP 3 0.852 100 0.271 Contact Map
2vdaB 1 0.0561 93 0.957 Contact Map
2o4vA 3 0.7287 92.8 0.957 Contact Map
2fgqX 3 0.704 92 0.958 Contact Map
2zfgA 3 0.722 91.3 0.959 Contact Map
1phoA 3 0.6973 89.8 0.96 Contact Map
3vy8X 3 0.7018 86.2 0.963 Contact Map
2wjrA 1 0.4372 85.8 0.963 Contact Map
4fqeA 1 0.3812 83.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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